Inflammatory Rhabdomyoblastic Tumor
Inflammatory rhabdomyoblastic tumor is a recently introduced name for neoplasms currently included in the World Health Organization classification of soft tissue tumors under the rubric inflammatory leiomyosarcoma. Inflammatory rhabdomyoblastic tumor is an excellent example of how surgical pathologists working in conjunction with tumor biologists can greatly improve tumor classification to the benefit of patients. Over the last 28 years, understanding of this entity has undergone a fascinating evolution. This review serves as a summary of the latest findings in inflammatory rhabdomyoblastic tumor research and a diagnosti...
Source: Surgical Pathology Clinics - August 5, 2023 Category: Pathology Authors: Michael Michal Source Type: research
Sclerosing Epithelioid Fibrosarcoma
Sclerosing epithelioid fibrosarcoma (SEF) is a distinctive sarcoma that may arise in nearly any soft tissue site or bone. While there has been past controversy as to whether it is related to low-grade fibromyxoid sarcoma (LGFMS), it has been shown to behave far more aggressively than LGFMS. SEF has a propensity to metastasize to the lungs and bone and arise within the abdominal cavity. Histologically, it is characterized by uniform nuclei embedded in a densely collagenous stroma simulating osteoid. By immunohistochemistry, it is often strongly positive for MUC4. The majority (75%) have EWSR1 gene rearrangement, most common...
Source: Surgical Pathology Clinics - August 5, 2023 Category: Pathology Authors: Laura M. Warmke, Wendong Yu, Jeanne M. Meis Source Type: research
Liver Pathology: Diagnostic Challenges, Practical Considerations and Emerging Concepts
SURGICAL PATHOLOGY CLINICS (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - August 2, 2023 Category: Pathology Authors: Lei Zhao Source Type: research
Copyright
ELSEVIER (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - August 2, 2023 Category: Pathology Source Type: research
Contributors
JASON L. HORNICK, MD, PhD (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - August 2, 2023 Category: Pathology Source Type: research
Contents
Lei Zhao (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - August 2, 2023 Category: Pathology Source Type: research
Forthcoming Issues
Gastrointestinal Pathology (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - August 2, 2023 Category: Pathology Source Type: research
Superficial CD34-Positive Fibroblastic Tumor
Superficial CD34-positive fibroblastic tumor is a mesenchymal neoplasm of “intermediate malignancy” recently included in the fifth edition of the World Health Organization classification of soft tissue and bone tumors. In this review, we summarize the current knowledge on this rare entity with a special focus on its clinicopathological features, morphologic spectrum, and differential diagnosis. We also provide data regarding recent discoveries on its molecular profile and discuss its prognosis and management. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - August 1, 2023 Category: Pathology Authors: Raul Perret, Isabelle Hostein Source Type: research
Soft Tissue Perivascular Epithelioid Cell Tumors
Perivascular epithelioid cell tumors (PEComas) are a heterogenous group of mesenchymal neoplasms with a mixed myomelanocytic immunophenotype. PEComa-family tumors include angiomyolipoma, lymphangioleiomyomatosis, and a large category of rare neoplasms throughout the body that are now classified under the umbrella term “PEComa.” This review focuses on recent advances in the clinicopathological and molecular features of PEComas, with an emphasis on PEComas that originate in soft tissue. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - August 1, 2023 Category: Pathology Authors: Phoebe M. Hammer, Serena Y. Tan Source Type: research
CIC-Rearranged Sarcoma
CIC-rearranged sarcoma is a rare type of small round cell sarcoma. The tumors often affect the deep soft tissues of patients in a wide age range. They are highly aggressive, respond poorly to chemotherapy, and have a worse outcome than Ewing sarcoma. CIC-rearranged sarcoma has characteristic and recognizable histology, including lobulated growth, focal myxoid changes, round to epithelioid cells, and minimal variation of nuclear size and shape. Nuclear ETV4 and WT1 expression are useful immunohistochemical findings. CIC fusion can be demonstrated using various methods; however, even next-generation sequencing suffers from i...
Source: Surgical Pathology Clinics - August 1, 2023 Category: Pathology Authors: Naohiro Makise, Akihiko Yoshida Source Type: research
Myxoid Pleomorphic Liposarcoma
Myxoid pleomorphic liposarcoma (MPLPS) shows a strong predilection for the mediastinum and can affect a wide age range. Clinically, MPLPS exhibits aggressive behavior and demonstrates a worse overall and progression-free survival than myxoid/round cell liposarcoma (MRLPS) and pleomorphic liposarcoma (PLPS). Histologically, MPLPS is characterized by hybrid morphologic features of MRLPS and PLPS, including myxoid stroma, chicken wire-like vasculature, univacuolated and multivacuolated lipoblasts, and high-grade pleomorphic sarcomatous components. In terms of molecular features, MPLPS is distinct from other lipomatous tumors ...
Source: Surgical Pathology Clinics - August 1, 2023 Category: Pathology Authors: Josephine K. Dermawan Source Type: research
Calcified Chondroid Mesenchymal Neoplasms
Calcified chondroid mesenchymal neoplasms (CCMN) represent a morphologic spectrum of related tumors. Historically, chondroid matrix or chondroblastoma-like features have been described in soft tissue chondroma, tenosynovial giant cell tumors (especially of the temporomandibular joint (TMJ) region), and in a subset of tophaceous pseudogout. Recently, these tumors have been found to share FN1-receptor tyrosine kinase (RTK) fusions. This review discusses the clinical, morphologic, immunohistochemical, and molecular genetic features of CCMN. The distinction from morphologic mimics is also discussed. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - August 1, 2023 Category: Pathology Authors: Erica Y. Kao, Eleanor Y. Chen Source Type: research
Frontiers in Soft Tissue Tumor Pathology
Soft tissue pathology encompasses an exceptionally diverse array of histologically, clinically, and molecularly distinctive neoplasms. With careful morphologic studies now increasingly buttressed by high-throughput approaches for molecular analysis, the list of soft tissue tumor entities seemingly grows by the day, even as our understanding of existing entities continues to evolve. This rapid growth of knowledge, daunting as it may seem, offers the opportunity for pathologists to have an increasingly impactful role in driving appropriate treatment of even the rarest of tumors. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - July 28, 2023 Category: Pathology Authors: Gregory W. Charville Tags: Preface Source Type: research
Pathologic Evaluation of Therapeutic Biomarkers in Colorectal Adenocarcinoma
Molecular testing is an essential component of the pathologic evaluation of colorectal carcinoma providing diagnostic, prognostic, and predictive therapeutic information. Mismatch repair status evaluation is required for all tumors. Advanced and metastatic tumors also require determination of tumor mutational burden, KRAS, NRAS, and BRAF mutation status, ERBB2 amplification status, and NTRK and RET gene rearrangement status to guide therapy. Multiple assays, including immunohistochemistry, microsatellite instability testing, MLH1 promoter methylation, and next-generation sequencing, are typically needed. Pathologists must ...
Source: Surgical Pathology Clinics - July 23, 2023 Category: Pathology Authors: Esther Baranov, Jonathan A. Nowak Source Type: research
Artificial Intelligence-Enabled Gastric Cancer Interpretations
This article provides an overview of all of these applications of AI pertaining to gastric cancer. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - July 18, 2023 Category: Pathology Authors: Mustafa Yousif, Liron Pantanowitz Source Type: research
