Copyright
ELSEVIER (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - August 30, 2022 Category: Pathology Source Type: research
Contributors
JASON L. HORNICK, MD, PhD (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - August 30, 2022 Category: Pathology Source Type: research
Contents
Aatur D. Singhi (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - August 30, 2022 Category: Pathology Source Type: research
Forthcoming Issues
Genitourinary Pathology (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - August 30, 2022 Category: Pathology Source Type: research
Total Pancreatectomy with Islet Autotransplantation
Total pancreatectomy with islet autotransplantation (TPIAT) is a surgical procedure undertaken in some patients with severe pain or disability from recurrent acute and chronic pancreatitis (CP). TPIAT provides a rare opportunity to study human pancreas tissue from patients affected with pancreatitis, and particularly from patients with genetic forms of pancreatitis. Research to date suggests distinct histopathology and potentially differential pathophysiology of distinct etiologies of CP. Histopathology specimens have helped better define the success and limitations of clinical diagnostic imaging tools, such as magnetic re...
Source: Surgical Pathology Clinics - August 3, 2022 Category: Pathology Authors: Sad é M.B. Finn, Melena D. Bellin Source Type: research
The Diagnostic Challenge of Evaluating Small Biopsies from the Pancreatobiliary System
Examination of fine needle aspirations and small core biopsies of the pancreas can be an extremely difficult and treacherous area for the diagnostic pathologist. The pancreas often yields small and often fragmented specimens, which, in combination with the morphologic overlap between numerous neoplastic and nonneoplastic mimickers, generate multiple potential diagnostic pitfalls. The authors review this challenging topic and provide insight into resolving these pitfalls using morphologic pattern recognition and ancillary testing. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - August 2, 2022 Category: Pathology Authors: Elizabeth D. Thompson, M. Lisa Zhang, Christopher J. VandenBussche Source Type: research
The Cytomorphologic and Molecular Assessment of Bile Duct Brushing Specimens
Biliary duct brushing cytology is the standard of care for the assessment of bile duct strictures but suffers from low sensitivity for the detection of a high-risk stricture. Pathologic diagnosis of strictures is optimized by integration of cytomorphology and molecular analysis with fluorescence in situ hybridization or next-generation sequencing. Bile duct cancers are genetically heterogeneous, requiring analysis of multiple gene panels to increase sensitivity. Using molecular analysis as an ancillary test for bile duct brushing samples aids in the identification of mutations that support the diagnosis of a high-risk stri...
Source: Surgical Pathology Clinics - August 2, 2022 Category: Pathology Authors: Caroline F. Hilburn, Martha B. Pitman Source Type: research
Advances in the Surgical Treatment of Pancreatic Cancer
Three recent advances in the surgical approach to pancreatic cancer over the past decade have improved both short- and long-term outcomes for patients with nonmetastatic, operable pancreatic cancer. These include (1) minimally invasive pancreatectomy to reduce operative morbidity while adhering to principles of open oncologic resections, (2) neoadjuvant chemotherapy to treat radiographically occult metastatic disease and improve locoregional control, and (3) applying irreversible electroporation as an adjunct to surgery, allowing a fraction of locally advanced pancreatic cancer to be resected. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - August 2, 2022 Category: Pathology Authors: Jian Zheng, Alessandro Paniccia, Amer H. Zureikat Source Type: research
The Evolving Paradigm of Germline Testing in Pancreatic Ductal Adenocarcinoma and Implications for Clinical Practice
Identification of deleterious germline mutations in pancreatic ductal adenocarcinoma (PDAC) patients can have therapeutic implications for the patients and result in cascade testing and prevention in their relatives. Universal testing for germline mutations is now considered standard of care in patients with PDAC, regardless of family history, personal history, or age. Here, we highlight the commonly identified germline mutations in PDAC patients as well as the impact of multigene panel testing. We further discuss therapeutic implications of germline testing on the index cases, and the impact of cascade testing on cancer e...
Source: Surgical Pathology Clinics - August 2, 2022 Category: Pathology Authors: Chirayu Mohindroo, Ana De Jesus-Acosta, Matthew B. Yurgelun, Anirban Maitra, Maureen Mork, Florencia McAllister Source Type: research
The Molecular Pathogenesis and Targeted Therapies for Cholangiocarcinoma
Cholangiocarcinoma (CCA) is a group of malignancies of the bile ducts with high mortality rates and limited treatment options. In the past decades, remarkable efforts have been dedicated toward elucidating the specific molecular signaling pathways and oncogenic loops driving cholangiocarcinogenesis to ultimately develop more effective therapies. Despite some recent advances, an extensive intra- and inter-tumor heterogeneity together with a poorly understood immunosuppressive microenvironment significantly compromises the efficacy of available treatments. Here, we provide a concise review of the latest advances and current ...
Source: Surgical Pathology Clinics - August 2, 2022 Category: Pathology Authors: Nesteene Joy Param, Emily R. Bramel, Daniela Sia Source Type: research
Prognostic and Predictive Biomarkers for Pancreatic Neuroendocrine Tumors
Pancreatic neuroendocrine tumors (PanNETs) represent a clinically challenging disease because these tumors vary in clinical presentation, natural history, and prognosis. Novel prognostic biomarkers are needed to improve patient stratification and treatment options. Several putative prognostic and/or predictive biomarkers (eg, alternative lengthening of telomeres, ATRX/DAXX loss) have been independently validated. Additionally, recent transcriptomic and epigenetic studies focusing on endocrine differentiation have identified PanNET subtypes that display similarities to either α-cells or β-cells and differ in clinical outc...
Source: Surgical Pathology Clinics - August 2, 2022 Category: Pathology Authors: Wenzel M. Hackeng, Hussein A. Assi, Florine H.M. Westerbeke, Lodewijk A.A. Brosens, Christopher M. Heaphy Source Type: research
Mixed Neuroendocrine-Non-Neuroendocrine Neoplasms of the Pancreas
Pancreatic mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs) are rare neoplasms, composed of at least two components. The neuroendocrine part is always present. Histology is the most important tool for the diagnosis, but in the case of MiNEN, it is also important for the use of immunohistochemistry, which should include neuroendocrine but also ductal and acinar markers. Each component should be specifically described in the final pathology report, including the percentage on the entire tumor mass. The prognosis of MiNEN is very heterogeneous and depends on the different tumor components. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - August 2, 2022 Category: Pathology Authors: Vassilena Tsvetkova, Claudio Luchini Source Type: research
The Histopathology of Neoadjuvant-Treated (NAT) Pancreatic Ductal Adenocarcinoma
Examination of pancreatic ductal adenocarcinoma after NAT with the intent of diagnosis and outcome prediction remains a challenging task. The lack of a uniform approach to macroscopically assess these cases along with variations in sampling adds to the complexity. Several TRG systems have been proposed to correlate with an overall survival. In clinical practice, most of these TRG schemes have shown low level of interobserver agreement arguing for a need of larger studies and more innovative ways to assess outcome in this population. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - August 2, 2022 Category: Pathology Authors: Ahmed Bakhshwin, Daniela S. Allende Source Type: research
Life After Amsterdam: Placental Pathology Consensus Recommendations and Beyond
The Amsterdam Placental Workshop Group Consensus Statement on Sampling and Definitions of Placental Lesions has become widely accepted and is increasingly used as the universal language to describe the most common pathologic lesions found in the placenta. This review summarizes the most salient aspects of this seminal publication and the subsequent emerging literature based on Amsterdam definitions and criteria, with emphasis on publications relating to diagnosis, grading, and staging of placental pathologic conditions. We also provide an overview of the recent expert recommendations on the pathologic grading of placenta a...
Source: Surgical Pathology Clinics - June 1, 2022 Category: Pathology Authors: Jonathan C. Slack, Carlos Parra-Herran Source Type: research
Update on Ovarian Sex Cord –Stromal Tumors
This article focuses on the recent advances in ovarian sex cord –stromal tumors, predominantly in the setting of their molecular underpinnings. The integration of genetic information with morphologic and immunohistochemical findings in this rare subset of tumors is of clinical significance from refining the diagnostic and prognostic stratifications to genetic counseling. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - June 1, 2022 Category: Pathology Authors: Zehra Ordulu Source Type: research
