Dysplastic Nevi
Dysplastic nevi are distinctive melanocytic lesions in the larger group of atypical nevi. They often are multiple and sporadic with genetic features intermediate between common acquired nevi and melanoma. Dysplastic nevi may be multiple, familial, and seen in patients with familial melanoma syndrome. Although their behavior is benign, they rarely represent a precursor to melanoma. If clinically suspicious, dysplastic nevi should be removed for adequate histopathologic examination and to exclude possibility of melanoma. Partial sampling should be avoided because reliable separation from melanoma requires visualization of th...
Source: Surgical Pathology Clinics - April 28, 2021 Category: Pathology Authors: Katharina Wiedemeyer, Wolfgang Hartschuh, Thomas Brenn Source Type: research
Dermatopathology in the Molecular Age
The field of dermatopathology remains one of the most dynamic subspecialties in all of pathology. Accurate diagnoses typically require a systematic integration of histopathologic features together with clinical, immunohistochemical, and molecular findings. As the arsenal of molecular studies applied to skin lesions expands, the complexity of this integration increases. In this issue, we assembled leaders across the spectrum of dermatopathology to provide comprehensive reviews and updates on various topics in the field. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - April 28, 2021 Category: Pathology Authors: Michael T. Tetzlaff Tags: Preface Source Type: research
Sclerosing Polycystic Adenoma
Sclerosing polycystic adenoma (SPA) is the more appropriate name for sclerosing polycystic adenosis. SPA is an uncommon salivary gland lesion with a constellation of unusual histologic findings that were originally interpreted as analogous to breast fibrocystic changes. The histologic findings in SPA include fibrosis, cystic alterations, apocrine metaplasia, and proliferations of ducts, acini, and myoepithelial cells in variable proportions. Because of its unusual mixed histology, SPA may be confused with a variety of lesions, ranging from reactive conditions to benign or even malignant neoplasms. The features of SPA are r...
Source: Surgical Pathology Clinics - January 30, 2021 Category: Pathology Authors: Justin A. Bishop, Lester D.R. Thompson Source Type: research
Lymphoepithelial Carcinoma of Salivary Glands
This article summarizes the findings of 438 cases in a review of the literature. Concurrent lymphoepithelial lesions may suggest a primary tumor. The tumor shows a nonkeratinizing carcinoma intimately associated with a rich lymphohistiocytic infiltrate, destroying adjacent salivary gland tissue. Irrespective of race or ethnicity, the tumors usually express Epstein-Barr virus, with Epstein-Barr virus encoded small RNA (EBER) and/or latent membrane protein-1 (LMP-1), although a subset does not. There is an overall good prognosis of about 80% at 5 years. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - January 30, 2021 Category: Pathology Authors: Lester D.R. Thompson, Rumeal D. Whaley Source Type: research
Emerging Entities in Salivary Pathology
In recent years, increased molecular testing and improved immunohistochemical panels have facilitated more specific classification of salivary gland carcinomas, leading to recognition of several novel tumor types and unique histologic variants. Sclerosing microcystic adenocarcinoma, microsecretory adenocarcinoma, and secretory myoepithelial carcinoma are three such recently described entities that demonstrate low-grade cytology, production of prominent secretory material, and variable amounts of sclerotic stroma. This review provides a practical overview of these important and overlapping emerging entities in salivary glan...
Source: Surgical Pathology Clinics - January 30, 2021 Category: Pathology Authors: Lisa M. Rooper Source Type: research
Updates on “Under the Radar” Salivary Gland Tumors
There have been a number of exciting advances in salivary gland tumor pathology in the past 10 years. In particular, molecular findings, which have a drastic impact on diagnosis, classification, and even therapy, are advancing at a rapid pace. While considerable attention has been given, appropriately, to relatively common tumors like pleomorphic adenoma, secretory carcinoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma, this issue of Surgical Pathology Clinics focuses on the recent discoveries involving salivary gland tumors that are rarer, and therefore, may be less well known. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - January 30, 2021 Category: Pathology Authors: Justin A. Bishop Tags: Preface Source Type: research
Copyright
ELSEVIER (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - January 30, 2021 Category: Pathology Source Type: research
Contributors
JASON L. HORNICK, MD, PhD (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - January 30, 2021 Category: Pathology Source Type: research
Contents
Justin A. Bishop (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - January 30, 2021 Category: Pathology Source Type: research
Forthcoming Issues
Dermatopathology (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - January 30, 2021 Category: Pathology Source Type: research
Intraductal Carcinomas of the Salivary Gland
Intraductal carcinoma of the salivary gland is a rare tumor characterized by intracystic proliferations of papillary, cribriform, and solid architecture of small uniform epithelial cells, reminiscent of ductal carcinoma in situ of the breast. Recent literature has identified 4 distinctive subtypes: the intercalated duct type, apocrine type, mixed/hybrid type, and oncocytic type, all with corresponding immunohistochemical and molecular findings. Although these tumors are typically in situ, as evidenced by a retained myoepithelial layer, they can demonstrate minimal invasion or, rarely, widespread invasive growth. Their over...
Source: Surgical Pathology Clinics - January 5, 2021 Category: Pathology Authors: Emilija Todorovic, Ilan Weinreb Source Type: research
Basal Cell Adenoma and Basal Cell Adenocarcinoma
Basal cell adenoma (BCA) and basal cell adenocarcinoma (BCAC) are uncommon biphasic salivary gland tumors having morphologic similarities to other biphasic salivary gland neoplasms having differentiation toward the intercalated ducts of the salivary gland. Both tumors show mixtures of trabecular, tubular, solid, and membranous solid patterns. BCAC is separated from BCA primarily by the presence of invasion in the former. The diagnosis of BCA and BCAC is best carried out with hematoxylin and eosin –stained sections and careful attention to detail of tumors in the differential diagnosis, including adenoid cystic carcinoma,...
Source: Surgical Pathology Clinics - January 5, 2021 Category: Pathology Authors: Robert A. Robinson Source Type: research
Sialadenoma Papilliferum
Sialadenoma papilliferum (SP) is a rare, benign salivary gland neoplasm sharing similar histopathologic features and harboring the same genetic alterations, BRAF V600E or HRAS mutations, with syringocystadenoma papilliferum. SP most commonly occurs in the hard palate and in older adults. Clinically, SP is most likely to be diagnosed as a squamous papilloma. Microscopically, SP shows an exophytic papillary epithelial proliferation and a contiguously endophytic ductal proliferation. Two distinct subtypes are identified: classic SP and oncocytic SP. Conservative surgical treatment seems to be adequate with a low recurrence. S...
Source: Surgical Pathology Clinics - January 5, 2021 Category: Pathology Authors: Min-Shu Hsieh, Justin A. Bishop, Julia Yu Fong Chang Source Type: research
Myoepithelial Carcinoma
Myoepithelial carcinoma (MECA) may overlap histologically with other salivary gland neoplasms, especially pleomorphic adenoma. MECA is characterized by cellular, uniform growth of myoepithelial cells and multinodular expansile invasive pattern with zonal cellular distribution. It may arise de novo or in association with pleomorphic adenoma (myoepithelial carcinoma ex pleomorphic adenoma). By immunohistochemistry, MECA is positive for cytokeratins and at least one of the myoepithelial markers, including S100. PLAG1 fusion is the most common genetic alteration. Carcinoma ex pleomorphic adenoma and necrosis correlate with wor...
Source: Surgical Pathology Clinics - January 5, 2021 Category: Pathology Authors: Bin Xu, Nora Katabi Source Type: research
