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Intranasal administration of antiseizure medications in chronic and emergency treatment: Hopes and challenges
Epilepsy is one of the most prevalent neurological disorder, affecting approximately 70 million individuals worldwide [1]. Despite the development and approval of numerous antiseizure medications (ASMs), nearly 30% of epilepsy patients exhibit resistance to pharmacotherapy [2]. The medical consequences staying behind inadequate seizure control comprise premature mortality, physical harm, societal exclusion, stigma, heightened prevalence of depression and anxiety, and an overall diminished quality of life [1]. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - January 4, 2024 Category: Neurology Authors: Natalia Chmielewska, Janusz Szyndler Tags: Review Source Type: research

Epilepsy-associated genes: discovery, clinical significance, and underlying principles of genetic medicine
The broad use of next-generation sequencing has led to the identification of an increasing number of epilepsy-associated genes. These new discoveries will benefit the clinical diagnosis, management, and genetic counselling of people with epilepsy. This Special Issue (SI) presents novel scientific contributions in this field, providing new insights into the genetics of epilepsy. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - January 2, 2024 Category: Neurology Authors: Wei-Ping Liao Tags: Editorial Source Type: research

Epilepsy-associated genes: discovery, clinical significance, and the underlying principle of genetic medicine
With the wide application of next-generation sequencing, an increasing number of epilepsy-associated genes have been identified, which will benefit the clinical diagnosis, management, and genetic consulting of epilepsy. This Special Issue (SI) presents novel scientific contributions in this field, providing novel insights into genetic epilepsy. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - January 2, 2024 Category: Neurology Authors: Wei-Ping Liao Tags: Editorial Source Type: research

Metabolic causes of pediatric developmental & epileptic encephalopathies (DEE)- genetic variant analysis in a south Indian cohort
Inborn errors of metabolism (IEM) are caused by defects in genes involved in biochemical pathways which control metabolism and neuronal function. Although IEM are rare genetic diseases, epilepsy is a common presenting feature.. Early identification and diagnosis is important because some are treatable with variable developmental prognosis [1,2]. Often the epilepsy phenotypes associated with IEM can potentially evolve as developmental and epileptic encephalopathy (DEE). The severity of epilepsy may range from infrequent seizures to anti-seizure medication (ASM) resistant phenotypes including status epilepticus. (Source: Sei...
Source: Seizure: European Journal of Epilepsy - January 2, 2024 Category: Neurology Authors: Manna Jose, Alfiya Fasaludeen, Harini Pavuluri, Pavan Kumar Rudrabhatla, Soumya V. Chandrasekharan, Jithu Jose, Moinak Banerjee, Soumya Sundaram, Ashalatha Radhakrishnan, Ramshekhar N. Menon Source Type: research

Editorial Board
(Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - January 1, 2024 Category: Neurology Source Type: research

Resting-state brain activity distinguishes patients with generalised epilepsy from others
Epilepsy is a chronic medical condition characterised by the recurrence of unprovoked seizures, which are paroxysmal events caused by pathological neuronal discharges in the brain [1]. It is categorised into three types according to the 2017 operational classification of epileptic seizures by the International League Against Epilepsy [2]: generalised epilepsy (GE), focal epilepsy (FE), and combined generalised and focal epilepsy. Diagnostic classification is clinically important because different therapeutic strategies are used for each type [3]. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - January 1, 2024 Category: Neurology Authors: Galymzhan Issabekov, Takahiro Matsumoto, Hideyuki Hoshi, Keisuke Fukasawa, Sayuri Ichikawa, Yoshihito Shigihara Source Type: research

Measuring Quality and Safety of Epilepsy Monitoring Units In Brazil: Adoption of Quality Indicators
Epilepsy is a prevalent neurologic condition worldwide, with estimated lifetime prevalence rates of 5.8 per 1,000 in developed countries and 10.3 per 1,000 in urban areas and 15.4 per 1,000 in rural areas of developing countries [1]. However, due to variations in study methodology and limited data in many parts of the developing world, the true prevalence of epilepsy remains uncertain [1,2]. Brazil, in particular, lacks comprehensive data; however, published reports estimate the lifetime prevalence of epilepsy to be between 9.2 and 18.6 per 1,000, similar to other low-income countries [3 –6]. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - January 1, 2024 Category: Neurology Authors: Leonardo Cordenonzi Pedroso de Albuquerque, Carolina Machado Torres, Carlos Eduardo Alves Batista, D ébora Rosilei Miquini de Freitas Cunha, Jorge Wladimir Junqueira Bizzi, Marino Muxfeldt Bianchin Source Type: research

Clinical characteristics and associated factors of posttraumatic epilepsy after traumatic brain injury in children: a retrospective case-control study
Traumatic brain injury (TBI) is a significant global health concern, impacting approximately 69 million individuals annually1 and is associated with several physical and cognitive complications, including seizure and epilepsy.2,3 These seizures, referred to as posttraumatic seizures (PTS), can manifest at different time intervals following the injury. PTS classification depends upon the time of seizure onset relative to the injury, comprising immediate PTS (7 days post-injury). (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - December 31, 2023 Category: Neurology Authors: Yi Li, Duan Wang, Xuanzi Zhou, Jiayu Liu, Yongzhu Jia, Nong Xiao Source Type: research

Neurodevelopmental outcomes in a cohort of Australian families with self-limited familial epilepsy of neonatal/infantile onset
Self-limited familial epilepsy (SeLFE) with neonatal/infantile onset is a genetic epilepsy characterised by focal seizures with onset day 1 of life to 23 months.[1] Three syndromes are defined by the International League Against Epilepsy according to the age of seizure onset: 1) self-limited familial neonatal epilepsy (1-28 days)- “SeLNE”, 2) self-limited familial infantile epilepsy (1-23 months)-“SeLIE” and 3) self-limited familial neonatal-infantile epilepsy “SeLFNIE” with seizure onset in both the neonatal and/or infantile period. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - December 26, 2023 Category: Neurology Authors: Dr Emily A Innes, Ms Fleur Annette Le Marne, Ms Rebecca Macintosh, Dr Suzanne M. Nevin, Dr Nancy E Briggs, Dr Sinthu Vivekanandarajah, Dr Richard I Webster, Dr Rani K Sachdev, Prof Ann M E Bye Source Type: research

Multiple Sclerosis and Seizures: a Retrospective Observational Study in a Multiple Sclerosis Autoimmunity Center of Excellence
The prevalence of epilepsy in patients with multiple sclerosis (MS) is three to six times the prevalence in the general adult population[1]. While 1-1.5% of the general population have seizures, approximately 2-5% of people with MS have seizures. The cumulative incidence of epilepsy is also higher rising with increasing disease duration  [2]. Mechanisms resulting in increased seizure risk are not fully understood. Seizures occur at different MS stages, perhaps suggesting different pathophysiology and management approach[3,4]. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - December 26, 2023 Category: Neurology Authors: Emily R. Nurre, Anna Shah, Craig J. Hansen, Catherine Dowling, Smathorn Thakolwiboon, Yang Mao-Draayer, Temenuzhka G. Mihaylova Source Type: research

Utilisation of specialist epilepsy services and antiseizure medication adherence rates in a cohort of people with epilepsy (PWE) accessing emergency care
An epilepsy-related attendance at A&E is associated an increased risk of subsequent death within 6 months. Although further work is required to provide a definitive explanation to account for these findings, in the interim it would seem reasonable that services are designed to ensure timely access and provide support at a time of greatest risk. We aim to determine the frequency of patients accessing specialist neurology services following an epilepsy-related admission/unscheduled care episode and consider ASM adherence at the point of attendance. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - December 26, 2023 Category: Neurology Authors: M Taha, S Hanif, G Dickson, J Todd, D Fyfe, S MacBride-Stewart, R Hassett, AD Marshall, CA Heath Source Type: research

Neurological Autoantibody Prevalence in Chronic Epilepsy: Clinical and Neuropathologic Findings
Seizure is a common symptom of autoimmune encephalitis [1], and in the latest International League Against Epilepsy (ILAE) classifications guideline of epilepsy, immune etiology was listed as one of six etiologies [2]. In recent decades, the term “autoimmune epilepsy” has been increasingly used in publications; however, some are controversial, as “autoimmune epilepsy” has been applied to seizures in the acute phase of immune-mediated encephalitis [3–5]. Epilepsy is a chronic brain disorder that is different from seizures; therefore , some experts emphasize that autoimmune epilepsy should be differentiated from au...
Source: Seizure: European Journal of Epilepsy - December 25, 2023 Category: Neurology Authors: Kui Zhou, Le Zhang, Sisi Shen, Jing-Fang Lin, Jie-Rui Wang, Dong Zhou, Jin-Mei Li, Xiutian Sima Source Type: research

Diffusion Tensor Imaging in Photosensitive and Nonphotosensitive Juvenile Myoclonic Epilepsy
Juvenile myoclonic epilepsy (JME) is an idiopathic epilepsy (IGE) syndrome with well-defined clinical and electrophysiological features. Reflex epileptic mechanisms, such as photosensitivity, are also closely related to the nature of JME and are important for understanding JME pathogenesis [1,2]. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - December 22, 2023 Category: Neurology Authors: Dilan Acar, Emel Ur Ozcelik, Bet ül Baykan, Nerses Bebek, Tamer Demiralp, Ali Bayram Source Type: research

Detection of pathogenic mutations in epilepsy-associated genes does not necessarily mean seizures or SUDEP
Letter to the Editor (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - December 19, 2023 Category: Neurology Authors: Josef Finsterer Tags: Letter to the editor Source Type: research

Optimal duration for recording EEG in children and adolescents- a prospective interventional study
An EEG (electroencephalogram) is crucial for diagnosing, monitoring, and syndromic classification of epilepsy [1]. In individuals experiencing seizures, an epileptiform EEG displaying generalized spike and wave discharges predicts a five-year recurrence risk of 58%, compared to 26% for those with a non-epileptiform EEG [2]. A single 30-minute outpatient EEG reveals interictal epileptiform discharges (IEDs) in 29-56% of epilepsy patients, increasing to 82% with repeated EEGs [3 –5]. The cumulative yield after a second and third EEG following a first unprovoked seizure or newly diagnosed epilepsy is 40-70% [6]. (Source: Se...
Source: Seizure: European Journal of Epilepsy - December 19, 2023 Category: Neurology Authors: Arvinder Wander, Biswaroop Chakrabarty, Sheffali Gulati, Prashant Jauhari, R.M. Pandey, Ashish Upadhyay Source Type: research