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Measuring Glutamate Levels in the Brains of Fibromyalgia Patients and a Potential Role for Glutamate in the Pathophysiology of Fibromyalgia Symptoms: A Systematic Review
Discussion: Although the cause of FM remains inconclusive, there is converging data in favor of a dysregulation of pain processing in the central nervous system of FM patients, particularly associated with an increase in cerebral glutamate levels. Furthermore, there is evidence to support an association between increased glutamate levels and an increase in FM symptoms. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - September 6, 2017 Category: Anesthesiology Tags: Review Article Source Type: research

Acupuncture for the Treatment of Chronic Pain in the Military Population: Factors Associated With Treatment Outcomes
Discussion: The use of electrical stimulation and higher baseline pain score were associated with a positive treatment outcome, while the presence of a psychological comorbidity diminished the likelihood of treatment success. Practitioners should consider using electrical stimulation more frequently, and addressing psychopathology before or concurrent to treatment, when initiating acupuncture. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - September 6, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

Chronic Lateral Epicondylalgia Does Not Exhibit Mechanical Pain Modulation in Response to Noxious Conditioning Heat Stimulus
This study aimed to determine whether LE exhibits a less efficacious CPM compared with that in pain-free controls. Results: Results: Twenty participants with LE, aged 50.7 years (SD=7.05) and who had their condition for 10.2 months (range: 2 to 80 mo), were matched by age and sex to 22 pain-free participants. All participants indicated their PPT over the lateral epicondyle(s) before and during a conditioning noxious heat stimulus that was applied over the calf. A CPM score was calculated as the difference between the PPT before and during the heat pain-conditioning stimulus expressed as a percentage of PPT before the heat...
Source: The Clinical Journal of Pain - September 6, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

Capsaicin 8% Patch Repeat Treatment in Nondiabetic Peripheral Neuropathic Pain: A 52-Week, Open-Label, Single-Arm, Safety Study
Conclusions: Generally, capsaicin 8% patch repeat treatment over 52 weeks was well tolerated, with variable alteration in sensory function and minimal chance of complete sensory loss. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - September 6, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

Comparisons in Muscle Function and Training Rehabilitation Outcomes Between Avoidance-Endurance Model Subgroups
This study sought to examine whether or not the avoidance-endurance model subgroups, FAR, distress-endurers (DER), eustress-endurers (EER), and adaptive responders (AR), differed in physical measures and outcomes after training therapy. Materials and Methods: A total of 137 chronic low back pain patients were assessed before, at the end of, and 6 months after a 6-month rehabilitation training. Patients performed maximum back extension strength and trunk range-of-motion measures, flexion-relaxation tests, and completed the following questionnaires: Avoidance-Endurance Questionnaire, Roland-Morris Disability Questionnaire, ...
Source: The Clinical Journal of Pain - September 6, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

Smoking May Increase Postoperative Opioid Consumption in Patients Who Underwent Distal Gastrectomy With Gastroduodenostomy for Early Stomach Cancer: A Retrospective Analysis
This study evaluated whether smokers require higher doses of opioid to reduce pain when they undergo surgery. Methods: A retrospective review of 236 patients who had intravenous patient-controlled analgesia after distal gastrectomy with gastroduodenostomy between October 2013 and September 2014 was performed to analyze the difference in postoperative opioid requirements between smokers and nonsmokers. Total opioid consumption was observed from the day of operation to postoperative day 2. Patients were grouped into smokers (N=117) and nonsmokers (N=119) for comparison. Simple and multiple regression analyses were performed...
Source: The Clinical Journal of Pain - September 6, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

A Network Analysis of Depressive Symptoms in Individuals Seeking Treatment for Chronic Pain
Discussion: Consistent with past research with patients undergoing treatment for major depression, the current findings are supportive of a model in which depressive symptoms are causally connected within a network rather than being manifestations of a common underlying disorder. The research and clinical implications of the findings, such as developing treatments targeting the most central symptoms, are discussed. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - September 6, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

Treatment Adherence in Child and Adolescent Chronic Migraine Patients: Results From the Cognitive-Behavioral Therapy and Amitriptyline Trial
Discussion: Our findings demonstrate that youth with chronic migraine who agree to be a part of a clinical trial do quite well at attending therapy sessions, and report that they are adherent to completing home/practice between sessions and taking medication. These results lend further support to consideration of CBT+A as a first-line treatment for youth with chronic migraine and suggest that measurement of adherence when this treatment is provided in practice will be important. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - September 6, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

Multidimensional Prognostic Modelling in People With Chronic Axial Low Back Pain
This study entered multidimensional data (demographics, pain characteristics, pain responses to movement, behaviors associated with pain, pain sensitivity, psychological, social, health, lifestyle) at baseline, and interventions undertaken, into prognostic models for pain intensity, disability, global rating of change and bothersomeness at 1-year. Results: The prognostic model for higher pain intensity (explaining 23.2% of the variance) included higher baseline pain intensity and punishing spousal interactions, and lower years in education, while participating in exercise was prognostic of lower pain intensity. The model ...
Source: The Clinical Journal of Pain - September 6, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

Provoked Vestibulodynia: A Comparative Examination of Mental Health, Sleep, Sexual Functioning, and Relationship Adjustment
Discussion: These results indicate that women with PVD and PHN experience similar mental health difficulties, but women with PHN experience more severe impact on their day-to-day functioning and mood. These results support the classification of PVD as a chronic pain condition, as both the pain groups differed from pain-free control participants on a range of measures. Finally, the presence of mental health difficulties and poorer sexual functioning highlights the importance of conducting biopsychosocial pain assessments. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - September 6, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

Duloxetine as an Analgesic Reduces Opioid Consumption After Spine Surgery: A Randomized, Double-Blind, Controlled Study
This study was prospective, double-blind, randomized, and placebo controlled. Patients received either 60 mg duloxetine or an identical placebo 1 hour before surgery and again the following morning. The study participants were allocated into 2 groups: Group C (control) participants received the placebo and Group D (duloxetine) participants received 60 mg duloxetine. The total consumption of fentanyl 48 hours after surgery was measured. Secondary end points were pain scores and the presence or absence of adverse effects, such as headache, nausea, vomiting, itching, dizziness, and drowsiness. Results: Demographic characteri...
Source: The Clinical Journal of Pain - September 6, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

Postoperative Analgesia by a Transversus Abdominis Plane Block Using Different Concentrations of Ropivacaine for Abdominal Surgery: A Meta-Analysis
This study aimed to identify the optimal ropivacaine concentration of TAPB using a meta-analysis. Materials and Methods: This study consisted of a meta-analysis of randomized controlled trials (RCTs). We searched online databases, including PubMed, Embase, the Cochrane Database of Systematic Reviews, and Web of Science. RCTs investigating the 24-hour postoperative opioid consumption and the rest and dynamic pain scores 2, 12, and 24 hours after surgery were included in this analysis. We also assessed opioid-related side-effects and patient satisfaction 24 hours after surgery. Results: Nineteen RCTs (1217 patients) were i...
Source: The Clinical Journal of Pain - August 9, 2017 Category: Anesthesiology Tags: Review Articles Source Type: research

A Review of Adult and Pediatric Neuropathic Pain Assessment Tools
Conclusions: This article summarizes the various screening and assessment tools available to clinicians for evaluating NP. Despite the availability of the 15 tools discussed, a deficiency remains, particularly in the pediatric realm. To date, there is no well-validated NP assessment tool for children younger than 5 years, no pediatric NP screening tool that has been validated outside the domain of chemotherapy-induced peripheral neuropathy, and no consistent recommendation regarding the optimal tool to use with pediatric patients who have chronic pain. These areas, as well as others, would benefit from further research and...
Source: The Clinical Journal of Pain - August 9, 2017 Category: Anesthesiology Tags: Review Articles Source Type: research

The Association Between Headaches and Temporomandibular Disorders is Confounded by Bruxism and Somatic Symptoms
The objective of this observational study was to establish the possible presence of confounders on the association between temporomandibular disorders (TMD) and headaches in a patient population from a TMD and Orofacial Pain Clinic. Materials and Methods: Several subtypes of headaches have been diagnosed: self-reported headache, (probable) migraine, (probable) tension-type headache, and secondary headache attributed to TMD. The presence of TMD was subdivided into 2 subtypes: painful TMD and function-related TMD. The associations between the subtypes of TMD and headaches were evaluated by single regression models. To study...
Source: The Clinical Journal of Pain - August 9, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

Sensory Symptom Profiles of Patients With Neuropathic Pain After Spinal Cord Injury
Conclusions: Classification of SCI-NP patients into the 5 groups identified in the present study based on their distinct sensory symptom profiles may allow identification of those most likely to respond to a specific analgesic approach. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - August 9, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

Ethnicity, Cortisol, and Experimental Pain Responses Among Persons With Symptomatic Knee Osteoarthritis
Discussion: Consistent with previous findings in young healthy adults, cold-pressor pain responses are related to pre-CPT cortisol concentrations in NHW persons with knee OA but not in their AA counterparts. Additional studies are required to better understand this finding. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - August 9, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

Mediators of Treatment Effect in the Back In Action Trial: Using Latent Growth Modeling to Take Change Over Time Into Account
Discussion: Fear-avoidance beliefs were found to mediate the effect of treatment on disability outcome. Measurement of all potential mediator variables in future studies would help to more strongly identify which factors explain observed treatment effects. Latent growth modelling was found to be a useful technique to apply to studies of treatment mediation, suggesting that future studies could use this approach. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - August 9, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

Pain Catastrophizing is Not Associated With Spinal Nociceptive Processing in People With Chronic Widespread Pain
Discussion: Despite increased excitability and decreased inhibition of spinal nociception in patients with chronic widespread pain, we could find no evidence of a significant relationship between pain catastrophizing and measures of spinal nociceptive processing. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - August 9, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

Cold Pain Threshold Identifies a Subgroup of Individuals With Knee Osteoarthritis That Present With Multimodality Hyperalgesia and Elevated Pain Levels
This study aimed to establish the extent to which patients with knee osteoarthritis (OA) demonstrate widespread cold, heat, and pressure hyperalgesia. OA participants with widespread cold hyperalgesia were compared with the remaining OA cohort to determine whether they could be distinguished in terms of hyperalgesia, pain report, pain quality, and physical function. Methods: A total of 80 participants with knee OA and 40 matched healthy, pain-free controls participated. OA participants completed a washout of their usual medication. Quantitative sensory testing was completed at 3 sites using standard methods. Cold pain thr...
Source: The Clinical Journal of Pain - August 9, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

Assessing Prescribing Trends of Adjuvant Medication Therapy in Outpatients With a Diagnosis of Noncancer Chronic Pain
Discussion: Overall adjuvant usage dramatically increased during the study period. Analysis of data demonstrated adjuvant use in chronic pain varied based patient-specific characteristics. These results may allow clinicians, policy makers, and medical educators to identify potential gaps in adjuvant use in certain populations and target areas for clinical, populations-based, and educational improvements in managing NCCP. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - August 9, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

Symptoms of Depression and Risk of Low Back Pain: A Prospective Co-Twin Study
Discussion: The magnitude of the association between depression and LBP seems to be small and may be confounded by genetic and early shared environment influences, although firm conclusions could not be made due to small sample size in the case-control analysis. In addition, the observed association is dependent on the method of assessment used for both conditions. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - August 9, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

Health Care Utilization and Cost in Children and Adolescents With Chronic Pain: Analysis of Health Care Claims Data 1 Year Before and After Intensive Interdisciplinary Pain Treatment
Objectives: The aim of this study was to analyze changes in health care utilization and cost among a sample of highly impaired children and adolescents who sought a 3-week intensive interdisciplinary pain treatment (IIPT). Materials and Methods: Claims data from 7 statutory health insurance companies were analyzed for 65 children and adolescents who sought IIPT at the German Paediatric Pain Centre. The annual health care utilization and cost were determined for the following 4 areas: outpatient care, inpatient care, medications, and remedies and aids. We analyzed the changes in resource utilization in the year before (pre...
Source: The Clinical Journal of Pain - August 9, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

Recommendations for Self-Report Outcome Measures in Vulvodynia Clinical Trials
Discussion: Measures that are specific to vulvovaginal pain are ideal for adoption in PVD clinical trials, and many such measures currently exist that allow the relevant IMMPACT domains to be captured. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - July 10, 2017 Category: Anesthesiology Tags: Review Article Source Type: research

Bilateral Sensory Changes and High Burden of Disease in Patients With Chronic Pain and Unilateral Nondermatomal Somatosensory Deficits: A Quantitative Sensory Testing and Clinical Study
Discussion: This may indicate a distinct sensory profile in chronic non-neuropathic pain and NDSD, probably attributable to altered central pain processing and sensitization. The presence of NDSD in chronic non-neuropathic pain may be regarded as a marker for higher burden of pain disease. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - July 10, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

Chronic Pain and Obesity Within a Pediatric Interdisciplinary Pain Clinic Setting: A Preliminary Examination of Current Relationships and Future Directions
This study aims to both replicate and extend this research base. Methods: A retrospective chart review of 99 patients presenting for evaluation in a pediatric pain clinic was conducted. Demographic information, including patient weight status, and self-report measures completed by both patients and their parents, including the Pain Frequency-Severity-Duration scale, the Functional Disability Inventory, and the Pain Catastrophizing Scale were examined. Results: Abdominal pain was the most frequently reported primary pain diagnosis category, with headache, diffuse musculoskeletal, localized musculoskeletal, and back pain c...
Source: The Clinical Journal of Pain - July 10, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

Smoking Status and Opioid-related Problems and Concerns Among Men and Women on Chronic Opioid Therapy
This study contributes to an understanding of perceived problems and concerns with COT among current, former, and never smokers with chronic noncancer pain. Results suggest that current and former smokers may be a difficult population to target to decrease COT, given that they perceive fewer problems with prescription opioid use, despite higher odds of having an opioid use disorder (males and females) and greater opioid doses (males only). (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - July 10, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

Interrater Agreement of Manual Palpation for Identification of Myofascial Trigger Points: A Systematic Review and Meta-Analysis
Discussion: Use of manual palpation for identification of MTrPs is unreliable, and future investigation should focus on integration with more reliable techniques. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - July 10, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

Procedural Pain in Palliative Care: Is It Breakthrough Pain? A Multicenter National Prospective Study to Assess Prevalence, Intensity, and Treatment of Procedure-related Pain in Patients With Advanced Disease
Objective: To assess the prevalence of breakthrough pain (BTP) provoked by 6 common procedures in patients with advanced disease. Methods: A prospective, cross-sectional, multicenter, national study was performed in 23 palliative care units in Italy. Patients were recruited if they were undergoing one of the following procedures as part of normal care: turning, personal hygiene care, transfer from bed to chair, bladder catheterization, pressure ulcer care, and subcutaneous drug administration. The Numerical Rating Scale was used to measure pain intensity before, during, and after the procedure. Results: One thousand seve...
Source: The Clinical Journal of Pain - July 10, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

Testing the Interpersonal Theory of Suicide in Chronic Pain
Discussion: These findings are in line with some, but not all, of the major predictions of the interpersonal theory of suicide. In general, however, they support the relevance of the theory for individuals with chronic pain. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - July 10, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

What’s in a Name? Health Care Providers’ Perceptions of Pediatric Pain Patients Based on Diagnostic Labels
The objective of this study was to evaluate the influence of diagnostic labels on pediatric health care providers’ perceptions of pediatric chronic pain patients. Materials and Methods: Using an online survey, providers were randomly assigned to 1 of 2 vignette conditions (differing only in diagnostic label provided) and completed questionnaires about their perceptions of the vignette patient. Results: Responses from 58 participants were analyzed. The 2 groups, based on diagnostic conditions used (fibromyalgia and chronic widespread pain) did not differ significantly on general demographics and health care provider...
Source: The Clinical Journal of Pain - July 10, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

Impact of Abuse on Adjustment and Chronic Pain Disability: A Structural Equation Model
Conclusions: The current model has important implications in understanding the interplay of factors involved in adjustment of individuals with chronic pain. Sexual abuse did not have a direct effect on pain-related disability. However, indirect effects through other psychosocial factors were demonstrated. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - July 10, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

A Pilot Comparison of a Smartphone App With or Without 2-Way Messaging Among Chronic Pain Patients: Who Benefits From a Pain App?
This study recruited 105 chronic pain patients to use a smartphone pain app and half of the patients (N=52) had 2-way messaging available through the app. All patients completed baseline measures and were asked to record their progress every day for 3 months, with the opportunity to continue for 6 months. All participants were supplied a Fitbit to track daily activity. Summary line graphs were posted to each of the patients’ electronic medical records and physicians were notified of their patient’s progress. Results: Ninety patients successfully downloaded the pain app. Average age of the participants was 47.1...
Source: The Clinical Journal of Pain - July 10, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

Characterization of the Adverse Effects Induced by Acetaminophen and Nonsteroidal Anti-Inflammatory Drugs Based on the Analysis of the Japanese Adverse Drug Event Report Database
Conclusions: These findings may help clinicians select an appropriate drug for patients considering their backgrounds, instead of choosing merely based on the class of the drug, for example, cyclooxygenase selectivity. This selection, based on the characteristic information on AEs occurring in clinical settings, might be more suitable for patients. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - July 10, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

A Systematic Review and Meta-Analysis of Migraine and Suicidal Ideation
Conclusions: A meta-analysis of available studies suggests a modest positive association between migraine and suicidal ideation. Further studies allowing for a more comprehensive investigation of the association between migraine and the full range of suicidal behaviors are warranted. A larger and more robust evidence-base may be useful to inform the clinical screening and diagnoses of comorbid conditions in migraineurs. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - June 8, 2017 Category: Anesthesiology Tags: Review Articles Source Type: research

Early Prescription Opioid Use for Musculoskeletal Disorders and Work Outcomes: A Systematic Review of the Literature
The objective of this study was to conduct a systematic review to determine whether early receipt of opioids is associated with future work outcomes among workers with MSDs compared with other analgesics, no analgesics, or placebo. Methods: MEDLINE, EMBASE, CINAHL, and CENTRAL were searched from inception to 2014 and reference lists were scanned. Studies were included if opioids were prescribed within 12 weeks of MSD onset. Eligible outcomes included absenteeism, work status, receiving disability payments, and functional status. Two reviewers independently reviewed articles for relevance, risk of bias, and data extraction...
Source: The Clinical Journal of Pain - June 8, 2017 Category: Anesthesiology Tags: Review Articles Source Type: research

Perioperative Factors Associated With Chronic Central Pain After the Resection of Intramedullary Spinal Cord Tumor
Discussion: Decline in JOA score, intraoperative hypotension, and postoperative corticosteroids are independently associated with postsurgical chronic central pain. Intraoperative hypotension and the use of postoperative corticosteroids can be avoided or modified during perioperative management. As results from animal studies have indicated that the administration of corticosteroids may intensify chronic pain, further studies in larger cohorts are required to definitively determine the effect of corticosteroids on postsurgical central pain. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - June 8, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

Pain in Extrapyramidal Neurodegenerative Diseases
Objective: Pain is one of the most common nonmotor symptoms of Parkinson disease (PD) and other Parkinson plus syndromes, with a major effect on quality of life. The aims of the study were to examine the prevalence and characteristics of pain in PD and other Parkinson plus syndromes and patient use and response to pain medications. Methods: The cohort consisted of 371 patients: 300 (81%) with PD and 71 (19%) with Parkinson plus syndromes. Data on clinical parameters and pain were collected by questionnaire. Disease severity was measured with the Unified PD Rating Scale for patients with PD. Results: Pain was reported by ...
Source: The Clinical Journal of Pain - June 8, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

Chronic Pain and Itch are Common, Morbid Sequelae Among Individuals Who Receive Tissue Autograft After Major Thermal Burn Injury
Objective: Pain and itch symptoms are common after major thermal burn injury (MThBI)—requiring tissue autografting. To our knowledge, no prospective longitudinal studies have characterized pain and itch outcomes after tissue autografting and associations between and functional interference caused by such symptoms. Materials and Methods: We prospectively evaluated burn graft site and tissue donor site pain and itch severity (0 to 10, numeric rating scale) over 1 year among a representative cohort of MThBI survivors (n=96) who received tissue autografting within 14 days of MThBI. Results: Nearly all participants had ...
Source: The Clinical Journal of Pain - June 8, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

Pressure Pain Threshold and Anxiety in Adolescent Females With and Without Juvenile Fibromyalgia: A Pilot Study
This study is a first step toward investigating mechanisms of altered pain processing in adolescents with JFM. Adolescents with JFM were found be more sensitive to pressure pain than their healthy peers, which suggests a propensity for sensitization of peripheral and/or central nociceptive information often reported in adult fibromyalgia, and which does not appear to be affected by anxiety. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - June 8, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

Impaired Pain Modulation in Fibromyalgia Patients in Response to Social Distress Manipulation
Discussion: These results are in line with previous studies demonstrating altered pain inhibition in FM patients, and suggest that unlike PFC or other non-“stress–related” chronic pain conditions, being socially included may increase pain perception in FM patients. Possible underlying mechanisms and clinical relevance are discussed. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - June 8, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

Comparison of Ultrasonography-guided Bilateral Intercostal Nerve Blocks and Conventional Patient-controlled Intravenous Analgesia for Pain Control After the Nuss Procedure in Children: A Prospective Randomized Study
Conclusions: Our study suggests that UG-ICNBs might be more effective than PCIA for postoperative analgesia in children who undergo the Nuss procedure for PE. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - June 8, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

Psychological Predictors of Acute Postoperative Pain After Hysterectomy for Benign Causes
Discussion: Hysterectomy patients at risk for high APOP intensity could be characterized by the psychological variables used, whereas their predictive value for analgesic consumption was limited. The high predictive potency of pain-specific psychological variables should be considered for further improvement of pain management and prevention, because pain-specific variables such as pain anxiety can be the target of focal psychological interventions when preparing for surgery. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - June 8, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

Evaluating the Association Between Acute and Chronic Pain After Surgery: Impact of Pain Measurement Methods
Aim/Objectives/Background: There is a need to predict chronic (Z3mo) postsurgical pain (CPSP). Acute ( (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - June 8, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

Pain Sensitivity and its Relation to Spreading on the Body, Intensity, Frequency, and Duration of Pain: A Cross-Sectional Population-based Study (SwePain)
This study compares PSQ in individuals with and without pain and clarifies how pain sensitivity relates to spreading of pain on the body, and to intensity, frequency, duration of pain and to age and sex. Materials and Methods: A total of 5905 individuals with pain and 572 individuals without pain from the general population in southeastern Sweden completed and returned a postal questionnaire. Results: The mean PSQ score was 3.9 (95% confidence interval [CI], 3.88-3.98) in individuals with pain and 3.5 (95% CI, 3.38-3.64) in pain-free individuals. Hence, PSQ was the highest among individuals with pain, with a difference o...
Source: The Clinical Journal of Pain - June 8, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

Efficacy and Safety of Once-Daily Controlled-Release Pregabalin for the Treatment of Patients With Postherpetic Neuralgia: A Double-Blind, Enriched Enrollment Randomized Withdrawal, Placebo-Controlled Trial
Objectives: To assess efficacy and safety of once-daily controlled-release (CR) formulation of pregabalin in patients with postherpetic neuralgia. Methods: An enriched enrollment, randomized withdrawal trial, with 6-week single-blind pregabalin treatment phase and 13-week double-blind phase, where patients with ≥50% decrease in mean pain score at single-blind end point from baseline were randomized (1:1) to pregabalin CR (82.5 to 660 mg/d) or placebo. Primary efficacy outcome was time to loss of therapeutic response (LTR) ( (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - June 8, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

Acceptance and Commitment Therapy (ACT) for Chronic Pain: A Systematic Review and Meta-Analyses
The objective of this review was to determine the clinical effectiveness of ACT for chronic pain in adults when compared with control conditions and other active treatments. Methods: The searches of this systematic review were conducted in the Cochrane library, MEDLINE, EMBASE, CINAHL Plus (EBSCO), and PsycINFO. Grey literature, reference list, and reverse citation searches were also completed. Results: Eleven trials were included. ACT was favored over controls (no alternative intervention or treatment as usual). Significant, medium to large effect sizes were found for measures of pain acceptance and psychological flexib...
Source: The Clinical Journal of Pain - May 17, 2017 Category: Anesthesiology Tags: Review Articles Source Type: research

Spinal Cord Stimulation for Refractory Angina Pectoris: A Systematic Review and Meta-analysis
Discussion: The current meta-analysis suggested that SCS was a potential alternative in the treatment of PAP patients. Further investigation for finding the appropriate intensity of stimulation is required before this treatment should be widely recommended and applied. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - May 17, 2017 Category: Anesthesiology Tags: Review Articles Source Type: research

Getting Back to Living: Further Evidence for the Efficacy of an Interdisciplinary Pediatric Pain Treatment Program
This study examined key functional outcomes following a 3-week interdisciplinary pediatric pain rehabilitation program for adolescents with chronic pain. Maintenance of gains was evaluated at 3-month follow-up. Methods: Participants included 171 adolescents (12 to 18 y of age) with chronic pain who completed a hospital-based outpatient pediatric pain rehabilitation program. Participants completed measures of functional disability, depressive symptoms, pain catastrophizing, opioid use, school attendance, and pain severity at admission, discharge, and at 3-month follow-up. Results: Similar to other interdisciplinary pediat...
Source: The Clinical Journal of Pain - May 17, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

Struggling With Adversities of Life: The Role of Forgiveness in Patients Suffering from Fibromyalgia
Discussion: Forgiveness of self and others is beneficially associated with pain, health, quality of life, and anger in FM participants at levels that are of similar size and direction as in healthy controls. However, FM participants manifest lower levels of forgiveness of self and others. Therapeutic promotion of forgiveness as a psychosocial coping strategy may help patients with FM to better manage psychological and physical symptoms, thereby enhancing well-being. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - May 17, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research

Novel Metrics in the Longitudinal Evaluation of Pain Data in Sickle Cell Disease
Conclusions: The longitudinal collection of pain data with the inclusion of hospital data during periods of hospitalization is feasible and acceptable in patients with SCD over periods of 30 to 60 days. Long-term collection of pain diary data, while informative, is associated with higher rates of missing data. Novel metrics of pain have the potential to better describe intraindividual and interindividual variation in pain, inform studies of the transition from acute to chronic pain as well as contribute patient-reported end points of pain for interventional clinical trials of pain in SCD. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - May 17, 2017 Category: Anesthesiology Tags: Original Articles Source Type: research