Changes in Pain and Psychosocial Functioning and Transition to Chronic Pain in Pediatric Sickle Cell Disease: A Cohort Follow-up Study
This study aimed to: (1) examine changes in pain, psychosocial functioning, and health care utilization among children and adolescents with sickle cell disease (SCD) over a 2-year period and (2) identify baseline biopsychosocial variables associated with the development and maintenance of chronic SCD pain at follow-up.
Materials and Methods:
Forty-two youth (8 to 18 y old) with SCD completed a battery of self-report measures at baseline and 2-year follow-up. Analgesic, Anesthetic, and Addiction Clinical Trial Translational Innovations Opportunities and Networks and American Pain Society Pain Taxonomy (AAPT) diagnostic...
Source: The Clinical Journal of Pain - May 11, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research
Effect on Opioids Requirement of Early Administration of Intranasal Ketamine for Acute Traumatic Pain
Objectives:
To evaluate the efficacy and safety of early administration of low-dose intranasal ketamine on reducing the need for opioid and nonopioid analgesic agents in emergency department (ED) patients with acute moderate to severe acute limbs’ trauma pain.
Patients and Methods:
This is a double-blind, randomized, prospective, controlled study conducted in the ED. The included patients were randomly assigned to intranasal pulverization of ketamine or placebo. Protocol treatment was given at the triage. The primary outcome is the need for opioids during ED stay. Secondary outcome included the requirement of nonopi...
Source: The Clinical Journal of Pain - May 11, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research
Neurological Complication Rates of Epidural Injections and Selective Nerve Blocks: A Comparison of Steroid Use Patterns
Discussion:
At the cervicothoracic level, the incidence rate of neurological complications with particulate steroid injections was higher than that with nonparticulate steroid injections. Injections with nonparticulate steroids and without steroids were equally safe. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - May 11, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research
Quality of Life in Youth With Chronic Pain: An Examination of Youth and Parent Resilience and Risk Factors
Discussion:
The results are discussed in the context of the resilience-risk framework and current understandings of the role of parental factors for pediatric chronic pain. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - May 11, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research
Contribution of COMT and BDNF Genotype and Expression to the Risk of Transition From Acute to Chronic Low Back Pain
Discussion:
CLBP was characterized by higher reported pain burden and augmented hypersensitivity at LBP onset. COMT expression and genotype were associated with acute pain burden and likelihood of transition to CLBP. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - May 11, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research
Sex Bias and Genotype Influence on Opioid Safety Profile in Chronic Low Back Pain
Conclusions:
Sex bias affects female patients resulting in a CLBP diagnostic delay and a different analgesic safety profile. Moreover, the individual’s genetic background might be useful to predict certain AEs in opioid-naive patients under an opioid titration procedure. Addressing sex in necessary to resolve inequalities in health care access. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - May 11, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research
The Influence of a Positive Empathetic Interaction on Conditioned Pain Modulation and Manipulation-induced Analgesia in People With Lateral Epicondylalgia
Objective:
Conditioned pain modulation (CPM) and manipulation-induced analgesia (MIA) are 2 forms of endogenous analgesia. Many forms of analgesia can be influenced by the nature of the patient-clinician interaction. The aim of this study was to evaluate the influence of an empathetic and supportive interaction on CPM and MIA in people with lateral epicondylalgia (LE).
Material and Methods:
In a double-blind, randomized, controlled trial, 68 participants with LE were assigned to 2 groups: the empathetic and neutral interaction groups. The interactions were carried out by a trained, professional role-play actor, playin...
Source: The Clinical Journal of Pain - May 11, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research
Efficacy and Safety of Tapentadol Immediate Release for Acute Pain: A Systematic Review and Meta-Analysis
Objective:
Tapentadol (TAP) immediate release (IR) is a newer opioid option for acute pain. The aim of this systematic review was to examine the efficacy and safety of TAP IR compared with other opioids for acute pain.
Methods:
A systematic literature search as conducted using the Cochrane Library, Embase, International Pharmaceutical Abstracts, MEDLINE, PubMed, and Web of Science. The search included all randomized controlled trials and observational studies examining TAP IR versus other orally administered IR opioids for acute pain. The protocol for this study was registered on PROSPERO (CRD42018110267).
Results:
...
Source: The Clinical Journal of Pain - April 7, 2020 Category: Anesthesiology Tags: Review Articles Source Type: research
A Systematic Review of Clinical Practice Guidelines for Acute Procedural Pain on Neonates
Discussion:
The results of this review show that there is a need to improve the methodological quality of guidelines for procedural pain in newborns. The set of recommendations for procedural pain prevention needs to involve not only pharmacological and nonpharmacological pain treatment but also parents and interprofessional collaboration. It is also essential to take into account facilitators, barriers, and the context to improve pain management. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - April 7, 2020 Category: Anesthesiology Tags: Review Articles Source Type: research
Association Between Inflammatory Biomarkers and Nonspecific Low Back Pain: A Systematic Review
Discussion:
Our findings support the notion of a positive association between inflammatory biomarkers and nonspecific LBP, specifically for CRP, TNFs, and IL-6. Although further high quality longitudinal studies are needed to confirm these findings and evaluate the magnitude of these associations, our findings suggest a role of inflammation in the pathogenesis of nonspecific LBP. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - April 7, 2020 Category: Anesthesiology Tags: Review Articles Source Type: research
Social Factors, Disability, and Depressive Symptoms in Adults With Chronic Pain
Discussion:
The study provides important new findings regarding the associations between social factors and physical and psychological functioning of individuals with chronic pain, supporting biopsychosocial models. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - April 7, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research
Variables Associated With Administration of Nurse-initiated Analgesia in Pediatric Triage
We examined variables that influence the provision of analgesia in a pediatric emergency department that uses TNIA.
Methods:
A 4-year retrospective cohort study of all children with triage pain scores ≥1 was conducted. Data on demographics and patients’ and nurses’ characteristics were collected. Logistic regression analyses were used to examine the effect of multiple variables on the provision of any analgesia and opioid analgesia.
Results:
Overall, 28,746 children had triage pain scores ≥1; 14,443 (50.2%) patients received analgesia of any type and 1888 (6.6%) received opioid analgesia. Mean time to any ana...
Source: The Clinical Journal of Pain - April 7, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research
Attitudes Towards and Management of Opioid-induced Hyperalgesia: A Survey of Chronic Pain Practitioners
Discussion:
Most clinicians agreed that OIH is a complication of opioid therapy, but were divided regarding the prevalence of OIH, etiological factors, and optimal management. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - April 7, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research
Investigating the Effect of Perioperative Chlorzoxazone on Acute Postoperative Pain After Total Hip and Knee Replacement Surgery
Conclusion:
The current study demonstrated no analgesic effects of postoperative chlorzoxazone administration compared with placebo on acute or chronic postoperative pain 12 months following TKR and THR. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - April 7, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research
Validating Invalidation: Examining the Construct Validity of the Illness Invalidation Inventory Among Individuals With Chronic Low Back Pain
Discussion:
The 2-factor model of the 3*I “family members” subscale identified in the current study reflects previous findings and extends the psychometric validity of the 3*I to a US multiethnic sample of individuals with CLBP. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - April 7, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research
