Para This, Fibromin That
CDC73 alterations are associated with three main parathyroid lesions according to the World Health Organization (WHO) classification of tumors of the endocrine system. These include hyperparathyroidism-jaw tumor (HPT-JT) syndrome-associated adenomas, atypical parathyroid tumors (APTs), and parathyroid carcinomas (PCs). The loss of nuclear parafibromin expression, which serves as a surrogate marker for the underlying CDC73 alteration, encompasses these tumors under the term parafibromin-deficient parathyroid tumors. They have distinct morphologic features of more abundant eosinophilic cytoplasm with perinuclear clearing sur...
Source: Surgical Pathology Clinics - December 9, 2022 Category: Pathology Authors: Emad Ababneh, Vania Nos é Source Type: research
All Together Now
Neuroendocrine neoplasms (NENs) span virtually all organ systems and exhibit a broad spectrum of behavior, from indolent to highly aggressive. Historically, nomenclature and grading practices have varied widely across, and even within, organ systems. However, certain core features are recapitulated across anatomic sites, including characteristic morphology and the crucial role of proliferative activity in prognostication. A recent emphasis on unifying themes has driven an increasingly standardized approach to NEN classification, as delineated in the World Health Organization ’s Classification of Tumours series. Here, we ...
Source: Surgical Pathology Clinics - December 9, 2022 Category: Pathology Authors: Pari Jafari, Aliya N. Husain, Namrata Setia Source Type: research
Preoperative, Intraoperative, and Postoperative Parathyroid Pathology
Parathyroid disease typically presents with parathyroid hyperfunction as result of neoplasia or a consequence of non-neoplastic systemic disease. Given the parathyroid gland is a hormonally active organ with broad physiologic implications and serologically accessible markers for monitoring, the diagnosis of parathyroid disease is predominantly a clinical pathologic correlation. We provide the current pathological correlates of parathyroid disease and discuss preoperative, intraoperative, and postoperative pathology consultative practice for optimal patient care. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - December 9, 2022 Category: Pathology Authors: Hailey L. Gosnell, Peter M. Sadow Source Type: research
Scarless Surgery
Transoral endocrine surgery (TES) is a scarless approach to thyroidectomy and parathyroidectomy for well-selected patients. Criteria for the TES approach to thyroidectomy include thyroid diameter less than or equal to 10 cm, benign nodule less than or equal to 6 cm, or confirmed or suspected malignant nodule less than or equal to 2 cm. Although fragmentation of surgical specimens has been reported in TES, additional studies are needed to evaluate the implications of TES on pathologic examination. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - December 9, 2022 Category: Pathology Authors: Jordan M. Broekhuis, Benjamin C. James, Raymon H. Grogan Source Type: research
Endocrine Pathology: Practical Suggestions, Emerging Diagnostics, and New Frontiers
This issue on Endocrine Pathology in Surgical Pathology Clinics tackles common and challenging problems in thyroid and parathyroid pathology, emerging clinically relevant molecular findings in endocrine neoplasms and syndromes, and new horizons in diagnosis and treatment of endocrine tumors. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - December 9, 2022 Category: Pathology Authors: Nicole A. Cipriani Tags: Preface Source Type: research
A Triumvirate:
Risk stratification is essential in the preoperative evaluation and management of thyroid nodules, most of which are benign. Advances in DNA and RNA sequencing have shed light on the molecular drivers of thyroid cancer. Molecular testing of cytologically indeterminate nodules has helped refine risk stratification, triage patients for surgery, and determine the extent of surgery. Molecular platforms with high negative predictive values can help identify nodules that may be spared surgery and can be managed conservatively. Here we discuss the importance of integrating cytomorphologic, molecular, and histologic features to he...
Source: Surgical Pathology Clinics - December 8, 2022 Category: Pathology Authors: Jaylou M. Velez Torres, Youley Tjendra, Darcy A. Kerr Source Type: research
Testicular Cancer
Testicular tumors are the most common solid tumors in young men, the vast majority of which are of germ cell origin. The staging of human cancers is paramount to correct patient management. Staging systems have passed through several developments leading to the release of the most recent 8th edition of the American Joint Committee for Cancer (AJCC) staging manual, which is based on the current understanding of tumor behavior and spread. In this review, the authors summarize the current AJCC staging of the germ cell tumors, highlight essential concepts, and provide insight into the most important parameters of testicular tu...
Source: Surgical Pathology Clinics - November 5, 2022 Category: Pathology Authors: Khaleel I. Al-Obaidy, Martin J. Magers, Muhammad T. Idrees Source Type: research
Applications of Digital and Computational Pathology and Artificial Intelligence in Genitourinary Pathology Diagnostics
As machine learning (ML) solutions for genitourinary pathology image analysis are fostered by a progressively digitized laboratory landscape, these integrable modalities usher in a revolution in histopathological diagnosis. As technology advances, limitations stymying clinical artificial intelligence (AI) will not be extinguished without thorough validation and interrogation of ML tools by pathologists and regulatory bodies alike. ML solutions deployed in clinical settings for applications in prostate pathology yield promising results. Recent breakthroughs in clinical artificial intelligence for genitourinary pathology dem...
Source: Surgical Pathology Clinics - November 5, 2022 Category: Pathology Authors: Ankush Uresh Patel, Sambit K. Mohanty, Anil V. Parwani Source Type: research
Dedication
This issue is dedicated to our friend and colleague, Dr Ondrej Hes, who was fondly known by those close to him as Ondra. Sadly, he passed away suddenly on July 2, 2022. Ondra was a coauthor of the article entitled, “Kidney Tumors: New and Emerging Kidney Tumor Entities,” in this issue and was a world-renowned pathologist and an eminent figure in the international urologic pathology community. He was a great scholar and pathologist, credited for the recognition of many renal tumor entities and subtypes that have reshaped the understanding and diagnosis of contemporary renal tumor pathology. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - November 5, 2022 Category: Pathology Authors: Kiril Trpkov, Ming Zhou Source Type: research
Genitourinary Pathology
SURGICAL PATHOLOGY CLINICS (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - November 5, 2022 Category: Pathology Authors: Ming Zhou Source Type: research
Copyright
ELSEVIER (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - November 5, 2022 Category: Pathology Source Type: research
Contributors
JASON L. HORNICK, MD, PhD (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - November 5, 2022 Category: Pathology Source Type: research
Contents
Ming Zhou and Kiril Trpkov (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - November 5, 2022 Category: Pathology Source Type: research
Forthcoming Issues
Endocrine Pathology (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - November 5, 2022 Category: Pathology Source Type: research
Cribriform Lesions of the Prostate Gland
"Cribriform lesions of the prostate represent an important and often diagnostically challenging spectrum of prostate pathology. These lesions range from normal anatomical variation, benign proliferative lesions, premalignant, suspicious to frankly malignant and biologically aggressive entities. The concept of cribriform prostate adenocarcinoma (CrP4) and intraductal carcinoma of the prostate (IDC-P), in particular, has evolved significantly in recent years with a growing body of evidence suggesting that the presence of these morphologies is important for clinical decision-making in prostate cancer management. Therefore, ac...
Source: Surgical Pathology Clinics - October 12, 2022 Category: Pathology Authors: Qi Cai, Rajal B. Shah Source Type: research
