Early experience with universal SARS-CoV-2 testing in a New York-based reproductive endocrinology ‎practice
We report here on early results from asingle-center academic NewYork fertility practice utilizing universal SARS-CoV-2 screening. This mixed prospective retrospective cohort included 164 patients who underwent at least one SARS-CoV-2 screening test for fertility treatment between May and July2020. Patients completed 1 to 3 nasopharyngeal SARS-CoV-2 tests per cycle and remained symptom-free to continue fertility treatments. SARS-CoV-2 test results, past results, history of Covid-19 infection, and patient/cycle characteristics were recorded and tabulated through October2020. Outcomes included positive SARS-CoV-2 RNA tests, r...
Source: Systems Biology in Reproductive Medicine - March 17, 2021 Category: Reproduction Medicine Authors: Julian A Gingold Sharon Galperin Sabrina Fowler Michelle Kappy Staci Pollack Manvinder Singh Harry Lieman Sangita Jindal Source Type: research

Investigating the impact of different strategies for endometrial preparation in frozen cycles considering normal responders undergoing IVF/ICSI cycles: a multicenter retrospective cohort study
In conclusion, HRC with GnRHa appears to be superior to HRC without GnRHa, concerning live birth and miscarriage, especially when the number of embryos transferred are ≥2 and irrespective of day of transfer. The use of progesterone vaginal tabs compared to gel or combinations is associated with better outcomes. Age is a significant predictor of a negative hCG test and clinical pregnancy rates. A properly conducted RCT is needed to evaluate the optimal frozen embryo transfer preparation strategy.Abbreviations: SD: standard deviation; BMI: body mass index; PCOS: polycystic ovarian syndrome; IQR: interquartile range; FSH: ...
Source: Systems Biology in Reproductive Medicine - March 17, 2021 Category: Reproduction Medicine Authors: Charalampos Siristatidis Theodosios Arkoulis Nikolaos Christoforidis George Salamalekis Nikoleta Koutlaki Vasilios Karageorgiou Dimitrios Profer Nikolaos Vlahos George Galazios Source Type: research

Early experience with universal SARS-CoV-2 testing in a New York-based reproductive endocrinology ‎practice
We report here on early results from asingle-center academic NewYork fertility practice utilizing universal SARS-CoV-2 screening. This mixed prospective retrospective cohort included 164 patients who underwent at least one SARS-CoV-2 screening test for fertility treatment between May and July2020. Patients completed 1 to 3 nasopharyngeal SARS-CoV-2 tests per cycle and remained symptom-free to continue fertility treatments. SARS-CoV-2 test results, past results, history of Covid-19 infection, and patient/cycle characteristics were recorded and tabulated through October2020. Outcomes included positive SARS-CoV-2 RNA tests, r...
Source: Systems Biology in Reproductive Medicine - March 17, 2021 Category: Reproduction Medicine Authors: Julian A Gingold Sharon Galperin Sabrina Fowler Michelle Kappy Staci Pollack Manvinder Singh Harry Lieman Sangita Jindal Source Type: research

Investigating the impact of different strategies for endometrial preparation in frozen cycles considering normal responders undergoing IVF/ICSI cycles: a multicenter retrospective cohort study
In conclusion, HRC with GnRHa appears to be superior to HRC without GnRHa, concerning live birth and miscarriage, especially when the number of embryos transferred are ≥2 and irrespective of day of transfer. The use of progesterone vaginal tabs compared to gel or combinations is associated with better outcomes. Age is a significant predictor of a negative hCG test and clinical pregnancy rates. A properly conducted RCT is needed to evaluate the optimal frozen embryo transfer preparation strategy.Abbreviations: SD: standard deviation; BMI: body mass index; PCOS: polycystic ovarian syndrome; IQR: interquartile range; FSH: ...
Source: Systems Biology in Reproductive Medicine - March 17, 2021 Category: Reproduction Medicine Authors: Charalampos Siristatidis Theodosios Arkoulis Nikolaos Christoforidis George Salamalekis Nikoleta Koutlaki Vasilios Karageorgiou Dimitrios Profer Nikolaos Vlahos George Galazios Source Type: research

Early experience with universal SARS-CoV-2 testing in a New York-based reproductive endocrinology ‎practice
We report here on early results from asingle-center academic NewYork fertility practice utilizing universal SARS-CoV-2 screening. This mixed prospective retrospective cohort included 164 patients who underwent at least one SARS-CoV-2 screening test for fertility treatment between May and July2020. Patients completed 1 to 3 nasopharyngeal SARS-CoV-2 tests per cycle and remained symptom-free to continue fertility treatments. SARS-CoV-2 test results, past results, history of Covid-19 infection, and patient/cycle characteristics were recorded and tabulated through October2020. Outcomes included positive SARS-CoV-2 RNA tests, r...
Source: Systems Biology in Reproductive Medicine - March 17, 2021 Category: Reproduction Medicine Authors: Julian A Gingold Sharon Galperin Sabrina Fowler Michelle Kappy Staci Pollack Manvinder Singh Harry Lieman Sangita Jindal Source Type: research

Investigating the impact of different strategies for endometrial preparation in frozen cycles considering normal responders undergoing IVF/ICSI cycles: a multicenter retrospective cohort study
In conclusion, HRC with GnRHa appears to be superior to HRC without GnRHa, concerning live birth and miscarriage, especially when the number of embryos transferred are ≥2 and irrespective of day of transfer. The use of progesterone vaginal tabs compared to gel or combinations is associated with better outcomes. Age is a significant predictor of a negative hCG test and clinical pregnancy rates. A properly conducted RCT is needed to evaluate the optimal frozen embryo transfer preparation strategy.Abbreviations: SD: standard deviation; BMI: body mass index; PCOS: polycystic ovarian syndrome; IQR: interquartile range; FSH: ...
Source: Systems Biology in Reproductive Medicine - March 17, 2021 Category: Reproduction Medicine Authors: Charalampos Siristatidis Theodosios Arkoulis Nikolaos Christoforidis George Salamalekis Nikoleta Koutlaki Vasilios Karageorgiou Dimitrios Profer Nikolaos Vlahos George Galazios Source Type: research

Early experience with universal SARS-CoV-2 testing in a New York-based reproductive endocrinology ‎practice
We report here on early results from asingle-center academic NewYork fertility practice utilizing universal SARS-CoV-2 screening. This mixed prospective retrospective cohort included 164 patients who underwent at least one SARS-CoV-2 screening test for fertility treatment between May and July2020. Patients completed 1 to 3 nasopharyngeal SARS-CoV-2 tests per cycle and remained symptom-free to continue fertility treatments. SARS-CoV-2 test results, past results, history of Covid-19 infection, and patient/cycle characteristics were recorded and tabulated through October2020. Outcomes included positive SARS-CoV-2 RNA tests, r...
Source: Systems Biology in Reproductive Medicine - March 17, 2021 Category: Reproduction Medicine Authors: Julian A Gingold Sharon Galperin Sabrina Fowler Michelle Kappy Staci Pollack Manvinder Singh Harry Lieman Sangita Jindal Source Type: research

Investigating the impact of different strategies for endometrial preparation in frozen cycles considering normal responders undergoing IVF/ICSI cycles: a multicenter retrospective cohort study
In conclusion, HRC with GnRHa appears to be superior to HRC without GnRHa, concerning live birth and miscarriage, especially when the number of embryos transferred are ≥2 and irrespective of day of transfer. The use of progesterone vaginal tabs compared to gel or combinations is associated with better outcomes. Age is a significant predictor of a negative hCG test and clinical pregnancy rates. A properly conducted RCT is needed to evaluate the optimal frozen embryo transfer preparation strategy.Abbreviations: SD: standard deviation; BMI: body mass index; PCOS: polycystic ovarian syndrome; IQR: interquartile range; FSH: ...
Source: Systems Biology in Reproductive Medicine - March 17, 2021 Category: Reproduction Medicine Authors: Charalampos Siristatidis Theodosios Arkoulis Nikolaos Christoforidis George Salamalekis Nikoleta Koutlaki Vasilios Karageorgiou Dimitrios Profer Nikolaos Vlahos George Galazios Source Type: research

Early experience with universal SARS-CoV-2 testing in a New York-based reproductive endocrinology ‎practice
We report here on early results from asingle-center academic NewYork fertility practice utilizing universal SARS-CoV-2 screening. This mixed prospective retrospective cohort included 164 patients who underwent at least one SARS-CoV-2 screening test for fertility treatment between May and July2020. Patients completed 1 to 3 nasopharyngeal SARS-CoV-2 tests per cycle and remained symptom-free to continue fertility treatments. SARS-CoV-2 test results, past results, history of Covid-19 infection, and patient/cycle characteristics were recorded and tabulated through October2020. Outcomes included positive SARS-CoV-2 RNA tests, r...
Source: Systems Biology in Reproductive Medicine - March 17, 2021 Category: Reproduction Medicine Authors: Julian A Gingold Sharon Galperin Sabrina Fowler Michelle Kappy Staci Pollack Manvinder Singh Harry Lieman Sangita Jindal Source Type: research

Investigating the impact of different strategies for endometrial preparation in frozen cycles considering normal responders undergoing IVF/ICSI cycles: a multicenter retrospective cohort study
In conclusion, HRC with GnRHa appears to be superior to HRC without GnRHa, concerning live birth and miscarriage, especially when the number of embryos transferred are ≥2 and irrespective of day of transfer. The use of progesterone vaginal tabs compared to gel or combinations is associated with better outcomes. Age is a significant predictor of a negative hCG test and clinical pregnancy rates. A properly conducted RCT is needed to evaluate the optimal frozen embryo transfer preparation strategy.Abbreviations: SD: standard deviation; BMI: body mass index; PCOS: polycystic ovarian syndrome; IQR: interquartile range; FSH: ...
Source: Systems Biology in Reproductive Medicine - March 17, 2021 Category: Reproduction Medicine Authors: Charalampos Siristatidis Theodosios Arkoulis Nikolaos Christoforidis George Salamalekis Nikoleta Koutlaki Vasilios Karageorgiou Dimitrios Profer Nikolaos Vlahos George Galazios Source Type: research

Early experience with universal SARS-CoV-2 testing in a New York-based reproductive endocrinology ‎practice
We report here on early results from asingle-center academic NewYork fertility practice utilizing universal SARS-CoV-2 screening. This mixed prospective retrospective cohort included 164 patients who underwent at least one SARS-CoV-2 screening test for fertility treatment between May and July2020. Patients completed 1 to 3 nasopharyngeal SARS-CoV-2 tests per cycle and remained symptom-free to continue fertility treatments. SARS-CoV-2 test results, past results, history of Covid-19 infection, and patient/cycle characteristics were recorded and tabulated through October2020. Outcomes included positive SARS-CoV-2 RNA tests, r...
Source: Systems Biology in Reproductive Medicine - March 17, 2021 Category: Reproduction Medicine Authors: Julian A Gingold Sharon Galperin Sabrina Fowler Michelle Kappy Staci Pollack Manvinder Singh Harry Lieman Sangita Jindal Source Type: research

Investigating the impact of different strategies for endometrial preparation in frozen cycles considering normal responders undergoing IVF/ICSI cycles: a multicenter retrospective cohort study
In conclusion, HRC with GnRHa appears to be superior to HRC without GnRHa, concerning live birth and miscarriage, especially when the number of embryos transferred are ≥2 and irrespective of day of transfer. The use of progesterone vaginal tabs compared to gel or combinations is associated with better outcomes. Age is a significant predictor of a negative hCG test and clinical pregnancy rates. A properly conducted RCT is needed to evaluate the optimal frozen embryo transfer preparation strategy.Abbreviations: SD: standard deviation; BMI: body mass index; PCOS: polycystic ovarian syndrome; IQR: interquartile range; FSH: ...
Source: Systems Biology in Reproductive Medicine - March 17, 2021 Category: Reproduction Medicine Authors: Charalampos Siristatidis Theodosios Arkoulis Nikolaos Christoforidis George Salamalekis Nikoleta Koutlaki Vasilios Karageorgiou Dimitrios Profer Nikolaos Vlahos George Galazios Source Type: research

Early experience with universal SARS-CoV-2 testing in a New York-based reproductive endocrinology ‎practice
We report here on early results from asingle-center academic NewYork fertility practice utilizing universal SARS-CoV-2 screening. This mixed prospective retrospective cohort included 164 patients who underwent at least one SARS-CoV-2 screening test for fertility treatment between May and July2020. Patients completed 1 to 3 nasopharyngeal SARS-CoV-2 tests per cycle and remained symptom-free to continue fertility treatments. SARS-CoV-2 test results, past results, history of Covid-19 infection, and patient/cycle characteristics were recorded and tabulated through October2020. Outcomes included positive SARS-CoV-2 RNA tests, r...
Source: Systems Biology in Reproductive Medicine - March 17, 2021 Category: Reproduction Medicine Authors: Julian A Gingold Sharon Galperin Sabrina Fowler Michelle Kappy Staci Pollack Manvinder Singh Harry Lieman Sangita Jindal Source Type: research

Investigating the impact of different strategies for endometrial preparation in frozen cycles considering normal responders undergoing IVF/ICSI cycles: a multicenter retrospective cohort study
In conclusion, HRC with GnRHa appears to be superior to HRC without GnRHa, concerning live birth and miscarriage, especially when the number of embryos transferred are ≥2 and irrespective of day of transfer. The use of progesterone vaginal tabs compared to gel or combinations is associated with better outcomes. Age is a significant predictor of a negative hCG test and clinical pregnancy rates. A properly conducted RCT is needed to evaluate the optimal frozen embryo transfer preparation strategy.Abbreviations: SD: standard deviation; BMI: body mass index; PCOS: polycystic ovarian syndrome; IQR: interquartile range; FSH: ...
Source: Systems Biology in Reproductive Medicine - March 17, 2021 Category: Reproduction Medicine Authors: Charalampos Siristatidis Theodosios Arkoulis Nikolaos Christoforidis George Salamalekis Nikoleta Koutlaki Vasilios Karageorgiou Dimitrios Profer Nikolaos Vlahos George Galazios Source Type: research

Early experience with universal SARS-CoV-2 testing in a New York-based reproductive endocrinology ‎practice
We report here on early results from asingle-center academic NewYork fertility practice utilizing universal SARS-CoV-2 screening. This mixed prospective retrospective cohort included 164 patients who underwent at least one SARS-CoV-2 screening test for fertility treatment between May and July2020. Patients completed 1 to 3 nasopharyngeal SARS-CoV-2 tests per cycle and remained symptom-free to continue fertility treatments. SARS-CoV-2 test results, past results, history of Covid-19 infection, and patient/cycle characteristics were recorded and tabulated through October2020. Outcomes included positive SARS-CoV-2 RNA tests, r...
Source: Systems Biology in Reproductive Medicine - March 17, 2021 Category: Reproduction Medicine Authors: Julian A Gingold Sharon Galperin Sabrina Fowler Michelle Kappy Staci Pollack Manvinder Singh Harry Lieman Sangita Jindal Source Type: research

Investigating the impact of different strategies for endometrial preparation in frozen cycles considering normal responders undergoing IVF/ICSI cycles: a multicenter retrospective cohort study
In conclusion, HRC with GnRHa appears to be superior to HRC without GnRHa, concerning live birth and miscarriage, especially when the number of embryos transferred are ≥2 and irrespective of day of transfer. The use of progesterone vaginal tabs compared to gel or combinations is associated with better outcomes. Age is a significant predictor of a negative hCG test and clinical pregnancy rates. A properly conducted RCT is needed to evaluate the optimal frozen embryo transfer preparation strategy.Abbreviations: SD: standard deviation; BMI: body mass index; PCOS: polycystic ovarian syndrome; IQR: interquartile range; FSH: ...
Source: Systems Biology in Reproductive Medicine - March 17, 2021 Category: Reproduction Medicine Authors: Charalampos Siristatidis Theodosios Arkoulis Nikolaos Christoforidis George Salamalekis Nikoleta Koutlaki Vasilios Karageorgiou Dimitrios Profer Nikolaos Vlahos George Galazios Source Type: research

Early experience with universal SARS-CoV-2 testing in a New York-based reproductive endocrinology ‎practice
We report here on early results from asingle-center academic NewYork fertility practice utilizing universal SARS-CoV-2 screening. This mixed prospective retrospective cohort included 164 patients who underwent at least one SARS-CoV-2 screening test for fertility treatment between May and July2020. Patients completed 1 to 3 nasopharyngeal SARS-CoV-2 tests per cycle and remained symptom-free to continue fertility treatments. SARS-CoV-2 test results, past results, history of Covid-19 infection, and patient/cycle characteristics were recorded and tabulated through October2020. Outcomes included positive SARS-CoV-2 RNA tests, r...
Source: Systems Biology in Reproductive Medicine - March 17, 2021 Category: Reproduction Medicine Authors: Julian A Gingold Sharon Galperin Sabrina Fowler Michelle Kappy Staci Pollack Manvinder Singh Harry Lieman Sangita Jindal Source Type: research

Investigating the impact of different strategies for endometrial preparation in frozen cycles considering normal responders undergoing IVF/ICSI cycles: a multicenter retrospective cohort study
In conclusion, HRC with GnRHa appears to be superior to HRC without GnRHa, concerning live birth and miscarriage, especially when the number of embryos transferred are ≥2 and irrespective of day of transfer. The use of progesterone vaginal tabs compared to gel or combinations is associated with better outcomes. Age is a significant predictor of a negative hCG test and clinical pregnancy rates. A properly conducted RCT is needed to evaluate the optimal frozen embryo transfer preparation strategy.Abbreviations: SD: standard deviation; BMI: body mass index; PCOS: polycystic ovarian syndrome; IQR: interquartile range; FSH: ...
Source: Systems Biology in Reproductive Medicine - March 17, 2021 Category: Reproduction Medicine Authors: Charalampos Siristatidis Theodosios Arkoulis Nikolaos Christoforidis George Salamalekis Nikoleta Koutlaki Vasilios Karageorgiou Dimitrios Profer Nikolaos Vlahos George Galazios Source Type: research

Early experience with universal SARS-CoV-2 testing in a New York-based reproductive endocrinology ‎practice
We report here on early results from asingle-center academic NewYork fertility practice utilizing universal SARS-CoV-2 screening. This mixed prospective retrospective cohort included 164 patients who underwent at least one SARS-CoV-2 screening test for fertility treatment between May and July2020. Patients completed 1 to 3 nasopharyngeal SARS-CoV-2 tests per cycle and remained symptom-free to continue fertility treatments. SARS-CoV-2 test results, past results, history of Covid-19 infection, and patient/cycle characteristics were recorded and tabulated through October2020. Outcomes included positive SARS-CoV-2 RNA tests, r...
Source: Systems Biology in Reproductive Medicine - March 17, 2021 Category: Reproduction Medicine Authors: Julian A Gingold Sharon Galperin Sabrina Fowler Michelle Kappy Staci Pollack Manvinder Singh Harry Lieman Sangita Jindal Source Type: research

Investigating the impact of different strategies for endometrial preparation in frozen cycles considering normal responders undergoing IVF/ICSI cycles: a multicenter retrospective cohort study
In conclusion, HRC with GnRHa appears to be superior to HRC without GnRHa, concerning live birth and miscarriage, especially when the number of embryos transferred are ≥2 and irrespective of day of transfer. The use of progesterone vaginal tabs compared to gel or combinations is associated with better outcomes. Age is a significant predictor of a negative hCG test and clinical pregnancy rates. A properly conducted RCT is needed to evaluate the optimal frozen embryo transfer preparation strategy.Abbreviations: SD: standard deviation; BMI: body mass index; PCOS: polycystic ovarian syndrome; IQR: interquartile range; FSH: ...
Source: Systems Biology in Reproductive Medicine - March 17, 2021 Category: Reproduction Medicine Authors: Charalampos Siristatidis Theodosios Arkoulis Nikolaos Christoforidis George Salamalekis Nikoleta Koutlaki Vasilios Karageorgiou Dimitrios Profer Nikolaos Vlahos George Galazios Source Type: research

Early experience with universal SARS-CoV-2 testing in a New York-based reproductive endocrinology ‎practice
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - March 17, 2021 Category: Sexual Medicine Authors: Julian A. Gingold Sharon Galperin Sabrina Fowler Michelle Kappy Staci Pollack Manvinder Singh Harry Lieman Sangita Jindal Source Type: research

Investigating the impact of different strategies for endometrial preparation in frozen cycles considering normal responders undergoing IVF/ICSI cycles: a multicenter retrospective cohort study
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - March 17, 2021 Category: Sexual Medicine Authors: Charalampos Siristatidis Theodosios Arkoulis Nikolaos Christoforidis George Salamalekis Nikoleta Koutlaki Vasilios Karageorgiou Dimitrios Profer Nikolaos Vlahos George Galazios Source Type: research

COVID-19 and human reproduction: A pandemic that packs a serious punch
Syst Biol Reprod Med. 2021 Feb;67(1):3-23. doi: 10.1080/19396368.2020.1855271.ABSTRACTThe COVID-19 pandemic has led to a worldwide health emergency that has impacted 188 countries at last count. The rapid community transmission and relatively high mortality rates with COVID-19 in modern times are relatively unique features of this flu pandemic and have resulted in an unparalleled global health crisis. SARS-CoV-2, being a respiratory virus, mainly affects the lungs, but is capable of infecting other vital organs, such as brain, heart and kidney. Emerging evidence suggests that the virus also targets male and female reproduc...
Source: Systems Biology in Reproductive Medicine - March 15, 2021 Category: Reproduction Medicine Authors: George Anifandis Helen G Tempest Rafael Oliva Grace M Swanson Mara Simopoulou Charles A Easley Michael Primig Christina I Messini Paul J Turek Peter Sutovsky Steve J Ory Stephen A Krawetz Source Type: research

SBiRM in the time of COVID-19
Syst Biol Reprod Med. 2021 Feb;67(1):1-2. doi: 10.1080/19396368.2021.1865012.NO ABSTRACTPMID:33719830 | DOI:10.1080/19396368.2021.1865012 (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - March 15, 2021 Category: Reproduction Medicine Authors: Stephen A Krawetz Source Type: research

Peroxisome Proliferator-Activated Receptors (PPAR), fatty acids and microRNAs: Implications in women delivering low birth weight babies
Syst Biol Reprod Med. 2021 Feb;67(1):24-41. doi: 10.1080/19396368.2020.1858994.ABSTRACTLow birth weight (LBW) babies are associated with neonatal morbidity and mortality and are at increased risk for noncommunicable diseases (NCDs) in later life. However, the molecular determinants of LBW are not well understood. Placental insufficiency/dysfunction is the most frequent etiology for fetal growth restriction resulting in LBW and placental epigenetic processes are suggested to be important regulators of pregnancy outcome. Early life exposures like altered maternal nutrition may have long-lasting effects on the health of the o...
Source: Systems Biology in Reproductive Medicine - March 15, 2021 Category: Reproduction Medicine Authors: Deepali P Sundrani Aishwarya R Karkhanis Sadhana R Joshi Source Type: research

A machine learning system with reinforcement capacity for predicting the fate of an ART embryo
Syst Biol Reprod Med. 2021 Feb;67(1):64-78. doi: 10.1080/19396368.2020.1822953.ABSTRACTThe aim of this work was to construct a score issued from a machine learning system with self-improvement capacity able to predict the fate of an ART embryo incubated in a time lapse monitoring (TLM) system. A retrospective study was performed. For the training data group, 110 couples were included and, 891 embryos were cultured. For the global setting data group, 201 couples were included, and 1186 embryos were cultured. No image analysis was used; morphokinetic parameters from the first three days of embryo culture were used to perform...
Source: Systems Biology in Reproductive Medicine - March 15, 2021 Category: Reproduction Medicine Authors: Sandrine Giscard d'Estaing Elsa Labrune Maxence Forcellini Cecile Edel Bruno Salle Jacqueline Lornage Mehdi Benchaib Source Type: research

COVID-19 and human reproduction: A pandemic that packs a serious punch
Syst Biol Reprod Med. 2021 Feb;67(1):3-23. doi: 10.1080/19396368.2020.1855271.ABSTRACTThe COVID-19 pandemic has led to a worldwide health emergency that has impacted 188 countries at last count. The rapid community transmission and relatively high mortality rates with COVID-19 in modern times are relatively unique features of this flu pandemic and have resulted in an unparalleled global health crisis. SARS-CoV-2, being a respiratory virus, mainly affects the lungs, but is capable of infecting other vital organs, such as brain, heart and kidney. Emerging evidence suggests that the virus also targets male and female reproduc...
Source: Systems Biology in Reproductive Medicine - March 15, 2021 Category: Reproduction Medicine Authors: George Anifandis Helen G Tempest Rafael Oliva Grace M Swanson Mara Simopoulou Charles A Easley Michael Primig Christina I Messini Paul J Turek Peter Sutovsky Steve J Ory Stephen A Krawetz Source Type: research

SBiRM in the time of COVID-19
Syst Biol Reprod Med. 2021 Feb;67(1):1-2. doi: 10.1080/19396368.2021.1865012.NO ABSTRACTPMID:33719830 | DOI:10.1080/19396368.2021.1865012 (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - March 15, 2021 Category: Reproduction Medicine Authors: Stephen A Krawetz Source Type: research

Peroxisome Proliferator-Activated Receptors (PPAR), fatty acids and microRNAs: Implications in women delivering low birth weight babies
Syst Biol Reprod Med. 2021 Feb;67(1):24-41. doi: 10.1080/19396368.2020.1858994.ABSTRACTLow birth weight (LBW) babies are associated with neonatal morbidity and mortality and are at increased risk for noncommunicable diseases (NCDs) in later life. However, the molecular determinants of LBW are not well understood. Placental insufficiency/dysfunction is the most frequent etiology for fetal growth restriction resulting in LBW and placental epigenetic processes are suggested to be important regulators of pregnancy outcome. Early life exposures like altered maternal nutrition may have long-lasting effects on the health of the o...
Source: Systems Biology in Reproductive Medicine - March 15, 2021 Category: Reproduction Medicine Authors: Deepali P Sundrani Aishwarya R Karkhanis Sadhana R Joshi Source Type: research

A machine learning system with reinforcement capacity for predicting the fate of an ART embryo
Syst Biol Reprod Med. 2021 Feb;67(1):64-78. doi: 10.1080/19396368.2020.1822953.ABSTRACTThe aim of this work was to construct a score issued from a machine learning system with self-improvement capacity able to predict the fate of an ART embryo incubated in a time lapse monitoring (TLM) system. A retrospective study was performed. For the training data group, 110 couples were included and, 891 embryos were cultured. For the global setting data group, 201 couples were included, and 1186 embryos were cultured. No image analysis was used; morphokinetic parameters from the first three days of embryo culture were used to perform...
Source: Systems Biology in Reproductive Medicine - March 15, 2021 Category: Reproduction Medicine Authors: Sandrine Giscard d'Estaing Elsa Labrune Maxence Forcellini Cecile Edel Bruno Salle Jacqueline Lornage Mehdi Benchaib Source Type: research

A machine learning system with reinforcement capacity for predicting the fate of an ART embryo
Volume 67, Issue 1, February 2021, Page 64-78 . (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - March 10, 2021 Category: Sexual Medicine Authors: Sandrine Giscard d ’Estaing Elsa Labrune Maxence Forcellini Cecile Edel Bruno Salle Jacqueline Lornage Mehdi Benchaib Source Type: research

Peroxisome Proliferator-Activated Receptors (PPAR), fatty acids and microRNAs: Implications in women delivering low birth weight babies.
Volume 67, Issue 1, February 2021, Page 24-41 . (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - March 10, 2021 Category: Sexual Medicine Authors: Deepali P. Sundrani Aishwarya R. Karkhanis Sadhana R. Joshi Source Type: research

COVID-19 and human reproduction: A pandemic that packs a serious punch
Volume 67, Issue 1, February 2021, Page 3-23 . (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - March 10, 2021 Category: Sexual Medicine Authors: George Anifandis Helen G. Tempest Rafael Oliva Grace M. Swanson Mara Simopoulou Charles A. Easley Michael Primig Christina I. Messini Paul J. Turek Peter Sutovsky Steve J. Ory Stephen A. Krawetz Source Type: research

SBiRM in the time of COVID-19
Volume 67, Issue 1, February 2021, Page 1-2 . (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - March 10, 2021 Category: Sexual Medicine Authors: Stephen A. Krawetz Source Type: research

Molecular differential analysis of uterine leiomyomas and leiomyosarcomas through weighted gene network and pathway tracing approaches
This study provides vital clues for molecular distinction of UL and ULMS which could further assist in identification of specific diagnostic markers and therapeutic targets.Abbreviations UL: Uterine Leiomyomas; ULMS: Uterine Leiomyosarcoma; Myo: Myometrium; DEGs: Differential Expressed Genes; RMA: Robust Multiarray Average; DC: Degree of Centrality; BC: Betweenness of Centrality; CGC: Cancer Gene Census; FDR: False Discovery Rate; TCGA: Cancer Genome Atlas; BP: Biological Process; CC: Cellular Components; MF: Molecular Function; PPI: Protein-Protein Interaction.PMID:33685300 | DOI:10.1080/19396368.2021.1876179 (Source: Sys...
Source: Systems Biology in Reproductive Medicine - March 9, 2021 Category: Reproduction Medicine Authors: Nora Naif Sahly Babajan Banaganapalli Ahmed N Sahly Ali H Aligiraigri Khalidah K Nasser Thoraia Shinawi Arif Mohammed Abdulhakeem S Alamri Nabeel Bondagji Ramu Elango Noor Ahmad Shaik Source Type: research

Molecular differential analysis of uterine leiomyomas and leiomyosarcomas through weighted gene network and pathway tracing approaches
This study provides vital clues for molecular distinction of UL and ULMS which could further assist in identification of specific diagnostic markers and therapeutic targets.Abbreviations UL: Uterine Leiomyomas; ULMS: Uterine Leiomyosarcoma; Myo: Myometrium; DEGs: Differential Expressed Genes; RMA: Robust Multiarray Average; DC: Degree of Centrality; BC: Betweenness of Centrality; CGC: Cancer Gene Census; FDR: False Discovery Rate; TCGA: Cancer Genome Atlas; BP: Biological Process; CC: Cellular Components; MF: Molecular Function; PPI: Protein-Protein Interaction.PMID:33685300 | DOI:10.1080/19396368.2021.1876179 (Source: Sys...
Source: Systems Biology in Reproductive Medicine - March 9, 2021 Category: Reproduction Medicine Authors: Nora Naif Sahly Babajan Banaganapalli Ahmed N Sahly Ali H Aligiraigri Khalidah K Nasser Thoraia Shinawi Arif Mohammed Abdulhakeem S Alamri Nabeel Bondagji Ramu Elango Noor Ahmad Shaik Source Type: research

Molecular differential analysis of uterine leiomyomas and leiomyosarcomas through weighted gene network and pathway tracing approaches
This study provides vital clues for molecular distinction of UL and ULMS which could further assist in identification of specific diagnostic markers and therapeutic targets.Abbreviations UL: Uterine Leiomyomas; ULMS: Uterine Leiomyosarcoma; Myo: Myometrium; DEGs: Differential Expressed Genes; RMA: Robust Multiarray Average; DC: Degree of Centrality; BC: Betweenness of Centrality; CGC: Cancer Gene Census; FDR: False Discovery Rate; TCGA: Cancer Genome Atlas; BP: Biological Process; CC: Cellular Components; MF: Molecular Function; PPI: Protein-Protein Interaction.PMID:33685300 | DOI:10.1080/19396368.2021.1876179 (Source: Sys...
Source: Systems Biology in Reproductive Medicine - March 9, 2021 Category: Reproduction Medicine Authors: Nora Naif Sahly Babajan Banaganapalli Ahmed N Sahly Ali H Aligiraigri Khalidah K Nasser Thoraia Shinawi Arif Mohammed Abdulhakeem S Alamri Nabeel Bondagji Ramu Elango Noor Ahmad Shaik Source Type: research

Molecular differential analysis of uterine leiomyomas and leiomyosarcomas through weighted gene network and pathway tracing approaches
This study provides vital clues for molecular distinction of UL and ULMS which could further assist in identification of specific diagnostic markers and therapeutic targets.Abbreviations UL: Uterine Leiomyomas; ULMS: Uterine Leiomyosarcoma; Myo: Myometrium; DEGs: Differential Expressed Genes; RMA: Robust Multiarray Average; DC: Degree of Centrality; BC: Betweenness of Centrality; CGC: Cancer Gene Census; FDR: False Discovery Rate; TCGA: Cancer Genome Atlas; BP: Biological Process; CC: Cellular Components; MF: Molecular Function; PPI: Protein-Protein Interaction.PMID:33685300 | DOI:10.1080/19396368.2021.1876179 (Source: Sys...
Source: Systems Biology in Reproductive Medicine - March 9, 2021 Category: Reproduction Medicine Authors: Nora Naif Sahly Babajan Banaganapalli Ahmed N Sahly Ali H Aligiraigri Khalidah K Nasser Thoraia Shinawi Arif Mohammed Abdulhakeem S Alamri Nabeel Bondagji Ramu Elango Noor Ahmad Shaik Source Type: research

Molecular differential analysis of uterine leiomyomas and leiomyosarcomas through weighted gene network and pathway tracing approaches
This study provides vital clues for molecular distinction of UL and ULMS which could further assist in identification of specific diagnostic markers and therapeutic targets.Abbreviations UL: Uterine Leiomyomas; ULMS: Uterine Leiomyosarcoma; Myo: Myometrium; DEGs: Differential Expressed Genes; RMA: Robust Multiarray Average; DC: Degree of Centrality; BC: Betweenness of Centrality; CGC: Cancer Gene Census; FDR: False Discovery Rate; TCGA: Cancer Genome Atlas; BP: Biological Process; CC: Cellular Components; MF: Molecular Function; PPI: Protein-Protein Interaction.PMID:33685300 | DOI:10.1080/19396368.2021.1876179 (Source: Sys...
Source: Systems Biology in Reproductive Medicine - March 9, 2021 Category: Reproduction Medicine Authors: Nora Naif Sahly Babajan Banaganapalli Ahmed N Sahly Ali H Aligiraigri Khalidah K Nasser Thoraia Shinawi Arif Mohammed Abdulhakeem S Alamri Nabeel Bondagji Ramu Elango Noor Ahmad Shaik Source Type: research

Molecular differential analysis of uterine leiomyomas and leiomyosarcomas through weighted gene network and pathway tracing approaches
This study provides vital clues for molecular distinction of UL and ULMS which could further assist in identification of specific diagnostic markers and therapeutic targets.Abbreviations UL: Uterine Leiomyomas; ULMS: Uterine Leiomyosarcoma; Myo: Myometrium; DEGs: Differential Expressed Genes; RMA: Robust Multiarray Average; DC: Degree of Centrality; BC: Betweenness of Centrality; CGC: Cancer Gene Census; FDR: False Discovery Rate; TCGA: Cancer Genome Atlas; BP: Biological Process; CC: Cellular Components; MF: Molecular Function; PPI: Protein-Protein Interaction.PMID:33685300 | DOI:10.1080/19396368.2021.1876179 (Source: Sys...
Source: Systems Biology in Reproductive Medicine - March 9, 2021 Category: Reproduction Medicine Authors: Nora Naif Sahly Babajan Banaganapalli Ahmed N Sahly Ali H Aligiraigri Khalidah K Nasser Thoraia Shinawi Arif Mohammed Abdulhakeem S Alamri Nabeel Bondagji Ramu Elango Noor Ahmad Shaik Source Type: research

Molecular differential analysis of uterine leiomyomas and leiomyosarcomas through weighted gene network and pathway tracing approaches
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - March 9, 2021 Category: Sexual Medicine Authors: Nora Naif Sahly Babajan Banaganapalli Ahmed N. Sahly Ali H. Aligiraigri Khalidah K. Nasser Thoraia Shinawi Arif Mohammed Abdulhakeem S. Alamri Nabeel Bondagji Ramu Elango Noor Ahmad Shaik Source Type: research

An update on platelet-rich plasma (PRP) therapy in endometrium and ovary related infertilities: clinical and molecular aspects
Syst Biol Reprod Med. 2021 Feb 25:1-12. doi: 10.1080/19396368.2020.1862357. Online ahead of print.ABSTRACTAdministration of platelet-rich plasma (PRP) is one of the well-recommended strategies for the treatment of endometrium- and ovary-associated infertility. Due to the autologous source of PRP, minimal risks for disease transmission and immunogenic and allergic responses are expected in this method. Despite the extensive use of PRP in medicine, its precise mechanism of action in endometrial and ovarian tissues is still unknown. Nevertheless, the induction of cell proliferation, chemotaxis, regeneration, extracellular mat...
Source: Systems Biology in Reproductive Medicine - February 26, 2021 Category: Reproduction Medicine Authors: Hamed Hajipour Laya Farzadi Zeinab Latifi Neda Keyhanvar Nazli Navali Amir Fattahi Mohammad Nouri Ralf Dittrich Source Type: research

An update on platelet-rich plasma (PRP) therapy in endometrium and ovary related infertilities: clinical and molecular aspects
Syst Biol Reprod Med. 2021 Feb 25:1-12. doi: 10.1080/19396368.2020.1862357. Online ahead of print.ABSTRACTAdministration of platelet-rich plasma (PRP) is one of the well-recommended strategies for the treatment of endometrium- and ovary-associated infertility. Due to the autologous source of PRP, minimal risks for disease transmission and immunogenic and allergic responses are expected in this method. Despite the extensive use of PRP in medicine, its precise mechanism of action in endometrial and ovarian tissues is still unknown. Nevertheless, the induction of cell proliferation, chemotaxis, regeneration, extracellular mat...
Source: Systems Biology in Reproductive Medicine - February 26, 2021 Category: Reproduction Medicine Authors: Hamed Hajipour Laya Farzadi Zeinab Latifi Neda Keyhanvar Nazli Navali Amir Fattahi Mohammad Nouri Ralf Dittrich Source Type: research

An update on platelet-rich plasma (PRP) therapy in endometrium and ovary related infertilities: clinical and molecular aspects
Syst Biol Reprod Med. 2021 Feb 25:1-12. doi: 10.1080/19396368.2020.1862357. Online ahead of print.ABSTRACTAdministration of platelet-rich plasma (PRP) is one of the well-recommended strategies for the treatment of endometrium- and ovary-associated infertility. Due to the autologous source of PRP, minimal risks for disease transmission and immunogenic and allergic responses are expected in this method. Despite the extensive use of PRP in medicine, its precise mechanism of action in endometrial and ovarian tissues is still unknown. Nevertheless, the induction of cell proliferation, chemotaxis, regeneration, extracellular mat...
Source: Systems Biology in Reproductive Medicine - February 26, 2021 Category: Reproduction Medicine Authors: Hamed Hajipour Laya Farzadi Zeinab Latifi Neda Keyhanvar Nazli Navali Amir Fattahi Mohammad Nouri Ralf Dittrich Source Type: research

An update on platelet-rich plasma (PRP) therapy in endometrium and ovary related infertilities: clinical and molecular aspects
Syst Biol Reprod Med. 2021 Feb 25:1-12. doi: 10.1080/19396368.2020.1862357. Online ahead of print.ABSTRACTAdministration of platelet-rich plasma (PRP) is one of the well-recommended strategies for the treatment of endometrium- and ovary-associated infertility. Due to the autologous source of PRP, minimal risks for disease transmission and immunogenic and allergic responses are expected in this method. Despite the extensive use of PRP in medicine, its precise mechanism of action in endometrial and ovarian tissues is still unknown. Nevertheless, the induction of cell proliferation, chemotaxis, regeneration, extracellular mat...
Source: Systems Biology in Reproductive Medicine - February 26, 2021 Category: Reproduction Medicine Authors: Hamed Hajipour Laya Farzadi Zeinab Latifi Neda Keyhanvar Nazli Navali Amir Fattahi Mohammad Nouri Ralf Dittrich Source Type: research

An update on platelet-rich plasma (PRP) therapy in endometrium and ovary related infertilities: clinical and molecular aspects
Syst Biol Reprod Med. 2021 Feb 25:1-12. doi: 10.1080/19396368.2020.1862357. Online ahead of print.ABSTRACTAdministration of platelet-rich plasma (PRP) is one of the well-recommended strategies for the treatment of endometrium- and ovary-associated infertility. Due to the autologous source of PRP, minimal risks for disease transmission and immunogenic and allergic responses are expected in this method. Despite the extensive use of PRP in medicine, its precise mechanism of action in endometrial and ovarian tissues is still unknown. Nevertheless, the induction of cell proliferation, chemotaxis, regeneration, extracellular mat...
Source: Systems Biology in Reproductive Medicine - February 26, 2021 Category: Reproduction Medicine Authors: Hamed Hajipour Laya Farzadi Zeinab Latifi Neda Keyhanvar Nazli Navali Amir Fattahi Mohammad Nouri Ralf Dittrich Source Type: research

An update on platelet-rich plasma (PRP) therapy in endometrium and ovary related infertilities: clinical and molecular aspects
Syst Biol Reprod Med. 2021 Feb 25:1-12. doi: 10.1080/19396368.2020.1862357. Online ahead of print.ABSTRACTAdministration of platelet-rich plasma (PRP) is one of the well-recommended strategies for the treatment of endometrium- and ovary-associated infertility. Due to the autologous source of PRP, minimal risks for disease transmission and immunogenic and allergic responses are expected in this method. Despite the extensive use of PRP in medicine, its precise mechanism of action in endometrial and ovarian tissues is still unknown. Nevertheless, the induction of cell proliferation, chemotaxis, regeneration, extracellular mat...
Source: Systems Biology in Reproductive Medicine - February 26, 2021 Category: Reproduction Medicine Authors: Hamed Hajipour Laya Farzadi Zeinab Latifi Neda Keyhanvar Nazli Navali Amir Fattahi Mohammad Nouri Ralf Dittrich Source Type: research

An update on platelet-rich plasma (PRP) therapy in endometrium and ovary related infertilities: clinical and molecular aspects
Syst Biol Reprod Med. 2021 Feb 25:1-12. doi: 10.1080/19396368.2020.1862357. Online ahead of print.ABSTRACTAdministration of platelet-rich plasma (PRP) is one of the well-recommended strategies for the treatment of endometrium- and ovary-associated infertility. Due to the autologous source of PRP, minimal risks for disease transmission and immunogenic and allergic responses are expected in this method. Despite the extensive use of PRP in medicine, its precise mechanism of action in endometrial and ovarian tissues is still unknown. Nevertheless, the induction of cell proliferation, chemotaxis, regeneration, extracellular mat...
Source: Systems Biology in Reproductive Medicine - February 26, 2021 Category: Reproduction Medicine Authors: Hamed Hajipour Laya Farzadi Zeinab Latifi Neda Keyhanvar Nazli Navali Amir Fattahi Mohammad Nouri Ralf Dittrich Source Type: research

An update on platelet-rich plasma (PRP) therapy in endometrium and ovary related infertilities: clinical and molecular aspects
Syst Biol Reprod Med. 2021 Feb 25:1-12. doi: 10.1080/19396368.2020.1862357. Online ahead of print.ABSTRACTAdministration of platelet-rich plasma (PRP) is one of the well-recommended strategies for the treatment of endometrium- and ovary-associated infertility. Due to the autologous source of PRP, minimal risks for disease transmission and immunogenic and allergic responses are expected in this method. Despite the extensive use of PRP in medicine, its precise mechanism of action in endometrial and ovarian tissues is still unknown. Nevertheless, the induction of cell proliferation, chemotaxis, regeneration, extracellular mat...
Source: Systems Biology in Reproductive Medicine - February 26, 2021 Category: Reproduction Medicine Authors: Hamed Hajipour Laya Farzadi Zeinab Latifi Neda Keyhanvar Nazli Navali Amir Fattahi Mohammad Nouri Ralf Dittrich Source Type: research

An update on platelet-rich plasma (PRP) therapy in endometrium and ovary related infertilities: clinical and molecular aspects
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - February 26, 2021 Category: Sexual Medicine Authors: Hamed Hajipour Laya Farzadi Zeinab Latifi Neda Keyhanvar Nazli Navali Amir Fattahi Mohammad Nouri Ralf Dittrich Source Type: research