An Evaluation of the Effect of the OxyContin Reformulation on Unintentional Fatal and Nonfatal Overdose
This study did not detect an overall effect of the OxyContin reformulation on OD in insured patients under regular medical care. There is a suggestion of a modestly reduced OxyContin-associated OD risk following the reformulation but only in commercially insured individuals receiving single-opioid regimens. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - May 18, 2022 Category: Anesthesiology Tags: Original Articles Source Type: research
Adductor Canal Blocks With Bupivacaine and Magnesium After Same-day Discharge Total Knee Arthroplasty Improve Postoperative Pain Relief and Decrease Opioid Consumption: A Prospective Randomized Controlled Trial
Conclusion:
The addition of magnesium to local anesthetic in ACB decreases pain scores and opioid consumption, without increasing nausea, when compared with ACB with local anesthetic alone. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - May 18, 2022 Category: Anesthesiology Tags: Original Articles Source Type: research
Differences in Quantitative Sensory Testing Outcomes Between Patients With Low Back Pain in Primary Care and Pain-free Controls
Objectives:
Quantitative Sensory Testing (QST) is used to test somatosensory functioning in on people with chronic LBP in secondary/tertiary health care facilities. Studies using QST-testing on LBP populations in primary care are scarce. Central Sensitization Inventory (CSI) measures central sensitization (CS)-related symptoms and studies investigating the differences between QST-testing and participants with LBP with a positive and negative score on the CSI questionnaire are also rare. This case-control study investigates differences of an extensive QST-measurement between patients with acute, chronic LBP, and pain-fr...
Source: The Clinical Journal of Pain - May 18, 2022 Category: Anesthesiology Tags: Original Articles Source Type: research
Predictors of Pain and Disability Outcomes Following Spinal Surgery for Chronic Low Back and Radicular Pain: A Systematic Review
In conclusion, absence of spinal stenosis potentially predicts greater pain relief and preoperative sensory loss likely predicts reduction in disability. Overall, QoE for most identified associations was low/very low. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - April 20, 2022 Category: Anesthesiology Tags: Review Article Source Type: research
Pain Characteristics, Fear-avoidance Variables, and Pelvic Floor Function as Predictors of Treatment Response to Physical Therapy in Women With Provoked Vestibulodynia
This study identified PVD secondary subtype, lower PFM tone, and higher fear of pain as significant predictors of better treatment response to PT in women with PVD. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - April 20, 2022 Category: Anesthesiology Tags: Original Articles Source Type: research
Negative Mood Regulation Expectancies (NMRE) as a Moderator of the Association Between Stress and Treatment Outcomes in Interdisciplinary Chronic Pain Treatment
Discussion:
NMRE appear to play an important role for the outcome of inpatient treatment for chronic pain. Due to their buffering effect on the negative association between stress and therapy outcome, they should be targeted in the treatment of chronic pain. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - April 20, 2022 Category: Anesthesiology Tags: Original Articles Source Type: research
Efficacy and Safety of a New Sustained-release Pregabalin Formulation Compared With Immediate-release Pregabalin in Patients With Peripheral Neuropathic Pain: A Randomized Noninferiority Phase 3 Trial
This study investigated whether a new sustained-release (SR) pregabalin formulation is noninferior to immediate-release (IR) pregabalin in alleviating peripheral neuropathic pain in Korean patients.
Materials and Methods:
This was a randomized, double-blind, active-controlled phase 3 study of patients with diabetic peripheral neuropathy or postherpetic neuralgia from 41 sites in South Korea in 2017-2018. Eligible patients were randomized (1:1) to receive once-daily SR pregabalin or twice-daily IR pregabalin (150 to 600 mg/d) in a double-dummy manner for 12 weeks according to a stratified permuted block randomizati...
Source: The Clinical Journal of Pain - April 20, 2022 Category: Anesthesiology Tags: Original Articles Source Type: research
Measuring Clinically Meaningful Change in Outcomes for Youth With Chronic Pain Following Graded Exposure Treatment
Discussion:
Examining reliable and clinically meaningful change (vs. statistical significance alone) provides a way to examine treatment response to an intervention and to enhance the interpretability of findings, helping to bridge the gap between clinical trials and clinical practice by providing guidelines for interpretation. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - April 20, 2022 Category: Anesthesiology Tags: Original Articles Source Type: research
Evaluation of Analgesic Efficacy and Opioid-sparing Effect of Duloxetine After Arthroscopic Rotator Cuff Repair: A Randomized Clinical Trial
This study aimed to evaluate the analgesic efficacy and opioid-sparing effect of duloxetine in adults having arthroscopic rotator cuff repair, as well as its clinical safety.
Methods:
In this randomized trial, 120 adults having arthroscopic rotator repair were randomized to receive perioperative oral duloxetine or placebo. The primary outcome was patient self-reported pain score (Visual Analog Scale: 0 to 10) at rest and opioid consumption within postoperative 2 days. Other outcomes included adverse effects, changes of thromboelastogram, and hemoglobin indicators before and after the operation.
Results:
A tot...
Source: The Clinical Journal of Pain - April 20, 2022 Category: Anesthesiology Tags: Original Articles Source Type: research
Adverse Events Associated With 10-kHz Dorsal Column Spinal Cord Stimulation: A 5-Year Analysis of the Manufacturer and User Facility Device Experience (MAUDE) Database
Conclusion:
This retrospective 5-year analysis of complications from10-kHz SCS provides a real-world assessment of safety data unique for this stimulation modality. This analysis may help inform future clinical decisions, lead to device enhancement and optimization, and improve mitigation of risks to provide safe and efficacious use of 10-kHz SCS. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - April 20, 2022 Category: Anesthesiology Tags: Original Articles Source Type: research
Comparison Between Preoperative Methadone and Buprenorphine Use on Postoperative Opioid Requirement: A Retrospective Cohort Study
Objectives:
Buprenorphine is a partial agonist at mu-opioid receptors and competes for these receptors with other opioids in vitro. Whether patients on buprenorphine maintenance require high doses of opioid analgesics to attain adequate postoperative pain control has not been determined. We evaluated differences in acute postoperative opioid consumption and pain burden between patients taking buprenorphine and those taking methadone preoperatively.
Materials and Methods:
A retrospective review of medical records of 928 patients, of whom 195 were on buprenorphine and 733 were on methadone preoperatively, was perf...
Source: The Clinical Journal of Pain - April 20, 2022 Category: Anesthesiology Tags: Original Articles Source Type: research
Authors’ Response to Letter to the Editor of Van Boxem et al Titled “Systematic Review on Epidural Steroid Injections: Quo Vadis?”
No abstract available (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - March 11, 2022 Category: Anesthesiology Tags: Letter to the Editor Source Type: research
Are Changes in Sleep Quality/Quantity or Baseline Sleep Parameters Related to Changes in Clinical Outcomes in Patients With Nonspecific Chronic Low Back Pain?: A Systematic Review
Discussion:
This is the first systematic review to accentuate that improved self-reported sleep quality/quantity may be associated with improved pain/disability, although it remains unclear whether baseline sleep quality/quantity is a prognostic factor for CLBP. These findings highlight the importance of understanding the mechanisms underlying the relation between sleep and CLBP, which may inform the necessity of assessing or treating sleep disturbance in people with CLBP. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - March 11, 2022 Category: Anesthesiology Tags: Review Articles Source Type: research
The Role of Spinal Cord Stimulation in Reducing Opioid Use in the Setting of Chronic Neuropathic Pain: A Systematic Review
Discussion:
SCS is an effective treatment for many types of chronic pain and can reduce or eliminate chronic opioid use. Preimplantation opioid dose may impact discontinuation of opioid use postimplantation and the effectiveness of SCS in the relief of chronic pain. More research is needed to support and strengthen clinical recommendations for initiation of SCS use at lower daily opioid dose. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - March 11, 2022 Category: Anesthesiology Tags: Review Articles Source Type: research
The Analgesic Effect of Ultrasound-guided Bilateral Pectointercostal Fascial Plane Block on Sternal Wound Pain After Open Heart Surgeries: A Randomized Controlled Study
Conclusion:
pectointercostal fascial block is an effective technique in reducing morphine consumption and controlling poststernotomy pain after cardiac surgeries. Also, it may have a role in better postoperative respiratory outcomes. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - March 11, 2022 Category: Anesthesiology Tags: Original Articles Source Type: research
