Systems Biology in Reproductive Medicine 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Effects of first and second division modes on euploidy acquisition in human embryo
Syst Biol Reprod Med. 2024 Dec;70(1):52-58. doi: 10.1080/19396368.2024.2311643. Epub 2024 Mar 1.ABSTRACTThe aim of this study was to non-invasively investigate euploid embryos using methods other than pre-implantation genetic testing for aneuploidy. The study focused on direct cleavage (DC) observed during early embryo development. We also investigated the relationship between the mode of early embryo division and embryo ploidy. Embryos were divided into the normal cleavage (NC) and DC groups, and the DC group was further subdivided into the DC-First (DC-F) and DC-Second (DC-S) groups, depending on whether DC was observed ...
Source: Systems Biology in Reproductive Medicine - March 1, 2024 Category: Reproduction Medicine Authors: Yamato Mizobe Yukari Kuwatsuru Yuko Kuroki Yumiko Fukumoto Mari Tokudome Harue Moewaki Tokiko Iwakawa Kazuhiro Takeuchi Source Type: research
Effects of first and second division modes on euploidy acquisition in human embryo
Syst Biol Reprod Med. 2024 Dec;70(1):52-58. doi: 10.1080/19396368.2024.2311643. Epub 2024 Mar 1.ABSTRACTThe aim of this study was to non-invasively investigate euploid embryos using methods other than pre-implantation genetic testing for aneuploidy. The study focused on direct cleavage (DC) observed during early embryo development. We also investigated the relationship between the mode of early embryo division and embryo ploidy. Embryos were divided into the normal cleavage (NC) and DC groups, and the DC group was further subdivided into the DC-First (DC-F) and DC-Second (DC-S) groups, depending on whether DC was observed ...
Source: Systems Biology in Reproductive Medicine - March 1, 2024 Category: Reproduction Medicine Authors: Yamato Mizobe Yukari Kuwatsuru Yuko Kuroki Yumiko Fukumoto Mari Tokudome Harue Moewaki Tokiko Iwakawa Kazuhiro Takeuchi Source Type: research
Effects of first and second division modes on euploidy acquisition in human embryo
Syst Biol Reprod Med. 2024 Dec;70(1):52-58. doi: 10.1080/19396368.2024.2311643. Epub 2024 Mar 1.ABSTRACTThe aim of this study was to non-invasively investigate euploid embryos using methods other than pre-implantation genetic testing for aneuploidy. The study focused on direct cleavage (DC) observed during early embryo development. We also investigated the relationship between the mode of early embryo division and embryo ploidy. Embryos were divided into the normal cleavage (NC) and DC groups, and the DC group was further subdivided into the DC-First (DC-F) and DC-Second (DC-S) groups, depending on whether DC was observed ...
Source: Systems Biology in Reproductive Medicine - March 1, 2024 Category: Reproduction Medicine Authors: Yamato Mizobe Yukari Kuwatsuru Yuko Kuroki Yumiko Fukumoto Mari Tokudome Harue Moewaki Tokiko Iwakawa Kazuhiro Takeuchi Source Type: research
Effects of first and second division modes on euploidy acquisition in human embryo
Volume 70, Issue 1, December 2024, Page 52-58 . (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - March 1, 2024 Category: Sexual Medicine Authors: Yamato MizobeYukari KuwatsuruYuko KurokiYumiko FukumotoMari TokudomeHarue MoewakiTokiko IwakawaKazuhiro TakeuchiTakeuchi Ladies Clinic/Center for Reproductive Medicine, Kagoshima, Japan Source Type: research
Engineered exosome as a biological nanoplatform for drug delivery of Rosmarinic acid to improve implantation in mice with induced endometritis
In this study, rosmarinic acid (RA) is used as an anti-inflammatory agent that encapsulates in exosomes and is used to attenuate lipopolysaccharide (LPS)-induced endometritis and improve implantation. For this purpose, exosomes were loaded with RA and then administrated into the animal groups, including RA, exosome, RA plus exosome (RA + Exo), and RA-loaded exosomes (RALExo) groups. The concentrations of RA or exosomes used in this study were 10 mg/kg, and the compounds were injected into the uterine horn 24 h following the induction of endometritis. Upon the presence of inflammation detected by the histopathological metho...
Source: Systems Biology in Reproductive Medicine - February 7, 2024 Category: Reproduction Medicine Authors: Morteza Taravat Reza Asadpour Razi Jafari Jozani Amir Fattahi Monireh Khordadmehr Hamed Hajipour Source Type: research
Hydroxycitric acid and capsaicin combination alleviates obesity-induced testicular apoptosis, oxidative stress and inflammation
Syst Biol Reprod Med. 2024 Dec;70(1):20-37. doi: 10.1080/19396368.2024.2306403. Epub 2024 Feb 7.ABSTRACTRecent research in rodents suggests that oxidative stress, inflammation, and apoptosis in the testes caused by high-fat diets (HFD) are a cause of male infertility. To investigate the therapeutic efficacy of the combination of hydroxycitric acid and capsaicin (HCC) against male reproductive disorders, we developed an HFD-induced obese rat model. Rats received HFD supplementation for 21 weeks, which induced obesity. From week 16, HCC (100 mg/kg body weight) was administered to investigate its potential to treat testicular...
Source: Systems Biology in Reproductive Medicine - February 7, 2024 Category: Reproduction Medicine Authors: V V Sathibabu Uddandrao Seshathri Eraniappan Asokan Balakrishnan Ramajayam Sengottuvelu Singaravel Anitha Roy Brahma Naidu Parim Chandrasekaran Ponnusamy Saravanan Ganapathy Ponmurugan Ponnusamy Vadivukkarasi Sasikumar Source Type: research
Preimplantation genetic testing as a preventive strategy for the transmission of mitochondrial DNA disorders
Syst Biol Reprod Med. 2024 Dec;70(1):38-51. doi: 10.1080/19396368.2024.2306389. Epub 2024 Feb 7.ABSTRACTMitochondrial diseases are distinct types of metabolic and/or neurologic abnormalities that occur as a consequence of dysfunction in oxidative phosphorylation, affecting several systems in the body. There is no effective treatment modality for mitochondrial disorders so far, emphasizing the clinical significance of preventing the inheritance of these disorders. Various reproductive options are available to reduce the probability of inheriting mitochondrial disorders, including in vitro fertilization (IVF) using donated o...
Source: Systems Biology in Reproductive Medicine - February 7, 2024 Category: Reproduction Medicine Authors: Xinpeng Lan Wu Liji Ao Ji Li Source Type: research
Engineered exosome as a biological nanoplatform for drug delivery of Rosmarinic acid to improve implantation in mice with induced endometritis
In this study, rosmarinic acid (RA) is used as an anti-inflammatory agent that encapsulates in exosomes and is used to attenuate lipopolysaccharide (LPS)-induced endometritis and improve implantation. For this purpose, exosomes were loaded with RA and then administrated into the animal groups, including RA, exosome, RA plus exosome (RA + Exo), and RA-loaded exosomes (RALExo) groups. The concentrations of RA or exosomes used in this study were 10 mg/kg, and the compounds were injected into the uterine horn 24 h following the induction of endometritis. Upon the presence of inflammation detected by the histopathological metho...
Source: Systems Biology in Reproductive Medicine - February 7, 2024 Category: Reproduction Medicine Authors: Morteza Taravat Reza Asadpour Razi Jafari Jozani Amir Fattahi Monireh Khordadmehr Hamed Hajipour Source Type: research
Hydroxycitric acid and capsaicin combination alleviates obesity-induced testicular apoptosis, oxidative stress and inflammation
Syst Biol Reprod Med. 2024 Dec;70(1):20-37. doi: 10.1080/19396368.2024.2306403. Epub 2024 Feb 7.ABSTRACTRecent research in rodents suggests that oxidative stress, inflammation, and apoptosis in the testes caused by high-fat diets (HFD) are a cause of male infertility. To investigate the therapeutic efficacy of the combination of hydroxycitric acid and capsaicin (HCC) against male reproductive disorders, we developed an HFD-induced obese rat model. Rats received HFD supplementation for 21 weeks, which induced obesity. From week 16, HCC (100 mg/kg body weight) was administered to investigate its potential to treat testicular...
Source: Systems Biology in Reproductive Medicine - February 7, 2024 Category: Reproduction Medicine Authors: V V Sathibabu Uddandrao Seshathri Eraniappan Asokan Balakrishnan Ramajayam Sengottuvelu Singaravel Anitha Roy Brahma Naidu Parim Chandrasekaran Ponnusamy Saravanan Ganapathy Ponmurugan Ponnusamy Vadivukkarasi Sasikumar Source Type: research
Preimplantation genetic testing as a preventive strategy for the transmission of mitochondrial DNA disorders
Syst Biol Reprod Med. 2024 Dec;70(1):38-51. doi: 10.1080/19396368.2024.2306389. Epub 2024 Feb 7.ABSTRACTMitochondrial diseases are distinct types of metabolic and/or neurologic abnormalities that occur as a consequence of dysfunction in oxidative phosphorylation, affecting several systems in the body. There is no effective treatment modality for mitochondrial disorders so far, emphasizing the clinical significance of preventing the inheritance of these disorders. Various reproductive options are available to reduce the probability of inheriting mitochondrial disorders, including in vitro fertilization (IVF) using donated o...
Source: Systems Biology in Reproductive Medicine - February 7, 2024 Category: Reproduction Medicine Authors: Xinpeng Lan Wu Liji Ao Ji Li Source Type: research
Engineered exosome as a biological nanoplatform for drug delivery of Rosmarinic acid to improve implantation in mice with induced endometritis
In this study, rosmarinic acid (RA) is used as an anti-inflammatory agent that encapsulates in exosomes and is used to attenuate lipopolysaccharide (LPS)-induced endometritis and improve implantation. For this purpose, exosomes were loaded with RA and then administrated into the animal groups, including RA, exosome, RA plus exosome (RA + Exo), and RA-loaded exosomes (RALExo) groups. The concentrations of RA or exosomes used in this study were 10 mg/kg, and the compounds were injected into the uterine horn 24 h following the induction of endometritis. Upon the presence of inflammation detected by the histopathological metho...
Source: Systems Biology in Reproductive Medicine - February 7, 2024 Category: Reproduction Medicine Authors: Morteza Taravat Reza Asadpour Razi Jafari Jozani Amir Fattahi Monireh Khordadmehr Hamed Hajipour Source Type: research
Hydroxycitric acid and capsaicin combination alleviates obesity-induced testicular apoptosis, oxidative stress and inflammation
Syst Biol Reprod Med. 2024 Dec;70(1):20-37. doi: 10.1080/19396368.2024.2306403. Epub 2024 Feb 7.ABSTRACTRecent research in rodents suggests that oxidative stress, inflammation, and apoptosis in the testes caused by high-fat diets (HFD) are a cause of male infertility. To investigate the therapeutic efficacy of the combination of hydroxycitric acid and capsaicin (HCC) against male reproductive disorders, we developed an HFD-induced obese rat model. Rats received HFD supplementation for 21 weeks, which induced obesity. From week 16, HCC (100 mg/kg body weight) was administered to investigate its potential to treat testicular...
Source: Systems Biology in Reproductive Medicine - February 7, 2024 Category: Reproduction Medicine Authors: V V Sathibabu Uddandrao Seshathri Eraniappan Asokan Balakrishnan Ramajayam Sengottuvelu Singaravel Anitha Roy Brahma Naidu Parim Chandrasekaran Ponnusamy Saravanan Ganapathy Ponmurugan Ponnusamy Vadivukkarasi Sasikumar Source Type: research
Preimplantation genetic testing as a preventive strategy for the transmission of mitochondrial DNA disorders
Syst Biol Reprod Med. 2024 Dec;70(1):38-51. doi: 10.1080/19396368.2024.2306389. Epub 2024 Feb 7.ABSTRACTMitochondrial diseases are distinct types of metabolic and/or neurologic abnormalities that occur as a consequence of dysfunction in oxidative phosphorylation, affecting several systems in the body. There is no effective treatment modality for mitochondrial disorders so far, emphasizing the clinical significance of preventing the inheritance of these disorders. Various reproductive options are available to reduce the probability of inheriting mitochondrial disorders, including in vitro fertilization (IVF) using donated o...
Source: Systems Biology in Reproductive Medicine - February 7, 2024 Category: Reproduction Medicine Authors: Xinpeng Lan Wu Liji Ao Ji Li Source Type: research
Engineered exosome as a biological nanoplatform for drug delivery of Rosmarinic acid to improve implantation in mice with induced endometritis
In this study, rosmarinic acid (RA) is used as an anti-inflammatory agent that encapsulates in exosomes and is used to attenuate lipopolysaccharide (LPS)-induced endometritis and improve implantation. For this purpose, exosomes were loaded with RA and then administrated into the animal groups, including RA, exosome, RA plus exosome (RA + Exo), and RA-loaded exosomes (RALExo) groups. The concentrations of RA or exosomes used in this study were 10 mg/kg, and the compounds were injected into the uterine horn 24 h following the induction of endometritis. Upon the presence of inflammation detected by the histopathological metho...
Source: Systems Biology in Reproductive Medicine - February 7, 2024 Category: Reproduction Medicine Authors: Morteza Taravat Reza Asadpour Razi Jafari Jozani Amir Fattahi Monireh Khordadmehr Hamed Hajipour Source Type: research
