The Role of Preoperative Radiologic Severity, Sensory Testing, and Temporal Summation on Chronic Postoperative Pain Following Total Knee Arthroplasty
This study investigated associations between preoperative TSP, thermal sensitivity, and radiologic severity for the development of chronic postoperative pain after TKA. Methods: Radiologic KOA (Kellgren and Lawrence), TSP, and thermal stimuli were collected, preoperatively. Clinical knee pain intensity (VAS 0-10) was assessed before and 12 months following TKA. Patients were categorized into a chronic postoperative pain group if they experienced (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - February 8, 2018 Category: Anesthesiology Tags: Original Articles Source Type: research

Response: Prescription Opioid Use and the Risk of Disability
No abstract available (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - January 17, 2018 Category: Anesthesiology Tags: Letters to the Editor Source Type: research

Omega-6: Omega-3 PUFA Ratio, Pain, Functioning, and Distress in Adults With Knee Pain
Objectives: Osteoarthritis (OA) is associated with inflammation, chronic pain, functional limitations, and psychosocial distress. High omega-3 (n-3) polyunsaturated fatty acids (PUFAs) are associated with lower levels of inflammatory mediators, anti-nociception, and adaptive cognitive/emotional functioning. High omega-6 (n-6) PUFAs are associated with inflammation, nociception, and psychological distress. While findings related to n-3 supplementation in knee OA are mixed, consideration of the n-6:n-3 ratio and additional outcome measures may provide improved understanding of the potential relevance of these fatty acids i...
Source: The Clinical Journal of Pain - January 17, 2018 Category: Anesthesiology Tags: Original Articles Source Type: research

Influence of OPRM1 Polymorphism on Postoperative Pain After Intrathecal Morphine Administration in Italian Patients Undergoing Elective Cesarean Section
Discussion: In the Italian population participating in this study there was a different incidence of pruritus in the postcesarean period in response to intrathecal opioids related to OPRM1 gene polymorphism, but not of postoperative pain. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - January 17, 2018 Category: Anesthesiology Tags: Original Articles Source Type: research

Combination Drug Therapy of Pioglitazone and D-cycloserine Attenuates Chronic Orofacial Neuropathic Pain and Anxiety by Improving Mitochondrial Function Following Trigeminal Nerve Injury
Discussion: The DCS/PIO combination uncoupled mitochondrial respiration in the TIC model to improve cortical mitochondrial dysfunction, as well as reduced nociceptive and anxiety behaviors present in mice with centralized chronic neuropathic nerve injury. Combining these drugs could be a beneficial treatment for patients with depression, anxiety, or other psychological conditions due to their chronic pain status. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - January 17, 2018 Category: Anesthesiology Tags: Original Articles Source Type: research

The Experience of Pain Dismissal in Adolescence
Conclusions: One in 10 young adults reported at least one instance of dismissed pain and half of these instances involved a parent or medical provider. Results suggest a lasting negative impact of perceived dismissal. Pain in adolescence is a complicated experience and the current study indicates that parents and physicians need further guidance on how best to respond to reports of pain. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - January 17, 2018 Category: Anesthesiology Tags: Original Articles Source Type: research

Patient-controlled Intravenous Analgesia With Combination of Dexmedetomidine and Sufentanil on Patients After Abdominal Operation: A Prospective, Randomized, Controlled, Blinded, Multicenter Clinical Study
Objective: To investigate the effect of combination of dexmedetomidine and sufentanil on patient-controlled intravenous analgesia (PCIA) in patients after abdominal operation and to assess the safety and validity of this treatment. Methods: This is a prospective, randomized controlled, blinded, multicenter clinical study. A total of 210 patients from 9 clinical research centers underwent selective abdominal operation with general anesthesia were enrolled in the study, including laparoscopic-assisted abdominal operation on stomach, intestines or open surgery on stomach, intestines, kidneys and liver, the American Socie...
Source: The Clinical Journal of Pain - January 17, 2018 Category: Anesthesiology Tags: Original Articles Source Type: research

The Effectiveness of Transcranial Direct Current Stimulation as an Add-on Modality to Graded Motor Imagery for Treatment of Complex Regional Pain Syndrome: A Randomized Proof of Concept Study
Discussion: We found no added value of tDCS combined with GMI treatments for reducing pain in patients with chronic CRPS. However, given that GMI+sham tDCS induced no significant change, further studies comparing GMI+tDCS and tDCS alone are needed to further document tDCS’s effect in CRPS. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - January 17, 2018 Category: Anesthesiology Tags: Original Articles Source Type: research

Opioid-sparing Effects of SoluMatrix Indomethacin in a Phase 3 Study in Patients With Acute Postoperative Pain
Objectives: To report the opioid-sparing effects of SoluMatrix indomethacin, developed using SoluMatrix Fine Particle Technology, in a phase 3 study in patients with acute pain following bunionectomy. Methods: This phase 3, placebo-controlled study randomized 462 patients with moderate-to-severe pain following bunionectomy surgery to receive SoluMatrix indomethacin 40 mg 3 times daily, SoluMatrix indomethacin 40 mg twice daily, SoluMatrix indomethacin 20 mg 3 times daily, celecoxib 400-mg loading dose followed by 200 mg twice daily, or placebo. Patients were permitted to receive opioid-containing rescue medication thr...
Source: The Clinical Journal of Pain - January 17, 2018 Category: Anesthesiology Tags: Original Articles Source Type: research

Investigating the Fear Avoidance Model in People With Whiplash: The Association Between Fear of Movement and In Vivo Activity
Discussion: Our data suggests measures of Fear Avoidance Model are not related to general physical activity in people with WAD. Investigation of movements specific to the cervical spine and alternative explanatory models may be required. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - January 17, 2018 Category: Anesthesiology Tags: Original Articles Source Type: research

Pain-related Activity Management Patterns and Function in Patients With Fibromyalgia Syndrome
Discussion: The findings confirm the importance of pain-related activity management patterns as predictors of patient function, and support the necessity of addressing these factors in chronic pain treatment. In addition, the results suggest that targeting increases in activity pacing and decreases in pain avoidance, specifically, might yield the best patient outcomes. However, further research to evaluate this possibility is necessary. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - January 17, 2018 Category: Anesthesiology Tags: Original Articles Source Type: research

Brief Psychological Screening Questions Can be Useful for Ruling Out Psychological Conditions in Patients With Chronic Pain
Objectives: Psychological symptoms are highly prevalent in chronic pain patients. Timely and accurate identification may enable individualized treatment and improve outcomes. The aims of this study were to (1) investigate the concurrent validity of brief psychological screening questions assessing anxiety, fear of movement, stress, pain catastrophization, and depression in chronic pain patients, and (2) to determine screening question cut-points at which the likely probability of having these psychological states was (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - January 17, 2018 Category: Anesthesiology Tags: Original Articles Source Type: research

Evaluation of a Clinical Protocol to Assess and Diagnose Neuropathic Pain During Acute Hospital Admission: Results From Traumatic Spinal Cord Injury
This study demonstrates a high incidence and early onset of NP in traumatic spinal cord injury during acute hospital care, with an earlier emergence in participants with incomplete injury. The NP clinical protocol ensured continuous assessment and documentation of NP while decreasing the time to an initial screen, but did not impact diagnosis. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - January 17, 2018 Category: Anesthesiology Tags: Original Articles Source Type: research

Association Between Clinical and Neurophysiological Outcomes in Patients With Mechanical Neck Pain and Whiplash-associated Disorders
Objectives: To investigate the association between pain, disability, trigger points (TrPs), and pressure pain thresholds (PPTs) in patients with mechanical neck pain (MNP) or whiplash-associated disorders (WAD). Materials and Methods: In total, 46 MNP and 51 WAD patients underwent a physical examination consisting of cervical range of motion, PPTs in the upper trapezius and tibialis anterior muscles, TrPs examination in the upper trapezius, and collection of clinical data including disability, pain intensity, and spontaneous symptomatic pain area. Results: A significantly moderate positive association between pain ...
Source: The Clinical Journal of Pain - January 17, 2018 Category: Anesthesiology Tags: Original Articles Source Type: research

Prescription Opioid Use and the Risk of Disability
No abstract available (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - January 17, 2018 Category: Anesthesiology Tags: Letters to the Editor Source Type: research

Response: Prescription Opioid Use and the Risk of Disability
No abstract available (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - January 5, 2018 Category: Anesthesiology Tags: Letters to the Editor Source Type: research

Omega-6: Omega-3 PUFA Ratio, Pain, Functioning, and Distress in Adults With Knee Pain
Objectives: Osteoarthritis (OA) is associated with inflammation, chronic pain, functional limitations, and psychosocial distress. High omega-3 (n-3) polyunsaturated fatty acids (PUFAs) are associated with lower levels of inflammatory mediators, anti-nociception, and adaptive cognitive/emotional functioning. High omega-6 (n-6) PUFAs are associated with inflammation, nociception, and psychological distress. While findings related to n-3 supplementation in knee OA are mixed, consideration of the n-6:n-3 ratio and additional outcome measures may provide improved understanding of the potential relevance of these fatty acids i...
Source: The Clinical Journal of Pain - January 5, 2018 Category: Anesthesiology Tags: Original Articles Source Type: research

Influence of OPRM1 Polymorphism on Postoperative Pain After Intrathecal Morphine Administration in Italian Patients Undergoing Elective Cesarean Section
Discussion: In the Italian population participating in this study there was a different incidence of pruritus in the postcesarean period in response to intrathecal opioids related to OPRM1 gene polymorphism, but not of postoperative pain. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - January 5, 2018 Category: Anesthesiology Tags: Original Articles Source Type: research

Combination Drug Therapy of Pioglitazone and D-cycloserine Attenuates Chronic Orofacial Neuropathic Pain and Anxiety by Improving Mitochondrial Function Following Trigeminal Nerve Injury
Discussion: The DCS/PIO combination uncoupled mitochondrial respiration in the TIC model to improve cortical mitochondrial dysfunction, as well as reduced nociceptive and anxiety behaviors present in mice with centralized chronic neuropathic nerve injury. Combining these drugs could be a beneficial treatment for patients with depression, anxiety, or other psychological conditions due to their chronic pain status. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - January 5, 2018 Category: Anesthesiology Tags: Original Articles Source Type: research

The Experience of Pain Dismissal in Adolescence
Conclusions: One in 10 young adults reported at least one instance of dismissed pain and half of these instances involved a parent or medical provider. Results suggest a lasting negative impact of perceived dismissal. Pain in adolescence is a complicated experience and the current study indicates that parents and physicians need further guidance on how best to respond to reports of pain. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - January 5, 2018 Category: Anesthesiology Tags: Original Articles Source Type: research

Patient-controlled Intravenous Analgesia With Combination of Dexmedetomidine and Sufentanil on Patients After Abdominal Operation: A Prospective, Randomized, Controlled, Blinded, Multicenter Clinical Study
Objective: To investigate the effect of combination of dexmedetomidine and sufentanil on patient-controlled intravenous analgesia (PCIA) in patients after abdominal operation and to assess the safety and validity of this treatment. Methods: This is a prospective, randomized controlled, blinded, multicenter clinical study. A total of 210 patients from 9 clinical research centers underwent selective abdominal operation with general anesthesia were enrolled in the study, including laparoscopic-assisted abdominal operation on stomach, intestines or open surgery on stomach, intestines, kidneys and liver, the American Socie...
Source: The Clinical Journal of Pain - January 5, 2018 Category: Anesthesiology Tags: Original Articles Source Type: research

The Effectiveness of Transcranial Direct Current Stimulation as an Add-on Modality to Graded Motor Imagery for Treatment of Complex Regional Pain Syndrome: A Randomized Proof of Concept Study
Discussion: We found no added value of tDCS combined with GMI treatments for reducing pain in patients with chronic CRPS. However, given that GMI+sham tDCS induced no significant change, further studies comparing GMI+tDCS and tDCS alone are needed to further document tDCS’s effect in CRPS. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - January 5, 2018 Category: Anesthesiology Tags: Original Articles Source Type: research

Opioid-sparing Effects of SoluMatrix Indomethacin in a Phase 3 Study in Patients With Acute Postoperative Pain
Objectives: To report the opioid-sparing effects of SoluMatrix indomethacin, developed using SoluMatrix Fine Particle Technology, in a phase 3 study in patients with acute pain following bunionectomy. Methods: This phase 3, placebo-controlled study randomized 462 patients with moderate-to-severe pain following bunionectomy surgery to receive SoluMatrix indomethacin 40 mg 3 times daily, SoluMatrix indomethacin 40 mg twice daily, SoluMatrix indomethacin 20 mg 3 times daily, celecoxib 400-mg loading dose followed by 200 mg twice daily, or placebo. Patients were permitted to receive opioid-containing rescue medication thr...
Source: The Clinical Journal of Pain - January 5, 2018 Category: Anesthesiology Tags: Original Articles Source Type: research

Investigating the Fear Avoidance Model in People With Whiplash: The Association Between Fear of Movement and In Vivo Activity
Discussion: Our data suggests measures of Fear Avoidance Model are not related to general physical activity in people with WAD. Investigation of movements specific to the cervical spine and alternative explanatory models may be required. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - January 5, 2018 Category: Anesthesiology Tags: Original Articles Source Type: research

Pain-related Activity Management Patterns and Function in Patients With Fibromyalgia Syndrome
Discussion: The findings confirm the importance of pain-related activity management patterns as predictors of patient function, and support the necessity of addressing these factors in chronic pain treatment. In addition, the results suggest that targeting increases in activity pacing and decreases in pain avoidance, specifically, might yield the best patient outcomes. However, further research to evaluate this possibility is necessary. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - January 5, 2018 Category: Anesthesiology Tags: Original Articles Source Type: research

Brief Psychological Screening Questions Can be Useful for Ruling Out Psychological Conditions in Patients With Chronic Pain
Objectives: Psychological symptoms are highly prevalent in chronic pain patients. Timely and accurate identification may enable individualized treatment and improve outcomes. The aims of this study were to (1) investigate the concurrent validity of brief psychological screening questions assessing anxiety, fear of movement, stress, pain catastrophization, and depression in chronic pain patients, and (2) to determine screening question cut-points at which the likely probability of having these psychological states was (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - January 5, 2018 Category: Anesthesiology Tags: Original Articles Source Type: research

Evaluation of a Clinical Protocol to Assess and Diagnose Neuropathic Pain During Acute Hospital Admission: Results From Traumatic Spinal Cord Injury
This study demonstrates a high incidence and early onset of NP in traumatic spinal cord injury during acute hospital care, with an earlier emergence in participants with incomplete injury. The NP clinical protocol ensured continuous assessment and documentation of NP while decreasing the time to an initial screen, but did not impact diagnosis. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - January 5, 2018 Category: Anesthesiology Tags: Original Articles Source Type: research

Association Between Clinical and Neurophysiological Outcomes in Patients With Mechanical Neck Pain and Whiplash-associated Disorders
Objectives: To investigate the association between pain, disability, trigger points (TrPs), and pressure pain thresholds (PPTs) in patients with mechanical neck pain (MNP) or whiplash-associated disorders (WAD). Materials and Methods: In total, 46 MNP and 51 WAD patients underwent a physical examination consisting of cervical range of motion, PPTs in the upper trapezius and tibialis anterior muscles, TrPs examination in the upper trapezius, and collection of clinical data including disability, pain intensity, and spontaneous symptomatic pain area. Results: A significantly moderate positive association between pain ...
Source: The Clinical Journal of Pain - January 5, 2018 Category: Anesthesiology Tags: Original Articles Source Type: research

Prescription Opioid Use and the Risk of Disability
No abstract available (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - January 5, 2018 Category: Anesthesiology Tags: Letters to the Editor Source Type: research

Lumbar Tactile Acuity in Patients With Low Back Pain and Healthy Controls: Systematic Review and Meta-Analysis
Discussion: A gap of knowledge regarding tactile acuity in populations with acute and chronic non-neuropathic LBP needs to be addressed in future research as this may significantly help the understanding of the causality of tactile acuity alterations. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - December 7, 2017 Category: Anesthesiology Tags: Review Article Source Type: research

Obesity Moderates the Effects of Motivational Interviewing Treatment Outcomes in Fibromyalgia
Objective: Obesity is a common comorbid condition among patients with fibromyalgia (FM). Our objective was to assess if obesity moderates the treatment benefits of exercise-based motivational interviewing (MI) for FM. Materials and Methods: This is a secondary data analysis of a completed clinical trial of 198 FM patients who were randomized to receive either MI or attention control (AC). Using body mass index (BMI) to divide participants into obese (BMI≥30 kg/m2) and nonobese (BMI (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - December 7, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

Elevated Production of Nociceptive CC Chemokines and sE-Selectin in Patients With Low Back Pain and the Effects of Spinal Manipulation: A Nonrandomized Clinical Trial
Background: The involvement of inflammatory components in the pathophysiology of low back pain (LBP) is poorly understood. It has been suggested that spinal manipulative therapy (SMT) may exert anti-inflammatory effects. Purpose: The purpose of this study was to determine the involvement of inflammation-associated chemokines (CC series) in the pathogenesis of nonspecific LBP and to evaluate the effect of SMT on that process. Methods: Patients presenting with nonradicular, nonspecific LBP (minimum pain score 3 on 10-point visual analog scale) were recruited according to stringent inclusion criteria. They were evalua...
Source: The Clinical Journal of Pain - December 7, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

Mindfulness-based Cognitive Therapy and Persistent Pain in Women Treated for Primary Breast Cancer: Exploring Possible Statistical Mediators Results From a Randomized Controlled Trial
Discussion: The results of the present study may have clinical implications. An increased focus on the proposed mediators may optimize the clinical use of MBCT for persistent pain in women treated for breast cancer. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - December 7, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

Efficacy of Postoperative Analgesia of Local Ketamine Wound Instillation Following Total Thyroidectomy: A Randomized, Double-blind, Controlled Clinical Trial
Conclusions: Local wound ketamine instillation provided superior postoperative analgesia with lower incidence of side effects in comparison with IM ketamine and placebo following total thyroidectomy. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - December 7, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

Preoperative Pain Neuroscience Education Combined With Knee Joint Mobilization for Knee Osteoarthritis: A Randomized Controlled Trial
This study aimed to first compare the effects of a preoperative treatment combining pain neuroscience education (PNE) with knee joint mobilization versus biomedical education with knee joint mobilization on central sensitization (CS) in patients with knee osteoarthritis, both before and after surgery. Second, we wanted to compare the effects of both interventions on knee pain, disability, and psychosocial variables. Materials and Methods: Forty-four patients with knee osteoarthritis were allocated to receive 4 sessions of either PNE combined with knee joint mobilization or biomedical education with knee joint mobilizati...
Source: The Clinical Journal of Pain - December 7, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

Orexin Receptor Antagonism in Painful Diabetic Neuropathy: A Phase 2 Trial With Filorexant
Discussion: These data do not provide evidence for the efficacy of nightly filorexant for the treatment of PDN. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - December 7, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

Sensitivity of the DN4 in Screening for Neuropathic Pain Syndromes
This study examined the sensitivity of the Douleur Neuropathique en 4 Questions (DN4) in screening for various neuropathic pain syndromes. Materials and Methods: This prospective observational study was conducted in 7 Canadian academic pain centers between April 2008 and December 2011. All newly admitted patients (n=2199) were approached and 789 eligible participants form the sample for this analysis. Baseline data included demographics, disability, health-related quality of life, and pain characteristics. Diagnosis of probable or definite neuropathic pain was on the basis of history, neurological examination, and ancil...
Source: The Clinical Journal of Pain - December 7, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

Attentional Avoidance is Associated With Increased Pain Sensitivity in Patients With Chronic Posttraumatic Pain and Comorbid Posttraumatic Stress
This study investigated AB for linguistic pain-related stimuli and trauma-related stimuli, and clinical and thermal sensitivity in patients with chronic posttraumatic pain with and without PTSD. Materials and Methods: In total, 34 patients with chronic posttraumatic cervical pain performed the visual attentional probe task assessing patterns of selective attentional responding to trauma cues and to pain cues. The task used short (500 ms) and long (1250 ms) stimulus exposure durations to ensure sensitivity to both the orienting and maintenance of attention. Heat pain threshold was assessed at the nonpainful hand. Clinica...
Source: The Clinical Journal of Pain - December 7, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

Patients With Knee Osteoarthritis Who Score Highly on the PainDETECT Questionnaire Present With Multimodality Hyperalgesia, Increased Pain, and Impaired Physical Function
This study aimed to determine whether those with a higher “positive neuropathic” score on the PainDETECT questionnaire also had greater pain, hypersensitivity, and reduced function compared with individuals with knee OA with lower PainDETECT scores. Materials and Methods: In total, 130 participants with knee OA completed the PainDETECT, Western Ontario and McMaster Universities Arthritis Index (WOMAC), and Pain Quality Assessment Scale questionnaires. Quantitative sensory testing was carried out at 3 sites (both knees and elbow) using standard methods. Cold and heat pain thresholds were tested using a Peltie...
Source: The Clinical Journal of Pain - December 7, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

Contribution of Endocannabinoid Gene Expression and Genotype on Low Back Pain Susceptibility and Chronicity
Background: A major research emphasis has been focused on defining the molecular changes that occur from acute to chronic pain to identify potential therapeutic targets for chronic pain. As the endocannabinoid system is dynamically involved in pain signaling, a plausible mechanism that may contribute to chronic pain vulnerability involves alterations in the amount of circulating endocannabinoids. Therefore, this study sought to examine cannabinoid type 1 (CNR1), type 2 (CNR2) receptors, fatty acid amide hydrolase (FAAH), and the vanilloid receptor (transient receptor potential cation channel subfamily V member 1 [TRPV1])...
Source: The Clinical Journal of Pain - December 7, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

Expectancy Reduces Symptoms but not Functional Impairment Following Exercise-induced Musculoskeletal Injury
Discussion: Positive expectations before a sham treatment enhanced reduction in pain intensity but did not improve functional impairments following exercise-induced acute musculoskeletal injury. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - December 7, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

Common Pediatric Pain Disorders and Their Clinical Associations
Conclusions: In light of their extensive associations, the common pain conditions, persistent pain, restless legs syndrome, iron deficiency, anxiety and depression, are likely to involve common etiological mechanisms that warrant further investigation. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - November 9, 2017 Category: Anesthesiology Tags: Review Articles Source Type: research

Effects of Single Nucleotide Polymorphisms on Surgical and Postsurgical Opioid Requirements: A Systematic Review and Meta-Analysis
Discussion: Investigation of single changes in 1 gene can only yield limited information regarding genetic effects on opioid requirements. Rapid development of whole genome sequencing enables information on all genetic modifications that may affect analgesic response to be collected. The information collected must include data on the individual’s metabolic enzymes, as well as information on drug receptors and enzymes responsible for drug degradation, so that a personal profile can be built up which will predict individual response to drugs, and guide clinicians on the type and dosage of drug to use. (Source: The Clin...
Source: The Clinical Journal of Pain - November 9, 2017 Category: Anesthesiology Tags: Review Articles Source Type: research

Reduced Sufentanil Doses are Effective for Postoperative Analgesia After Ductal Closure in Extremely Premature Infants: A 10 Years Retrospective Cohort Study
The objective of the study was to assess the efficacy of reduced sufentanil doses for postoperative analgesia following surgical ductal closure in extremely premature infants. Methods: This was a retrospective, single-center, cohort study comparing 2 sufentanil dosing regimens used between 2001 and 2010 and included all infants born at (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - November 9, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

Mixed Pain Can Be Discerned in the Primary Care and Orthopedics Settings in Spain: A Large Cross-Sectional Study
Conclusions: Patients with mixed pain showed more clinical complexity than patients with other types of pain. The consideration of mixed pain as an independent pathophysiological category may be justifiable on empirical clinical grounds. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - November 9, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

The Fear-Avoidance Components Scale (FACS): Responsiveness to Functional Restoration Treatment in a Chronic Musculoskeletal Pain Disorder (CMPD) Population
In this study, 426 chronic musculoskeletal pain disorder patients were admitted to a Functional Restoration Program (FRP). They were categorized into 5 FACS severity levels, from subclinical to extreme, at admission, and again at discharge. Associations with objective lifting performance and other patient-reported psychosocial measures were determined at admission and discharge, and objective work outcomes for this predominantly disabled cohort, were assessed 1 year later. Results: Those patients in the severe and extreme FACS severity groups at admission were more likely to “drop out” of treatment than those ...
Source: The Clinical Journal of Pain - November 9, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

Age Interactions on Pain Sensitization in Patients With Severe Knee Osteoarthritis and Controls
This study investigated the influence of age on pressure hyperalgesia, TSP, and CPM in patients with KOA and controls. Materials and Methods: One hundred thirty-three severe KOA patients and 50 age-matched and sex-matched asymptomatic controls were assessed by cuff algometry and handheld pressure algometry. Pain sensitivity was assessed around the head of the gastrocnemius muscle to identify mild pain detection threshold (MPDT) and pressure tolerance threshold (PTT). TSP was assessed by visual analogue scale scores of the pain evoked by 10 repetitive cuff stimulations. CPM was assessed as the difference in PTT before and ...
Source: The Clinical Journal of Pain - November 9, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

PPARĪ³ Agonists Attenuate Trigeminal Neuropathic Pain
Discussion: This is the first study localizing PPARγ immunoreactivity throughout the brainstem trigeminal sensory spinal nucleus (spV) and its increase three weeks after TIC nerve injury. This is also the first study to demonstrate that activation of PPARγ attenuates trigeminal hypersensitivity in the mouse TIC nerve injury model. The findings presented here suggest the possibility of utilizing the FDA approved diabetic treatment drug, PIO, as a new therapeutic that targets PPARγ for treatment of patients suffering from orofacial neuropathic pain. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - November 9, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

Altered Functional Connectivity in Sickle Cell Disease Exists at Rest and During Acute Pain Challenge
This study identified and characterized the neural correlates of possible central sensitization in SCD. We found functional connectivity abnormalities in individuals with SCD in the brain’s somatosensory network, salience network, and default mode network during both an unstructured resting state and paradigm involving acute pain challenge. Discussion: There was evidence for both increased and decreased connectivity which is consistent with findings in other chronic pain disorders. Preliminary evidence was found that subcortical brain regions might contribute to neurodevelopmental abnormalities in chronic pain. The ...
Source: The Clinical Journal of Pain - November 9, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

Peripheral Nerve Block as a Supplement to Light or Deep General Anesthesia in Elderly Patients Receiving Total Hip Arthroplasty: A Prospective Randomized Study
Conclusions: Lumbosacral plexus block reduced the need for opioids and offered satisfactory postoperative analgesia. It led to better postoperative outcomes in combination with intraoperative light sedation (high bispectral index). (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - November 9, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research