Monocyte-derived extracellular trap (MET) formation induces aggregation and affects motility of human spermatozoa in vitro
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - June 18, 2019 Category: Sexual Medicine Authors: Mabel Schulz Fabiola Zambrano Hans-Christian Schuppe Florian Wagenlehner Anja Taubert Ulrich Gaertner R ául Sánchez Carlos Hermosilla Source Type: research

New insights into sperm with total globozoospermia: Increased fatty acid oxidation and centrin1 alteration
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - June 17, 2019 Category: Sexual Medicine Authors: Elena Moretti Giulia Collodel Maria Cristina Salvatici Giuseppe Belmonte Cinzia Signorini Source Type: research

New insights into sperm with total globozoospermia: Increased fatty acid oxidation and centrin1 alteration.
Abstract Sperm morphology and lipid profile have a relevant role in male fertility. We explore the status of the sperm centriole, essential structure for human fertilization and the role of fatty acid oxidation in globozoospermia, a rare sperm pathology causing infertility. A case of globozoospermia was characterized by light and electron microscopy, sperm immunolocalization was performed for centrin1, 8-iso-PGF2α and peroxisome proliferator γ activated receptor gamma (PPARγ). In semen and sperm pellet, F2-isoprostanes (F2-IsoPs) levels were determined. Finally, the cytosolic phospholipase A2 (cP...
Source: Systems Biology in Reproductive Medicine - June 17, 2019 Category: Reproduction Medicine Authors: Moretti E, Collodel G, Salvatici MC, Belmonte G, Signorini C Tags: Syst Biol Reprod Med Source Type: research

New insights into sperm with total globozoospermia: Increased fatty acid oxidation and centrin1 alteration
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - June 17, 2019 Category: Sexual Medicine Authors: Elena Moretti Giulia Collodel Maria Cristina Salvatici Giuseppe Belmonte Cinzia Signorini Source Type: research

Ultrastructural identification of CD9 positive extracellular vesicles released from human embryos and transported through the zona pellucida
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - May 28, 2019 Category: Sexual Medicine Authors: Parshvi Vyas Hanna Balakier Clifford L. Librach Source Type: research

Ultrastructural identification of CD9 positive extracellular vesicles released from human embryos and transported through the zona pellucida.
In conclusion, the results of the study provide evidence that human preimplantation embryos at all developmental stages secrete EVs into the perivitelline space, which then traverse through the ZP, and are then released into the surrounding culture medium. Abbreviations: EVs: extracellular vesicles; ZP: zona pellucida; CD9, CD63, and CD81: tetraspanin EV markers; NTA: nanoparticle tracking analysis; ESCRT: endosomal sorting complexes required for transport; SEM: scanning electron microscopy; TEM: transmission electron microscopy; TE: trophectoderm; ICM: inner cell mass; PVS: perivitelline space; MI: metaphase I; MII: metap...
Source: Systems Biology in Reproductive Medicine - May 28, 2019 Category: Reproduction Medicine Authors: Vyas P, Balakier H, Librach CL Tags: Syst Biol Reprod Med Source Type: research

Ultrastructural identification of CD9 positive extracellular vesicles released from human embryos and transported through the zona pellucida
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - May 28, 2019 Category: Sexual Medicine Authors: Parshvi Vyas Hanna Balakier Clifford L. Librach Source Type: research

Effect of resistin on estradiol and progesterone secretion from human luteinized granulosa cells in culture
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - May 17, 2019 Category: Sexual Medicine Authors: Christina I. Messini Anna Vasilaki Evangelia Korona George Anifandis Panagiotis Georgoulias Konstantinos Dafopoulos Antonios Garas Alexandros Daponte Ioannis E. Messinis Source Type: research

Effect of resistin on estradiol and progesterone secretion from human luteinized granulosa cells in culture.
This study indicates an inhibitory effect of resistin on the secretion of estradiol and progesterone by human luteinized granulosa cells in vitro. It is likely that this adipokine locally affects ovarian function in women. Abbreviations: 3β-HSD: 3β-hydroxysteroid dehydrogenase; CAP1: cyclase-associated protein 1; DCN: decorin; FIZZ: Found in Inflammatory Zones; hCG: human chorionic gonadotropin; IGF1: insulin-like growth factor type 1; IVF: in vitro fertilization; PCOS: polycystic ovary syndrome; RIA: radioimmunoassay; ROR1: receptor tyrosine kinase-like orphan receptor-1; TLR4: Toll-like receptor 4. PMID: 3...
Source: Systems Biology in Reproductive Medicine - May 17, 2019 Category: Reproduction Medicine Authors: Messini CI, Vasilaki A, Korona E, Anifandis G, Georgoulias P, Dafopoulos K, Garas A, Daponte A, Messinis IE Tags: Syst Biol Reprod Med Source Type: research

Effect of resistin on estradiol and progesterone secretion from human luteinized granulosa cells in culture
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - May 17, 2019 Category: Sexual Medicine Authors: Christina I. Messini Anna Vasilaki Evangelia Korona George Anifandis Panagiotis Georgoulias Konstantinos Dafopoulos Antonios Garas Alexandros Daponte Ioannis E. Messinis Source Type: research

Dietary fluted pumpkin seeds induce reversible oligospermia and androgen insufficiency in adult rats
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - May 13, 2019 Category: Sexual Medicine Authors: Rex-Clovis C. Njoku Sunny O. Abarikwu Augustine A. Uwakwe Chidimma J. Mgbudom-Okah Chioma Yvonne Ezirim Source Type: research

Dietary fluted pumpkin seeds induce reversible oligospermia and androgen insufficiency in adult rats.
Abstract Some components of the human diets are believed to be promising male contraceptive agents. The present study examined the antispermatogenic efficacy, reversibility and toxicity of fluted pumpkin seed-supplemented diet (DFPS) in adult male Wistar rats. Adult rats were given DFPS at 2.5, 5 and 10% for 60 days followed by 60 days post-treatment period. The control animals received normal standard rat diet not supplemented with fluted pumpkin seeds. The sperm quality variables, testosterone and follicle-stimulating hormone (FSH), oxidative status of the testis, steroidogenic enzymes and gamma-glutam...
Source: Systems Biology in Reproductive Medicine - May 13, 2019 Category: Reproduction Medicine Authors: Njoku RC, Abarikwu SO, Uwakwe AA, Mgbudom-Okah CJ, Ezirim CY Tags: Syst Biol Reprod Med Source Type: research

Dietary fluted pumpkin seeds induce reversible oligospermia and androgen insufficiency in adult rats
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - May 13, 2019 Category: Sexual Medicine Authors: Rex-Clovis C. Njoku Sunny O. Abarikwu Augustine A. Uwakwe Chidimma J. Mgbudom-Okah Chioma Yvonne Ezirim Source Type: research

Possible role of androgen receptor gene in therapeutic response of infertile men with hypogonadotropic hypogonadism
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - April 28, 2019 Category: Sexual Medicine Authors: Vida Firouzi Parnaz Borjian Boroujeni Zeinab Rokhsat Talab Maryam Mohammadi Mohammad Ali Sadighi Gilani Marjan Sabbaghian Anahita Mohseni Meybodi Source Type: research

Autophagy in male reproduction
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - April 24, 2019 Category: Sexual Medicine Authors: Yinci Zhu Qingqing Yin Dandan Wei Zhenyu Yang Yanzhi Du Yi Ma Source Type: research

Autophagy in male reproduction.
Abstract Autophagy is a fundamental process that exists in all eukaryotic organisms, with a primary function of catabolizing undesirable components to provide energy and essential materials. Increasing evidence illustrates that autophagy is invovled in a broad range of cellular events within the male reproductive system. In the process of spermatogenesis, autophagy is crucial for the formation of specific structures that guarantee successful spermatogenesis, as well as for the degradation of certain constituents. The underlying connections between autophagy and androgen binding protein, lipid metabolism and testos...
Source: Systems Biology in Reproductive Medicine - April 24, 2019 Category: Reproduction Medicine Authors: Zhu Y, Yin Q, Wei D, Yang Z, Du Y, Ma Y Tags: Syst Biol Reprod Med Source Type: research

Autophagy in male reproduction
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - April 24, 2019 Category: Sexual Medicine Authors: Yinci Zhu Qingqing Yin Dandan Wei Zhenyu Yang Yanzhi Du Yi Ma Source Type: research

Improvement of embryonic development and clinical outcomes of germinal vesicle stage oocytes using a microvibration culture system
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - April 19, 2019 Category: Sexual Medicine Authors: Seong-Ho Yang San-Hyun Yoon Jae-Hoon Jung Jin-Ho Lim Yong Ko Source Type: research

Do serum androgens influence blastocysts ploidy in karyotypically normal women?
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - April 17, 2019 Category: Sexual Medicine Authors: Micha ł Kunicki Patrycja Skowro ńska Ewa Pastuszek Grzegorz Jakiel Roman Smolarczyk Krzysztof Łukaszuk Source Type: research

Do serum androgens influence blastocysts ploidy in karyotypically normal women?
Abstract The aim of the study was to determine if serum testosterone (T) and dehydroepiandrosterone (DHEAS) levels are a factor in determining increased risk for embryonic aneuploidy in karyotypically normal women undergoing in vitro fertilization (IVF) and preimplantation genetic testing screening for aneuploidy (PGT-A). This is a retrospective cohort study of IVF cycles with PGT-A performed during 2015-2016. A total of 256 cycles with 725 embryos were initially considered for inclusion. A total of 208 cycles and 595 embryos determined to be either euploid or aneuploid were included in the analysis. The mean age ...
Source: Systems Biology in Reproductive Medicine - April 17, 2019 Category: Reproduction Medicine Authors: Kunicki M, Skowrońska P, Pastuszek E, Jakiel G, Smolarczyk R, Łukaszuk K Tags: Syst Biol Reprod Med Source Type: research

Do serum androgens influence blastocysts ploidy in karyotypically normal women?
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - April 17, 2019 Category: Sexual Medicine Authors: Micha ł Kunicki Patrycja Skowro ńska Ewa Pastuszek Grzegorz Jakiel Roman Smolarczyk Krzysztof Łukaszuk Source Type: research

The association of Intron 4 VNTR and Glu298Asp polymorphisms of the nitric oxide synthetase 3 gene and vasculogenic erectile dysfunction in Turkish men
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - April 12, 2019 Category: Sexual Medicine Authors: Ersan Arda Arzu Ay Hakan Akdere Esra Akdeniz Source Type: research

Clinical application of NGS-based SNP haplotyping for the preimplantation genetic diagnosis of primary open angle glaucoma
Volume 65, Issue 3, June 2019, Page 258-263 . (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - April 12, 2019 Category: Sexual Medicine Authors: Xingzhe Ji Zhou Zhang Juanzi Shi Bin He Source Type: research

Clinical application of NGS-based SNP haplotyping for the preimplantation genetic diagnosis of primary open angle glaucoma.
In this study, we applied NGS as part of PGD to effectively detect POAG prior to embryo implantation and avoid the prospect of pregnancy termination in event of vertical inheritance of POAG. We used the technique of multiple annealing and looping based amplification cycles (MALBAC) to conduct whole genome amplification (WGA) and to reduce the allele dropout (ADO). We also employed Sanger sequencing to directly detect the mutation c.1109 C > T in MYOC and NGS-based single nucleotide polymorphism (SNP) haplotyping to distinguish the chromosomes that carried the mutation. Copy number variation (CNV) analysis...
Source: Systems Biology in Reproductive Medicine - April 12, 2019 Category: Reproduction Medicine Authors: Ji X, Zhang Z, Shi J, He B Tags: Syst Biol Reprod Med Source Type: research

The association of Intron 4 VNTR and Glu298Asp polymorphisms of the nitric oxide synthetase 3 gene and vasculogenic erectile dysfunction in Turkish men.
Abstract Several studies have focused on the impaired role of endothelial nitric oxide synthase (NOS3) gene polymorphism and its association to erectile dysfunction (ED). However, currently controversial results have been reported due to their significant heterogeneity. The present study aimed to assess the genotypic distribution and the allelic frequency of Intron 4 VNTR and Glu298Asp gene polymorphisms in vasculogenic ED patients compared to healthy controls of a specific region of Turkey. A total of 75 patients with ED (median age: 56, IQR:10.5) and 75 healthy controls (median age: 56, IQR:10.5) were prospectiv...
Source: Systems Biology in Reproductive Medicine - April 12, 2019 Category: Reproduction Medicine Authors: Arda E, Ay A, Akdere H, Akdeniz E Tags: Syst Biol Reprod Med Source Type: research

The association of Intron 4 VNTR and Glu298Asp polymorphisms of the nitric oxide synthetase 3 gene and vasculogenic erectile dysfunction in Turkish men
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - April 12, 2019 Category: Sexual Medicine Authors: Ersan Arda Arzu Ay Hakan Akdere Esra Akdeniz Source Type: research

Clinical application of NGS-based SNP haplotyping for the preimplantation genetic diagnosis of primary open angle glaucoma
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - April 12, 2019 Category: Sexual Medicine Authors: Xingzhe Ji Zhou Zhang Juanzi Shi Bin He Source Type: research

Evaluation of the antioxidative enzymes in the seminal plasma of infertile men: Contribution to classic semen quality analysis
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - April 9, 2019 Category: Sexual Medicine Authors: Vesna Otasevic Andjelika Kalezic Biljana Macanovic Aleksandra Jankovic Ana Stancic Eliana Garalejic Aleksandra Korac Bato Korac Source Type: research

Association of Luteinizing hormone and LH receptor gene polymorphism with susceptibility of Polycystic ovary syndrome
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - April 8, 2019 Category: Sexual Medicine Authors: Ritu Deswal Smiti Nanda Amita Suneja Dang Source Type: research

Individual assessment of bovine embryo development using a homemade chamber reveals kinetic patterns of success and failure to reach blastocyst stage
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - April 8, 2019 Category: Sexual Medicine Authors: Clara Slade Oliveira B. A. F. de Barros C. A. S. Monteiro P. M. S. Rosa G. R. Leal R. V. Serapi ão L. S. A. Camargo Source Type: research

Individual assessment of bovine embryo development using a homemade chamber reveals kinetic patterns of success and failure to reach blastocyst stage.
o LSA Abstract Most early developmental data are lost in bovine embryo culture systems. We developed and validated a method for culture of bovine embryos in groups that allow individual assessment. An autoclavable low-cost multiembryo chamber (MEC) was prepared using a polyester mesh fixed to a glass coverslip. Embryonic development was not affected by MEC. Compared to conventional bovine culture system (oil-covered drops, control), cleavage (C, 71.2 ± 7.8%; MEC, 74.3 ± 6.0%), blastocyst rate (C, 29.9 ± 4.4%; MEC, 28.3 ± 5.0%) and blastocyst cell ...
Source: Systems Biology in Reproductive Medicine - April 8, 2019 Category: Reproduction Medicine Authors: Oliveira CS, de Barros BAF, Monteiro CAS, Rosa PMS, Leal GR, Serapião RV, Camargo LSA Tags: Syst Biol Reprod Med Source Type: research

Association of Luteinizing hormone and LH receptor gene polymorphism with susceptibility of Polycystic ovary syndrome.
The objective of this study was to assess the association of LHβ (rs1056917) and lutropin receptor (LHR) (rs61996318) polymorphism with polycystic ovarian syndrome and to interrelate the levels of luteinizing hormone (LH) with severity of clinical manifestations of PCOS. Three hundred women of reproductive age were enrolled in this retrospective case-control study. Rotterdam Criteria was used to diagnose PCOS patients. Nucleotide mutations of LH and LHR gene was analyzed using polymerase chain reaction-restriction fragment length polymorphism. High LH levels were found in 88% of PCOS patients. LHβ TC and CC genot...
Source: Systems Biology in Reproductive Medicine - April 8, 2019 Category: Reproduction Medicine Authors: Deswal R, Nanda S, Dang AS Tags: Syst Biol Reprod Med Source Type: research

Association of Luteinizing hormone and LH receptor gene polymorphism with susceptibility of Polycystic ovary syndrome
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - April 8, 2019 Category: Sexual Medicine Authors: Ritu Deswal Smiti Nanda Amita Suneja Dang Source Type: research

Individual assessment of bovine embryo development using a homemade chamber reveals kinetic patterns of success and failure to reach blastocyst stage
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - April 8, 2019 Category: Sexual Medicine Authors: Clara Slade Oliveira B. A. F. de Barros C. A. S. Monteiro P. M. S. Rosa G. R. Leal R. V. Serapi ão L. S. A. Camargo Source Type: research

Monosodium glutamate daily oral supplementation: study of its effects on male reproductive system on rat model
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - February 18, 2019 Category: Sexual Medicine Authors: Fatin Farhana Jubaidi Ramya Dewi Mathialagan Mahanem Mat Noor Izatus Shima Taib Siti Balkis Budin Source Type: research

Monosodium glutamate daily oral supplementation: study of its effects on male reproductive system on rat model.
Abstract Monosodium glutamate (MSG) is widely used in food preparation industry and has been consumed regularly. Previous studies had reported on effects of MSG when given at extremely high dosages, the results are not applicable to human equivalent intake. Therefore, the present study aimed to evaluate the effect of MSG on sperm quality and changes in reproductive organs of adult male rats when taken at average human daily intake (ADI). Twenty-four adult male rats were randomly assigned into three groups; NC (Normal control), MSG60 and MSG120 where MSG was given orally at 60 mg/kg and 120 mg/kg to each respective...
Source: Systems Biology in Reproductive Medicine - February 17, 2019 Category: Reproduction Medicine Authors: Jubaidi FF, Mathialagan RD, Noor MM, Taib IS, Budin SB Tags: Syst Biol Reprod Med Source Type: research

The impact of endometriosis on early embryo morphokinetics: a case-control study
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - February 11, 2019 Category: Sexual Medicine Authors: Fazilet Kubra Boynukalin Munevver Serdarogullari Meral Gultomruk Onder Coban Necati Findikli Mustafa Bahceci Source Type: research

The impact of endometriosis on early embryo morphokinetics: a case-control study.
Abstract The aim of this study was to evaluate the possible effects of endometriosis on early embryo development, by comparing the morphokinetic development of embryos obtained from women with clinically confirmed endometriosis with the ones obtained from tubal factor infertility cases. A total of 82 cycles/patients including 53 cycles with endometriosis and 29 cycles with tubal factor infertility were evaluated. A total of 439 embryos were scored for embryo morphokinetics. Age, body mass index, fertilization rates were similar within the groups. However, the number of previous ART trials was found to be higher (p
Source: Systems Biology in Reproductive Medicine - February 11, 2019 Category: Reproduction Medicine Authors: Boynukalin FK, Serdarogullari M, Gultomruk M, Coban O, Findikli N, Bahceci M Tags: Syst Biol Reprod Med Source Type: research

Systems Biology in Reproductive Medicine 2019.
PMID: 30696309 [PubMed - in process] (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - February 1, 2019 Category: Reproduction Medicine Authors: Krawetz SA Tags: Syst Biol Reprod Med Source Type: research

Systems Biology in Reproductive Medicine 2019
Volume 65, Issue 1, February 2019, Page 1-2 . (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - January 30, 2019 Category: Sexual Medicine Authors: Stephen A. Krawetz Source Type: research

Prenatal stress decreases sperm quality, mature follicles and fertility in rats
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - January 28, 2019 Category: Sexual Medicine Authors: Diana Garc ía-Vargas Lizbeth Ju árez-Rojas Susana Rojas Maya Socorro Retana-M árquez Source Type: research

Prenatal stress decreases sperm quality, mature follicles and fertility in rats.
-Márquez S Abstract Prenatal stress disrupts reproductive function in females and males. These alterations have primarily been related to maternal corticosteroid fetal programming due to the stress response, affecting the fetus and causing long-lasting effects. The aim of this study was to investigate the influence of prenatal stress on male and female fertility. Dams were exposed to stress by immersion in cold water twice a day for the last week of gestation (days 15-21). In the adulthood, sperm quality, mature follicles, sexual hormones and fertility were assessed in female and male progeny. The results i...
Source: Systems Biology in Reproductive Medicine - January 28, 2019 Category: Reproduction Medicine Authors: García-Vargas D, Juárez-Rojas L, Rojas Maya S, Retana-Márquez S Tags: Syst Biol Reprod Med Source Type: research

Prenatal stress decreases sperm quality, mature follicles and fertility in rats
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - January 28, 2019 Category: Sexual Medicine Authors: Diana Garc ía-Vargas Lizbeth Ju árez-Rojas Susana Rojas Maya Socorro Retana-M árquez Source Type: research

Improvement of sperm motility of Oncorhynchus mykiss and Salvelinus fontinalis by L-tryptophan
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - January 26, 2019 Category: Sexual Medicine Authors: Mehmet Kocaba ş Filiz Kutluyer Özlem Ertekin Önder Aksu Nadir Ba şçınar Source Type: research