Frequent azoospermia in patients with testicular germ cell cancer and a history of cryptorchidism: a report of nine cases and review of the literature
This study analyzed semen parameters in patients with testicular germ cell cancer and a history of cryptorchidism. Among testicular cancer patients referred for sperm cryopreservation, the semen of 9 patients with a history of cryptorchidism, including three cases of bilateral cryptorchidism and one case of cryptorchidism with bilateral metachronous tumor, was analyzed. Eight patients underwent orchidopexy during childhood. The tumor was observed on the contralateral side of the undescended testis, except in the bilateral metachronous tumor and cryptorchidism cases. Five patients, including the one who developed a metachro...
Source: Systems Biology in Reproductive Medicine - February 25, 2021 Category: Reproduction Medicine Authors: Jun Hagiuda Ken Nakagawa Mototsugu Oya Source Type: research

Extracellular vesicle cargo of the male reproductive tract and the paternal preconception environment
Syst Biol Reprod Med. 2021 Feb 25:1-9. doi: 10.1080/19396368.2020.1867665. Online ahead of print.ABSTRACTThe molecular composition of extracellular vesicles (EVs) is emerging as a novel biomarker in many areas of research including reproductive health. EVs transport biological molecules such as RNA and protein to facilitate cell-to-cell communication among cells of the male reproductive tract. Human and animal studies have shown that EVs present in seminal plasma or in the male reproductive tract contain important cargo that are important for successful reproductive outcomes. Small non-coding RNAs (sncRNA) have been at the...
Source: Systems Biology in Reproductive Medicine - February 25, 2021 Category: Reproduction Medicine Authors: Ahmet Ayaz Emily Houle J Richard Pilsner Source Type: research

Frequent azoospermia in patients with testicular germ cell cancer and a history of cryptorchidism: a report of nine cases and review of the literature
This study analyzed semen parameters in patients with testicular germ cell cancer and a history of cryptorchidism. Among testicular cancer patients referred for sperm cryopreservation, the semen of 9 patients with a history of cryptorchidism, including three cases of bilateral cryptorchidism and one case of cryptorchidism with bilateral metachronous tumor, was analyzed. Eight patients underwent orchidopexy during childhood. The tumor was observed on the contralateral side of the undescended testis, except in the bilateral metachronous tumor and cryptorchidism cases. Five patients, including the one who developed a metachro...
Source: Systems Biology in Reproductive Medicine - February 25, 2021 Category: Reproduction Medicine Authors: Jun Hagiuda Ken Nakagawa Mototsugu Oya Source Type: research

Extracellular vesicle cargo of the male reproductive tract and the paternal preconception environment
Syst Biol Reprod Med. 2021 Feb 25:1-9. doi: 10.1080/19396368.2020.1867665. Online ahead of print.ABSTRACTThe molecular composition of extracellular vesicles (EVs) is emerging as a novel biomarker in many areas of research including reproductive health. EVs transport biological molecules such as RNA and protein to facilitate cell-to-cell communication among cells of the male reproductive tract. Human and animal studies have shown that EVs present in seminal plasma or in the male reproductive tract contain important cargo that are important for successful reproductive outcomes. Small non-coding RNAs (sncRNA) have been at the...
Source: Systems Biology in Reproductive Medicine - February 25, 2021 Category: Reproduction Medicine Authors: Ahmet Ayaz Emily Houle J Richard Pilsner Source Type: research

Frequent azoospermia in patients with testicular germ cell cancer and a history of cryptorchidism: a report of nine cases and review of the literature
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - February 25, 2021 Category: Sexual Medicine Authors: Jun Hagiuda Ken Nakagawa Mototsugu Oya Source Type: research

Extracellular vesicle cargo of the male reproductive tract and the paternal preconception environment
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - February 25, 2021 Category: Sexual Medicine Authors: Ahmet Ayaz Emily Houle J. Richard Pilsner Source Type: research

c-Fos is upregulated in the genital tubercle of DEHP-induced hypospadiac rats and the prepuce of patients with hypospadias
This study aimed to investigate the expression of Fos proto-oncogene, AP-1 transcription factor subunit (c-Fos) in the genital tubercle (GT) of rats with di(2-ethylhexyl) phthalate (DEHP)-induced hypospadias and in the prepuce of patients with hypospadias compared with unaffected controls. Pregnant rats were given 750 mg/kg/day DEHP orally from gestational days 12-19. Western blotting showed that c-Fos expression was increased in DEHP-induced hypospadiac male offspring. In addition, 30 prepuce tissue specimens obtained during hypospadias repair surgery were divided into 2 groups: the mild hypospadias group (n = 15) and the...
Source: Systems Biology in Reproductive Medicine - February 23, 2021 Category: Reproduction Medicine Authors: Han Xiang Shao Wang Xiaoyan Kong Yihang Yu Lianju Shen Chunlan Long Xing Liu Guang-Hui Wei Source Type: research

c-Fos is upregulated in the genital tubercle of DEHP-induced hypospadiac rats and the prepuce of patients with hypospadias
This study aimed to investigate the expression of Fos proto-oncogene, AP-1 transcription factor subunit (c-Fos) in the genital tubercle (GT) of rats with di(2-ethylhexyl) phthalate (DEHP)-induced hypospadias and in the prepuce of patients with hypospadias compared with unaffected controls. Pregnant rats were given 750 mg/kg/day DEHP orally from gestational days 12-19. Western blotting showed that c-Fos expression was increased in DEHP-induced hypospadiac male offspring. In addition, 30 prepuce tissue specimens obtained during hypospadias repair surgery were divided into 2 groups: the mild hypospadias group (n = 15) and the...
Source: Systems Biology in Reproductive Medicine - February 23, 2021 Category: Reproduction Medicine Authors: Han Xiang Shao Wang Xiaoyan Kong Yihang Yu Lianju Shen Chunlan Long Xing Liu Guang-Hui Wei Source Type: research

c-Fos is upregulated in the genital tubercle of DEHP-induced hypospadiac rats and the prepuce of patients with hypospadias
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - February 23, 2021 Category: Sexual Medicine Authors: Han Xiang Shao Wang Xiaoyan Kong Yihang Yu Lianju shen Chunlan Long Xing Liu Guang-Hui Wei Source Type: research

Successful four-factor preimplantation genetic testing: α- and β-thalassemia, human leukocyte antigen typing, and aneuploidy screening
Syst Biol Reprod Med. 2021 Jan 25:1-9. doi: 10.1080/19396368.2020.1832158. Online ahead of print.ABSTRACTOur study established an effective next-generation sequencing (NGS) protocol for four-factor preimplantation genetic testing (PGT) using α- and β-thalassemia, human leukocyte antigen (HLA) typing, and aneuploidy screening. Three couples, in whom both partners were α- and β-double thalassemia carriers, underwent PGT between 2016 and 2018. These individuals sought an opportunity for hematopoietic stem cell transplantation to save their children from β-thalassemia major. A total of 35 biopsied tr...
Source: Systems Biology in Reproductive Medicine - January 26, 2021 Category: Reproduction Medicine Authors: Dongjia Chen Xiaoting Shen Yan Xu Chenhui Ding Qingjian Ye Yiping Zhong Yanwen Xu Canquan Zhou Source Type: research

Successful four-factor preimplantation genetic testing: α- and β-thalassemia, human leukocyte antigen typing, and aneuploidy screening
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - January 26, 2021 Category: Sexual Medicine Authors: Dongjia Chen Xiaoting Shen Yan Xu Chenhui Ding Qingjian Ye Yiping Zhong Yanwen Xu Canquan Zhou Source Type: research

Successful four-factor preimplantation genetic testing: α- and β-thalassemia, human leukocyte antigen typing, and aneuploidy screening.
Successful four-factor preimplantation genetic testing: α- and β-thalassemia, human leukocyte antigen typing, and aneuploidy screening. Syst Biol Reprod Med. 2021 Jan 25;:1-9 Authors: Chen D, Shen X, Xu Y, Ding C, Ye Q, Zhong Y, Xu Y, Zhou C Abstract Our study established an effective next-generation sequencing (NGS) protocol for four-factor preimplantation genetic testing (PGT) using  α- and β-thalassemia, human leukocyte antigen (HLA) typing, and aneuploidy screening. Three couples, in whom both partners were α- and β-double thalassemia carriers, underwent PGT b...
Source: Systems Biology in Reproductive Medicine - January 25, 2021 Category: Reproduction Medicine Authors: Chen D, Shen X, Xu Y, Ding C, Ye Q, Zhong Y, Xu Y, Zhou C Tags: Syst Biol Reprod Med Source Type: research

Microfluidic sperm selection yields higher sperm quality compared to conventional method in ICSI program: A pilot study
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Source: Systems Biology in Reproductive Medicine - January 16, 2021 Category: Sexual Medicine Authors: Fatemeh Anbari Mohammad Ali khalili Abdul Munaf Sultan Ahamed Esmat Mangoli Ali Nabi Fatemeh Dehghanpour Mojdeh Sabour Source Type: research

Microfluidic sperm selection yields higher sperm quality compared to conventional method in ICSI program: A pilot study.
Abstract An appropriate preparation technique, should be capable of isolating highquality spermatozoa for intracytoplasmic sperm injection (ICSI). The aim was to assess sperm quality parameters, DNA integrity, embryo development, and clinical outcomes using a practical and accessible Microfluidic Sperm Sorting (MSS) technique. A total of 95 ICSI cases performed using sperm samples were prepared with our MSS (group 1) or by Direct Swim Up (DSU; control) method (group 2). Both sperm quality parameters and sperm DNA fragmentation (SDF) were compared between the groups. DNA fragmentation was assessed using Sperm Chrom...
Source: Systems Biology in Reproductive Medicine - January 15, 2021 Category: Reproduction Medicine Authors: Anbari F, Khalili MA, Sultan Ahamed AM, Mangoli E, Nabi A, Dehghanpour F, Sabour M Tags: Syst Biol Reprod Med Source Type: research

Effect of ovarian stimulation on embryo aneuploidy and mosaicism rate.
Bernabeu R Abstract There is a high incidence of chromosome abnormalities in human embryos that leads to a failed IVF cycle. Different studies have shown that maternal age is the determining factor in the appearance of chromosomal alterations in the embryo. However, the possible influence of ovarian stimulation on oocyte and embryo aneuploidies and mosaicism is controversial. A retrospective study was carried out in which 835 embryos from 280 couples undergoing reproductive treatment using their oocytes were chromosomally analyzed. A binary logistic regression analysis was performed to evaluate the relationship b...
Source: Systems Biology in Reproductive Medicine - January 7, 2021 Category: Reproduction Medicine Authors: Cascales A, Lledó B, Ortiz JA, Morales R, Ten J, Llácer J, Bernabeu R Tags: Syst Biol Reprod Med Source Type: research

Correlation between anti-Mullerian hormone levels and antral follicle counts in polycystic ovary and metabolic syndromes.
Abstract Anti-Mullerian hormone (AMH) is expressed by the granulosa cells of the pre-antral and small antral follicles in the ovary. AMH serum levels are significantly higher in women with polycystic ovary syndrome (PCOS) due to an increased antral follicle counts (AFC) and a higher production of AMH per antral follicle. This research is a cohort study design with a sample size of 60 female patients with (n = 30) and without PCOS (n = 30) in which the relationship between AMH serum level and other hormonal markers was explored. The following measurements were taken from the patients on the fift...
Source: Systems Biology in Reproductive Medicine - January 7, 2021 Category: Reproduction Medicine Authors: Fu H, Lin Y, Deng X, Wu L Tags: Syst Biol Reprod Med Source Type: research

Correlation between anti-Mullerian hormone levels and antral follicle counts in polycystic ovary and metabolic syndromes
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Source: Systems Biology in Reproductive Medicine - January 7, 2021 Category: Sexual Medicine Authors: Huo Fu Youshi Lin Xueqing Deng Lin Wu Source Type: research

Effect of ovarian stimulation on embryo aneuploidy and mosaicism rate
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - January 7, 2021 Category: Sexual Medicine Authors: Alba Cascales Belen Lled ó Jose A. Ortiz Ruth Morales Jorge Ten Joaquin Ll ácer Rafael Bernabeu Source Type: research

Comparison of commercially available chamber slides for computer-aided analysis of human sperm
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Source: Systems Biology in Reproductive Medicine - December 30, 2020 Category: Sexual Medicine Authors: Fereshteh Dardmeh Mahmoud Heidari Hiva Alipour Source Type: research

Comparison of proteomic profiles from the testicular tissue of males with impaired and normal spermatogenesis
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - December 30, 2020 Category: Sexual Medicine Authors: Jiaying Liang Yichun Zheng Weihong Zeng Liuqing Chen Shaofen Yang Peng Du Yujiang Wang Xingsu Yu Xiqian Zhang Source Type: research

Orchestrating the expression levels of sperm mRNAs reveals CCDC174 as an important determinant of semen quality and bull fertility
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Source: Systems Biology in Reproductive Medicine - November 16, 2020 Category: Sexual Medicine Authors: Sellappan Selvaraju Divakar Swathi Laxman Ramya Maharajan Lavanya Santhanahalli Siddalingappa Archana Muniandy Sivaram Source Type: research

Orchestrating the expression levels of sperm mRNAs reveals CCDC174 as an important determinant of semen quality and bull fertility.
Abstract Bulls with acceptable semen quality vary in actual field fertility and this can be elucidated by studying the expression levels of mRNAs in the sperm. The present study aimed at assessing the variations in the sperm gene expression levels of PRM1, CCDC174, RPL36A, TMCO2, SWI5 and OIT3 in bulls differing in fertility status. Frozen semen samples from Holstein-Friesian bulls were classified into high-fertile (n = 8, average field conception rate = 46.1 ± 0.51, p
Source: Systems Biology in Reproductive Medicine - November 15, 2020 Category: Reproduction Medicine Authors: Selvaraju S, Swathi D, Ramya L, Lavanya M, Archana SS, Sivaram M Tags: Syst Biol Reprod Med Source Type: research

Modification of late human embryo development after blastomere removal on day 3 for preimplantation genetic testing
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Source: Systems Biology in Reproductive Medicine - November 5, 2020 Category: Sexual Medicine Authors: Jenna Lammers Arnaud Reignier Sophie Loubersac Sana Chtourou Tiphaine Lefebvre Paul Barri ère Thomas Fr éour Source Type: research

Modification of late human embryo development after blastomere removal on day 3 for preimplantation genetic testing.
acute;our T Abstract The purpose of our study was to use a time-lapse monitoring (TLM) system to determine if day 3 blastomere biopsy for preimplantation genetic testing (PGT) had an impact on subsequent morphokinetic parameters at the morula and blastocyst stages. In this retrospective monocentric study conducted between May 2013 and August 2017, we compared late morphokinetic parameters in embryos undergoing day 3 blastomere biopsy for PGT and in control non-biopsied embryos obtained in intracytoplasmic sperm injection (ICSI) cycles for male infertility. All embryos in both groups were cultured in a TLM system. ...
Source: Systems Biology in Reproductive Medicine - November 4, 2020 Category: Reproduction Medicine Authors: Lammers J, Reignier A, Loubersac S, Chtourou S, Lefebvre T, Barrière P, Fréour T Tags: Syst Biol Reprod Med Source Type: research

Astaxanthin inhibiting oxidative stress damage of placental trophoblast cells in vitro
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - October 26, 2020 Category: Sexual Medicine Authors: Jiu-Yuan Fu Yang Jing Yan-Ping Xiao Xiao-Hua Wang Yan-Wei Guo Yan-Ju Zhu Source Type: research

Astaxanthin inhibiting oxidative stress damage of placental trophoblast cells in vitro.
This study aimed at exploring the potential effects of astaxanthin (ATX) on oxidative stress damaged placental trophoblast cell line HTR-8/SVneo. Oxidative stress-induced damaged through H2O2 treatment was checked by MTS CellTiter 96® cell viability, 2',7'-dichlorofluorescein diacetate (DCFH-DA) induced fluorescence, the level of the intracellular malondialdehyde (MDA), and the detection of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and catalase (CAT). Different concentrations of ATX were applied, and then the proliferation rate, apoptotic percentage, cell cycle distribution, invasion test and relative...
Source: Systems Biology in Reproductive Medicine - October 25, 2020 Category: Reproduction Medicine Authors: Fu JY, Jing Y, Xiao YP, Wang XH, Guo YW, Zhu YJ Tags: Syst Biol Reprod Med Source Type: research

Sperm performance in oligoasthenoteratozoospermic patients is induced by a nutraceuticals mix, containing mainly myo-inositol.
Abstract The action of myo-inositol (MI), belonging to the inositol family, has been shown to improve sperm quality. To further elucidate the efficacy of this substance in male fertility, we investigated in vivo the effects of a nutraceuticals mix, containing mainly myo-inositol (MI) and in vitro the action of the MI on human male gamete performance. Sperm samples were evaluated from 51 men: 21 healthy normozoospermic and 30 oligoasthenoteratozoospermic (OAT). In the latter group, 15 patients were orally treated with the nutraceutical mix and in the remaining 15 patients only MI was used directly on their ejaculat...
Source: Systems Biology in Reproductive Medicine - October 23, 2020 Category: Reproduction Medicine Authors: Santoro M, Aquila S, Russo G Tags: Syst Biol Reprod Med Source Type: research

Sperm performance in oligoasthenoteratozoospermic patients is induced by a nutraceuticals mix, containing mainly myo-inositol
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - October 23, 2020 Category: Sexual Medicine Authors: Marta Santoro Saveria Aquila Giampiero Russo Source Type: research

Increased levels of angiotensin II type 1 receptor autoantibodies in female infertility
Volume 67, Issue 2, April 2021, Page 160-167 . (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - October 19, 2020 Category: Sexual Medicine Authors: Fang Liu Guifang Yang Ruixia Guo Li Xue Lijuan Wang Jingjing Guo Xiaoli Yang Source Type: research

Increased levels of angiotensin Ⅱ type 1 receptor autoantibodies in female infertility
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - October 19, 2020 Category: Sexual Medicine Authors: Fang Liu Guifang Yang Ruixia Guo Li Xue Lijuan Wang Jingjing Guo Xiaoli Yang Source Type: research

Increased levels of angiotensin Ⅱ type 1 receptor autoantibodies in female infertility.
In this study, the level of serum anti-angiotensin II type 1 receptor autoantibodies (AT1-AA) was determined. It was found that the positive rate of AT1-AA in serum of infertile women is higher than that of healthy non-pregnant women. Spearman correlation analysis showed that AT1-AA was negatively correlated with oocyte maturation rate (r = -0.29, P
Source: Systems Biology in Reproductive Medicine - October 18, 2020 Category: Reproduction Medicine Authors: Liu F, Yang G, Guo R, Xue L, Wang L, Guo J, Yang X Tags: Syst Biol Reprod Med Source Type: research

Reducing misdiagnosis caused by maternal cell contamination in genetic testing for early pregnancy loss
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - October 16, 2020 Category: Sexual Medicine Authors: Ludmila Volozonoka Linda Gailite Dmitrijs Perminov Liene Kornejeva Violeta Fodina Inga Kempa Anna Miskova Source Type: research

Reducing misdiagnosis caused by maternal cell contamination in genetic testing for early pregnancy loss.
Abstract The analysis of products of conception (POC) is clinically important to establish the cause of early pregnancy loss. Data from such analyses can lead to specific interventions in subsequent natural or assisted conceptions. The techniques available to examine the chromosomal composition of POC have limitations and can give misleading results when maternal cell contamination (MCC) is overlooked. The aim of this study was to develop a protocol for MCC assessment and to formulate POC material handling, testing, and reporting recommendations. Using array comparative genomic hybridization, we tested 86 POC samp...
Source: Systems Biology in Reproductive Medicine - October 15, 2020 Category: Reproduction Medicine Authors: Volozonoka L, Gailite L, Perminov D, Kornejeva L, Fodina V, Kempa I, Miskova A Tags: Syst Biol Reprod Med Source Type: research

Clomiphene citrate improved testosterone and sperm concentration in hypogonadal males.
Abstract When considering empirical medical management (EMT) options for men with unexplained infertility (UI), clomiphene citrate (CC) has been shown to positively influence sperm parameters in hypogonadal men. Unfortunately, the optimal cut point for defining hypogonadism for this patient population has not been established. We hypothesized that hypogonadal men with UI having the lowest serum total testosterone (TT) ( 264 ng/dL group. We performed our study based on an IRB-approved retrospective chart review of 83 males with UI receiving more than 90 days of 50 mg daily CC. Serum TT and semen character...
Source: Systems Biology in Reproductive Medicine - October 12, 2020 Category: Reproduction Medicine Authors: Delu A, Kiltz RJ, Kuznetsov VA, Trussell TL Tags: Syst Biol Reprod Med Source Type: research

Clomiphene citrate improved testosterone and sperm concentration in hypogonadal males
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - October 12, 2020 Category: Sexual Medicine Authors: Ava Delu Robert J. Kiltz Vladimir A. Kuznetsov T. L. Trussell Source Type: research

Comparing endometrial receptivity array to histologic dating of the endometrium in women with a history of implantation failure
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - September 30, 2020 Category: Sexual Medicine Authors: Arianne M. Cohen Xiang Y. Ye Terence J. Colgan Ellen M. Greenblatt Crystal Chan Source Type: research

Comparing endometrial receptivity array to histologic dating of the endometrium in women with a history of implantation failure.
This study aimed to compare the two tests to assess their concordance and to examine the ability of the ERA to successfully predict implantation and pregnancy in a subsequent personalized embryo transfer. A retrospective review was done of 97 patients with a history of implantation failure who underwent an ERA, 35 of whom had histologic dating on the same sample. ERA and histology were classified as 'concordant' when samples were receptive by both tests or non-receptive by both tests. The ERA result was then used to personalize the embryo transfer day, and pregnancy rates from the first subsequent frozen transfer cycle wer...
Source: Systems Biology in Reproductive Medicine - September 29, 2020 Category: Reproduction Medicine Authors: Cohen AM, Ye XY, Colgan TJ, Greenblatt EM, Chan C Tags: Syst Biol Reprod Med Source Type: research

Betaine ameliorates impaired steroidogenesis and apoptosis in mice granulosa cells induced by high glucose concentration
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Source: Systems Biology in Reproductive Medicine - September 27, 2020 Category: Sexual Medicine Authors: Kosar Abbasi Samie Mohammad Reza Tabandeh Mahsa Afrough Source Type: research

Betaine ameliorates impaired steroidogenesis and apoptosis in mice granulosa cells induced by high glucose concentration.
Abstract Betaine is a bioactive peptide whose beneficial effects on diabetes complications have been considered, previously. The present study aimed to investigate the possible protective effects of betaine against hyperglycemia-induced steroidogenesis impairment and apoptosis in mice granulosa cells. Ovarian granulosa cells were isolated from C57/BL6 mice and cultured in steroidogenesis medium (SM) containing 30 ng/ml FSH and 0.5 µM testosterone. The cells were cultured in SM containing low (5 mM) or high (30 mM) glucose concentrations for 24 h in the presence or absence of betaine ...
Source: Systems Biology in Reproductive Medicine - September 26, 2020 Category: Reproduction Medicine Authors: Samie KA, Tabandeh MR, Afrough M Tags: Syst Biol Reprod Med Source Type: research

The role of ORC4 in enucleation of Murine Erythroleukemia (MEL) cells is similar to that in oocyte polar body extrusion
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - September 24, 2020 Category: Sexual Medicine Authors: Hieu Nguyen Anna Ung W. Steven Ward Source Type: research

The role of ORC4 in enucleation of Murine Erythroleukemia (MEL) cells is similar to that in oocyte polar body extrusion.
Abstract The Origin Replication Complex subunit 4 (ORC4) is one in six subunits of the Origin Replication Complexes (ORCs) which is essential for initiating licensing at DNA replication origins and recruiting adaptor molecules necessary for various cellular processes. Previously, we reported that ORC4 also plays a vital role in polar body extrusion (PBE) during oogenesis in which half the chromosomes are extruded from the oocyte. We hypothesized that ORC4 might play a broader role in chromatin elimination. We tested its role in enucleation during the development of erythrocytes. Murine erythroleukemia (MEL) cells ...
Source: Systems Biology in Reproductive Medicine - September 23, 2020 Category: Reproduction Medicine Authors: Nguyen H, Ung A, Ward WS Tags: Syst Biol Reprod Med Source Type: research

Chronic effects of maternal tobacco-smoke exposure and/or α-lipoic acid treatment on reproductive parameters in female rat offspring
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Source: Systems Biology in Reproductive Medicine - September 20, 2020 Category: Sexual Medicine Authors: Elif Erdem Guzel Nalan Kaya Ahmet Tektemur Nazife Ulker Ahmet Yardimci Ramazan Fazil Akkoc Sinan Canpolat Ibrahim Enver Ozan Source Type: research

Chronic effects of maternal tobacco-smoke exposure and/or α-lipoic acid treatment on reproductive parameters in female rat offspring.
Chronic effects of maternal tobacco-smoke exposure and/or α-lipoic acid treatment on reproductive parameters in female rat offspring. Syst Biol Reprod Med. 2020 Sep 20;:1-13 Authors: Erdem Guzel E, Kaya N, Tektemur A, Ulker N, Yardimci A, Akkoc RF, Canpolat S, Ozan IE Abstract Prenatal tobacco-smoke exposure negatively affects the reproductive functions of female offspring and oxidative stress plays a major role at this point. Alpha-lipoic acid (ALA), well known as a biological antioxidant, has been used as a nutritional supplement and as a therapeutic agent in the treatment of certain complicat...
Source: Systems Biology in Reproductive Medicine - September 19, 2020 Category: Reproduction Medicine Authors: Erdem Guzel E, Kaya N, Tektemur A, Ulker N, Yardimci A, Akkoc RF, Canpolat S, Ozan IE Tags: Syst Biol Reprod Med Source Type: research

SARS-CoV-2 and the reproductive system: assessment of risk and recommendations for infection control in reproductive departments
Volume 66, Issue 6, December 2020, Page 343-346 . (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - September 17, 2020 Category: Sexual Medicine Authors: Guanjian Li Weiran Li Bin Song Huan Wu Dongdong Tang Chao Wang Xiaojin He Yunxia Cao Source Type: research

SARS-CoV-2 and the reproductive system: assessment of risk and considerations for infection control in reproductive departments
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - September 16, 2020 Category: Sexual Medicine Authors: Guanjian Li Weiran Li Bin Song Huan Wu Dongdong Tang Chao Wang Xiaojin He Yunxia Cao Source Type: research

SARS-CoV-2 and the reproductive system: assessment of risk and considerations for infection control in reproductive departments.
Abstract The World Health Organization has declared the outbreak of the coronavirus disease COVID-19, caused by SARS-CoV-2, a pandemic. This novel infectious disease has rapidly become a global health threat. Currently, there are limited data on the extent of reproductive system damage caused by COVID-19. We reviewed the potential risks for complications in the reproductive system caused by COVID-19 infection. In addition, based on the latest American Society for Reproductive Medicine (ASRM), and European Society of Human Reproduction and Embryology (ESHRE), recommendations regarding clinical and patient managemen...
Source: Systems Biology in Reproductive Medicine - September 15, 2020 Category: Reproduction Medicine Authors: Li G, Li W, Song B, Wu H, Tang D, Wang C, He X, Cao Y Tags: Syst Biol Reprod Med Source Type: research

The anti-Mullerian hormone as a predictor of early pregnancy loss in subfertile women.
According to this study, AMH level and age are both powerful predictors of early pregnancy loss. While chronological age is already well known as a factor related to early pregnancy loss, AMH was also considered when individualizing risk prediction for early pregnancy loss. PMID: 32914650 [PubMed - as supplied by publisher] (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - September 10, 2020 Category: Reproduction Medicine Authors: Hong S, Chang E, Han EJ, Min SG, Kim S, Kang MK, Cha DH, Shim SH, Park HJ Tags: Syst Biol Reprod Med Source Type: research

The anti-Mullerian hormone as a predictor of early pregnancy loss in subfertile women
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - September 10, 2020 Category: Sexual Medicine Authors: Soyeon Hong Eunmi Chang E. Jung Han Seung Gi Min Sohyun Kim Min Kyu Kang Dong Hyun Cha So Hyun Shim Hee Jin Park Source Type: research

Sperm content of TXNDC8 reflects sperm chromatin structure, pregnancy establishment, and incidence of multiple births after ART.
Abstract Male germline-specific thioredoxin domain containing 8 (TXNDC8; alias SPTRX3) accumulates indefective human spermatozoa. We assessed the efficiency of two-step semen purification inremoving spermatozoa carrying TXNDC8, and examined the relationship of TXNDC8 with theoutcomes of assisted reproductive therapy (ART), conventional semen parameters, and sperm DNA integrity in sperm chromatin structure assay (SCSA). Semen samples (n = 255) from 91 ART couples were screened in two independent trials, both including a two-step, gradient-and-swim-up separation procedure yielding A-samples (raw semen), B-samples (g...
Source: Systems Biology in Reproductive Medicine - August 26, 2020 Category: Reproduction Medicine Authors: Ahlering P, Sutovsky M, Gliedt D, Branson K, Miranda Vizuete A, Sutovsky P Tags: Syst Biol Reprod Med Source Type: research

Sperm content of TXNDC8 reflects sperm chromatin structure, pregnancy establishment, and incidence of multiple births after ART
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - August 26, 2020 Category: Sexual Medicine Authors: Peter Ahlering Miriam Sutovsky Douglas Gliedt Kellie Branson Antonio Miranda Vizuete Peter Sutovsky Source Type: research