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Driving regulations for epilepsy in Europe
: Across Europe, there are differences regarding driving restrictions for patients with epilepsies and seizures. In the light of increasing mobility, knowledge about those different regulations is of high importance for counseling patients, and physicians. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - May 22, 2023 Category: Neurology Authors: Leona M öller, Günter Krämer, Lena Habermehl, Katja Menzler, Susanne Knake Source Type: research

Diagnosis and treatment of late-onset myoclonic epilepsy in Down syndrome (LOMEDS): a systematic review with individual patients ’ data analysis
Down syndrome (DS), caused by chromosome 21 trisomy, is the most common cause of genetic-related intellectual disability. According to recent epidemiological studies, almost 1 in 400-1500 newborns every year is diagnosed with DS. Individuals with DS may present heterogenous clinical pictures, including congenital heart diseases, hypothyroidism, diabetes, obstructive sleep apnea, hearing loss, vision problems, and developmental and behavioral disorders. Several neurological comorbidities can be associated with DS including movement disorders (e.g., myoclonus, parkinsonism, chorea), Alzheimer's Disease (AD), cerebrovascular ...
Source: Seizure: European Journal of Epilepsy - May 20, 2023 Category: Neurology Authors: Clarissa Corniello, Fedele Dono, Giacomo Evangelista, Stefano Consoli, Sibilla De Angelis, Sara Cipollone, Davide Liviello, Gaetano Polito, Sara Melchiorre, Mirella Russo, Alberto Granzotto, Francesca Anzellotti, Marco Onofrj, Astrid Thomas, Stefano L. Se Tags: Review Source Type: research

Simon Shorvon: The idea of epilepsy, a medical and social history of epilepsy
Book Review: Simon Shorvon, The idea of epilepsy, a medical and social history of epilepsy in the modern era (1860-2020), Cambridge: Cambridge University Press, 2023. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - May 19, 2023 Category: Neurology Authors: Markus Reuber Tags: Book review Source Type: research

At home EEG monitoring technologies for people with epilepsy and intellectual disabilities: A scoping review
Conducting electroencephalography in people with intellectual disabilities (PwID) can be challenging, but the high proportion of PwID who experience seizures make it an essential part of their care. To reduce hospital-based monitoring, interventions are being developed to enable high-quality EEG data to be collected at home. This scoping review aims to summarise the current state of remote EEG monitoring research, potential benefits and limitations of the interventions, and inclusion of PwID in this research. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - May 17, 2023 Category: Neurology Authors: Madison Milne-Ives, Jonas Dunn-Henriksen, Lykke Blaabjerg, Brendan Mclean, Rohit Shankar, Edward Meinert Tags: Review Source Type: research

Anti-seizure medication prescription in epilepsy patients in South Korea: A seven-year population-based retrospective cohort study
Epilepsy is a common but serious neurological disease affecting an estimated 50 million people worldwide, with an estimated prevalence of 0.5 –1%.[1] Epileptic seizures are caused by dysfunction of neurons and neuronal networks in the brain and are clinically diagnosed after 2 or more unprovoked seizures or with supporting laboratory data.[2] Anti-seizure medication (ASM) is the most widely used treatment for epilepsy.[3] (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - May 16, 2023 Category: Neurology Authors: Yoonhyuk Jang, Han Sang Lee, Min Sun Kim, Juneyoung Lee, Ki-Young Jung Source Type: research

Long-term analysis of adrenocorticotropic hormone monotherapy for infantile epileptic spasms syndrome with periventricular leukomalacia
Developmental and epileptic encephalopathy often begins with epileptic spasms before 2 years of age. West Syndrome, a type of developmental and epileptic encephalopathy, is characterised by epileptic spasms in clusters, hypsarrhythmia on interictal electroencephalography (EEG), and developmental delay [1]. West Syndrome is also called infantile spasms. In recent years, the International League Against Epilepsy has revised the terminology for the classification and definition of epilepsy for neonates and infants. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - May 15, 2023 Category: Neurology Authors: Ryuki Matsuura, Shin-ichiro Hamano, Yuko Hirata, Rikako Takeda, Hirokazu Takeuchi, Reiko Koichihara, Kenjiro Kikuchi, Akira Oka Source Type: research

Interstitial 6q deletion in a patient presenting with drug-resistant epilepsy and Prader-Willi like phenotype: an electroclinical description with literature review
Microdeletions of chromosome 6q are associated with different phenotypes and, to date, about 100 patients have been described in the literature. Despite the lack of a definite phenotype-genotype correlation, Hopkin et al. proposed a classification according to the location of the deletion in the long arm of chromosome 6: proximal (6q11 –q16), interstitial (6q15–q25), and terminal (6q25-qter) [1–3]. Clinically, patients with interstitial deletions usually show facial and body dysmorphisms, variable degrees of developmental delay, limbs and visceral malformations, and, notably, Prader–Willi (PWS)-like features, inclu...
Source: Seizure: European Journal of Epilepsy - May 14, 2023 Category: Neurology Authors: Gianni Cutillo, Raffaello Bonacchi, Giordano Cecchetti, Anna Bellini, Marco Vabanesi, Alberto Zambon, Maria Grazia Natali Sora, Cristina Baldoli, Ubaldo Del Carro, Fabio Minicucci, Giovanna F. Fanelli, Massimo Filippi Source Type: research

Association between gout and epilepsy in adults – a retrospective cohort study with 244,964 primary care outpatients
Recently there has been a rising interest in the identification of possible risk factors for epilepsies. In the present study, we investigated the potential association between gout and epilepsy in an outpatient cohort in Germany. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - May 11, 2023 Category: Neurology Authors: Corinna Doege, Marie Therese Pfeifer, Mark Luedde, Karel Kostev Source Type: research

Therapeutic drug monitoring and the therapeutic reference range of Levetiracetam for Chinese patients: problems and issues
Epilepsy is a chronic neurological disease and the single most common brain disorder worldwide. It affects individuals of all ages, races, social status, and nations. More than 70 million people have been diagnosed with epilepsy worldwide and nearly 90% of them live in developing regions [1,2]. Approximately, 9 million patients with epilepsy have been reported in China accounting for nearly 20% of the cases worldwide, with an annual growth rate of 40,000 [3]. Antiseizure drugs are the cornerstone of epilepsy treatment. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - May 11, 2023 Category: Neurology Authors: Min Shi, Chenxi Liu, Lien He, Huizheng Wu, Yin Wu Source Type: research

Common genetic epilepsies, pathogenicity of genes/variants, and genetic dependence
The remarks in the letter[1] reveal the authors' deep insight into current challenges in genetic studies. They refer to three critical questions: how to identify the causative genes of common diseases like genetic generalized epilepsy (GGE); how to determine gene-disease associations, especially for some genes with questionable epileptogenic effects such as EFHC1 and CACNA1H; and how to evaluate the pathogenicity of variants in a given gene and their clinical implication, as in the case of variants of SLC2A1 (encoding GLUT1). (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - May 10, 2023 Category: Neurology Authors: Na He, Bin Li, Zhi-Jian Lin, Peng Zhou, Tao Su, Wei-Ping Liao Source Type: research

Association of first anti-seizure medication choice with injuries in older adults with newly diagnosed epilepsy
Anti-seizure medications (ASMs) are commonly prescribed in older adults as the risk of recurrent unprovoked seizures (epilepsy incidence) in the adult population increases exponentially in older age.[1,2] Resultantly, seizure prevalence approximately doubles between age 50 and 80 and commonly co-occurs with other comorbidities such as cerebrovascular or neurodegenerative disease.[3] Older adults may be particularly vulnerable to the side effects of ASMs because of aging-associated metabolic changes. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - May 7, 2023 Category: Neurology Authors: Leah J. Blank, Parul Agarwal, Churl-Su Kwon, Nathalie Jett é Source Type: research

The Prevalence of a False Positive Diagnosis of Epilepsy: A Meta-Analysis
We recently read an article [1] by Yu et al. with great interest and appreciate the author's efforts to address the frequency of false-positive diagnosis of epilepsy. As a healthcare professional working in the field of neurology, I found this review very insightful in revealing the current state of epilepsy misdiagnosis and its potential risks. These findings will help decrease false-positive diagnosis of epilepsy. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - May 5, 2023 Category: Neurology Authors: Takafumi Kubota, Satoshi Kodama, Naoto Kuroda Tags: Letter to the editor Source Type: research

Retrospective Chart Review Study of Use of Cannabidiol (CBD) Independent of Concomitant Clobazam Use in Patients with Lennox-Gastaut Syndrome or Dravet Syndrome
The objective of this retrospective chart review study was to evaluate the seizure reduction, retention, and safety profile of CBD treatment without concomitant clobazam in patients with LGS or DS. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - May 5, 2023 Category: Neurology Authors: Rima Nabbout, Alexis Arzimanoglou, St éphane Auvin, Patrick Berquin, Archana Desurkar, Douglas Fuller, Charlotte Nortvedt, Patrizia Pulitano, Anna Rosati, Victor Soto, Vicente Villanueva, J. Helen Cross Source Type: research

Neural representations of self-perception of voice: An intracortical evoked potential analysis based on an adolescent with right temporal lobe epilepsy
The neural bases for language perception and our own ‘voice have been studied elsewhere using Transcranial Magnetic Stimulation, functional Magnetic Resonance Imaging and Direct Cortical Stimulation. The adaptive importance of recognizing own ‘voice and differentiate it from the others it is the paramount importance since it is related to the abil ity to identify a person. The bilateral middle and superior temporal gyrus (STG), the bilateral inferior frontal gyrus, and right precuneus are involved in person-identity recognition by a vocal sound. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - May 4, 2023 Category: Neurology Authors: Rene Andrade-Machado, Pradeep Javarayee, Jennifer I Koop, Raquel Farias-Moeller, Irene Kim, Sean M Lew Tags: Short communication Source Type: research

Bilateral Tonic Seizures vs. Bilateral Tonic Events in Critically ill Patients: Differences in Semiology
The differential diagnosis of non-epileptic tonic events (NTEs) often includes epileptic tonic seizures (ETS), and is a common reason to order an electroencephalogram (EEG) and brain imaging. Not infrequently, NTEs can be misinterpreted as seizures [1]. Most severe NTEs in critically ill patients are often related to decerebrate or decorticate rigidity in the setting of increased intracranial pressure or a direct result of brainstem injury [2,3]. Differentiating epileptic seizures from movements mimicking seizures and establishing a correct diagnosis can result in significant changes in treatment [4]. (Source: Seizure: Eur...
Source: Seizure: European Journal of Epilepsy - May 4, 2023 Category: Neurology Authors: Roohi Katyal, Takafumi Kubota, Michael De Georgia, Hans O. L üders, Guadalupe Fernandez-Baca Vaca Source Type: research