Systematic Review and Synthesis of Mechanism-based Classification Systems for Pain Experienced in the Musculoskeletal System
This study aimed to (1) systematically review mechanism-based classifications of pain experienced in the musculoskeletal system; (2) synthesize and thematically analyze classifications, using the International Association for the Study of Pain categories of nociceptive, neuropathic, and nociplastic as an initial foundation; and (3) identify convergence and divergence between categories, terminology, and descriptions of each mechanism-based pain classification. Materials and Methods: Databases were searched for papers that discussed a mechanism-based classification of pain experienced in the musculoskeletal system. Termi...
Source: The Clinical Journal of Pain - September 5, 2020 Category: Anesthesiology Tags: Review Article Source Type: research

Baseline Characteristics of a Dyadic Cohort of Mothers With Chronic Pain and Their Children
Discussion: While maternal PGs map broadly onto several dimensions of maternal functioning, they were not significantly related to child pain or function. Results may help identify potential protective factors in the intergenerational transmission of risk for chronic pain. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - September 5, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research

Plasma Concentrations of Select Inflammatory Cytokines Predicts Pain Intensity 48 Hours Post-Shoulder Muscle Injury
Objectives: The relationship between elevated inflammatory cytokine levels and peak pain intensity following acute musculoskeletal injury has not been fully elucidated in high risk subgroups. Identifying the role that these cytokines have on pain responses may help with developing tailored therapeutic approaches. Methods: Data were collected from 54 participants who were vulnerable to a robust pain response and delayed recovery following musculoskeletal injury. Participants completed baseline active and resting pain measurements and a blood draw before an exercised induced shoulder muscle injury. Participants returned...
Source: The Clinical Journal of Pain - September 5, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research

Evidence for Continuing Buprenorphine in the Perioperative Period
Discussion: On the basis of our findings, we implemented a policy at our institution for the continuation of perioperative buprenorphine whenever possible. Our work reveals crucial targets for the education of perioperative healthcare providers and the importance of coordination among all perioperative services and providers. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - September 5, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research

Pain Catastrophizing, Self-reported Disability, and Temporal Summation of Pain Predict Self-reported Pain in Low Back Pain Patients 12 Weeks After General Practitioner Consultation: A Prospective Cohort Study
This study investigated whether pain sensitization mechanisms, the Pain Catastrophizing Scale (PCS), and Start Back Screening Tool were associated with pain in recurrent LBP patients 12 weeks after consulting their general practitioner (GP). Materials and Methods: In 45 LBP patients, pressure pain thresholds, temporal summation of pain (TSP), conditioned pain modulation (CPM), the Roland Morris Disability Questionnaire (RMDQ), and the PCS were assessed before consultation. Patients were classified into low to medium or high risk of poor prognosis on the basis of the Start Back Screening Tool. Worst pain within the last ...
Source: The Clinical Journal of Pain - September 5, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research

Why do Patients Engage in Pain Behaviors? A Qualitative Study Examining the Perspective of Patients and Partners
In conclusion, partners are more likely to attribute negative motives to the patient’s pain behaviors, which may lead to their hostility toward patients. The findings of this study provide new insights into motives of pain behaviors from the perspective of patients and partners, which can inform couple-based interventions in terms of effective pain communication. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - September 5, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research

Mechanisms of Mindfulness Meditation, Cognitive Therapy, and Mindfulness-based Cognitive Therapy for Chronic Low Back Pain
This study evaluated theoretically derived mechanisms and common therapeutic factors to test their role in accounting for pain-related outcome change during group-delivered cognitive therapy, mindfulness meditation, and mindfulness-based cognitive therapy for chronic low back pain. Methods: A secondary analysis of a pilot randomized controlled trial was used to explore the primary mechanisms of pretreatment to posttreatment changes in pain control beliefs, mindful observing, and pain catastrophizing, and the secondary common factor mechanisms of therapeutic alliance, group cohesion, and amount of at-home skill practice ...
Source: The Clinical Journal of Pain - September 5, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research

Comorbid Pain and Cognitive Impairment in a Nationally Representative Adult Population: Prevalence and Associations With Health Status, Health Care Utilization, and Satisfaction With Care
Discussion: Our data suggest that individuals with comorbid chronic pain and CI are in a much higher state of self-reported disability than those with chronic pain or CI alone. Best practice guidelines are generally silent on multidisciplinary, integrated care for these comorbid conditions, increasing the potential for inadequate care. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - September 5, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research

Assessing Benefit of Dexmedetomidine on Postoperative Neurocognitive Disorders: Important Issues That Should Be Acknowledged
No abstract available (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - August 13, 2020 Category: Anesthesiology Tags: Letter to the Editor Source Type: research

Opioid-induced Constipation: A Review of Health-related Quality of Life, Patient Burden, Practical Clinical Considerations, and the Impact of Peripherally Acting μ-Opioid Receptor Antagonists
The objective of this study was to provide an overview of opioid-induced constipation (OIC) and its influence on disease burden and quality of life (QOL). Methods: This is a narrative review. Results: For many patients, opioid-related side effects, the most common being OIC, have the potential to significantly impair patients’ QOL. Patients with OIC often experience substantial overall burden (ie, increases in anxiety and depression, impairments in activities of daily living, low self-esteem, feelings of embarrassment) and economic burden (ie, higher health care costs, more frequent doctor visits, increased out...
Source: The Clinical Journal of Pain - August 13, 2020 Category: Anesthesiology Tags: Review Article Source Type: research

Sleep Characteristics in Adults With and Without Chronic Musculoskeletal Pain: The Role of Mental Distress and Pain Catastrophizing
Objectives: Sleep disturbance is associated with persistence and exacerbation of chronic pain. As this relationship seems to be bidirectional, factors underpinning sleep disturbance may prove important in multimodal rehabilitation approaches. The aim of this cross-sectional study was to examine the impact of psychological symptoms on subjective and objective sleep measures in patients with chronic musculoskeletal pain (CMP), as compared with pain-free controls. Materials and Methods: Sleep was assessed by self-report questionnaires, actigraphy, and polysomnography recordings in 56 patients (75.0% female; Mage=41.7&thi...
Source: The Clinical Journal of Pain - August 13, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research

Reliability, Discriminative, and Prognostic Validity of the Multidimensional Symptom Index in Musculoskeletal Trauma
Discussion: The MSI holds promise as a tool for evaluating change, screening for MDD, and identifying those at high or low risk of poor recovery. The results favor sensitivity over specificity. The labile nature of the acute pain symptoms and a truncated distribution of Nonsomatic Symptoms scores in that group both require some caution in interpretation. The MSI appears to be a potentially useful tool for rapid pain phenotyping, evaluation, and quick screening purposes in clinical practice. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - August 13, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research

Impaired School Functioning in Children With Chronic Pain: A National Perspective
This study extends evidence linking chronic pain status to poorer school functioning in a large, national sample. Poor school functioning is a pressing public concern affecting children with chronic pain. Health care providers, educators, policymakers, and families should work together to ensure that needs are met for this vulnerable population. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - August 13, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research

The Effects of a Pain Psychology and Neuroscience Self-Evaluation Internet Intervention: A Randomized Controlled Trial
Discussion: A brief PPN self-evaluation intervention, presented on-line, can yield short-term improvements in musculoskeletal pain severity and interference, especially for people with spinal/localized pain rather than FM, perhaps because the psychology/neuroscience perspective is more novel for such patients. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - August 13, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research

Development and Initial Evaluation of the Patterns of Activity Measure—Pain Short Form
Discussion: The short-form of the POAM-P possesses good psychometric properties and correlates well with the long-form of the measure. It appears to be a promising addition to existing measures of pain-related activity. It may be useful as an addition to questionnaire batteries that comprehensively assess the psychosocial functioning of individuals with ongoing pain. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - August 13, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research

Increased Experimental Pain Sensitivity in Chronic Pain Patients Who Developed Opioid Use Disorder
We examined for differences in response to static and dynamic experimental pain stimuli between individuals with chronic nonmalignant pain who developed OUD after starting opioid therapy (n=20) and those on opioid therapy who did not (n=20). During a single experimental session, participants underwent cold pressor and quantitative sensory testing pain assays, and objective and subjective responses were compared between groups; the role of pain catastrophizing in mediating pain responses was examined. Results: Results suggested that both groups of opioid-dependent patients were similarly hyperalgesic to the cold pressor ...
Source: The Clinical Journal of Pain - August 13, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research

Race, Social Status, and Depressive Symptoms: A Moderated Mediation Analysis of Chronic Low Back Pain Interference and Severity
The objective of this study was to assess whether self-identified race moderated the relationship between perceived social status and cLBP outcomes (pain interference and pain severity) and investigate whether race moderated the indirect relationship between perceived social status and pain outcomes via depressive symptoms. Methods: Fifty-seven blacks and 48 whites with cLBP were recruited as part of a large ongoing study. Depressive symptoms, objective and subjective measures of socioeconomic status, and pain outcomes were measured. Hayes’ moderated mediation model was used to estimate conditional direct and indi...
Source: The Clinical Journal of Pain - August 13, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research

What Works? Processes of Change in a Transdiagnostic Exposure Treatment for Patients With Chronic Pain and Emotional Problems
Discussion: Our findings provide initial support for the transdiagnostic theoretical underpinnings of the hybrid treatment model. Using a hybrid treatment approach that centers on teaching patients emotion-regulation skills before commencing broad exposure successfully influenced both pain-related dysregulation and general emotion dysregulation, which in turn was associated with better treatment outcomes. It appears central to address these processes in pain patients with comorbid emotional problems, especially among patients scoring high on measures of catastrophizing, fear-avoidance, and nonacceptance of pain. (Source:...
Source: The Clinical Journal of Pain - August 13, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research

Associations Among Sleep Disturbance, Pain Catastrophizing, and Pain Intensity for Methadone-maintained Patients With Opioid Use Disorder and Chronic Pain
This study examined the cross-sectional associations among pain intensity, pain catastrophizing, and sleep disturbance among patients receiving methadone maintenance treatment (MMT) for opioid use disorder (OUD) and reporting co-occurring chronic pain. Materials and Methods: Participants were 89 individuals with OUD and chronic pain drawn from a larger cross-sectional study of 164 MMT patients who completed a battery of self-report measures. The authors conducted 6 mediation models to test all possible pathways (ie, each variable tested as an independent variable, mediator, or dependent variable). Results: The only s...
Source: The Clinical Journal of Pain - August 13, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research

The Impact of Psychological Interventions on Posttraumatic Stress Disorder and Pain Symptoms: A Systematic Review and Meta-Analysis: Erratum
No abstract available (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - July 29, 2020 Category: Anesthesiology Tags: Erratum Source Type: research

Which Psychological Factors Are Involved in the Onset and/or Persistence of Musculoskeletal Pain? An Umbrella Review of Systematic Reviews and Meta-Analyses of Prospective Cohort Studies
The objective of this study was to summarize the current status of knowledge about the longitudinal association between vulnerability or protective psychological factors and the onset and/or persistence of musculoskeletal (MSK) pain. Methods: PubMed, CINAHL, PsycINFO, PubPsych, Scopus, Web of Science, gray literature, and manual screening of references were searched from inception to June 15, 2019. Systematic reviews with or without meta-analysis that explored the longitudinal association between psychological factors and the onset and/or persistence of MSK pain were identified. The AMSTAR-2 tool was used to assess the ...
Source: The Clinical Journal of Pain - July 29, 2020 Category: Anesthesiology Tags: Review Article Source Type: research

Dexmedetomidine 2 ppm Is Appropriate for the Enhancement Effect of Local Anesthetic Action of Lidocaine in Inferior Alveolar Nerve Block: A Preliminary, Randomized Cross-over Study
Objective: Local anesthesia is essential for pain management in dentistry. The duration of anesthetic action of the addition of 5.0 and 7.5 ppm of dexmedetomidine (DEX) was significantly longer than the addition of adrenaline, and the mean duration of anesthetic action of the addition of 2.5 ppm DEX was also longer than the addition of adrenaline. We hypothesized that it is possible to safely achieve an equal local anesthesia effect as with 1:80,000 adrenaline, without using adrenaline or felypressin, by the addition of (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - July 29, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research

A Randomized Controlled Comparison of Epidural Analgesia Onset Time and Adverse Reactions During Labor With Different Dose Combinations of Bupivacaine and Sufentanil
Objectives: The purpose was to compare the effects of 3 different dose combinations of bupivacaine and sufentanil on the onset of analgesia and the occurrence of side effects. Materials and Methods: One hundred sixty-nine pregnant women were randomly assigned to 3 groups: the B1S5 group received 0.1% bupivacaine+5 μg sufentanil in 15 mL; the B125S5 group received 0.125% bupivacaine+5 μg sufentanil in 15 mL; and the B1S10 group received 0.1% bupivacaine+10 μg sufentanil in 15 mL. The primary outcome was the analgesic onset time, and the secondary outcomes were mode of ...
Source: The Clinical Journal of Pain - July 29, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research

Exercise-induced Hypoalgesia Is Impaired in Chronic Whiplash-associated Disorders (WAD) With Both Aerobic and Isometric Exercise
This study aimed to: (1) compare EIH in participants with chronic whiplash-associated disorders (WAD) to asymptomatic controls, (2) determine if EIH differs between aerobic and isometric exercise, (3) determine predictors of EIH. Materials and Methods: A pre-post study investigated the effect of single sessions of submaximal aerobic treadmill walking and isometric knee extension on EIH in 40 participants with chronic WAD and 30 controls. Pressure pain thresholds were measured at the hand, cervical spine, and tibialis anterior. Pain intensity, reported previous week physical activity, temporal summation, and conditioned ...
Source: The Clinical Journal of Pain - July 29, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research

Can Headache Profile Predict Future Disability: A Cohort Study
Objective: The aim of this study was to determine if headache profile can predict future disability in patients with tension-type headache (TTH). Materials and Methods: Eighty-three individuals with TTH were recruited. To be included in the study participants needed to fulfill the International Headache Society classification’s criteria for episodic or chronic TTH form and to be at least 18 years old. Baseline clinical outcomes (headache and neck-related disability, kinesiophobia, self-efficacy, and anxiety) and physical outcomes (neck extensors muscles maximum voluntary contraction) were collected for all parti...
Source: The Clinical Journal of Pain - July 29, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research

No Evidence of Altered Reactivity to Experimentally Induced Pain Among Regular Cannabis Users
This study explored differences in measures of pain intensity and tolerance. The authors hypothesized that individuals who report frequent CU would demonstrate greater experimental pain sensitivity. Materials and Methods: Frequent cannabis users (≥3× per week; n=40) and nonusers (n=40) were compared on pain sensitivity, pain tolerance, and pain intensity in response to a cold-pressor task. Group differences were examined. Results: Frequent CU was not associated with hyperalgesia as cannabis users and nonusers did not exhibit differences on measures of pain tolerance (t(78)=−0.05; P=0.96), sensitivity (...
Source: The Clinical Journal of Pain - July 29, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research

Evaluation of the Efficacy of Prolonged Pregabalin Administration Before and After Surgery in Patients Undergoing Arthroscopic Anterior Cruciate Ligament Repair: A Prospective, Randomized, Double-blind Study
Discussion: A prolonged preoperative and postoperative pregabalin prescription for anterior cruciate ligament repair decreased the need for supplementary analgesics during the first 24 postoperative hours but increased dizziness. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - July 29, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research

Exploring the Psychometric Properties of the Current Opioid Misuse Measure Among Adults With Chronic Pain and Opioid Use
Discussion: Given the importance and relevance for opioid misuse in the context of chronic pain, it is important for researchers to continue assessing and providing psychometric evidence for the COMM. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - July 29, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research

Psychological Predictors of Perceived Age and Chronic Pain Impact in Individuals With and Without Knee Osteoarthritis
Discussion: These findings highlight the importance of a biopsychosocial approach in understanding the intersection between psychological and physical factors associated with chronic pain. Addressing negative self-perceptions of aging, while simultaneously augmenting positive affect, through psychological therapies may mitigate pain and disability. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - July 29, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research

Effects of Adding Oxycodone to Ropivacaine on Labor Analgesia: A Randomized Controlled Trial: Erratum
No abstract available (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - June 4, 2020 Category: Anesthesiology Tags: Erratum Source Type: research

Letter to the Editor of the Clinical Journal of Pain
No abstract available (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - June 4, 2020 Category: Anesthesiology Tags: Letter to the Editor Source Type: research

Pressure Pain Tolerance Predicts the Success of Emotional Awareness and Expression Therapy in Patients With Fibromyalgia
Discussion: Normal levels of pressure pain tolerance at baseline predicted greater improvement in clinical pain severity after EAET than CBT. Quantitative sensory testing may provide insights about individual responses to psychologically based therapies for individuals with chronic pain. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - June 4, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research

Comparison of Adductor Canal Block and Femoral Triangle Block for Total Knee Arthroplasty
Objectives: Adductor canal block (ACB) could provide effective postoperative pain control for patients after total knee arthroplasty (TKA). However, some authors pointed out that the ACB as originally described may be more similar to a femoral triangle block (FTB). Recent neuroanatomic evidences made the authors conjecture that the “true” ACB would provide superior analgesia compared with FTB. Therefore, the study was designed to determine the hypothesis that postoperative analgesia after TKA could be improved by a “true” ACB compared with FTB. Materials and Methods: Patients undergoing unilate...
Source: The Clinical Journal of Pain - June 4, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research

Perceptions of Pain Treatment in Pediatric Patients With Functional Gastrointestinal Disorders
Discussion: Participants were knowledgeable regarding chronic pain, but still indicated that receiving a definite diagnosis would be the most helpful intervention. Most had tried multiple interventions and did not believe that further medication, testing, or surgery would solve their pain. Instead, parents presenting at this Functional Abdominal Pain Program appeared most hopeful about the benefits of multidisciplinary treatment approaches including psychological interventions, a focus on activity and functioning, and complementary and alternative medicine interventions. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - June 4, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research

Acupuncture Versus Sham Acupuncture: A Meta-Analysis on Evidence for Longer-term Effects of Acupuncture in Musculoskeletal Disorders
Discussion: A significant difference in therapy effect, favoring acupuncture, was found for pain at (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - June 4, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research

Hypervigilance for Bodily Sensations in the Back During a Movement Task in People With Chronic and Recurrent Low Back Pain
Discussion: The current study confirmed that individuals preparing a movement attended more toward somatosensory stimuli at the lower back when anticipating back pain during the movement, as measured by the N96 SEP. However, no differences were found between participants with chronic low back pain or recurrent low back pain, or the pain-free controls. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - June 4, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research

Optimizing the Treatment of CRPS With Ketamine
This study aimed to develop a method that objectively measures the clinical benefits of ketamine infusions to treat complex regional pain syndrome (CRPS), thus making it possible, for the first time, to determine the optimal dosing of ketamine and duration of treatment to treat CRPS. Materials and Methods: All patients were diagnosed with hyperalgesia associated with CRPS. Patients underwent an outpatient, 4-day, escalating dose ketamine infusion. Hyperalgesia was measured using pain thresholds. Clinical outcome was determined without knowledge of the patient’s pain thresholds throughout treatment. Results: We ...
Source: The Clinical Journal of Pain - June 4, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research

Defining Recovery in Chronic Whiplash: A Qualitative Study
Discussion: Recovery is a multidimensional and complex construct. In addition to pain intensity and disability, measurement and conceptualization of recovery should focus on emotional well-being, self-perception, and the cultural values and beliefs of the individual. A positive therapeutic relationship, with attention to psychological and social influences, appears to be important in facilitating recovery and well-being. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - June 4, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research

Efficacy and Safety of Single and Multiple Doses of a Fixed-dose Combination of Ibuprofen and Acetaminophen in the Treatment of Postsurgical Dental Pain: Results From 2 Phase 3, Randomized, Parallel-group, Double-blind, Placebo-controlled Studies
Objectives: A previous pilot study demonstrated that various fixed-dose combinations (FDCs) of ibuprofen (IBU) and acetaminophen (APAP) provided analgesic efficacy comparable to a higher dose of IBU, with the same safety profile. These studies further evaluated the chosen FDC IBU/APAP 250/500 mg formulation. Materials and Methods: Two phase 3 dental pain studies enrolled healthy young patients with ≥moderate pain after ≥3 third molar extractions who received single-dose FDC IBU/APAP 250/500 mg, IBU 250 mg, APAP 650 mg, or placebo evaluated over 12 hours (study 1) or multiple-dose FDC ...
Source: The Clinical Journal of Pain - June 4, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research

Pain-related Self-efficacy Among People With Back Pain: A Systematic Review of Assessment Tools
Conclusions: Further research should focus on assessing validity and interpretability of these questionnaires, especially in pain-related target groups. Researchers should select questionnaires that are most appropriate for their study aims and the back pain population and contribute to further validation of these scales to best predict future behavior and develop intervention programs. This systematic review aids selection of pain-related assessment tools in back pain both in research and practice. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - May 11, 2020 Category: Anesthesiology Tags: Review Article Source Type: research

Utilization of Health Care Resources by Long-term Care Residents as a Function of Pain Status
Discussion: To our knowledge, this is the first large-scale project to examine the utilization of health care resources as a function of pain status among LTC facility residents. Improved pain management in LTC facilities could lead to reduced health care use. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - May 11, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research

Changes in Pain and Psychosocial Functioning and Transition to Chronic Pain in Pediatric Sickle Cell Disease: A Cohort Follow-up Study
This study aimed to: (1) examine changes in pain, psychosocial functioning, and health care utilization among children and adolescents with sickle cell disease (SCD) over a 2-year period and (2) identify baseline biopsychosocial variables associated with the development and maintenance of chronic SCD pain at follow-up. Materials and Methods: Forty-two youth (8 to 18 y old) with SCD completed a battery of self-report measures at baseline and 2-year follow-up. Analgesic, Anesthetic, and Addiction Clinical Trial Translational Innovations Opportunities and Networks and American Pain Society Pain Taxonomy (AAPT) diagn...
Source: The Clinical Journal of Pain - May 11, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research

Effect on Opioids Requirement of Early Administration of Intranasal Ketamine for Acute Traumatic Pain
Objectives: To evaluate the efficacy and safety of early administration of low-dose intranasal ketamine on reducing the need for opioid and nonopioid analgesic agents in emergency department (ED) patients with acute moderate to severe acute limbs’ trauma pain. Patients and Methods: This is a double-blind, randomized, prospective, controlled study conducted in the ED. The included patients were randomly assigned to intranasal pulverization of ketamine or placebo. Protocol treatment was given at the triage. The primary outcome is the need for opioids during ED stay. Secondary outcome included the requirement of no...
Source: The Clinical Journal of Pain - May 11, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research

Neurological Complication Rates of Epidural Injections and Selective Nerve Blocks: A Comparison of Steroid Use Patterns
Discussion: At the cervicothoracic level, the incidence rate of neurological complications with particulate steroid injections was higher than that with nonparticulate steroid injections. Injections with nonparticulate steroids and without steroids were equally safe. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - May 11, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research

Quality of Life in Youth With Chronic Pain: An Examination of Youth and Parent Resilience and Risk Factors
Discussion: The results are discussed in the context of the resilience-risk framework and current understandings of the role of parental factors for pediatric chronic pain. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - May 11, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research

Contribution of COMT and BDNF Genotype and Expression to the Risk of Transition From Acute to Chronic Low Back Pain
Discussion: CLBP was characterized by higher reported pain burden and augmented hypersensitivity at LBP onset. COMT expression and genotype were associated with acute pain burden and likelihood of transition to CLBP. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - May 11, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research

Sex Bias and Genotype Influence on Opioid Safety Profile in Chronic Low Back Pain
Conclusions: Sex bias affects female patients resulting in a CLBP diagnostic delay and a different analgesic safety profile. Moreover, the individual’s genetic background might be useful to predict certain AEs in opioid-naive patients under an opioid titration procedure. Addressing sex in necessary to resolve inequalities in health care access. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - May 11, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research

The Influence of a Positive Empathetic Interaction on Conditioned Pain Modulation and Manipulation-induced Analgesia in People With Lateral Epicondylalgia
Objective: Conditioned pain modulation (CPM) and manipulation-induced analgesia (MIA) are 2 forms of endogenous analgesia. Many forms of analgesia can be influenced by the nature of the patient-clinician interaction. The aim of this study was to evaluate the influence of an empathetic and supportive interaction on CPM and MIA in people with lateral epicondylalgia (LE). Material and Methods: In a double-blind, randomized, controlled trial, 68 participants with LE were assigned to 2 groups: the empathetic and neutral interaction groups. The interactions were carried out by a trained, professional role-play actor, playin...
Source: The Clinical Journal of Pain - May 11, 2020 Category: Anesthesiology Tags: Original Articles Source Type: research

Efficacy and Safety of Tapentadol Immediate Release for Acute Pain: A Systematic Review and Meta-Analysis
Objective: Tapentadol (TAP) immediate release (IR) is a newer opioid option for acute pain. The aim of this systematic review was to examine the efficacy and safety of TAP IR compared with other opioids for acute pain. Methods: A systematic literature search as conducted using the Cochrane Library, Embase, International Pharmaceutical Abstracts, MEDLINE, PubMed, and Web of Science. The search included all randomized controlled trials and observational studies examining TAP IR versus other orally administered IR opioids for acute pain. The protocol for this study was registered on PROSPERO (CRD42018110267). Results: ...
Source: The Clinical Journal of Pain - April 7, 2020 Category: Anesthesiology Tags: Review Articles Source Type: research

A Systematic Review of Clinical Practice Guidelines for Acute Procedural Pain on Neonates
Discussion: The results of this review show that there is a need to improve the methodological quality of guidelines for procedural pain in newborns. The set of recommendations for procedural pain prevention needs to involve not only pharmacological and nonpharmacological pain treatment but also parents and interprofessional collaboration. It is also essential to take into account facilitators, barriers, and the context to improve pain management. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - April 7, 2020 Category: Anesthesiology Tags: Review Articles Source Type: research