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Hydroxycitric acid and capsaicin combination alleviates obesity-induced testicular apoptosis, oxidative stress and inflammation
Syst Biol Reprod Med. 2024 Dec;70(1):20-37. doi: 10.1080/19396368.2024.2306403. Epub 2024 Feb 7.ABSTRACTRecent research in rodents suggests that oxidative stress, inflammation, and apoptosis in the testes caused by high-fat diets (HFD) are a cause of male infertility. To investigate the therapeutic efficacy of the combination of hydroxycitric acid and capsaicin (HCC) against male reproductive disorders, we developed an HFD-induced obese rat model. Rats received HFD supplementation for 21 weeks, which induced obesity. From week 16, HCC (100 mg/kg body weight) was administered to investigate its potential to treat testicular...
Source: Systems Biology in Reproductive Medicine - February 7, 2024 Category: Reproduction Medicine Authors: V V Sathibabu Uddandrao Seshathri Eraniappan Asokan Balakrishnan Ramajayam Sengottuvelu Singaravel Anitha Roy Brahma Naidu Parim Chandrasekaran Ponnusamy Saravanan Ganapathy Ponmurugan Ponnusamy Vadivukkarasi Sasikumar Source Type: research

Preimplantation genetic testing as a preventive strategy for the transmission of mitochondrial DNA disorders
Syst Biol Reprod Med. 2024 Dec;70(1):38-51. doi: 10.1080/19396368.2024.2306389. Epub 2024 Feb 7.ABSTRACTMitochondrial diseases are distinct types of metabolic and/or neurologic abnormalities that occur as a consequence of dysfunction in oxidative phosphorylation, affecting several systems in the body. There is no effective treatment modality for mitochondrial disorders so far, emphasizing the clinical significance of preventing the inheritance of these disorders. Various reproductive options are available to reduce the probability of inheriting mitochondrial disorders, including in vitro fertilization (IVF) using donated o...
Source: Systems Biology in Reproductive Medicine - February 7, 2024 Category: Reproduction Medicine Authors: Xinpeng Lan Wu Liji Ao Ji Li Source Type: research

Preimplantation genetic testing as a preventive strategy for the transmission of mitochondrial DNA disorders
Volume 70, Issue 1, December 2024, Page 38-51 . (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - February 7, 2024 Category: Sexual Medicine Authors: Xinpeng LanWu Liji AoJi Lia College of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, Chinab College of Mongolian Medicine and Pharmacy, Inner Mongolia University for Nationalities, Tongliao, Inner Mongolia, Chi Source Type: research

Engineered exosome as a biological nanoplatform for drug delivery of Rosmarinic acid to improve implantation in mice with induced endometritis
Volume 70, Issue 1, December 2024, Page 3-19 . (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - February 7, 2024 Category: Sexual Medicine Authors: Morteza TaravatReza AsadpourRazi Jafari JozaniAmir FattahiMonireh KhordadmehrHamed Hajipoura Department of Clinical Science, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iranb Department of Reproductive Biology, Faculty of Advanced Medica Source Type: research

Hydroxycitric acid and capsaicin combination alleviates obesity-induced testicular apoptosis, oxidative stress and inflammation
Volume 70, Issue 1, December 2024, Page 20-37 . (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - February 7, 2024 Category: Sexual Medicine Authors: V. V. Sathibabu UddandraoSeshathri EraniappanAsokan Balakrishnan Ramajayam Sengottuvelu SingaravelAnitha RoyBrahma Naidu ParimChandrasekaran Ponnusamy Saravanan GanapathyPonmurugan PonnusamyVadivukkarasi Sasikumara Department of Biochemistry, K.S. Rangasa Source Type: research

E-SBiRM
Syst Biol Reprod Med. 2024 Dec;70(1):1-2. doi: 10.1080/19396368.2024.2296824. Epub 2024 Jan 10.NO ABSTRACTPMID:38198356 | DOI:10.1080/19396368.2024.2296824 (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - January 10, 2024 Category: Reproduction Medicine Authors: Stephen A Krawetz Source Type: research

E-SBiRM
Volume 70, Issue 1, December 2024, Page 1-2 . (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - January 10, 2024 Category: Sexual Medicine Authors: Stephen A. KrawetzSBiRM: Systems Biology in Reproductive Medicine Charlotte B. Failing Professor of Fetal Therapy and Diagnosis, Department of Obstetrics and Gynecology, Molecular Medicine and Genetics, Wayne State University School of Medicine Source Type: research