A Systemic Approach to Complete the Multimodal Assessment Model of Pain
No abstract available (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - June 6, 2019 Category: Anesthesiology Tags: Letter to the Editor Source Type: research

The Co-occurrence of Pediatric Chronic Pain and Depression: A Narrative Review and Conceptualization of Mutual Maintenance
Discussion: Given the dearth of research on mutual maintenance in this area, this review and conceptual model could drive future research in this area. We argue for the development of tailored treatments for this unique population of youth to improve outcomes. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - June 6, 2019 Category: Anesthesiology Tags: Original Articles Source Type: research

Characterizing Social and Academic Aspects of School Anxiety in Pediatric Chronic Pain
Discussion: Present results offer a nuanced perspective into the underlying sources of school anxiety among adolescents with chronic pain. Our findings may inform future research efforts and targeted school functioning interventions. In particular, findings suggest that an individualized approach to the assessment of school anxiety which considers the unique sources of anxiety (eg, social vs. academic) may lay the groundwork for the refinement of school functioning interventions in pediatric chronic pain. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - June 6, 2019 Category: Anesthesiology Tags: Original Articles Source Type: research

Associations Between Physical Activity and Chronic Pain Severity in Youth With Chronic Abdominal Pain
Discussion: The current study highlights the importance of separating between-person and within-person differences when examining the relationship between physical activity and pain severity. Future studies should explore moderating factors that may help to explain random effects to better understand the types of individuals with positive or negative relationships between physical activity and pain severity. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - June 6, 2019 Category: Anesthesiology Tags: Original Articles Source Type: research

Empirical Grouping of Pain Zones in Fibromyalgia: A Preliminary Study
Discussion: WPIE has a normal distribution and shows better predictive qualities than WPIR. The emotional factor is conceptualized as emotional because of the relative importance of the right hemisphere in negative emotions and pain. The physical factor could be responsible for the decreased ability to coordinate left-right stepping. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - June 6, 2019 Category: Anesthesiology Tags: Original Articles Source Type: research

The Impact of Female Chronic Pelvic Pain Questionnaire (IF-CPPQ): A Validation Study
Discussion: The findings indicate that the IF-CPPQ is a reliable and valid measure of the impact of chronic pelvic pain on women. While the IF-CPPQ has the potential for multiple uses within research and clinical practice, further research is needed to determine the questionnaire’s ability to detect clinically meaningful changes with treatment. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - June 6, 2019 Category: Anesthesiology Tags: Original Articles Source Type: research

A Single Preoperative Administration of Dexamethasone, Low-dose Pregabalin, or a Combination of the 2, in Spinal Surgery, Does Not Provide a Better Analgesia Than a Multimodal Analgesic Protocol Alone
Discussion: In this surgical model with the given anesthetic and analgesic environment, there was no advantage gained by adding low-dose pregabalin or dexamethasone. The multimodal analgesic protocol applied to all patients may have reduced the size of the effect. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - June 6, 2019 Category: Anesthesiology Tags: Original Articles Source Type: research

Complications of Postoperative Epidural Analgesia For Oncologic Surgery: A Review of 18,895 Cases
We describe our experience with postoperative EA for oncologic surgery. Materials and Methods: We searched our Acute Pain Medicine database for cases in which postoperative EA was used between 2003 and 2012. We used word search to identify and catalog cases of neurological changes, magnetic resonance imaging or computed tomography of the spine, electromyography studies, and neurologist or neurosurgeon consultations. Medical records of patients with documented persistent neurological deficits and patients who had spine imaging or neurology consultations were reviewed further. In addition, we cross-checked medical records...
Source: The Clinical Journal of Pain - June 6, 2019 Category: Anesthesiology Tags: Original Articles Source Type: research

The Mediating Effect of Pain Catastrophizing on PTSD Symptoms and Pain Outcome
Discussion: Results suggest that pain catastrophizing may represent an important cognitive mechanism through which PTSD symptoms influence the experience of chronic pain. Psychosocial treatment approaches that directly target tendency to catastrophize in response to pain may hold the potential to have salutary effects on both chronic pain and PTSD. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - June 6, 2019 Category: Anesthesiology Tags: Original Articles Source Type: research

Presurgical Comorbidities as Risk Factors For Chronic Postsurgical Pain Following Total Knee Replacement
This study aimed to identify presurgical risk factors for the development of CPSP 5 years after TKR on the basis of medical records containing information with regard to comorbidities. Materials and Methods: Patients undergoing primary TKR surgery were contacted 5 years after TKR. Presurgical Knee Society Score and comorbidities were evaluated. Postsurgical knee pain at 5 years of follow-up was assessed on a Numeric Rating Scale (NRS, 0 to 10). Logistic regression models were utilized to identify patients with moderate-to-severe (NRS≥3) and mild-to-no (NRS (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - June 6, 2019 Category: Anesthesiology Tags: Original Articles Source Type: research

Associations Between Sleep Disturbance and Chronic Pain Intensity and Function: A Test of Direct and Indirect Pathways
Discussion: Sleep disturbance was related significantly with chronic pain intensity and function by both direct and indirect pathways. These results are consistent with an emerging literature highlighting the potential significance of sleep disturbance in chronic pain patients, and provide further support for addressing sleep disturbance in the assessment and management of chronic pain. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - June 6, 2019 Category: Anesthesiology Tags: Original Articles Source Type: research

Musculoskeletal Pain in Individuals With Inflammatory Bowel Disease Reflects Three Distinct Profiles
Conclusions: Study results suggest multiple mechanisms contributing to pain experiences in IBD, to include central mechanisms. Features related to demographics, extraintestinal manifestations, IBD subtype, and clinical IBD features were not predictors of subgroup membership. However, total comorbidity demonstrated association with pain subgroups in this population. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - June 6, 2019 Category: Anesthesiology Tags: Original Articles Source Type: research

Sleep and Pain: A Systematic Review of Studies of Mediation
The objective of this systematic review was to identify, synthesize, and critically appraise studies that have investigated putative mediators on the path between sleep and pain intensity. Methods: A systematic search of 5 electronic bibliographic databases (EMBASE, MEDLINE, CINAHL, PsycINFO, and the Cochrane Central Register of Controlled Trials) was conducted. Eligible studies had to apply a formal test of mediation to variables on the path between a sleep variable and pain intensity or vice versa. All searches, data extraction and quality assessment were conducted by at least 2 independent reviewers. Results: The ...
Source: The Clinical Journal of Pain - May 11, 2019 Category: Anesthesiology Tags: Original Article Source Type: research

Efficacy of the Buzzy Device for Pain Management During Needle-related Procedures: A Systematic Review and Meta-Analysis
Objective: This systematic review and meta-analysis examined the effectiveness of the Buzzy device combining cold and vibration for needle-related procedural pain in children. Materials and Methods: Databases search was conducted from inception to December 2017 to identify randomized controlled trials using the Buzzy device for pain management in children undergoing needle-related procedures. Selection of studies, data extraction, and assessment of risk of bias and quality of evidence were independently performed by 2 reviewers. Quantitative and qualitative analyses were conducted. Results: A total of 9 studies inv...
Source: The Clinical Journal of Pain - May 11, 2019 Category: Anesthesiology Tags: Review Article Source Type: research

School Absence Associated With Childhood Pain in the United States
The objective of this study was to estimate the national burden of school absenteeism associated with pain among 6 to 17-year-old children in the United States. Methods: Data were analyzed from a large, nationally representative sample from the 2012 National Health Interview Survey. Associations between pain and school absence were analyzed using multivariate negative binomial models controlling for sociodemographic and clinical characteristics. Results: The sample contained 8641 participants, of whom 30.3% reported pain over the preceding 12 months. Mean number of parent-reported school days missed across the entire...
Source: The Clinical Journal of Pain - May 11, 2019 Category: Anesthesiology Tags: Original Article Source Type: research

Opioid Use Disorder in Children and Adolescents: Risk Factors, Detection, and Treatment
Opioid medications are an important tool in the management of pain and have been used in clinical practice for centuries. However, due to the highly addictive nature of this class of medications coupled with the life-threatening side effect of respiratory depression, opioid misuse has become a significant public health crisis worldwide. Children and adolescents are at risk for opioid misuse, and early detection is imperative to facilitate treatment and improve outcomes. This review will address the current state of opioid misuse and treatment in children and adolescents in the United States. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - May 11, 2019 Category: Anesthesiology Tags: Special Topic Series on Opioid Therapeutics and Concerns in Pediatrics Source Type: research

Opioid-prescribing Patterns for Pediatric Patients in the United States
Discussion: There exist an urgent need to identify adolescents at increased risk for problematic opioid use behaviors following a receipt of medically prescribed opioids. The article closes with some general guidelines that providers may follow to reduce the risk of opioids in pediatric patients. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - May 11, 2019 Category: Anesthesiology Tags: Special Topic Series on Opioid Therapeutics and Concerns in Pediatrics Source Type: research

The Use of Opioids for Treatment of Pediatric Neuropathic Pain: A Literature Review
Pediatric neuropathic pain is caused by a spectrum of disorders that are generally challenging to treat. Many of the underlying altered neurological processes are being elucidated through mechanistic studies. Few randomized control trials have evaluated the use of opioids for the treatment of adult neuropathic pain conditions, and there have been none in pediatric populations. With sparse data to provide guidance and an incomplete understanding of the underlying mechanisms, the use of opioids remains unclear. Our clinical experience and typical risk versus benefit considerations suggest a limited, if any, role for using op...
Source: The Clinical Journal of Pain - May 11, 2019 Category: Anesthesiology Tags: Special Topic Series on Opioid Therapeutics and Concerns in Pediatrics Source Type: research

From Tramadol to Methadone: Opioids in the Treatment of Pain and Dyspnea in Pediatric Palliative Care
Conclusions: Tramadol appears to play a key role in treating episodes of inconsolability in children with progressive neurologic, metabolic, or chromosomally based condition with impairment of the central nervous system. However, the recent 2017 United States Food and Drug Administration (FDA) warning against pediatric use of tramadol does not seem to be based on clinical evidence, and therefore puts children at risk for unrelieved pain or increased respiratory depression. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - May 11, 2019 Category: Anesthesiology Tags: Special Topic Series on Opioid Therapeutics and Concerns in Pediatrics Source Type: research

The Role of Neuraxial Opioids in Pediatric Practice
Neuraxial-spinal and epidural-administration of opioids can be an effective method for controlling pain for children in a number of clinical settings. Understanding the basic pharmacologic and logistical concepts will make it easier for pediatricians to advocate for their patients, and support patients and families when circumstances suggest that neuraxial opioid treatment is appropriate. This review article summarizes the basic concepts of pharmacology, drug choice, side effects, and complications as well as situations in which neuraxial opioids are appropriate in children. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - May 11, 2019 Category: Anesthesiology Tags: Special Topic Series on Opioid Therapeutics and Concerns in Pediatrics Source Type: research

Opioids in the Management of Acute Pediatric Pain: An Update in a Time of Crisis
Management of acute pain in children is fundamental to our practice. Its myriad benefits include reduced suffering, improved patient satisfaction, more rapid recovery, and a reduced risk of developing postsurgical chronic pain. Although a multimodal analgesic approach is now routinely used, informed and judicious use of opioid receptor agonists remains crucial in this treatment paradigm, as long as the benefits and risks are fully understood. Further, an ongoing public health response to the current opioid crisis is required to help prevent new cases of opioid addiction, identify opioid-addicted individuals, and ensure acc...
Source: The Clinical Journal of Pain - May 11, 2019 Category: Anesthesiology Tags: Special Topic Series on Opioid Therapeutics and Concerns in Pediatrics Source Type: research

Opioid Pharmacology: Developmental Effects on Opioid Metabolism
Conclusions: Understanding how these variables change the pharmacokinetics and pharmacodynamics of each opioid is critical to the successful and safe management of pain in children. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - May 11, 2019 Category: Anesthesiology Tags: Special Topic Series on Opioid Therapeutics and Concerns in Pediatrics Source Type: research

Molecular Biology of Opioid Analgesia and Its Clinical Considerations
Understanding the molecular biology of opioid analgesia is essential for its proper implementation and mechanistic approach to its modulation in order to maximize analgesia and minimize undesired effects. By appreciating the molecular mechanisms intrinsic to opioid analgesia, one can manipulate a molecular target to augment or diminish a specific effect using adjuvant drugs, select an appropriate opioid for opioid rotation or define a molecular target for new opioid drug development. In this review, we present the cellular and molecular mechanisms of opioid analgesia and that of the associated phenomena of tolerance, depen...
Source: The Clinical Journal of Pain - May 11, 2019 Category: Anesthesiology Tags: Special Topic Series on Opioid Therapeutics and Concerns in Pediatrics Source Type: research

The Opioid Debate—PRO: Opioids Have an Important Role in Pain Management in Children
The increase in opioid-related deaths in the United States (and other countries) has prompted a national debate in medicine about the appropriateness of opioids for the treatment of acute and chronic pain, and specifically in children, if medical opioid use causes or increases the risk of opioid use disorder (OUD) later in life. Some in the medical community and in government advocate withholding opioids from children after an arbitrary number of days of treatment, regardless of diagnosis. Here, I argue that opioid experimentation and misuse is no more common in children and adolescents today than 2 or 3 decades ago, that ...
Source: The Clinical Journal of Pain - May 11, 2019 Category: Anesthesiology Tags: Special Topic Series on Opioid Therapeutics and Concerns in Pediatrics Source Type: research

The Opioid Wars—CON: The Risks of Opioids for Pain Management Outweigh the Benefits
The entire field of medicine, not just anesthesiology, has grown comfortable with the risks posed by opioids; but these risks are unacceptably high. It is time for a dramatic paradigm shift. If used at all for acute or chronic pain management, they should be used only after consideration and maximizing the use of nonopioid pharmacologic agents, regional analgesia techniques, and nonpharmacologic methods. Opioids poorly control pain, their intraoperative use may increase the risk of recurrence of some types of cancer, and they have a large number of both minor and serious side effects. Furthermore, there are a myriad of alt...
Source: The Clinical Journal of Pain - May 11, 2019 Category: Anesthesiology Tags: Special Topic Series on Opioid Therapeutics and Concerns in Pediatrics Source Type: research

With Apologies to Lennon and McCartney, All We Need is Data: Opioid Concerns in Pediatrics
No abstract available (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - May 11, 2019 Category: Anesthesiology Tags: Special Topic Series on Opioid Therapeutics and Concerns in Pediatrics Source Type: research

Transversus Thoracic Muscle Plane Block for Breast Surgery
No abstract available (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - April 9, 2019 Category: Anesthesiology Tags: Letters to the Editor Source Type: research

(Non) Pharmacological Modalities in Acute Procedural Pain
No abstract available (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - April 9, 2019 Category: Anesthesiology Tags: Letters to the Editor Source Type: research

Socially Assistive Robots for Helping Pediatric Distress and Pain: A Review of Current Evidence and Recommendations for Future Research and Practice
Conclusions: There is limited evidence suggesting that SAR interventions may reduce distress and no clear evidence showing reduction in pain for children in medical settings. Engineers are conducting interventions using SAR in pediatric populations. Health care providers should be engaged in technology research related to children to facilitate testing and improve the effectiveness of these systems. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - April 9, 2019 Category: Anesthesiology Tags: Review Articles Source Type: research

Support for My Video is Support for Me: A YouTube Scoping Review of Videos Including Adolescents With Chronic Pain
Discussion: Despite potential challenges associated with social media, YouTube may be a promising platform for provision of social support for adolescents with chronic pain. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - April 9, 2019 Category: Anesthesiology Tags: Review Articles Source Type: research

The Association Between Conditioned Pain Modulation and Manipulation-induced Analgesia in People With Lateral Epicondylalgia
This study assessed the association between CPM and MIA responses in people with lateral epicondylalgia. Materials and Methods: Seventy participants with lateral epicondylalgia were assessed for CPM followed by MIA. A single assessor measured pressure pain thresholds (PPT) before, during, and after cold water immersion (10°C) of the asymptomatic hand and contralateral lateral glide (CLG) mobilization of the neck. For analyses, linear mixed models evaluated differences in CPM and MIA responses. Pearson partial correlations and regression analyses evaluated the association between CPM and MIA PPT. Results: There wa...
Source: The Clinical Journal of Pain - April 9, 2019 Category: Anesthesiology Tags: Original Articles Source Type: research

The Effect of Patient Characteristics on Acupuncture Treatment Outcomes: An Individual Patient Data Meta-Analysis of 20,827 Chronic Pain Patients in Randomized Controlled Trials
Discussion: Of 5 patient characteristics tested, we found only baseline severity of pain to potentially moderate the effect of acupuncture treatment. For clinical practice, the evidence from this analysis does not justify stratifying chronic pain patients into subgroups that should or should not receive acupuncture on the basis of these 5 characteristics. Future acupuncture trials should assess other potentially important effect moderators. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - April 9, 2019 Category: Anesthesiology Tags: Original Articles Source Type: research

Youth With Chronic Pain and a History of Adverse Childhood Experiences in the Context of Multidisciplinary Pain Rehabilitation
Conclusions: ACEs history was not a significant factor in treatment outcomes for youth with chronic pain who presented to intensive pain rehabilitation. However, the difference in report of ACEs history across treatment settings indicates that ACEs may be a barrier for youth to engage in recommended outpatient treatment before presenting to pain rehabilitation. Research is needed to further examine this phenomenon. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - April 9, 2019 Category: Anesthesiology Tags: Original Articles Source Type: research

Exposure to Cold Unmasks Potential Biomarkers of Fibromyalgia Syndrome Reflecting Insufficient Sympathetic Responses to Stress
Discussion: The convergence of the effect of cold on 4 relatively simple measures of thermogenic, cardiovascular, and metabolic activity, each regulated by sympathetic activity, strongly indicate that individuals with FMS have impaired sympathetic responses to stress that are observable and highly significant even when measured in extraordinarily small sample populations. If insufficient sympathetic responses to stress are linked to FMS, stress may unmask and maximize these potential clinical biomarkers of FMS and be related to its etiology. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - April 9, 2019 Category: Anesthesiology Tags: Original Articles Source Type: research

Changes in the Organization of the Secondary Somatosensory Cortex While Processing Lumbar Proprioception and the Relationship With Sensorimotor Control in Low Back Pain
Objectives: Patients with nonspecific low back pain (NSLBP) rely more on the ankle compared with the lower back proprioception while standing, perform sit-to-stand-to-sit (STSTS) movements slower, and exhibit perceptual impairments at the lower back. However, no studies investigated whether these sensorimotor impairments relate to a reorganization of the primary and secondary somatosensory cortices (S1 and S2) and primary motor cortex (M1) during proprioceptive processing. Materials and Methods: Proprioceptive stimuli were applied at the lower back and ankle muscles during functional magnetic resonance imaging in 15 p...
Source: The Clinical Journal of Pain - April 9, 2019 Category: Anesthesiology Tags: Original Articles Source Type: research

Posttraumatic Stress Symptoms Mediate the Effects of Trauma Exposure on Clinical Indicators of Central Sensitization in Patients With Chronic Pain
Conclusions: Our findings suggest that trauma exposure is linked to elevated clinical markers of CS but a critical factor in this relationship is the mediating effect of current PTSD symptoms. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - April 9, 2019 Category: Anesthesiology Tags: Original Articles Source Type: research

Dexmedetomidine as an Adjuvant to Local Anesthetics in Transversus Abdominis Plane Block: A Systematic Review and Meta-analysis
The objective of this meta-analysis was to evaluate the analgesic effects of dexmedetomidine (DEX) in transversus abdominis plane (TAP) blocks for abdominal surgery. Methods: Electronic databases, including PubMed, EMBASE, Chinese National Knowledge Infrastructure (CNKI), Wan Fang, and the Cochrane Library, were conducted to collect the randomized controlled trials (RCTs) from inception to March 2018. RCTs investigating the impact of adding DEX to local anesthetics for TAP blocks were included in this analysis. Pain scores (at rest and movement), opioid consumption, the duration of the TAP block and the common adverse e...
Source: The Clinical Journal of Pain - March 7, 2019 Category: Anesthesiology Tags: Review Articles Source Type: research

Exploring the Role of Regional Anesthesia in the Treatment of the Burn-injured Patient: A Narrative Review of Current Literature
Discussion: RA techniques are an adjunct therapy currently used worldwide to improve patient pain outcomes and reduce the adverse effects associated with general anesthetic. RA presents a safe and effective intervention for acute pain resulting from burn-acquired injury. This review of current literature supports the use of RA as a treatment to manage pain associated with burn-related care procedures as an addition to multimodal pain treatment. To date there is limited evidence showing the use of RA in the burns’ patient population. In addition, there appear to be no particular risks to using the technique of RA in...
Source: The Clinical Journal of Pain - March 7, 2019 Category: Anesthesiology Tags: Review Articles Source Type: research

Effect of Local Anesthetic Versus Botulinum Toxin-A Injections for Myofascial Pain Disorders: A Systematic Review and Meta-Analysis
Conclusions: Additional studies are needed to determine sources of heterogeneity mediating the observed differences in effectiveness of local anesthetic and BTX-A injections among the studies. Additional replicative studies are also needed to delineate the relative efficacy and effectiveness of local anesthetic and BTX-A injection. The quantitative results of this study suggest that patients overall experience more pain relief with local anesthetic injections. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - March 7, 2019 Category: Anesthesiology Tags: Review Articles Source Type: research

Catechol-O-Methyltransferase (COMT) rs4680Val158Met Polymorphism is Associated With Widespread Pressure Pain Sensitivity and Depression in Women With Chronic, but not Episodic, Tension-Type Headache
Objectives: The aims of this study were: (1) to investigate the association between the rs4680Val158Met polymorphism in frequent episodic tension-type headache (FETTH) and chronic tension-type headache (CTTH); and (2) to analyze the association between the rs4680Val158Met polymorphism with clinical, psychological, or psychophysical variables. Methods: In total, 50 women with FETTH, 50 with CTTH, and 50 matched headache-free women participated. After amplifying Val158Met polymorphism by polymerase chain reaction, the genotype frequencies and allele distributions based on restriction fragment length polymorphism were as...
Source: The Clinical Journal of Pain - March 7, 2019 Category: Anesthesiology Tags: Original Articles Source Type: research

Multidisciplinary Treatment for Provoked Vestibulodynia: Treatment Trajectories, Predictors, and Moderators of Sexual Distress and Pain
This study examined women’s symptom trajectories over time, as well as baseline demographic, psychosocial and pain characteristics as predictors/ moderators of sexual pain and distress following treatment at a clinic using multidisciplinary concurrent methods. We also examined the impact of baseline variables on the probability of having low sexual distress scores following treatment. Materials and Methods: Women attending a multidisciplinary treatment program for PVD were invited to complete questionnaires before, following, and at 6 and 18 months after program completion. Questionnaires included the Female Sexua...
Source: The Clinical Journal of Pain - March 7, 2019 Category: Anesthesiology Tags: Original Articles Source Type: research

Effect of Preperitoneal Versus Epidural Analgesia on Postoperative Inflammatory Response and Pain Following Radical Cystectomy: A Prospective, Randomized Trial
Conclusion: Continuous preperitoneal analgesia better attenuated postoperative inflammatory response and provided a comparable overall analgesia to that with continuous epidural analgesia following radical cystectomy. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - March 7, 2019 Category: Anesthesiology Tags: Original Articles Source Type: research

TRPA1 Sensitization Produces Hyperalgesia to Heat but not to Cold Stimuli in Human Volunteers
Conclusions: The observation that the TRPA1 irritant cinnamaldehyde induced heat hyperalgesia at an effect sizes comparable with that of capsaicin attributes TRPA1 a role in human heat-induced pain. Results suggest the inclusion of heat pain as a major efficacy measure in human experimental studies of the effects of TRPA1 antagonists and the development of TRPA1 antagonists for clinical pain settings involving heat hyperalgesia. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - March 7, 2019 Category: Anesthesiology Tags: Original Articles Source Type: research

Variables Associated With the Use of Prophylactic Amitriptyline Treatment in Patients With Tension-type Headache
Conclusions: Prophylactic medication is used by TTH patients with higher headache frequency, higher headache burden, worse sleep quality, and higher depression. Lower effectiveness of prophylactic amitriptyline was associated with widespread pain hyperalgesia. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - March 7, 2019 Category: Anesthesiology Tags: Original Articles Source Type: research

Precollision Medical Diagnoses Predict Chronic Neck Pain Following Acute Whiplash Trauma
Objectives: The reason why some individuals develop chronic symptoms, whiplash-associated disorder, following whiplash trauma is poorly understood. We explored whether precollision pain-related diagnoses, medically unexplained symptoms, and psychiatric diagnoses are related to whiplash-associated disorder. Materials and Methods: A cohort of 719 individuals exposed to whiplash trauma and subsequently experiencing symptoms within 72 hours (whiplash-exposed cohort) and 3595 matched controls were included in this observational prospective study. At 12 months postcollision, the whiplash-exposed cohort rated their neck pain...
Source: The Clinical Journal of Pain - March 7, 2019 Category: Anesthesiology Tags: Original Articles Source Type: research

Telehealth Therapy Effects of Nurses and Mental Health Professionals From 2 Randomized Controlled Trials for Chronic Back Pain
Discussion: Results from these clinical trials suggest that the benefits of home-based, telehealth-delivered CBT and SC treatments for chronic back pain were comparable when delivered by a primary care nurse or mental health professional. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - March 7, 2019 Category: Anesthesiology Tags: Original Articles Source Type: research

Pain Catastrophizing and Function In Individuals With Chronic Musculoskeletal Pain: A Systematic Review and Meta-Analysis
Discussion: Despite the very low quality of the available evidence, the general consistency of the findings highlights the potential role that PC may play in delaying recovery from CMP. Research that uses higher quality study designs and procedures would allow for more definitive conclusions regarding the impact of PC on pain and function. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - February 7, 2019 Category: Anesthesiology Tags: Review Articles Source Type: research

Efficacy and Safety of Pregabalin in Neuropathic Pain Followed Spinal Cord Injury: A Review and Meta-Analysis of Randomized Controlled Trials
Objective: Pregabalin has been approved for the treatment of the neuropathic pain following spinal cord injury (SCI). We performed a systemic review and meta-analysis of randomized, controlled, multicenter trials to evaluate the efficacy and safety of pregabalin for SCI-induced neuropathic pain. Materials and Methods: Research searching was performed in PubMed and EMBASE databases and the Cochrane library in May 2018. Clinical controlled trials using pregabalin for the pain treatment following SCI in adults (18 y old and above) were included. Pain and safety-related adverse events were considered as outcomes. M...
Source: The Clinical Journal of Pain - February 7, 2019 Category: Anesthesiology Tags: Review Articles Source Type: research

The Psychological Predictors of Acute and Chronic Pain in Women Following Breast Cancer Surgery: A Systematic Review
This study aimed to identify a broader range of psychological predictors of acute and chronic pain following breast cancer surgery through a systematic review of relevant prospective studies. Methods: Web of Science, psychINFO, PubMed, and MEDLINE databases were searched to identify relevant prospective cohort studies. Studies were included if women were to undergo mastectomy or wide local excision, if psychological factors were assessed before surgery, and pain assessed after surgery. Results: Twelve studies (representing 11 independent cohorts) met the inclusion criteria and described 10 psychological predictors. A...
Source: The Clinical Journal of Pain - February 7, 2019 Category: Anesthesiology Tags: Review Articles Source Type: research

Cognitive Biases Toward Pain: Implications for a Neurocognitive Processing Perspective in Chronic Pain and its Interaction With Depression
Conclusions: Current research supports the importance of individual diagnosis of chronic pain patients and their response patterns of pain, psychological processing, and information processing. This leads to the conclusion that depressed pain patients need other clinical interventions when compared with depressed patients without pain. Previous research showed that a combination of a cognitive-behavioral therapy with mindfulness meditation seems to be a promising approach. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - February 7, 2019 Category: Anesthesiology Tags: Review Articles Source Type: research