Hematopathology
SURGICAL PATHOLOGY CLINICS (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - May 5, 2023 Category: Pathology Authors: Aliyah R. Sohani Source Type: research
Copyright
ELSEVIER (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - May 5, 2023 Category: Pathology Source Type: research
Contributors
JASON L. HORNICK, MD, PhD (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - May 5, 2023 Category: Pathology Source Type: research
Contents
Aliyah R. Sohani (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - May 5, 2023 Category: Pathology Source Type: research
Forthcoming Issues
Liver Pathology: Diagnostic Challenges, Practical Considerations and Emerging Concepts (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - May 5, 2023 Category: Pathology Source Type: research
Systemic Disease and the Liver-Part 1
The development of liver dysfunction in patients having various systemic diseases is common and has a broad differential diagnosis, at times being the initial manifestation of the disorder. Liver injury associated with systemic lupus erythematosus is heterogeneous and may present with nonspecific histology. Differentiating autoimmune hepatitis from lupus hepatitis is challenging on histologic grounds alone. Other systemic diseases that may present mostly with nonspecific findings are rheumatoid arthritis and celiac disease. More recently COVID-19 cholangiopathy and secondary sclerosing cholangitis have become increasingly ...
Source: Surgical Pathology Clinics - May 3, 2023 Category: Pathology Authors: Maria Isabel Fiel, Thomas D. Schiano Source Type: research
Systemic Disease and the Liver-Part 1: Systemic Lupus Erythematosus, Celiac Disease, Rheumatoid Arthritis and COVID-19
The development of liver dysfunction in patients having various systemic diseases is common and has a broad differential diagnosis, at times being the initial manifestation of the disorder. Liver injury associated with systemic lupus erythematosus is heterogeneous and may present with nonspecific histology. Differentiating autoimmune hepatitis from lupus hepatitis is challenging on histologic grounds alone. Other systemic diseases that may present mostly with nonspecific findings are rheumatoid arthritis and celiac disease. More recently COVID-19 cholangiopathy and secondary sclerosing cholangitis have become increasingly ...
Source: Surgical Pathology Clinics - May 3, 2023 Category: Pathology Authors: Maria Isabel Fiel, Thomas D. Schiano Source Type: research
Current Concepts in Nodal Peripheral T-Cell Lymphomas
This review summarizes the current understanding of mature T-cell neoplasms predominantly involving lymph nodes, including ALK-positive and ALK-negative anaplastic large cell lymphomas, nodal T-follicular helper cell lymphoma, Epstein-Barr virus –positive nodal T/NK-cell lymphoma, and peripheral T-cell lymphoma (PTCL), not otherwise specified. These PTCLs are clinically, pathologically, and genetically heterogeneous, and the diagnosis is made by a combination of clinical information, morphology, immunophenotype, viral positivity, and gene tic abnormalities. This review summarizes the pathologic features of common nodal P...
Source: Surgical Pathology Clinics - April 4, 2023 Category: Pathology Authors: Naoki Oishi, Andrew L. Feldman Source Type: research
Hodgkin Lymphoma and Its Differential Diagnosis
Hodgkin lymphoma is a B-cell neoplasm that typically presents with localized, nodal disease. Tissues are characterized by few large neoplastic cells, usually comprising less than 10% of tissue cellularity, present in a background of abundant nonneoplastic inflammatory cells. This inflammatory microenvironment, although key to the pathogenesis, can make diagnosis a challenge because reactive conditions, lymphoproliferative diseases, and other lymphoid neoplasms may mimic Hodgkin lymphoma and vice versa. This review provides an overview of the classification of Hodgkin lymphoma, its differential diagnosis, including emerging...
Source: Surgical Pathology Clinics - March 30, 2023 Category: Pathology Authors: Aliyah R. Sohani Source Type: research
Immunoglobulin G4-Related Disease, Lymphadenopathy, and Lymphoma
Lymphadenopathy occurring in patients with immunoglobulin G4 (IgG4)-related disease, termed IgG4-related lymphadenopathy, shows morphologic heterogeneity and overlap with other nonspecific causes of lymphadenopathy including infections, immune-related disorders, and neoplasms. This review describes the characteristic histopathologic features and diagnostic approach to IgG4-related disease and IgG4-related lymphadenopathy, with comparison to nonspecific causes of increased IgG4-positive plasma cells in lymph nodes, and with emphasis on distinction from IgG4-expressing lymphoproliferative disorders. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - March 27, 2023 Category: Pathology Authors: Jacob R. Bledsoe Source Type: research
Evolving Concepts in Diagnostic Hematopathology
This collection of articles in Surgical Pathology Clinics explores new diagnostic entities and concepts, areas of controversy or evolving understanding, and emerging techniques that aid in diagnosis, prognosis, or predictive response to targeted therapies, with a focus on lymphoid neoplasms. The publication of this issue follows the development of two updated paradigms of disease classification in our field: the 5th edition of the WHO Classification of Haematolymphoid Tumours and the 2022 International Consensus Classification. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - March 26, 2023 Category: Pathology Authors: Aliyah R. Sohani Tags: Preface Source Type: research
Diagnostic, Prognostic, and Predictive Role of Next-Generation Sequencing in Mature Lymphoid Neoplasms
Lymphoma is a clinically and biologically heterogeneous disease. Next-generation sequencing (NGS) has expanded our understanding of this heterogeneity at the genetic level, refining disease classification, defining new entities, and providing additional information that can be used in diagnosis and management. This review highlights some of the NGS findings in lymphoma and how they can be used as genetic biomarkers to aid diagnosis and prognosis and guide therapy. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - March 15, 2023 Category: Pathology Authors: Graham W. Slack Source Type: research
Breast Implant-Associated Anaplastic Large Cell Lymphoma
Pathologic staging including assessment of margins is essential for the proper management of patients with breast implant-associated anaplastic large-cell lymphoma (BIA-ALCL). As most patients present with effusion, cytologic examination with immunohistochemistry and/or flow cytometry immunophenotyping are essential for diagnosis. Upon a diagnosis of BIA-ALCL, en bloc resection is recommended. When a tumor mass is not identified, a systematic approach to fixation and sampling of the capsule, followed by pathologic staging and assessment of margins, is essential. Cure is likely when lymphoma is contained within the en bloc ...
Source: Surgical Pathology Clinics - March 10, 2023 Category: Pathology Authors: Mario L. Marques-Piubelli, L. Jeffrey Medeiros, John Stewart, Roberto N. Miranda Source Type: research
Molecular Diagnostics of Plasma Cell Neoplasms
Genetic characterization of myeloma at diagnosis by interphase fluorescence in situ hybridization and next-generation sequencing (NGS) can assist with risk stratification and treatment planning. Measurable residual disease (MRD) status after treatment, as evaluated by next-generation flow cytometry or NGS on bone marrow aspirate material, is one of the most important predictors of prognosis. Less-invasive tools for MRD assessment such as liquid biopsy approaches have also recently emerged as potential alternatives. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - March 10, 2023 Category: Pathology Authors: Megan J. Fitzpatrick, Mandakolathur R. Murali, Valentina Nardi Source Type: research
Immunodeficiency-Associated Epstein-Barr Virus-Positive B-cell Lymphoproliferative Disorders
Sources of immune deficiency and dysregulation (IDD) are being increasingly recognized and defined, as are IDD-related B-cell lymphoproliferative lesions and lymphomas occurring in these patients. In this review, basic biology of Epstein-Barr virus (EBV) as it relates to classification of EBV-positive B-cell lymphoproliferative disorders (LPDs) is reviewed. Also discussed is the new paradigm of classification of IDD-related LPDs adopted by the fifth edition World Health Organization classification. IDD-related EBV-positive B-cell hyperplasias, LPDs, and lymphomas are discussed with particular attention to unifying and uniq...
Source: Surgical Pathology Clinics - March 10, 2023 Category: Pathology Authors: Jennifer Chapman Source Type: research
