Salivary Duct Carcinoma
Salivary duct carcinoma (SDC) is a rare, aggressive salivary gland malignancy with significant mortality. Morphologically, most tumors are characterized by apocrine differentiation with a typical immunophenotype of androgen receptor positive/gross cystic disease fluid protein positive/estrogen receptor negative/progesterone receptor negative. Several morphologic variants of SDC exist, representing diagnostic pitfalls. Several differential diagnoses should be considered because prognosis, treatment, and management may be different from SDC. For SDC, current treatment strategies are aggressive and commonly include surgical e...
Source: Surgical Pathology Clinics - January 5, 2021 Category: Pathology Authors: Mobeen Rahman, Christopher C. Griffith Source Type: research
Polymorphous Adenocarcinoma
Polymorphous adenocarcinoma (PAC) is typically originated from the minor salivary glands and is characterized by cytology uniformity and architectural diversity. PAC commonly harbors PRKD1 E710D mutation. PAC has an excellent prognosis. However, greater than or equal to 10% papillary or greater than or equal to 30% cribriform pattern is an independent adverse prognostic factor. Cribriform adenocarcinoma of salivary gland (CASG) is a controversial entity that is considered within the same histologic spectrum of PAC in current classification schemes; however, it is regarded by some pathologists as a separate entity. CASG sho...
Source: Surgical Pathology Clinics - January 5, 2021 Category: Pathology Authors: Nora Katabi, Bin Xu Source Type: research
Genomic Analysis of Salivary Gland Cancer and Treatment of Salivary Gland Cancers
Salivary gland cancer is a heterogenous group of tumors that presents challenges with both diagnosis and therapy. Recent advances in the classification of salivary gland cancers have led to distinct histologic and genomic criteria that successfully differentiate between cancers with similar clinical behavior and appearance. Genomic abnormalities have led to the emergence of targeted therapies being used in their therapy with drastic improvements in outcomes as well as reductions in treatment-related toxicity. Dramatic results seen with molecular targets, such as HER2, TRK, and others, indicate that this approach has the po...
Source: Surgical Pathology Clinics - January 5, 2021 Category: Pathology Authors: Doreen Palsgrove, Sameer Allahabadi, Saad A. Khan Source Type: research
Epithelial –Myoepithelial Carcinoma
Epithelial –myoepithelial carcinoma is an uncommon low-grade salivary gland carcinoma. It is classically characterized by biphasic tubular structures composed of inner eosinophilic ductal cells and outer clear myoepithelial cells. In addition, epithelial–myoepithelial carcinoma sometimes shows various hist ologic features, including a cribriform pattern, basaloid appearance, and sebaceous differentiation. Because clear myoepithelial cells are also noted in other benign and malignant salivary gland tumors, the histologic variety and similarity with other tumor entities make the diagnosis of epithelial– myoepithelial c...
Source: Surgical Pathology Clinics - January 5, 2021 Category: Pathology Authors: Masato Nakaguro, Toshitaka Nagao Source Type: research
Papillary Neoplasms of the Salivary Duct System
This article discusses those papillary proliferations encountered in the salivary glands with a focus on intraductal papillary mucinous neoplasms and cystadenomas. Intraductal carcinomas and sialadenoma papilliferum are addressed in separate articles in this issue. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - December 14, 2020 Category: Pathology Authors: Abbas Agaimy Source Type: research
Wilms Tumor
Wilms tumor is the most common renal tumor of childhood. It is a biologically and morphologically diverse entity, with ongoing studies contributing to our understanding of the pathobiology of various subgroups of patients with Wilms tumor. The interplay of histologic examination and molecular interrogation is integral in prognostication and direction of therapy. This review provides an overview of some of the challenging aspects and pitfalls in pathologic assessment of Wilms tumor, along with discussion of current and up-and-coming markers of biological behavior with prognostic significance. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - November 11, 2020 Category: Pathology Authors: Lauren N. Parsons Source Type: research
Newcomers in Vascular Anomalies
This article reviews the pathologic and molecular genetic characteristics for select recently described vascular anomalies. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - November 11, 2020 Category: Pathology Authors: Alyaa Al-Ibraheemi Source Type: research
Pediatric and Infantile Fibroblastic/Myofibroblastic Tumors in the Molecular Era
This article is focused on using clinical and pathologic clues in conjunction with the increasingly relevant and available molecular techniques to classify, predict prognosis, and/or guide treatment in these tumors. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - November 11, 2020 Category: Pathology Authors: Jessica L. Davis, Erin R. Rudzinski Source Type: research
Strategies for the Neonatal Lung Biopsy
This article describes pathologic patterns in the neonatal lung and correlation with molecular abnormalities, where appropriate. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - November 11, 2020 Category: Pathology Authors: Jill Lipsett, Megan K. Dishop Source Type: research
Pediatric Liver Tumors
Malignant primary liver tumors are rare in children. Yet a wide histologic spectrum is seen, particularly in hepatoblastoma, the most common malignant liver tumor in children. Furthermore, there can be significant morphologic overlap with hepatocellular carcinoma, the second most common pediatric liver malignancy, and tumors with hybrid features of hepatoblastoma and hepatocellular carcinoma are also reported (currently placed in the provisional category of malignant hepatocellular neoplasm, not otherwise specified). This review provides detailed morphologic descriptions and updates in the evolving clinical context of thes...
Source: Surgical Pathology Clinics - November 11, 2020 Category: Pathology Authors: Soo-Jin Cho Source Type: research
Challenges & Updates in Pediatric Pathology
SURGICAL PATHOLOGY CLINICS (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - November 11, 2020 Category: Pathology Authors: Jessica L. Davis Source Type: research
Copyright
ELSEVIER (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - November 11, 2020 Category: Pathology Source Type: research
Contributors
JASON L. HORNICK, MD, PhD (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - November 11, 2020 Category: Pathology Source Type: research
Contents
Jessica L. Davis (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - November 11, 2020 Category: Pathology Source Type: research
Forthcoming Issues
Head and Neck Pathology (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - November 11, 2020 Category: Pathology Source Type: research
