Sarcoma of the Lung and Mediastinum
Primary sarcoma of the lung and mediastinum is rare. The diagnosis requires careful exclusion of sarcomatoid carcinoma, sarcomatoid mesothelioma, and metastases from extra-thoracic sites. This review summarizes the key morphologic, immunohistochemical, and molecular characteristics of sarcomas that are encountered in the lung and mediastinum. The tumor types discussed are synovial sarcoma, well-differentiated/dedifferentiated liposarcoma, myxoid pleomorphic liposarcoma, intimal sarcoma of the pulmonary artery, inflammatory myofibroblastic tumor, epithelioid hemangioendothelioma, primary pulmonary myxoid sarcoma, malignant ...
Source: Surgical Pathology Clinics - December 15, 2023 Category: Pathology Authors: Ken-ichi Yoshida, Akihiko Yoshida Source Type: research
Update on Silicosis
This article describes some of the well-established and new exposures, including denim sandblasting, artificial stone cutting, and some forms of “coal worker’s pneumoconiosis.” The authors re view the imaging and pathology of acute silicosis (silicoproteinosis), simple silicosis, and progressive massive fibrosis and summarize known and putative associations of silica exposure, including tuberculosis, lung cancer, connective tissue disease (especially systemic sclerosis), and vasculitis. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - December 11, 2023 Category: Pathology Authors: Andrew Churg, Nestor L. Muller Source Type: research
Thoracic Pathology —Learning from the Past to Inform the Future
Thoracic pathology is a diverse combination of neoplastic and nonneoplastic diseases, and given their breadth, thoracic pathology requires frequent reexamination. Such reexamination may include incorporation of novel technologies but also conceptual changes in our interpretation of even well-established entities. This issue of Surgical Pathology Clinics provides a glimpse into this challenging admixture of pathologic entitie s. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - December 9, 2023 Category: Pathology Authors: Alain C. Borczuk Tags: Preface Source Type: research
Smoking-Related Interstitial Lung Disease
In the twenty- first century, there is widespread agreement that in addition to lung cancer, emphysema, and chronic bronchitis, cigarette smoking causes accumulation of pigmented macrophages, interstitial fibrosis, and Langerhans cell proliferation in various permutations. These histologic changes remain subclinical in some patients and produce clinical manifestations and imaging abnormalities in others. Debate surrounds terminology of these lesions, which are often grouped together under the umbrella of “smoking-related interstitial lung disease.” This review summarizes modern concepts in our understanding of these ab...
Source: Surgical Pathology Clinics - December 7, 2023 Category: Pathology Authors: Sanjay Mukhopadhyay, Irene Sansano Source Type: research
Gastrointestinal Pathology
SURGICAL PATHOLOGY CLINICS (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - October 19, 2023 Category: Pathology Authors: Rondell P. Graham Source Type: research
Copyright
ELSEVIER (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - October 19, 2023 Category: Pathology Source Type: research
Contributors
JASON L. HORNICK, MD, PhD (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - October 19, 2023 Category: Pathology Source Type: research
Contents
Rondell P. Graham (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - October 19, 2023 Category: Pathology Source Type: research
Forthcoming Issues
Soft Tissue Pathology (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - October 19, 2023 Category: Pathology Source Type: research
Atypical Spindle Cell/Pleomorphic Lipomatous Tumor
Atypical spindle cell/pleomorphic lipomatous tumor (ASCPLT) is a rare soft tissue neoplasm, commonly arising in the subcutis (more common than deep soft tissue) of limbs and limb girdles during mid-adulthood. ASCPLT is histologically a lipogenic neoplasm with ill-defined margins composed of a variable amount of spindle to pleomorphic/multinucleated cells within a fibromyxoid stroma. ASCPLTs lack MDM2 amplification, but a large subset show RB1 deletion and variable expression of CD34. Though initially thought to be the malignant form of spindle cell lipoma, ASCPLTs are benign with local recurrences ( ∼10-15%) and no well-...
Source: Surgical Pathology Clinics - August 23, 2023 Category: Pathology Authors: Amir Qorbani, Andrew Horvai Source Type: research
Xanthogranulomatous Epithelial Tumors and Keratin-Positive Giant Cell Rich Tumors of Soft Tissue and Bone
Xanthogranulomatous epithelial tumor is a recently described soft tissue tumor characterized by subcutaneous location, partial encapsulation, a xanthogranulomatous inflammatory cell infiltrate, and keratin-positive mononuclear cells. It shares some morphologic features with keratin-positive, giant cell-rich soft tissue tumors. Both have recently been shown to harbor HMGA2::NCOR2 fusions. The relationship between these tumors and their differential diagnosis with other osteoclast-containing soft tissue tumors is discussed. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - August 8, 2023 Category: Pathology Authors: Andrew L. Folpe Source Type: research
Myxoinflammatory Fibroblastic Sarcoma
MIFS is a low-grade fibroblastic sarcoma that predilects to superficial distal extremity soft tissue. It is composed of plump spindled and epithelioid cells, inflammatory infiltrates, and mucin deposits in a fibrosclerotic stroma. Large epithelioid cells harboring bizarre nuclei and virocyte-like macronucleoli and pleomorphic pseudolipoblasts are characteristic. While conventional MIFS has locally recurrent potential but minimal metastatic risk, tumors with high-grade histologic features have a greater risk for recurrence and metastasis. Wide local excision is the recommended treatment. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - August 8, 2023 Category: Pathology Authors: Hao Wu, William B. Laskin Source Type: research
Sarcomas with EWSR1::Non-ETS Fusion (EWSR1::NFATC2 and EWSR1::PATZ1)
The wide application of increasingly advanced molecular studies in routine clinical practice has allowed a detailed, albeit still incomplete, genetic subclassification of undifferentiated round cell sarcomas. The WHO classification continues to include provisional molecular entities, whose clinicopathologic features are in the early stages of evolution. This review focuses on the clinicopathologic, molecular, and prognostic features of undifferentiated round cell sarcomas with EWSR1/FUS::NFATC2 or EWSR1::PATZ1 fusions. Classic histopathologic findings, uncommon variations, and diagnostic pitfalls are addressed, along with ...
Source: Surgical Pathology Clinics - August 7, 2023 Category: Pathology Authors: Isidro Machado, Antonio Llombart-Bosch, Gregory W. Charville, Samuel Navarro, Mar ía Purificación Domínguez Franjo, Julia A. Bridge, Konstantinos Linos Source Type: research
GLI1-Altered Mesenchymal Tumors
GLI1-altered mesenchymal tumors comprise an emerging group of neoplasms characterized by fusions or amplifications involving GLI1, a gene that encodes a key regulator of the Hedgehog signaling pathway. In recent years, tumors with GLI1 alterations have been reported across a variety of anatomic sites and a broad age range. Although these tumors can exhibit a wide morphologic spectrum and a variable immunophenotype, they frequently present with monomorphic ovoid cells arranged in distinctive nests with a rich, arborizing vascular network. Recent evidence indicates that they have the potential to metastasize, which suggests ...
Source: Surgical Pathology Clinics - August 5, 2023 Category: Pathology Authors: Jeffrey M. Cloutier, Darcy A. Kerr Source Type: research
Pleomorphic Dermal Sarcoma
Pleomorphic dermal sarcoma (PDS) is a rare cutaneous/subcutaneous neoplasm of purported mesenchymal differentiation that exists along a clinicopathologic spectrum with atypical fibroxanthoma (AFX). While PDS and AFX share histopathologic and immunohistochemical features, PDS exhibits deeper tissue invasion and has a higher rate of metastasis and local recurrence than AFX. Given its aggressive clinical course, early recognition and clinical management of PDS are essential for optimizing patient outcomes. This review aims to provide a brief overview of the clinicopathologic and molecular features, prognosis, and treatment of...
Source: Surgical Pathology Clinics - August 5, 2023 Category: Pathology Authors: Jasmine S. Saleh, Carli P. Whittington, Scott C. Bresler, Rajiv M. Patel Source Type: research
