Sperm epigenetics in the study of male fertility, offspring health, and potential clinical applications
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - February 13, 2017 Category: Sexual Medicine Authors: Timothy G. Jenkins Kenneth I. Aston Emma R. James Douglas T. Carrell Source Type: research

Efficacy and safety of varicocelectomies: A meta-analysis
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - February 13, 2017 Category: Sexual Medicine Authors: Renbin Yuan Hui Zhuo Dehong Cao Qiang Wei Source Type: research

Sperm epigenetics in the study of male fertility, offspring health, and potential clinical applications
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - February 13, 2017 Category: Sexual Medicine Authors: Timothy G. Jenkins Kenneth I. Aston Emma R. James Douglas T. Carrell Source Type: research

Efficacy and safety of varicocelectomies: A meta-analysis
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - February 13, 2017 Category: Sexual Medicine Authors: Renbin Yuan Hui Zhuo Dehong Cao Qiang Wei Source Type: research

Clinical outcome of cycles with oocyte degeneration after intracytoplasmic sperm injection
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - February 1, 2017 Category: Sexual Medicine Authors: Lanlan Liu Jiali Cai Ping Li Xiaoming Jiang Jianzhi Ren Source Type: research

Corrigendum.
Authors: PMID: 28139179 [PubMed - in process] (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - January 31, 2017 Category: Reproduction Medicine Tags: Syst Biol Reprod Med Source Type: research

Personalized precision reproductive medicine and diagnostics.
PMID: 28139180 [PubMed - in process] (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - January 31, 2017 Category: Reproduction Medicine Authors: Krawetz SA Tags: Syst Biol Reprod Med Source Type: research

Corrigendum
Volume 63, Issue 1, February 2017, Page 67-67 . (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - January 30, 2017 Category: Sexual Medicine Source Type: research

Personalized precision reproductive medicine and diagnostics
Volume 63, Issue 1, February 2017, Page 1-1 . (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - January 30, 2017 Category: Sexual Medicine Authors: Stephen A. Krawetz Source Type: research

Corrigendum
Volume 63, Issue 1, February 2017, Page 67-67 . (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - January 30, 2017 Category: Sexual Medicine Source Type: research

Personalized precision reproductive medicine and diagnostics
Volume 63, Issue 1, February 2017, Page 1-1 . (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - January 30, 2017 Category: Sexual Medicine Authors: Stephen A. Krawetz Source Type: research

Impaired spermatogenesis in the twitcher mouse: A morphological evaluation from the seminiferous tubules to epididymal transit
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - January 18, 2017 Category: Sexual Medicine Authors: Alice Luddi Martina Gori Laura Crifasi Camilla Marrocco Giuseppe Belmonte Elvira Costantino-Ceccarini Piomboni Paola Source Type: research

Impaired spermatogenesis in the twitcher mouse: A morphological evaluation from the seminiferous tubules to epididymal transit.
This study reveals that alterations in germ cell development can be initially detected at the stage VIII and IX of spermatogenesis. The disrupted spermatogenetic process leads to a reduced number of elongating spermatids and spermatozoa in these mutant animals. Electron microscopy analysis demonstrates major acrosomal and chromatin condensation defects in the mutants. In addition, in twitcher mice, the epididymal architecture is impaired, with stereocilia of caput and corpus broken, detached and completely spread out into the lumen. These findings indicate that seminolipid expression is crucial for proper development of sp...
Source: Systems Biology in Reproductive Medicine - January 18, 2017 Category: Reproduction Medicine Authors: Luddi A, Gori M, Crifasi L, Marrocco C, Belmonte G, Costantino-Ceccarini E, Paola P Tags: Syst Biol Reprod Med Source Type: research

Impaired spermatogenesis in the twitcher mouse: A morphological evaluation from the seminiferous tubules to epididymal transit
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - January 18, 2017 Category: Sexual Medicine Authors: Alice Luddi Martina Gori Laura Crifasi Camilla Marrocco Giuseppe Belmonte Elvira Costantino-Ceccarini Piomboni Paola Source Type: research

A sperm-specific proteome-scale metabolic network model identifies non-glycolytic genes for energy deficiency in asthenozoospermia
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - January 12, 2017 Category: Sexual Medicine Authors: Arvand Asghari Sayed-Amir Marashi Naser Ansari-Pour Source Type: research

A sperm-specific proteome-scale metabolic network model identifies non-glycolytic genes for energy deficiency in asthenozoospermia.
Abstract About 15% of couples experience difficulty in conceiving a child, of which half of the cases are thought to be male-related. Asthenozoospermia, or low sperm motility, is one of the frequent types of male infertility. Although energy metabolism is suggested to be central to the etiology of asthenozoospermia, very few attempts have been made to identify its underlying metabolic pathways. Here, we reconstructed SpermNet, the first proteome-scale model of the sperm cell by using whole-proteome data and the mCADRE algorithm. The reconstructed model was then analyzed using the COBRA toolbox. Genes were knocked-...
Source: Systems Biology in Reproductive Medicine - January 12, 2017 Category: Reproduction Medicine Authors: Asghari A, Marashi SA, Ansari-Pour N Tags: Syst Biol Reprod Med Source Type: research

A sperm-specific proteome-scale metabolic network model identifies non-glycolytic genes for energy deficiency in asthenozoospermia
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - January 12, 2017 Category: Sexual Medicine Authors: Arvand Asghari Sayed-Amir Marashi Naser Ansari-Pour Source Type: research

Age-related changes in gene expression patterns of immature and aged rat primordial follicles
Volume 63, Issue 1, February 2017, Page 37-48 . (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - January 2, 2017 Category: Sexual Medicine Authors: Vijayakumar Govindaraj Harshini Krishnagiri Payal Chakraborty Madavan Vasudevan A. Jagannadha Rao Source Type: research

Age-related changes in gene expression patterns of immature and aged rat primordial follicles.
Abstract Women are born with millions of primordial follicles which gradually decrease with increasing age and this irreversible supply of follicles completely exhausts at menopause. The fertility capacity of women diminishes in parallel with aging. The mechanisms for reproductive aging are not fully understood. We have observed a decline in Brca1 mediated DNA repair in aging rat primordial follicles. To further understand the age-related molecular changes, we performed microarray gene expression analysis using total RNA extracted from immature (18 to 20 day old) and aged (400 to 450 day old) rat primordial follic...
Source: Systems Biology in Reproductive Medicine - January 2, 2017 Category: Reproduction Medicine Authors: Govindaraj V, Krishnagiri H, Chakraborty P, Vasudevan M, Rao AJ Tags: Syst Biol Reprod Med Source Type: research

Age-related changes in gene expression patterns of immature and aged rat primordial follicles
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - January 2, 2017 Category: Sexual Medicine Authors: Vijayakumar Govindaraj Harshini Krishnagiri Payal Chakraborty Madavan Vasudevan A. Jagannadha Rao Source Type: research

Predicting the clinical outcome of ICSI by sperm head vacuole examination
Volume 63, Issue 1, February 2017, Page 29-36 . (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - December 23, 2016 Category: Sexual Medicine Authors: Khaled Pocate-Cheriet Ilan Heilikman Raphael Porcher Virginie Barraud-Lange Nathalie Sermondade Charlene Herbemont Jean Philippe Wolf Christophe Sifer Source Type: research

Predicting the clinical outcome of ICSI by sperm head vacuole examination
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - December 23, 2016 Category: Sexual Medicine Authors: Khaled Pocate-Cheriet Ilan Heilikman Raphael Porcher Virginie Barraud-Lange Nathalie Sermondade Charlene Herbemont Jean Philippe Wolf Christophe Sifer Source Type: research

Leptin and leptin-receptor polymorphisms in fertile and infertile men
Volume 63, Issue 1, February 2017, Page 7-14 . (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - December 15, 2016 Category: Sexual Medicine Authors: Saeid Khosropour Maryam Hamidi Amir Fattahi Iraj Khodadadi Manoochehr Karami Mohammad Fazilati Asad Vaisi-Raygani Heidar Tavilani Source Type: research

Leptin and leptin-receptor polymorphisms in fertile and infertile men.
Abstract The association of leptin (LEP) -2548G/A and/or leptin receptor (LEPR) Gln223Arg polymorphisms with male infertility and plasma FSH, LH, and testosterone (T) levels was examined. The genotypes and allele frequency distributions of LEP -2548G/A and LEPR Gln223Arg polymorphisms were investigated in 150 fertile and 150 infertile men by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Also, plasma levels of FSH, LH, and T were measured using commercial ELISA kits. Frequencies of AA, AG and GG genotypes of LEP-2548G/A polymorphism were statistically different in fertile and infert...
Source: Systems Biology in Reproductive Medicine - December 15, 2016 Category: Reproduction Medicine Authors: Khosropour S, Hamidi M, Fattahi A, Khodadadi I, Karami M, Fazilati M, Vaisi-Raygani A, Tavilani H Tags: Syst Biol Reprod Med Source Type: research

Leptin and leptin-receptor polymorphisms in fertile and infertile men
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - December 15, 2016 Category: Sexual Medicine Authors: Saeid Khosropour Maryam Hamidi Amir Fattahi Iraj Khodadadi Manoochehr Karami Mohammad Fazilati Asad Vaisi-Raygani Heidar Tavilani Source Type: research

Mitochondrial variations in the MT-ND4 and MT-TL1 genes are associated with male infertility
Volume 63, Issue 1, February 2017, Page 2-6 . (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - December 13, 2016 Category: Sexual Medicine Authors: Feng Ni Yun Zhou Wen-xiang Zhang Xue-mei Wang Xiao-min Song Hong Jiang Source Type: research

Mitochondrial variations in the MT-ND4 and MT-TL1 genes are associated with male infertility.
Abstract Mitochondrial gene mutations have been reported to be associated with sperm motility and the quality of semen. The aim of this study was to investigate whether the two mitochondrial genes (MT-ND4 and MT-TL1) are involved in Chinese male infertility. A total of 97 asthenospermia patients and 80 fertile controls were recruited in this case-control study. Genomic DNA were extracted from the sperm of all participants. Two mitochondrial DNA genes (MT-ND4 and MT-TL1) were amplified by using polymerase chain reaction (PCR) with the gene-specific primers and sequenced on an ABI 3730XL DNA sequencer. For the MT-ND...
Source: Systems Biology in Reproductive Medicine - December 13, 2016 Category: Reproduction Medicine Authors: Ni F, Zhou Y, Zhang WX, Wang XM, Song XM, Jiang H Tags: Syst Biol Reprod Med Source Type: research

Mitochondrial variations in the MT-ND4 and MT-TL1 genes are associated with male infertility
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - December 13, 2016 Category: Sexual Medicine Authors: Feng Ni Yun Zhou Wen-xiang Zhang Xue-mei Wang Xiao-min Song Hong Jiang Source Type: research

Granulocyte colony stimulating factor treatment of resistant thin endometrium in women with frozen-thawed blastocyst transfer
Volume 63, Issue 1, February 2017, Page 49-57 . (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - November 21, 2016 Category: Sexual Medicine Authors: Micha ł Kunicki Krzysztof Łukaszuk Joanna Liss Patrycja Skowro ńska Joanna Szczypta ńska Source Type: research

Granulocyte colony stimulating factor treatment of resistant thin endometrium in women with frozen-thawed blastocyst transfer
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - November 21, 2016 Category: Sexual Medicine Authors: Micha ł Kunicki Krzysztof Łukaszuk Joanna Liss Patrycja Skowro ńska Joanna Szczypta ńska Source Type: research

Initiative for standardization of reporting genetics of male infertility
Volume 63, Issue 1, February 2017, Page 58-66 . (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - November 20, 2016 Category: Sexual Medicine Authors: Eva Traven Ana Ogrinc Tanja Kunej Source Type: research

Initiative for standardization of reporting genetics of male infertility
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - November 20, 2016 Category: Sexual Medicine Authors: Eva Traven Ana Ogrinc Tanja Kunej Source Type: research

2016 Systems Biology in Reproductive Medicine selected highlights.
Authors: PMID: 27831849 [PubMed - in process] (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - November 11, 2016 Category: Reproduction Medicine Tags: Syst Biol Reprod Med Source Type: research

2016 Systems Biology in Reproductive Medicine selected highlights
Volume 62, Issue 6, December 2016, Page 423-425 . (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - November 9, 2016 Category: Sexual Medicine Source Type: research

In silico analysis of candidate proteins sharing homology with Streptococcus agalactiae proteins and their role in male infertility
Volume 63, Issue 1, February 2017, Page 15-28 . (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - October 31, 2016 Category: Sexual Medicine Authors: Rajeshwari Parida Luna Samanta Source Type: research

In silico analysis of candidate proteins sharing homology with Streptococcus agalactiae proteins and their role in male infertility.
Abstract Leukocytospermia is a physiologic condition defined as human semen with a leukocyte count of>1 x 10(6) cells/ml that is often correlated with male infertility. Moreover, bacteriospermia has been associated with leukocytospermia ultimately leading to male infertility. We have found that semen samples with>1 x 10(6)/ml leukocytes and/or bacteriospermia have oxidative predominance as evidenced by augmented protein carbonyl and lipid peroxidation status of the semen which is implicated in sperm dysfunction. It has been reported that Streptococcus agalactiae is present in bacteriospermic samples. Previou...
Source: Systems Biology in Reproductive Medicine - October 31, 2016 Category: Reproduction Medicine Authors: Parida R, Samanta L Tags: Syst Biol Reprod Med Source Type: research

In silico analysis of candidate proteins sharing homology with Streptococcus agalactiae proteins and their role in male infertility
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - October 31, 2016 Category: Sexual Medicine Authors: Rajeshwari Parida Luna Samanta Source Type: research

Dietary supplementation with docosahexaenoic acid (DHA) improves seminal antioxidant status and decreases sperm DNA fragmentation.
dea J, Landeras J Abstract The purpose of this study was to evaluate the effect of docosahexaenoic acid (DHA) dietary supplementation on semen quality, fatty acid composition, antioxidant capacity, and DNA fragmentation. In this randomized, double blind, placebo-controlled, parallel-group study, 74 subjects were recruited and randomly assigned to either the placebo group (n=32) or to the DHA group (n=42) to consume three 500-mg capsules of oil per day over 10 weeks. The placebo group received 1,500 mg/day of sunflower oil and the DHA group 1,500 mg/day of DHA-enriched oil. Seminal parameters (semen volume, sperm c...
Source: Systems Biology in Reproductive Medicine - October 27, 2016 Category: Reproduction Medicine Authors: Martínez-Soto JC, Domingo JC, Cordobilla B, Nicolás M, Fernández L, Albero P, Gadea J, Landeras J Tags: Syst Biol Reprod Med Source Type: research

Dietary supplementation with docosahexaenoic acid (DHA) improves seminal antioxidant status and decreases sperm DNA fragmentation
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - October 27, 2016 Category: Sexual Medicine Authors: Juan Carlos Mart ínez-Soto Joan Carles Domingo Bego ña Cordobilla Mar ía Nicolás Laura Fern ández Pilar Albero Joaqu ín Gadea Jos é Landeras Source Type: research

Single nucleotide polymorphisms of USP26 in azoospermic men.
We reported variations in the USP26 gene sequence in 82% of azoospermic and in 50% normospermic men. The synonymous variation c.576G>A has a frequency significantly different in the azoospermic (60.2%) and normozoospermic (23.6%) groups, while the frequencies in the two groups of both c.1090C>T and c.1737G>A missense mutations did not reach statistical significance. A cluster mutation (c.371insACA, c.494T>C) was detected in 2 normozoospermic men (2.7%). In the 5'UTR we identified the -33C>T variation both in azoospermic (3.8%) and in normozoospermic (2.7%) men. In a normozoospermic man we detected the nonsen...
Source: Systems Biology in Reproductive Medicine - October 10, 2016 Category: Reproduction Medicine Authors: Luddi A, Crifasi L, Quagliarello A, Governini L, De Leo V, Piomboni P Tags: Syst Biol Reprod Med Source Type: research

Single nucleotide polymorphisms of USP26 in azoospermic men
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - October 10, 2016 Category: Sexual Medicine Authors: Alice Luddi Laura Crifasi Antonella Quagliarello Laura Governini Vincenzo De Leo Paola Piomboni Source Type: research

Augmenting effect of vitrification on lipid peroxidation in mouse preantral follicle during cultivation: Modulation by coenzyme Q10
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - October 2, 2016 Category: Sexual Medicine Authors: Roya Hedayati Kashka Saeed Zavareh Taghi Lashkarbolouki Source Type: research

Functional assessment for elimination of mismatches in nuclear and whole cell extracts obtained from mouse and human blastocysts
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - September 29, 2016 Category: Sexual Medicine Authors: Pinar Tulay Souraya Jaroudi Alpesh Doshi Sioban B. SenGupta Source Type: research

Improving ICSI: A review from the spermatozoon perspective
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - September 19, 2016 Category: Sexual Medicine Authors: Mara Simopoulou Laertis Gkoles Panagiotis Bakas Polina Giannelou Theodoros Kalampokas Konstantinos Pantos Michael Koutsilieris Source Type: research

Seasonal variation of human sperm cells among 4,422 semen samples: A retrospective study in Turkey
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - September 8, 2016 Category: Sexual Medicine Authors: Runa Ozelci Saynur Y ılmaz Berna Dilbaz Funda Akp ınar Derya Akdag C ırık Serdar Dilbaz Asl ı Ocal Source Type: research

Laser assisted zona hatching does not lead to immediate impairment in human embryo quality and metabolism
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - September 5, 2016 Category: Sexual Medicine Authors: Shubhashree Uppangala Fiona D ’Souza Shivanand Pudakalakatti Hanudatta S. Atreya Keyur Raval Guruprasad Kalthur Satish Kumar Adiga Source Type: research

The maturation of murine spermatozoa membranes within the epididymis, a computational biology perspective.
In conclusion, this approach allows inferring interesting information, thus contributing to the knowledge on this process and suggesting staring points for further research. PMID: 27586844 [PubMed - in process] (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - September 3, 2016 Category: Reproduction Medicine Authors: Bernabò N, Agostino RD, Ordinelli A, Mattioli M, Barboni B Tags: Syst Biol Reprod Med Source Type: research

Chromosomal polymorphic variants increase aneuploidies in male gametes and embryos.
Bernabeu R Abstract Chromosomal polymorphisms involve heterochromatic regions and occur in the general population. However, previous studies have reported a higher incidence of these variants in infertile patients. The aim of this study was to examine the relationship between polymorphic variants and infertility and their association with aneuploidies in male gametes and embryos. We retrospectively considered 1,551 cytogenetic studies involving infertile patients (study group; n=866) and oocyte/sperm donors as the control group (n=685). We had detected 168 polymorphisms in the study group and 92 in the control gr...
Source: Systems Biology in Reproductive Medicine - August 24, 2016 Category: Reproduction Medicine Authors: Morales R, Lledó B, Ortiz JA, Ten J, Llácer J, Bernabeu R Tags: Syst Biol Reprod Med Source Type: research

Chromosomal polymorphic variants increase aneuploidies in male gametes and embryos
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - August 24, 2016 Category: Sexual Medicine Authors: Ruth Morales Bel én Lledó Jos é A. Ortiz Jorge Ten Joaquin Ll ácer Rafael Bernabeu Source Type: research