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Prevalence and comparison of psychological trauma and stressors in functional seizure patients from a public and private hospital
The relationship between psychological trauma or substantial psychological stressors and the development of functional seizures is well-known [1]. Similarly, coming from a socioeconomically marginalised background is a known risk factor for psychological distress and adverse events [2]. Consequently, investigating potential differences in the experiences of psychologically distressing events among patients with FS along socioeconomic lines becomes important. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - October 1, 2023 Category: Neurology Authors: Gabriele Vilyte, James Butler, Chrisma Pretorius Source Type: research

Healthcare Providers ’ Perspectives on Stigma when Working with People with Functional Seizures
Functional Seizures (FS) is a condition characterised by seizures which are not due to ictal epileptiform discharges in the brain that result in epilepsy, but which rather, are the result of psychological trauma or stressors. These seizures involve a paroxysmal disturbance in behaviour and cognitive functioning in relation to memory and consciousness [1]. It typically develops during adolescence or early adulthood; however, it can occur at any age, and is mostly associated with women [2]. Within the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), FS is categorised as a type of Conversion Disor...
Source: Seizure: European Journal of Epilepsy - October 1, 2023 Category: Neurology Authors: Tresan Samuels, Chrisma Pretorius Source Type: research

Drug-resistant focal epilepsy in a girl with SETD5-related intellectual disability
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Source: Seizure: European Journal of Epilepsy - September 30, 2023 Category: Neurology Authors: Ranjith Kumar Manokaran, Ayako Ochi, Elizabeth Kerr, Gregory Costain, Olivia Moran, Hiroshi Otsubo, Robyn Whitney, Puneet Jain Source Type: research

Seizures in Schuurs –Hoeijmakers syndrome patients may resolve spontaneously: A case report from China
Schuurs –Hoeijmakers syndrome (SHMS) is a rare autosomal dominant genetic condition characterised by abnormal facial features, varying degrees of neurodevelopmental disorder, intellectual disability, and seizures. The c.607C>T pathogenic variant in the phosphofurin acidic cluster sorting protein 1 (PACS1) gene is the most common genetic variant associated with SHMS. Here we present the case of a patient with SHMS in China who suffered from seizure clusters (SCs) starting 10 days after birth. The child gradually developed typical facial features of SHMS and showed abundant multiple spikes, spike-wave discharges, and slow ...
Source: Seizure: European Journal of Epilepsy - September 28, 2023 Category: Neurology Authors: Yun Wang, Guangshuang Lu, Yun Cheng, Jie Hu, Wu Yang Source Type: research

Epidemiology of focal onset seizures in children aged > 1 month to 4 years in Europe, United States, and Canada: A literature review
Epilepsy is defined as a disease characterized by the recurrence of unprovoked seizures [1,2]. It has a higher incidence during the first few years of life compared with later childhood and adolescence [3 –5]. On a population level, the highest age-specific incidences of>60 per 100,000 are observed in children under 5 years of age [5,6]. Seizures are divided into focal, generalized, and unknown onset seizures. A seizure is considered generalized in onset if it engages bilateral brain networks from onset, and focal if it begins in one region or hemisphere [2,7,8]. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - September 27, 2023 Category: Neurology Authors: Susanne Schubert-Bast, Moninder Kaur, Lars Joeres, Nadia Foskett, Robert Roebling, Adam Strzelczyk Tags: Review Source Type: research

Vagus Nerve Stimulation in refractory idiopathic generalised epilepsy: An Irish retrospective observational study
Idiopathic generalised epilepsies (IGE; also called genetic generalised epilepsies) comprise four distinct electroclinical syndromes: juvenile myoclonic epilepsy (JME), childhood absence epilepsy (CAE), juvenile absence epilepsy (JAE), and epilepsy with generalised tonic-clonic seizures (GTCS) alone [1,2]. Significant overlap exists between the different IGE syndromes, in particular between CAE and JAE [3], and patients may evolve from one IGE syndrome to another, for example, CAE to JME in adulthood [2]. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - September 25, 2023 Category: Neurology Authors: Javier Pe ña-Ceballos, Patrick B. Moloney, Antonio Valentin, Cara O'Donnell, Niamh Colleran, Brenda Liggan, Breege Staunton-Grufferty, Patricia Ennis, Roger Grogan, Gerard Mullins, Daniel J. Costello, Colin P. Doherty, Kieron J. Sweeney, Hany El Naggar, Source Type: research

The History of Motion Photography to Video Electroencephalography in the Study of Functional Seizures and Related Seizure Disorders: The First 100 Years
Before the modern development of video-electroencephalography (vEEG), there was a transitional period in history when our forefathers utilized photography to record seizure episodes. Charcot was the first to introduce photography in his study of epilepsy and related conditions. Charcot coined the term "hystero-epilepsy" to refer to a condition in which people with "acquired" neuroses symptoms resembling seizures [1]. He collaborated with photographer Londe to use images to capture hysteric seizure events. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - September 24, 2023 Category: Neurology Authors: Richard Ho, Enrique J. Carrazana Source Type: research

Epilepsy-associated genes: an update
The widespread applications of next-generation sequencing technologies have accelerated the discovery of genes associated with epilepsy. Genetic factors are believed to be the major contributors to the cause of epilepsy in up to 80% of people with epilepsy [1 –3]. In 2017, we summarized 977 genes that are associated with epilepsy based on clinical-genetic evidence [4]. Over the past six years, a great number of novel epilepsy-associated genes have been reported, which has led to encouraging progress in the field of epilepsy genetics. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - September 23, 2023 Category: Neurology Authors: Meng-Wen Zhang, Xiao-Yu Liang, Jie Wang, Liang-Di Gao, Han-Jun Liao, Yun-Hua He, Yong-Hong Yi, Na He, Wei-Ping Liao, China Epilepsy Gene 1.0 Project Source Type: research

Epileptogenic zone in Broca's area is resectable under awake surgery in accordance with the hodotopic framework: A case report
According to the hodotopic framework, execution of higher cognitive functions involves the interaction of multiple cortical regions via white matter fibers [1]. According to this concept, if the cortical regions that are responsible for higher cognitive functions are partially damaged, while the subcortical network is preserved, none or only transient symptoms may occur. When an epileptogenic zone (EZ) is located within the functionally dominant cortex, surgical resection is often avoided. However, we believe that these areas are resectable according to the hodotopic framework. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - September 20, 2023 Category: Neurology Authors: Takahiro Suzuki, Tomotaka Ishizaki, Satoshi Maesawa, Miki Hashida, Manabu Mutoh, Yoshiki Ito, Takafumi Tanei, Ryuta Saito Source Type: research

Incidence, severity and outcomes of COVID-19 in age and gender matched adults with and without epilepsy in Moscow: a historical cohort study
In December 2019, the World Health Organization declared the new illness - the Coronavirus disease 2019 (COVID-19) caused by the coronavirus 2 (SARS-CoV-2) [1], that led to increased mortality worldwide. There have been several subsequent waves of the pandemic, prophylactic measures and clinical recommendations have been developed, but the situation is still far from stable globally and outbreaks recur periodically. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - September 18, 2023 Category: Neurology Authors: Flora Rider, W. Allen Hauser, Alexander Yakovlev, Alexander Shpak, Alla Guekht Source Type: research

The Evolution of Epilepsy Surgery in Tuberous Sclerosis in Sweden: a national registry study
Tuberous sclerosis complex (TSC) is a rare genetic disorder caused by pathogenic heterozygous variants in the mechanistic target of rapamycin (mTOR) pathway regulators, TSC1 or TSC2 [1]. Disinhibition of mTOR leads to the growth of benign hamartomas in several organs. Epilepsy is the most prevalent neurological manifestation in patients with TSC, occurring in approximately 90% of patients and 80% (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - September 16, 2023 Category: Neurology Authors: Kevin Pearsson, Erik A. Eklund, Olof Rask, Ingmar Ros én, Håkan Sjunnesson, Maria Compagno-Strandberg Source Type: research

Status epilepticus in patients with glioblastoma: Clinical characteristics, risk factors, and epileptological outcome
Epileptic seizures are a common symptom in patients with glioblastoma. 50-70 % of all patients with glioblastoma will develop seizures during the course of their disease[1 –3]. With an incidence of 7-16 %, status epilepticus (SE) represents a less frequent, but severe complication of epilepsy in glioblastoma patients[4–8]. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - September 15, 2023 Category: Neurology Authors: Jenny Stritzelberger, Anna Gesmann, Imke Fuhrmann, Stefanie Balk, Caroline Reindl, Dominik Mad žar, Martin Uhl, Tamara M. Welte, Sebastian Brandner, Felix Eisenhut, Arnd Dörfler, Roland Coras, Werner Adler, Stefan Schwab, Florian Putz, Rainer Fietkau, L Source Type: research

Risk Factors for Preoperative and Postoperative Seizures in Patients with Glioblastoma According to the 2021 World Health Organization Classification
Glioblastoma (GBM) is the most common and aggressive malignant primary brain cancer. At least 30 –45% of adult patients with GBM experience seizures as the presenting clinical sign, and another 10% to 30% develop seizures at some point during their disease course. [1–3] Preoperative GBM-related seizures (PRS) are more common in younger patients, with a peak incidence in the third to fifth d ecades of life. [4] While PRS correlates with longer survival, postoperative seizures (POS) may be a potential tumor marker for disease progression or recurrence. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - September 15, 2023 Category: Neurology Authors: Anteneh M. Feyissa, Sofia S. Sanchez-Boluarte, Diogo Moniz-Garcia, Kaisorn L. Chaichana, Wendy J. Sherman, Brin E. Freund, William O. Tatum, Erik H. Middlebrooks, Joseph I. Sirven, Alfredo Quinones-Hinojosa Source Type: research

Real-World evidence on the use of cannabidiol for the treatment of drug resistant epilepsy not related to Lennox-Gastaut syndrome, Dravet syndrome or Tuberous Sclerosis Complex
Highly purified cannabidiol (CBD) with a known and constant composition has proven to be an effective and safe therapeutic alternative for the treatment of drug resistant epilepsy [1,2]. The results of several randomized controlled clinical trials have allowed it to be approved by various drug regulatory entities as adjuvant therapy in patients older than 2 years with drug resistant epilepsy associated with Lennox-Gastaut syndrome, Dravet syndrome or Tuberous Sclerosis Complex [3 –7]. However, the mechanism of action of CBD in epilepsy, although not fully described, is multifactorial and is not exclusively related to the...
Source: Seizure: European Journal of Epilepsy - September 15, 2023 Category: Neurology Authors: Camilo Espinosa-Jovel, Sandra Riveros, Carlos Bola ños-Almeida, Mateo Ramírez Salazar, Leidy Ceballos Inga, Laura Guío Source Type: research

Association between SCN1A polymorphism and risk of epilepsy in children: a systematic review and meta-analysis
Epilepsy is a neurological disorder characterized by recurrent and unprovoked seizures that affects people of various ages [1]. In particular, epilepsy in children deserves special attention because its pathogenesis appears to be distinct from that of adult epilepsy [2]. Therefore, research into their different genetic basis is essential for accurate diagnosis, risk stratification, and formulation of tailored therapeutic strategies. The etiology of epilepsy is complex and multifactorial, involving both genetic and environmental factors. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - September 15, 2023 Category: Neurology Authors: Zhihong Zhou, Shuihua Wu, Xin Zou, Shuo Gu Source Type: research