Impact of prenatal arsenic exposure on chronic adult diseases
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - June 6, 2018 Category: Sexual Medicine Authors: Jamie L. Young Lu Cai J. Christopher States Source Type: research

Impact of prenatal arsenic exposure on chronic adult diseases.
Abstract Exposure to environmental stressors during susceptible windows of development can result in negative health outcomes later in life, a concept known as the Developmental Origins of Health and Disease (DOHaD). There is a growing body of evidence that exposures to metals early in life (in utero and postnatal) increase the risk of developing adult diseases such as cancer, cardiovascular disease, non-alcoholic fatty liver disease, and diabetes. Of particular concern is exposure to the metalloid arsenic, a drinking water contaminant and worldwide health concern. Epidemiological studies of areas with high levels...
Source: Systems Biology in Reproductive Medicine - June 6, 2018 Category: Reproduction Medicine Authors: Young JL, Cai L, States JC Tags: Syst Biol Reprod Med Source Type: research

Metabolomics analysis of follicular fluid in women with ovarian endometriosis undergoing in vitro fertilization
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - May 28, 2018 Category: Sexual Medicine Authors: Abdullah Karaer Gorkem Tuncay Ak ın Mumcu Berat Dogan Source Type: research

Metabolomics analysis of follicular fluid in women with ovarian endometriosis undergoing in vitro fertilization.
Abstract The purpose of this study was to investigate whether a change in the follicular fluid metabolomics profile due to endometrioma is identifiable. Twelve women with ovarian endometriosis (aged
Source: Systems Biology in Reproductive Medicine - May 28, 2018 Category: Reproduction Medicine Authors: Karaer A, Tuncay G, Mumcu A, Dogan B Tags: Syst Biol Reprod Med Source Type: research

Effects of saturated palmitic acid and omega-3 polyunsaturated fatty acids on Sertoli cell apoptosis
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - May 25, 2018 Category: Sexual Medicine Authors: Xuechun Hu Xie Ge Wei Liang Yong Shao Jun Jing Cencen Wang Rong Zeng Bing Yao Source Type: research

Effects of saturated palmitic acid and omega-3 polyunsaturated fatty acids on Sertoli cell apoptosis.
Abstract Obesity is believed to negatively affect male semen quality and is accompanied by dysregulation of free fatty acid (FFA) metabolism in plasma. However, the implication of dysregulated FFA on semen quality and the involvement of Sertoli cells remain unclear. In the present study, we report obesity decreased Sertoli cell viability through dysregulated FFAs. We observed an increased rate of apoptosis in Sertoli cells, accompanied with elevated FFA levels, in the testes of obese mice that were provided a high-fat diet (HFD). Moreover, the levels of reactive oxygen species were elevated. Furthermore, we demons...
Source: Systems Biology in Reproductive Medicine - May 25, 2018 Category: Reproduction Medicine Authors: Hu X, Ge X, Liang W, Shao Y, Jing J, Wang C, Zeng R, Yao B Tags: Syst Biol Reprod Med Source Type: research

Impaired serotonin communication during juvenile development in rats diminishes adult sperm quality
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - May 23, 2018 Category: Sexual Medicine Authors: Juan D íaz-Ramos Maribel Flores-Flores Mar ía E. Ayala Andr és Aragón-Martínez Source Type: research

Impaired serotonin communication during juvenile development in rats diminishes adult sperm quality.
Martínez A Abstract Spermatogenesis and steroidogenesis are testicular functions regulated by gonadotrophins as well as other factors, including serotonin. Testicular serotonin acts as an autocrine regulator of testosterone secretion, but studies on its role in spermatogenesis and sperm quality are scarce. Here, we analyzed the effects of intratesticular inhibition of serotonin synthesis on gonadotrophins, testosterone, and sperm quality. Both testicles of 30-day-old rats were injected once with saline solution (SS) or distinct concentrations of p-chloroamphetamine (PCA) (0.03, 0.06, or 0.12 mg). At 65...
Source: Systems Biology in Reproductive Medicine - May 22, 2018 Category: Reproduction Medicine Authors: Díaz-Ramos J, Flores-Flores M, Ayala ME, Aragón-Martínez A Tags: Syst Biol Reprod Med Source Type: research

The clinical application of single-sperm-based SNP haplotyping for PGD of osteogenesis imperfecta
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - May 16, 2018 Category: Sexual Medicine Authors: Linjun Chen Zhenyu Diao Zhipeng Xu Jianjun Zhou Guijun Yan Haixiang Sun Source Type: research

ADAMTS1 and ADAMTS5 metalloproteases produced by Sertoli cells: a potential diagnostic marker in azoospermia
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - May 8, 2018 Category: Sexual Medicine Authors: Oya Sena Aydos Yunus Yukselten Sinan Ozkavukcu Asuman Sunguroglu Kaan Aydos Source Type: research

ADAMTS1 and ADAMTS5 metalloproteases produced by Sertoli cells: a potential diagnostic marker in azoospermia.
In this study, our aim was to detect protein levels of A Disintegrin and Metalloproteinase with Thrombospondin Motifs 1 and 5 (ADAMTS1 and ADAMTS5) proteases and to examine the effect of in vitro FSH supplementation on protease production in cultured Sertoli cells. The expression of metalloproteases, ADAMTS1, and ADAMTS5 were investigated in Sertoli cell cultures as well as in ejaculate of azoospermic men which then were compared with ejaculates of the fertile control group. A total of 15 azoospermic men, diagnosed as obstructive (OA, n = 5) and nonobstructive (NOA, n = 10) azoospermia were included in ...
Source: Systems Biology in Reproductive Medicine - May 8, 2018 Category: Reproduction Medicine Authors: Aydos OS, Yukselten Y, Ozkavukcu S, Sunguroglu A, Aydos K Tags: Syst Biol Reprod Med Source Type: research

Complex chromosomal aberrations in a fetus originating from oocytes with smooth endoplasmic reticulum (SER) aggregates
Volume 64, Issue 4, August 2018, Page 283-290 . (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - May 2, 2018 Category: Sexual Medicine Authors: Ioannis A. Sfontouris George T. Lainas Tryfon G. Lainas Efthimios Faros Maria Banti Katerina Kardara Katerina Anagnostopoulou Harris Kontos George K. Petsas Efstratios M. Kolibianakis Source Type: research

Complex chromosomal aberrations in a fetus originating from oocytes with smooth endoplasmic reticulum (SER) aggregates.
Abstract The presence of smooth endoplasmic reticulum aggregates (SERa) in the ooplasm is considered as the most severe oocyte dysmorphism due to its serious and potentially lethal outcomes in offspring. In the present case report, a couple underwent their first intracytoplasmic sperm injection (ICSI) cycle using a gonadotrophin releasing hormone (GnRH) antagonist protocol, followed by fetal ultrasound scanning and amniocentesis. SERa were observed in all oocytes retrieved. A singleton pregnancy was established. The second trimester fetal ultrasound scan revealed a female fetus with overlapping fingers in both han...
Source: Systems Biology in Reproductive Medicine - May 2, 2018 Category: Reproduction Medicine Authors: Sfontouris IA, Lainas GT, Lainas TG, Faros E, Banti M, Kardara K, Anagnostopoulou K, Kontos H, Petsas GK, Kolibianakis EM Tags: Syst Biol Reprod Med Source Type: research

A technical assessment of the porcine ejaculated spermatozoa for a sperm-specific RNA-seq analysis
Volume 64, Issue 4, August 2018, Page 291-303 . (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - April 26, 2018 Category: Sexual Medicine Authors: Marta G òdia Fabiana Quoos Mayer Julieta Nafissi Anna Castell ó Joan Enric Rodr íguez-Gil Armand S ánchez Alex Clop Source Type: research

A technical assessment of the porcine ejaculated spermatozoa for a sperm-specific RNA-seq analysis.
ánchez A, Clop A Abstract The study of the boar sperm transcriptome by RNA-seq can provide relevant information on sperm quality and fertility and might contribute to animal breeding strategies. However, the analysis of the spermatozoa RNA is challenging as these cells harbor very low amounts of highly fragmented RNA, and the ejaculates also contain other cell types with larger amounts of non-fragmented RNA. Here, we describe a strategy for a successful boar sperm purification, RNA extraction and RNA-seq library preparation. Using these approaches our objectives were: (i) to evaluate the sperm recovery rate...
Source: Systems Biology in Reproductive Medicine - April 26, 2018 Category: Reproduction Medicine Authors: Gòdia M, Mayer FQ, Nafissi J, Castelló A, Rodríguez-Gil JE, Sánchez A, Clop A Tags: Syst Biol Reprod Med Source Type: research

Association between thrombophilia gene polymorphisms and recurrent pregnancy loss risk in the Iranian population
Volume 64, Issue 4, August 2018, Page 274-282 . (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - April 16, 2018 Category: Sexual Medicine Authors: Razieh Bigdeli Mohammad Reza Younesi Erfan Panahnejad Vahid Asgary Samaneh Heidarzadeh Hoda Mazaheri Samira Louni Aligoudarzi Source Type: research

Identification of a novel mutation in FGFR1 gene in patients with Kallmann syndrome by high throughput sequencing.
Abstract Kallmann syndrome (KS) is a rare clinical and genetic heterogeneity disease, which is familial or sporadic. KS is known to have three patterns of inheritance: X linked recessive inheritance, autosomal dominant inheritance and rare autosomal recessive inheritance. Here, we report a sibling pedigree with autosomal dominant inheritance of KS, and we identified a novel heterozygous frameshift mutation c.299_300insCCGCAGACTCCGGCCTCTATGC (p.C101Rfs*17) in FGFR1 gene using whole-exome sequencing (WES). The mutation and affection status were cosegregated. The mutation is not present in the dbSNP, 1000 Genome, ExA...
Source: Systems Biology in Reproductive Medicine - April 15, 2018 Category: Reproduction Medicine Authors: Jin BF, Ji ZY, Su ZY, Mei LB, Huang XJ, Lin SB, Li P, Sha YW Tags: Syst Biol Reprod Med Source Type: research

Association between thrombophilia gene polymorphisms and recurrent pregnancy loss risk in the Iranian population.
Abstract Miscarriage is the most common complication in pregnancy. Considering the importance of the problem thrombophilia in pregnant women and its association with recurrent pregnancy loss (RPL), analysis of polymorphisms of genes involved in thrombophilia can be useful. We investigated the frequency and association between ten polymorphisms of seven thrombophilia genes and RPL in an Iranian population. This case-control study was conducted on 200 women with recurrent pregnancy loss and also on 200 women with at least one successful pregnancy as the control group. Using PCR-RFLP, DNA from samples were analyzed f...
Source: Systems Biology in Reproductive Medicine - April 15, 2018 Category: Reproduction Medicine Authors: Bigdeli R, Younesi MR, Panahnejad E, Asgary V, Heidarzadeh S, Mazaheri H, Aligoudarzi SL Tags: Syst Biol Reprod Med Source Type: research

Artificial oocyte activation with calcium ionophore for frozen sperm cycles
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - April 5, 2018 Category: Sexual Medicine Authors: Seda Karabulut Özlem Aksünger Can Ata Yusuf Sa ğıroglu İlknur Keskin Source Type: research

Artificial oocyte activation with calcium ionophore for frozen sperm cycles.
skin İ Abstract Fertilization problems are the major problems that may be faced in 30-55% of the patients during an intracytoplasmic sperm injection (ICSI) cycle. A successful oocyte activation depends on factors related to both sperm and oocyte, and one of the important factors that mediates the process is Ca2+ concentration within the oocyte. Artificial oocyte activation (AOA) is a method used for fertilization problems that commonly involve the usage of Ca2+ ionophores and is usually used in problems such as total fertilization failure (TFF) and globozoospermia. The aim of the present study was to investigate ...
Source: Systems Biology in Reproductive Medicine - April 5, 2018 Category: Reproduction Medicine Authors: Karabulut S, Aksünger Ö, Ata C, Sağıroglu Y, Keskin İ Tags: Syst Biol Reprod Med Source Type: research

Adding bovine seminal plasma prior to freezing improves post-thaw bull sperm kinematics but decreases mitochondrial activity.
Abstract Variations in fertility between bulls with comparable sperm quality could be due to differences in their seminal plasma (SP). The aim of this study was to investigate the effect of adding bovine SP from bulls of known fertility to SP-free sperm samples. After removal of SP by Single Layer Centrifugation, resuspended sperm pellets were treated with SP from high or low fertility bulls at 0% (control), 1%, or 5% before freezing. Sperm quality was evaluated after thawing. Data were analyzed using Proc MIXED, SAS®. Bovine SP at 1% or 5% SP1 and SP5, respectively, decreased average path velocity, curvilinea...
Source: Systems Biology in Reproductive Medicine - April 5, 2018 Category: Reproduction Medicine Authors: Nongbua T, Al-Essawe EM, Edman A, Johannisson A, Morrell JM Tags: Syst Biol Reprod Med Source Type: research

Grape seed procyanidins extract attenuates Cisplatin-induced oxidative stress and testosterone synthase inhibition in rat testes
Volume 64, Issue 4, August 2018, Page 246-259 . (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - April 3, 2018 Category: Sexual Medicine Authors: Minmin Tian Fangfang Liu Han Liu Qiong Zhang Lei Li Xiangbo Hou Jianxin Zhao Sheng Li Xuhong Chang Yingbiao Sun Source Type: research

Grape seed procyanidins extract attenuates Cisplatin-induced oxidative stress and testosterone synthase inhibition in rat testes.
In conclusion, the main protection exerted by GSPE on CIS-induced testicular toxicity is related to its effects including suppressing oxidative/nitrative stress and up-regulating expression of testosterone synthetase. ABBREVIATIONS: CIS: Cisplatin; GSPE: grape seed procyanidins extract; LH: luteinizing hormone; FSH: follicle-stimulating hormone; STAR: steroidogenic acute regulatory protein; CYP11A1: P450 side chain cleavage enzyme; HSD3B1: 3β-hydroxysteroid dehydrogenase; CYP17A1: 17α-hydroxylase; HSD17B: 17β-hydroxysteroid dehydrogenase; ROS: reactive oxygen species; O2-: superoxide anion; H2O2: hydro...
Source: Systems Biology in Reproductive Medicine - April 3, 2018 Category: Reproduction Medicine Authors: Tian M, Liu F, Liu H, Zhang Q, Li L, Hou X, Zhao J, Li S, Chang X, Sun Y Tags: Syst Biol Reprod Med Source Type: research

Clinical and neonatal outcomes of intrauterine insemination with frozen donor sperm
Volume 64, Issue 4, August 2018, Page 240-245 . (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - March 30, 2018 Category: Sexual Medicine Authors: Linjun Chen Lihua Zhu Changming Cai Guijun Yan Haixiang Sun Source Type: research

Clinical and neonatal outcomes of intrauterine insemination with frozen donor sperm.
Abstract This retrospective study evaluated the association between frozen donor sperm used for intrauterine insemination and clinical and neonatal outcomes, including 304 singleton pregnancies resulting from artificial insemination by the husband (AIH) and 173 singleton pregnancies resulting from artificial insemination by a donor (AID). The clinical outcomes for AID showed no increased risk of abortion, ectopic pregnancy or pregnancy complications compared to those for AIH. There were no differences in gender, gestational age or prematurity of live births between the two groups. However, the birthweight of live ...
Source: Systems Biology in Reproductive Medicine - March 30, 2018 Category: Reproduction Medicine Authors: Chen L, Zhu L, Cai C, Yan G, Sun H Tags: Syst Biol Reprod Med Source Type: research

Follicular fluid levels of anti-M üllerian hormone, insulin-like growth factor 1 and leptin in women with fertility disorders.
In conclusion, levels of AMH, IGF1 and leptin found in follicular fluid are sensitive markers for anovulatory fertility disorders. AMH, IGF1 and leptin levels in follicular fluid have no relation to the fertility disorders caused by endometriosis, fallopian tube damage or disorders with unknown etiology. ABBREVIATIONS: AMH: anti-Müllerian hormone; IGF1: insulin-like growth factor 1; PCOS: polycystic ovary syndrome. PMID: 29595066 [PubMed - as supplied by publisher] (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - March 29, 2018 Category: Reproduction Medicine Authors: Kucera R, Babuska V, Ulcova-Gallova Z, Kulda V, Topolcan O Tags: Syst Biol Reprod Med Source Type: research

A long-term follow-up study of men born with very low birth weight and their reproductive hormone profile.
dsjö G Abstract Environmental factors during the fetal period may adversely affect reproductive functions in men being born with very low birth weight (VLBW,
Source: Systems Biology in Reproductive Medicine - March 27, 2018 Category: Reproduction Medicine Authors: Hammar M, Larsson E, Bladh M, Finnström O, Gäddlin PO, Leijon I, Theodorsson E, Sydsjö G Tags: Syst Biol Reprod Med Source Type: research

Association between sperm mitochondrial ND2 gene variants and total fertilization failure
Volume 64, Issue 4, August 2018, Page 266-273 . (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - March 26, 2018 Category: Sexual Medicine Authors: Jin-Lan Zhang Gen-Hong Mao Xiao-Hui Huang Hong-Yang Chang Yi Zheng Xue Cao Source Type: research

Association between sperm mitochondrial ND2 gene variants and total fertilization failure.
This study suggests that the MT-ND2 gene variants might not be associated with TFF. ABBREVIATIONS: ATP: adenosine triphosphate; dNTP: deoxy-ribonucleoside triphosphate; FADH2: flavin adenine dinucleotide; FDR: false discovery rate; FSH: follicle-stimulating hormone; IVF: in vitro fertilization; LH: luteinizing hormone; MTATP6: mitochondrially encoded ATP synthase 6; MTCYB: mitochondrially encoded cytochrome b; mtDNA: mitochondrial DNA; MT-ND2: mitochondrial ND2; NADH: nicotinamide adenine dinucleotide; ND2: NADH dehydrogenase subunit 2; OXPHOS: oxidative phosphorylation; PCR: single nucleotide polymorphisms; SNPs: sin...
Source: Systems Biology in Reproductive Medicine - March 26, 2018 Category: Reproduction Medicine Authors: Zhang JL, Mao GH, Huang XH, Chang HY, Zheng Y, Cao X Tags: Syst Biol Reprod Med Source Type: research

Luteal-phase ovarian stimulation increases the number of mature oocytes in older women with severe diminished ovarian reserve.
The objective of this study was to assess whether follicular-phase stimulation (FPS) and luteal-phase stimulation (LPS) in the same menstrual cycle (double ovarian stimulation) in older women with severe DOR will produce a higher number of oocytes compared to FPS alone. Women with DOR (n = 69; mean age = 42.4) who underwent double ovarian stimulation for IVF were included. Women underwent ovarian stimulation in FPS using clomiphene citrate, letrozole, and gonadotropins followed by oocyte retrieval. The next day following oocyte retrieval, women underwent a second ovarian stimulation (LPS) using the same...
Source: Systems Biology in Reproductive Medicine - March 22, 2018 Category: Reproduction Medicine Authors: Rashtian J, Zhang J Tags: Syst Biol Reprod Med Source Type: research

Busulfan-mediated oxidative stress and genotoxicity decrease in sperm of Satureja Khuzestanica essential oil-administered mice
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - March 20, 2018 Category: Sexual Medicine Authors: Parva Nasimi Mohammad Reza Tabandeh Sayad Roohi Source Type: research

Busulfan-mediated oxidative stress and genotoxicity decrease in sperm of Satureja Khuzestanica essential oil-administered mice.
Abstract Here, we studied the protective effects of Satureja Khuzestanica essential oil (SKEO) as a potent anti-oxidant, against damage caused by chemotherapy with busulfan in testis and epididymal sperm of adult mice. The NMRI adult mice were assigned: G1: control, G2: was treated with busulfan (4 days, 3.2 mg/kg), G3: was treated with busulfan (4 days, 3.2 mg/kg) and SKEO (28 days, 225 mg/kg) at the same time, and G4: was pre-treated with SKEO (7 days, 225 mg/kg) and subsequently co-treated with busulfan (4 days, 3.2 mg/kg) and SKEO (28 days, 225 mg/kg)...
Source: Systems Biology in Reproductive Medicine - March 20, 2018 Category: Reproduction Medicine Authors: Nasimi P, Tabandeh MR, Roohi S Tags: Syst Biol Reprod Med Source Type: research

Treating donor cells with 2-PCPA corrects aberrant histone H3K4 dimethylation and improves cloned goat embryo development.
In this study, we investigated the influence of treating donor cells with trans-2-Phenylcyclopropylamine (2-PCPA), a specific inhibitor of lysine-specific demethylase 1 (LSD1), on embryogenesis, H3K4me2 level, and gene expression in cloned goat embryos. Treated goat fetal fibroblast cells (GFFs) with 2-PCPA served as donor cells for subsequent SCNT. Results showed that H3K4me2 levels in treated GFFs increased gradually with the increasing 2-PCPA concentration (p 
Source: Systems Biology in Reproductive Medicine - March 15, 2018 Category: Reproduction Medicine Authors: Mao T, Han C, Deng R, Wei B, Meng P, Luo Y, Zhang Y Tags: Syst Biol Reprod Med Source Type: research

Current status of sperm functional genomics and its diagnostic potential of fertility in bovine (Bos taurus)
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - March 14, 2018 Category: Sexual Medicine Authors: Sellappan Selvaraju Sivashanmugam Parthipan Lakshminarayana Somashekar B. Krishnan Binsila Atul P. Kolte Arunachalam Arangasamy Janivara Parameshwaraiah Ravindra Stephen A. Krawetz Source Type: research