Individual assessment of bovine embryo development using a homemade chamber reveals kinetic patterns of success and failure to reach blastocyst stage
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - April 8, 2019 Category: Sexual Medicine Authors: Clara Slade Oliveira B. A. F. de Barros C. A. S. Monteiro P. M. S. Rosa G. R. Leal R. V. Serapi ão L. S. A. Camargo Source Type: research

Monosodium glutamate daily oral supplementation: study of its effects on male reproductive system on rat model
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - February 18, 2019 Category: Sexual Medicine Authors: Fatin Farhana Jubaidi Ramya Dewi Mathialagan Mahanem Mat Noor Izatus Shima Taib Siti Balkis Budin Source Type: research

Monosodium glutamate daily oral supplementation: study of its effects on male reproductive system on rat model.
Abstract Monosodium glutamate (MSG) is widely used in food preparation industry and has been consumed regularly. Previous studies had reported on effects of MSG when given at extremely high dosages, the results are not applicable to human equivalent intake. Therefore, the present study aimed to evaluate the effect of MSG on sperm quality and changes in reproductive organs of adult male rats when taken at average human daily intake (ADI). Twenty-four adult male rats were randomly assigned into three groups; NC (Normal control), MSG60 and MSG120 where MSG was given orally at 60 mg/kg and 120 mg/kg to each respective...
Source: Systems Biology in Reproductive Medicine - February 17, 2019 Category: Reproduction Medicine Authors: Jubaidi FF, Mathialagan RD, Noor MM, Taib IS, Budin SB Tags: Syst Biol Reprod Med Source Type: research

The impact of endometriosis on early embryo morphokinetics: a case-control study
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - February 11, 2019 Category: Sexual Medicine Authors: Fazilet Kubra Boynukalin Munevver Serdarogullari Meral Gultomruk Onder Coban Necati Findikli Mustafa Bahceci Source Type: research

The impact of endometriosis on early embryo morphokinetics: a case-control study.
Abstract The aim of this study was to evaluate the possible effects of endometriosis on early embryo development, by comparing the morphokinetic development of embryos obtained from women with clinically confirmed endometriosis with the ones obtained from tubal factor infertility cases. A total of 82 cycles/patients including 53 cycles with endometriosis and 29 cycles with tubal factor infertility were evaluated. A total of 439 embryos were scored for embryo morphokinetics. Age, body mass index, fertilization rates were similar within the groups. However, the number of previous ART trials was found to be higher (p
Source: Systems Biology in Reproductive Medicine - February 11, 2019 Category: Reproduction Medicine Authors: Boynukalin FK, Serdarogullari M, Gultomruk M, Coban O, Findikli N, Bahceci M Tags: Syst Biol Reprod Med Source Type: research

Systems Biology in Reproductive Medicine 2019.
PMID: 30696309 [PubMed - in process] (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - February 1, 2019 Category: Reproduction Medicine Authors: Krawetz SA Tags: Syst Biol Reprod Med Source Type: research

Systems Biology in Reproductive Medicine 2019
Volume 65, Issue 1, February 2019, Page 1-2 . (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - January 30, 2019 Category: Sexual Medicine Authors: Stephen A. Krawetz Source Type: research

Prenatal stress decreases sperm quality, mature follicles and fertility in rats
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - January 28, 2019 Category: Sexual Medicine Authors: Diana Garc ía-Vargas Lizbeth Ju árez-Rojas Susana Rojas Maya Socorro Retana-M árquez Source Type: research

Prenatal stress decreases sperm quality, mature follicles and fertility in rats.
-Márquez S Abstract Prenatal stress disrupts reproductive function in females and males. These alterations have primarily been related to maternal corticosteroid fetal programming due to the stress response, affecting the fetus and causing long-lasting effects. The aim of this study was to investigate the influence of prenatal stress on male and female fertility. Dams were exposed to stress by immersion in cold water twice a day for the last week of gestation (days 15-21). In the adulthood, sperm quality, mature follicles, sexual hormones and fertility were assessed in female and male progeny. The results i...
Source: Systems Biology in Reproductive Medicine - January 28, 2019 Category: Reproduction Medicine Authors: García-Vargas D, Juárez-Rojas L, Rojas Maya S, Retana-Márquez S Tags: Syst Biol Reprod Med Source Type: research

Prenatal stress decreases sperm quality, mature follicles and fertility in rats
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - January 28, 2019 Category: Sexual Medicine Authors: Diana Garc ía-Vargas Lizbeth Ju árez-Rojas Susana Rojas Maya Socorro Retana-M árquez Source Type: research

Improvement of sperm motility of Oncorhynchus mykiss and Salvelinus fontinalis by L-tryptophan
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - January 26, 2019 Category: Sexual Medicine Authors: Mehmet Kocaba ş Filiz Kutluyer Özlem Ertekin Önder Aksu Nadir Ba şçınar Source Type: research

Improvement of sperm motility of Oncorhynchus mykiss and Salvelinus fontinalis by L-tryptophan.
cedil;ınar N Abstract Experiments were designed to test the influence of L-tryptophan supplementation of the extender on the sperm motility parameters and bacterial flora of brook trout (Salvelinus fontinalis) and rainbow trout (Oncorhynchus mykiss). The extender containing 0.3 M glucose in 10% Dimethyl sulfoxide (DMSO) was supplemented with 0, 0.5, 1, 2, and 4 mM L-tryptophan. Sperm samples stored for up to 12 days at 4°C for brook trout were motile while motility was not observed after six days of storage for rainbow trout. Diluted sperm samples were spread-plated onto Plate Count Agar (PCA) (Total Bac...
Source: Systems Biology in Reproductive Medicine - January 25, 2019 Category: Reproduction Medicine Authors: Kocabaş M, Kutluyer F, Ertekin Ö, Aksu Ö, Başçınar N Tags: Syst Biol Reprod Med Source Type: research

Predicting the functional and structural consequences of nsSNPs in human methionine synthase gene using computational tools
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - January 24, 2019 Category: Sexual Medicine Authors: Mansi Desai Jenabhai B. Chauhan Source Type: research

Predicting the functional and structural consequences of nsSNPs in human methionine synthase gene using computational tools.
Abstract Methionine synthase encoded by the MTR gene is one of the key enzymes involved in the SAM (S- Adenosyl Methionine) cycle catalyzing the conversion of homocysteine to methionine. Methionine plays an important role in the DNA, RNA, protein, phospholipids, and neurotransmitters methylation. It also maintains serum homocysteine level and indirectly regulates de novo nucleotide synthesis and repair. The current study predicted the functional consequences of nsSNPs in human MTR gene using SIFT, PolyPhen2, PROVEAN, SNAP2, PMut, nsSNPAnalyzer, PhD-SNP, SNPs&GO, I-Mutant, MuPro, and iPTREE-STAB. The PTM sites ...
Source: Systems Biology in Reproductive Medicine - January 24, 2019 Category: Reproduction Medicine Authors: Desai M, Chauhan JB Tags: Syst Biol Reprod Med Source Type: research

Predicting the functional and structural consequences of nsSNPs in human methionine synthase gene using computational tools
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - January 24, 2019 Category: Sexual Medicine Authors: Mansi Desai Jenabhai B. Chauhan Source Type: research

Preliminary functional inquiry of lncRNA ENST00000433673 in embryo implantation using bioinformatics analysis
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - January 16, 2019 Category: Sexual Medicine Authors: Dong Li Weihua Jiang Yiqun Jiang Shanshan Wang Junshun Fang Lihua Zhu Yinchun Zhu Guijun Yan Haixiang Sun Linjun Chen Ningyuan Zhang Source Type: research

Preliminary functional inquiry of lncRNA ENST00000433673 in embryo implantation using bioinformatics analysis.
Abstract Long non-coding RNAs (lncRNAs), a class of non-coding RNA, have been shown to be essential in many diseases, such as infertility. Here, we found three candidate lncRNAs, ENST00000414116, ENST00000433673, and ENST00000448179, that are highly expressed in the uterus endometrial tissues of normal patients compared to the tissues of patients with adenomyosis, endometriosis, and recurrent implantation failure. lncRNAs ENST00000414116 and ENST00000433673 showed high expression in endometrial stromal cells (ESCs) and endometrial epithelial cells (EECs), respectively, and lncRNA ENST00000448179 was specifically e...
Source: Systems Biology in Reproductive Medicine - January 16, 2019 Category: Reproduction Medicine Authors: Li D, Jiang W, Jiang Y, Wang S, Fang J, Zhu L, Zhu Y, Yan G, Sun H, Chen L, Zhang N Tags: Syst Biol Reprod Med Source Type: research

Preliminary functional inquiry of lncRNA ENST00000433673 in embryo implantation using bioinformatics analysis
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - January 16, 2019 Category: Sexual Medicine Authors: Dong Li Weihua Jiang Yiqun Jiang Shanshan Wang Junshun Fang Lihua Zhu Yinchun Zhu Guijun Yan Haixiang Sun Linjun Chen Ningyuan Zhang Source Type: research

LINC01541 overexpression attenuates the 17 β-Estradiol-induced migration and invasion capabilities of endometrial stromal cells
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - January 4, 2019 Category: Sexual Medicine Authors: Hong Mai Yeping Wei Yan Yin Shijin Huang Huisi Lin Yan Liao Xupeng Liu Xianfeng Chen Haijuan Shi Chuanzhong Liu Hong Xu Source Type: research

LINC01541 overexpression attenuates the 17 β-Estradiol-induced migration and invasion capabilities of endometrial stromal cells.
This study examined whether aberrant expression of LINC01541 contributes to the pathogenesis of endometriosis. Human endometrial stromal cells (ESCs) were stimulated with 10 nmol/L of 17β-Estradiol (17β-E2) to simulate ectopic cells found in endometriosis. Next, the levels of proteins related to the epithelial-mesenchymal transition (EMT), cell invasion, and metastasis were investigated. The effects of LINCO1541 silencing and overexpression were also examined in ESCs. Cell proliferation and apoptosis were detected by cell counting kit-8 and flow cytometry assays, respectively. ESCs stimulated with 17β-E...
Source: Systems Biology in Reproductive Medicine - January 4, 2019 Category: Reproduction Medicine Authors: Mai H, Wei Y, Yin Y, Huang S, Lin H, Liao Y, Liu X, Chen X, Shi H, Liu C, Xu H Tags: Syst Biol Reprod Med Source Type: research

LINC01541 overexpression attenuates the 17 β-Estradiol-induced migration and invasion capabilities of endometrial stromal cells
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - January 4, 2019 Category: Sexual Medicine Authors: Hong Mai Yeping Wei Yan Yin Shijin Huang Huisi Lin Yan Liao Xupeng Liu Xianfeng Chen Haijuan Shi Chuanzhong Liu Hong Xu Source Type: research

The relationship among sperm global DNA methylation, telomere length, and DNA fragmentation in varicocele: a cross-sectional study of 20 cases
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - January 2, 2019 Category: Sexual Medicine Authors: Viviane Paiva Santana Cristiana Libardi Miranda-Furtado Daiana Cristina Chielli Pedroso Matheus Credendio Eiras Maria Aparecida Carneiro Vasconcelos Ester Silveira Ramos Rodrigo Tocantins Calado Rui Alberto Ferriani Sandro Cassiano Esteves Rosana Maria do Source Type: research

The relationship among sperm global DNA methylation, telomere length, and DNA fragmentation in varicocele: a cross-sectional study of 20 cases.
Abstract Varicocele pathophysiology is related to increased oxidative stress, which might result in loss sperm DNA integrity as well as in genomic instability. Sperm telomere shortening and loss of global DNA methylation are the main features of genomic instability, leading to cell senescence and death, whereas sperm DNA fragmentation (SDF) characterizes the loss of chromatin integrity. We hypothesize that sperm genomic stability and DNA integrity is reduced in infertile men with moderate and large-sized varicoceles, thus being candidate markers of sperm quality in varicocele-related infertility. Here, we assessed...
Source: Systems Biology in Reproductive Medicine - January 2, 2019 Category: Reproduction Medicine Authors: Santana VP, Miranda-Furtado CL, Pedroso DCC, Eiras MC, Vasconcelos MAC, Ramos ES, Calado RT, Ferriani RA, Esteves SC, Dos Reis RM Tags: Syst Biol Reprod Med Source Type: research

The relationship among sperm global DNA methylation, telomere length, and DNA fragmentation in varicocele: a cross-sectional study of 20 cases
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - January 2, 2019 Category: Sexual Medicine Authors: Viviane Paiva Santana Cristiana Libardi Miranda-Furtado Daiana Cristina Chielli Pedroso Matheus Credendio Eiras Maria Aparecida Carneiro Vasconcelos Ester Silveira Ramos Rodrigo Tocantins Calado Rui Alberto Ferriani Sandro Cassiano Esteves Rosana Maria do Source Type: research

Effect of single-dose ibuprofen on follicular fluid levels of interleukins in poor responders undergoing in vitro fertilization
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - December 20, 2018 Category: Sexual Medicine Authors: Laurice Bou Nemer Haolin Shi Bruce Richard Carr Ruth Ann Word Orhan Bukulmez Source Type: research

Effect of single-dose ibuprofen on follicular fluid levels of interleukins in poor responders undergoing in vitro fertilization.
In conclusion, our data show that one dose of ibuprofen administered orally the day after trigger injection revealed a significant impact on the FF inflammatory milieu. Abbreviations: IVF: in vitro fertilization; MMP: matrix metalloproteinase; IL: interleukins; FF: follicular fluid; VEGF: vascular endothelial growth factor; NSAIDS: non-steroidal anti-inflammatories; POR: poor ovarian response; AMH: anti-Mullerian hormone; TAFC: total antral follicle count; HMG: human menopausal gonadotropin; hCG: human chorionic gonadotropin; COX: cyclooxygenase enzymes; PGH2: prostaglandin H2; RANTES: regulated on activation, normal T exp...
Source: Systems Biology in Reproductive Medicine - December 20, 2018 Category: Reproduction Medicine Authors: Bou Nemer L, Shi H, Carr BR, Word RA, Bukulmez O Tags: Syst Biol Reprod Med Source Type: research

Effect of single-dose ibuprofen on follicular fluid levels of interleukins in poor responders undergoing in vitro fertilization
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - December 20, 2018 Category: Sexual Medicine Authors: Laurice Bou Nemer Haolin Shi Bruce Richard Carr Ruth Ann Word Orhan Bukulmez Source Type: research

Molecular diagnostics of disorders of sexual development: an Indian survey and systems biology perspective
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - December 14, 2018 Category: Sexual Medicine Authors: MR Nagaraja Satya Prakash Gubbala C. R. Wilma Delphine Silvia Ramars Amanchy Source Type: research

Molecular diagnostics of disorders of sexual development: an Indian survey and systems biology perspective.
This study revealed mutations resulting in androgen insensitivity syndrome, 5α-reductase type 2 deficiency, and gonadal dysgenesis were commonly reported. Intriguingly, AR deficits were the most prevalent (32 mutations) and of 11/26 missense mutations were in exons 4-8 (encoding ligand binding domain). The unique features of SRD5A2 defects were p.R246Q (most prevalent) and p.G196S could be mutational hotspots, dual gene defects (p.A596T in AR and p.G196S in SRD5A2) in a patient with hypospadias and novel 8 nucleotide deletion (exon 1) found in a patient with perineal hypospadias. Deficits in SRY, WT1, DHH, NR5A1, and...
Source: Systems Biology in Reproductive Medicine - December 14, 2018 Category: Reproduction Medicine Authors: Nagaraja MR, Gubbala SP, Delphine Silvia CRW, Amanchy R Tags: Syst Biol Reprod Med Source Type: research

Molecular diagnostics of disorders of sexual development: an Indian survey and systems biology perspective
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - December 14, 2018 Category: Sexual Medicine Authors: MR Nagaraja Satya Prakash Gubbala C. R. Wilma Delphine Silvia Ramars Amanchy Source Type: research

Comparative study on risk for birth defects among infants after in vitro fertilization and intracytoplasmic sperm injection
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - December 10, 2018 Category: Sexual Medicine Authors: Jing Zhu Qianqian Zhu Yun Wang Bian Wang Qifeng Lyu Yanping Kuang Source Type: research

Comparative study on risk for birth defects among infants after in vitro fertilization and intracytoplasmic sperm injection.
Abstract This large retrospective study was conducted to compare the risk for birth defects among infants conceived by in vitro fertilization (IVF) with that among infants conceived by intracytoplasmic sperm injection (ICSI) and to explore the effect of frozen embryo transfer (FET) on the risk for birth defects among infants born by IVF and ICSI. All patients who received assisted reproductive technology (ART) treatment and who underwent childbirth during the period January 2005-August 2017 were included in this study. There were 18,221 births after ART included in the analysis; of these births, 12,649 were concei...
Source: Systems Biology in Reproductive Medicine - December 10, 2018 Category: Reproduction Medicine Authors: Zhu J, Zhu Q, Wang Y, Wang B, Lyu Q, Kuang Y Tags: Syst Biol Reprod Med Source Type: research

Comparative study on risk for birth defects among infants after in vitro fertilization and intracytoplasmic sperm injection
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - December 10, 2018 Category: Sexual Medicine Authors: Jing Zhu Qianqian Zhu Yun Wang Bian Wang Qifeng Lyu Yanping Kuang Source Type: research

Resveratrol improves sperm parameter and testicular apoptosis in cisplatin-treated rats: Effects on ERK1/2, JNK, and Akt pathways.
In conclusion, RES protects against Cis-induced testicular damage and reproductive dysfunction via improving testosterone levels, increasing sperm count, reducing testicular apoptosis via an antioxidant potential, inhibition of ER stress, P53, ERK1/2, JNK, and activation of Akt. Abbreviations: RES: resveratrol, Cis: cisplatin; ER: endoplasmic reticulum; ERK1/2: extracellular signal-regulated kinase1/2; SAPK/JNK: stress-activated protein kinase/c-Jun N-terminal kinase; Akt: protein kinase B; HPG axis: hypothalamic-pituitary-gonadal axis; PUFAs: polyunsaturated fatty acids; FSH: Follicular stimulating hormone; LH: Luteinizin...
Source: Systems Biology in Reproductive Medicine - December 3, 2018 Category: Reproduction Medicine Authors: Shati AA Tags: Syst Biol Reprod Med Source Type: research

Resveratrol improves sperm parameter and testicular apoptosis in cisplatin-treated rats: Effects on ERK1/2, JNK, and Akt pathways
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - December 3, 2018 Category: Sexual Medicine Authors: Ali A. Shati Source Type: research

Associations between biochemical components of human semen with seminal conditions
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - November 30, 2018 Category: Sexual Medicine Authors: Giulia Collodel Fabiola Nerucci Cinzia Signorini Francesca Iacoponi Elena Moretti Source Type: research

Special Issue in Honor of Gordon H. Dixon.
PMID: 30444444 [PubMed - in process] (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - November 19, 2018 Category: Reproduction Medicine Authors: Balhorn R, Davies PL, Kleene KC, Krawetz SA, Mezquita-Pla J, Oliva R, States JC, Tempest HG Tags: Syst Biol Reprod Med Source Type: research

Teratozoospermia with amorphous sperm head associate with abnormal chromatin condensation in a Chinese family
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - November 19, 2018 Category: Sexual Medicine Authors: Ying Ma Ning Xie Yi Li Baoping Zhang Dingxiong Xie Wei Zhang Qiuguang Li Hongmiao Yu Qianjing Zhang Yali Ni Xiaodong Xie Source Type: research

Special Issue in Honor of Gordon H. Dixon
Volume 64, Issue 6, December 2018, Page 399-402 . (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - November 16, 2018 Category: Sexual Medicine Authors: Rod Balhorn Peter L. Davies Kenneth Cole Kleene Stephen A. Krawetz Jovita Mezquita-Pla Rafael Oliva J. Christopher States Helen G. Tempest Source Type: research

Serum Anti-M üllerian hormone (AMH) in mothers with polycystic ovary syndrome (PCOS) and their term fetuses
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - November 14, 2018 Category: Sexual Medicine Authors: Laura Detti Mary E. Christiansen Ludwig Francillon Gini Ikuwezunma Michael P. Diamond Giancarlo Mari Ana M. Tobiasz Source Type: research

Serum Anti-M üllerian hormone (AMH) in mothers with polycystic ovary syndrome (PCOS) and their term fetuses.
Serum Anti-Müllerian hormone (AMH) in mothers with polycystic ovary syndrome (PCOS) and their term fetuses. Syst Biol Reprod Med. 2018 Nov 14;:1-8 Authors: Detti L, Christiansen ME, Francillon L, Ikuwezunma G, Diamond MP, Mari G, Tobiasz AM Abstract We sought to determine serum AMH levels in the maternal circulation, and the umbilical artery and vein, in normal women and women with PCOS, and their neonates at time of delivery. This represents a cross-sectional study of 57 pregnant patients who presented to the labor and delivery suite and subsequently delivered. We obtained maternal, as well as f...
Source: Systems Biology in Reproductive Medicine - November 14, 2018 Category: Reproduction Medicine Authors: Detti L, Christiansen ME, Francillon L, Ikuwezunma G, Diamond MP, Mari G, Tobiasz AM Tags: Syst Biol Reprod Med Source Type: research

Serum Anti-M üllerian hormone (AMH) in mothers with polycystic ovary syndrome (PCOS) and their term fetuses
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - November 14, 2018 Category: Sexual Medicine Authors: Laura Detti Mary E. Christiansen Ludwig Francillon Gini Ikuwezunma Michael P. Diamond Giancarlo Mari Ana M. Tobiasz Source Type: research