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Pharmacological investigation of vitamin E with combined oral contraceptives on INHBA gene against PCOS that intricate through melatonin PKC pathway
. (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - November 14, 2023 Category: Sexual Medicine Authors: Rukaiah Fatma BegumSumithra MohanDepartment of Pharmacology, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, India Source Type: research

Correspondence: Interpreting live birth rates following preimplantation genetic testing for aneuploidy: per embryo transferred or initiated cycle
Syst Biol Reprod Med. 2023 Oct;69(5):394-395. doi: 10.1080/19396368.2023.2261590. Epub 2023 Nov 1.NO ABSTRACTPMID:37812746 | DOI:10.1080/19396368.2023.2261590 (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - October 9, 2023 Category: Reproduction Medicine Authors: Pedro Augusto Ara újo Monteleone Tatiana Carvalho de Souza Bonetti Source Type: research

MEHP activates JNK to inhibit the migration of human foreskin fibroblasts
This study aimed to investigate the impact of mono(2-ethylhexyl) phthalate (MEHP) on the proliferation, apoptosis, and migration of human foreskin fibroblast cells (HFF-1) and the role of the JNK signaling pathway in cell migration. HFF-1 cells were randomly assigned to the control group with 0 MEHP exposure (M0) or the experimental groups with 25, 50, 100, 200, and 400 μmol/L MEHP exposure (M25, M50, M100, M200, and M400, respectively). After 24 and 48 h of MEHP exposure, the proliferation of HFF-1 cells in any group had no significant change. However, compared with the M0 group, the M200 and M400 groups presented substa...
Source: Systems Biology in Reproductive Medicine - October 9, 2023 Category: Reproduction Medicine Authors: Hu Zhang Xuan Yi Wei Hu Guoqiang Zhu Xiaowen Fu Wei Jin Long Qin Mingyong Li Source Type: research

Polyamines modulate mouse sperm motility
Syst Biol Reprod Med. 2023 Oct 9:1-15. doi: 10.1080/19396368.2023.2262714. Online ahead of print.ABSTRACTPolyamines are polycationic molecules which contains two or more amino groups (-NH3+) highly charged at physiological pH, and among them we found spermine, spermidine, putrescine, and cadaverine. They interact with proteins, nucleic acids, modulate Ca2+, K+, and Na+ channels, and protect sperm from oxidative stress. In this work, we evaluate the effect of spermine, spermidine, and putrescine on the total, progressive and kinematic parameters of motility, capacitation, acrosome reaction, also in presence and absence of t...
Source: Systems Biology in Reproductive Medicine - October 9, 2023 Category: Reproduction Medicine Authors: Lorena Rodr íguez-Páez Charmina Aguirre-Alvarado Germ án Chamorro-Cevallos Alc ántara-Farfán Veronica Calder ón-Espinosa Sandra Irel Castillo-P érez Hugo Carlos Armando Garc ía-Pérez Guadalupe Elizabeth Jim énez-Gutiérrez Joaqu ín Cordero-Mart Source Type: research

Correspondence: Interpreting live birth rates following preimplantation genetic testing for aneuploidy: per embryo transferred or initiated cycle
Syst Biol Reprod Med. 2023 Oct;69(5):394-395. doi: 10.1080/19396368.2023.2261590. Epub 2023 Nov 1.NO ABSTRACTPMID:37812746 | DOI:10.1080/19396368.2023.2261590 (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - October 9, 2023 Category: Reproduction Medicine Authors: Pedro Augusto Ara újo Monteleone Tatiana Carvalho de Souza Bonetti Source Type: research

MEHP activates JNK to inhibit the migration of human foreskin fibroblasts
This study aimed to investigate the impact of mono(2-ethylhexyl) phthalate (MEHP) on the proliferation, apoptosis, and migration of human foreskin fibroblast cells (HFF-1) and the role of the JNK signaling pathway in cell migration. HFF-1 cells were randomly assigned to the control group with 0 MEHP exposure (M0) or the experimental groups with 25, 50, 100, 200, and 400 μmol/L MEHP exposure (M25, M50, M100, M200, and M400, respectively). After 24 and 48 h of MEHP exposure, the proliferation of HFF-1 cells in any group had no significant change. However, compared with the M0 group, the M200 and M400 groups presented substa...
Source: Systems Biology in Reproductive Medicine - October 9, 2023 Category: Reproduction Medicine Authors: Hu Zhang Xuan Yi Wei Hu Guoqiang Zhu Xiaowen Fu Wei Jin Long Qin Mingyong Li Source Type: research

Polyamines modulate mouse sperm motility
Syst Biol Reprod Med. 2023 Oct 9:1-15. doi: 10.1080/19396368.2023.2262714. Online ahead of print.ABSTRACTPolyamines are polycationic molecules which contains two or more amino groups (-NH3+) highly charged at physiological pH, and among them we found spermine, spermidine, putrescine, and cadaverine. They interact with proteins, nucleic acids, modulate Ca2+, K+, and Na+ channels, and protect sperm from oxidative stress. In this work, we evaluate the effect of spermine, spermidine, and putrescine on the total, progressive and kinematic parameters of motility, capacitation, acrosome reaction, also in presence and absence of t...
Source: Systems Biology in Reproductive Medicine - October 9, 2023 Category: Reproduction Medicine Authors: Lorena Rodr íguez-Páez Charmina Aguirre-Alvarado Germ án Chamorro-Cevallos Alc ántara-Farfán Veronica Calder ón-Espinosa Sandra Irel Castillo-P érez Hugo Carlos Armando Garc ía-Pérez Guadalupe Elizabeth Jim énez-Gutiérrez Joaqu ín Cordero-Mart Source Type: research

Correspondence: Interpreting live birth rates following preimplantation genetic testing for aneuploidy: per embryo transferred or initiated cycle
Syst Biol Reprod Med. 2023 Oct;69(5):394-395. doi: 10.1080/19396368.2023.2261590. Epub 2023 Nov 1.NO ABSTRACTPMID:37812746 | DOI:10.1080/19396368.2023.2261590 (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - October 9, 2023 Category: Reproduction Medicine Authors: Pedro Augusto Ara újo Monteleone Tatiana Carvalho de Souza Bonetti Source Type: research

MEHP activates JNK to inhibit the migration of human foreskin fibroblasts
This study aimed to investigate the impact of mono(2-ethylhexyl) phthalate (MEHP) on the proliferation, apoptosis, and migration of human foreskin fibroblast cells (HFF-1) and the role of the JNK signaling pathway in cell migration. HFF-1 cells were randomly assigned to the control group with 0 MEHP exposure (M0) or the experimental groups with 25, 50, 100, 200, and 400 μmol/L MEHP exposure (M25, M50, M100, M200, and M400, respectively). After 24 and 48 h of MEHP exposure, the proliferation of HFF-1 cells in any group had no significant change. However, compared with the M0 group, the M200 and M400 groups presented substa...
Source: Systems Biology in Reproductive Medicine - October 9, 2023 Category: Reproduction Medicine Authors: Hu Zhang Xuan Yi Wei Hu Guoqiang Zhu Xiaowen Fu Wei Jin Long Qin Mingyong Li Source Type: research

Polyamines modulate mouse sperm motility
Syst Biol Reprod Med. 2023 Oct 9:1-15. doi: 10.1080/19396368.2023.2262714. Online ahead of print.ABSTRACTPolyamines are polycationic molecules which contains two or more amino groups (-NH3+) highly charged at physiological pH, and among them we found spermine, spermidine, putrescine, and cadaverine. They interact with proteins, nucleic acids, modulate Ca2+, K+, and Na+ channels, and protect sperm from oxidative stress. In this work, we evaluate the effect of spermine, spermidine, and putrescine on the total, progressive and kinematic parameters of motility, capacitation, acrosome reaction, also in presence and absence of t...
Source: Systems Biology in Reproductive Medicine - October 9, 2023 Category: Reproduction Medicine Authors: Lorena Rodr íguez-Páez Charmina Aguirre-Alvarado Germ án Chamorro-Cevallos Alc ántara-Farfán Veronica Calder ón-Espinosa Sandra Irel Castillo-P érez Hugo Carlos Armando Garc ía-Pérez Guadalupe Elizabeth Jim énez-Gutiérrez Joaqu ín Cordero-Mart Source Type: research

Correspondence: Interpreting live birth rates following preimplantation genetic testing for aneuploidy: per embryo transferred or initiated cycle
Syst Biol Reprod Med. 2023 Oct;69(5):394-395. doi: 10.1080/19396368.2023.2261590. Epub 2023 Nov 1.NO ABSTRACTPMID:37812746 | DOI:10.1080/19396368.2023.2261590 (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - October 9, 2023 Category: Reproduction Medicine Authors: Pedro Augusto Ara újo Monteleone Tatiana Carvalho de Souza Bonetti Source Type: research

MEHP activates JNK to inhibit the migration of human foreskin fibroblasts
This study aimed to investigate the impact of mono(2-ethylhexyl) phthalate (MEHP) on the proliferation, apoptosis, and migration of human foreskin fibroblast cells (HFF-1) and the role of the JNK signaling pathway in cell migration. HFF-1 cells were randomly assigned to the control group with 0 MEHP exposure (M0) or the experimental groups with 25, 50, 100, 200, and 400 μmol/L MEHP exposure (M25, M50, M100, M200, and M400, respectively). After 24 and 48 h of MEHP exposure, the proliferation of HFF-1 cells in any group had no significant change. However, compared with the M0 group, the M200 and M400 groups presented substa...
Source: Systems Biology in Reproductive Medicine - October 9, 2023 Category: Reproduction Medicine Authors: Hu Zhang Xuan Yi Wei Hu Guoqiang Zhu Xiaowen Fu Wei Jin Long Qin Mingyong Li Source Type: research

Polyamines modulate mouse sperm motility
Syst Biol Reprod Med. 2023 Oct 9:1-15. doi: 10.1080/19396368.2023.2262714. Online ahead of print.ABSTRACTPolyamines are polycationic molecules which contains two or more amino groups (-NH3+) highly charged at physiological pH, and among them we found spermine, spermidine, putrescine, and cadaverine. They interact with proteins, nucleic acids, modulate Ca2+, K+, and Na+ channels, and protect sperm from oxidative stress. In this work, we evaluate the effect of spermine, spermidine, and putrescine on the total, progressive and kinematic parameters of motility, capacitation, acrosome reaction, also in presence and absence of t...
Source: Systems Biology in Reproductive Medicine - October 9, 2023 Category: Reproduction Medicine Authors: Lorena Rodr íguez-Páez Charmina Aguirre-Alvarado Germ án Chamorro-Cevallos Alc ántara-Farfán Veronica Calder ón-Espinosa Sandra Irel Castillo-P érez Hugo Carlos Armando Garc ía-Pérez Guadalupe Elizabeth Jim énez-Gutiérrez Joaqu ín Cordero-Mart Source Type: research

Correspondence: Interpreting live birth rates following preimplantation genetic testing for aneuploidy: per embryo transferred or initiated cycle
Syst Biol Reprod Med. 2023 Oct;69(5):394-395. doi: 10.1080/19396368.2023.2261590. Epub 2023 Nov 1.NO ABSTRACTPMID:37812746 | DOI:10.1080/19396368.2023.2261590 (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - October 9, 2023 Category: Reproduction Medicine Authors: Pedro Augusto Ara újo Monteleone Tatiana Carvalho de Souza Bonetti Source Type: research

MEHP activates JNK to inhibit the migration of human foreskin fibroblasts
This study aimed to investigate the impact of mono(2-ethylhexyl) phthalate (MEHP) on the proliferation, apoptosis, and migration of human foreskin fibroblast cells (HFF-1) and the role of the JNK signaling pathway in cell migration. HFF-1 cells were randomly assigned to the control group with 0 MEHP exposure (M0) or the experimental groups with 25, 50, 100, 200, and 400 μmol/L MEHP exposure (M25, M50, M100, M200, and M400, respectively). After 24 and 48 h of MEHP exposure, the proliferation of HFF-1 cells in any group had no significant change. However, compared with the M0 group, the M200 and M400 groups presented substa...
Source: Systems Biology in Reproductive Medicine - October 9, 2023 Category: Reproduction Medicine Authors: Hu Zhang Xuan Yi Wei Hu Guoqiang Zhu Xiaowen Fu Wei Jin Long Qin Mingyong Li Source Type: research