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Health consequences and daily life modifications in children and adolescents with epilepsy during the COVID-19 pandemic - a systematic review
The novel coronavirus, a virus with a high potential for transmission [1 –3], was responsible for the recent pandemic (severe acute respiratory syndrome coronavirus 2 - SARS-CoV 2), which led to the implementation of social distancing measures around the world to control the virus spread and incidence of new cases [4]. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - April 27, 2023 Category: Neurology Authors: Janise Dal-Pai, Michele Paula Dos Santos, Natalie da Silveira Donida, Matheus Ribeiro Cesarino, Victor Hugo Mid ões Santana de Oliveira, Magda Lahorgue Nunes Source Type: research

Families ’ Knowledge Change in Paediatric Drug Resistant Epilepsy: A Novel Clinic Model
Epilepsy is a chronic condition that impacts over 95,000 Ontarians, of whom approximately 15,000 are children [1]. While most individuals with epilepsy can be treated effectively by a primary care provider or neurologist, an estimated 30% of those diagnosed will end up having drug resistant epilepsy (DRE), which is defined as experiencing seizures that do not respond to treatment with two or more appropriate antiepileptic drugs [2]. These children experience poor quality of life and represent a burden for the healthcare system due to frequent hospital admissions for seizure decompensation [3]. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - April 27, 2023 Category: Neurology Authors: Kregel Michelle, Coulson Sherry, Nabavi Nouri Maryam, Rochelle Sorzano, Andrade Andrea Source Type: research

COVID-19 vaccination uptake in people with epilepsy: Comment
Dear Editor, we would like to share ideas on the publication “COVID-19 vaccination uptake in people with epilepsy in wales [1].” Welsh electronic health records that were linked and anonymously stored in the Secure Anonymized Information Linkage (SAIL) Databank were used in a retrospective population cohort research carried out by Strafford et al. [1]. Ac cording to Strafford et al., vaccination rates were greater for both cohorts among older demographics, women, and residents of less impoverished areas [1]. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - April 26, 2023 Category: Neurology Authors: Amnuay Kleebayoon, Viroj Wiwanitkit Source Type: research

Non-epileptic paroxysmal events at pediatric video-electroencephalography monitoring unit over a 15-year period
Non-epileptic paroxysmal events (NEPEs) are common in pediatric patients and may be misdiagnosed as epileptic seizures. We aimed to study the distribution of NEPEs across age groups and with different comorbidities, and to correlate the patients' presenting symptoms with their final diagnosis after video-EEG. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - April 21, 2023 Category: Neurology Authors: Pinar Yavuz, Ceren Gunbey, Sevilay Karahan, Meral Topcu, Guzide Turanli, Dilek Yalnizoglu Source Type: research

A retrospective multicentric study on the effectiveness of intravenous brivaracetam in seizure clusters: Data from the Italian experience.
Seizure clusters (SC) are episodes of consecutive seizures occurring in a short while, with the patient returning to normal state in the inter-ictal period. Despite several efforts, a consensus to define SC among clinicians and researchers has not yet been reached. Consequently, several definitions of SC have been adopted, namely 3 or more seizures in 24 hours, 2 or more seizures in 24 hours and 2 or more seizures in 6 hours [1]. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - April 19, 2023 Category: Neurology Authors: Niccol ò Orlandi, Giuseppe d'Orsi, Giada Pauletto, Annacarmen Nilo, Luigi Sicurella, Francesca Pescini, Francesca Giglia, Angelo Labate, Angelina Laganà, Rosaria Renna, Salvatore M. Cavalli, Leila Zummo, Mario Coletti Moja, Catello Vollono, Annarita Sab Source Type: research

Gaps in Care Following First Time Seizure in an Underserved Region: A Retrospective Analysis
Epilepsy, one of the most common neurological diseases globally, affects around 50 million persons worldwide. [1] Approximately 80% of persons with epilepsy (PWE) live in low- or middle-income countries. [2] Current practice guidelines from the United Kingdom (UK) state that adult patients presenting with a single seizure should be seen by an epileptologist within four weeks of a first time seizure (FTS), which may be logistically challenging to implement in the United States. [3] The period following the initial seizure is time-sensitive, given that the length of seizure freedom following a FTS is inversely proportional t...
Source: Seizure: European Journal of Epilepsy - April 19, 2023 Category: Neurology Authors: Christopher Jenkins, Andrew Cabrera, Daniel M. Goldenholz, Travis Losey, Nancy A. Baker, Molly Estes, Charles M. Casassa Source Type: research

Circadian rhythm of blood pressure in patients with drug-resistant mesial temporal lobe epilepsy
Interictal autonomic dysfunction in patients with epilepsy (PWE) has been evaluated mainly at the cardiovascular level, with heart rate variability being the most studied parameter and alterations observed mainly in patients with temporal lobe epilepsy (TLE), Dravet syndrome and drug-resistant epilepsies [1]. Despite the fact that there have been some studies that have evaluated ictal and periictal blood pressure (BP) in PWE [2 –4], interictal BP and the possible alteration of its central control have not been widely evaluated: the prevalence of hypertension in PWE is similar to that in the general population [5]. (Sourc...
Source: Seizure: European Journal of Epilepsy - April 13, 2023 Category: Neurology Authors: Alejandro Viloria-Alebesque, Elena Bellosta-Diago, Mar ía Pilar Navarro-Pérez, Sonia Santos-Lasaosa, José Ángel Mauri-Llerda Source Type: research

Personalized seizure detection using logistic regression machine learning based on wearable ECG-monitoring device.
Wearable seizure detection devices alerting patients, caregivers and family of patients with epilepsy represent a vital asset for patients with intractable epilepsy, who have uncontrolled and unpredictable seizures[1]. In clinical practice reporting of the seizure frequency of the individual patient relies on seizure diaries logged by the patients or caregivers, however these are highly unreliable as more than half of seizures go unnoticed by the patients[2]. The erroneous seizure counts both leads to under and over prescription of anti-seizure drugs and furthermore bias clinical assessment of efficacy of anti-seizure drug...
Source: Seizure: European Journal of Epilepsy - April 13, 2023 Category: Neurology Authors: Jesper Jeppesen, Jakob Christensen, Peter Johansen, S ándor Beniczky Source Type: research

Developmental and/or Epileptic Encephalopathy with Spike-and-Wave Activation in Sleep in Saudi Arabia: Electroclinical, Etiologic, Genetic, and Outcome Multicenter Study
As per the International League Against Epilepsy (ILAE), the continuum of developmental and/or epileptic encephalopathy with spike-and-wave activation in sleep (D/EE-SWAS) is characterized by seizures, specific electroencephalogram (EEG) patterns with dominant slow-sleep activation of interictal discharges, and marked stagnation or regression of neuropsychological function. [1] The EEG pattern associated with D/EE-SWAS was first qualified as electrical status epilepticus during sleep and was studied by selecting patients with at least 85% spike and wave index (SWI) during non-rapid eye movement (REM) sleep. (Source: Seizur...
Source: Seizure: European Journal of Epilepsy - April 13, 2023 Category: Neurology Authors: Hanin Alsini, Abdulaziz Alghamdi, Shatha Alshafi, Khalid Hundallah, Sameer Almehmadi, Daad Alsowat, Suad Al-Yamani, Hanin Almuzaini, Ali Alwadie, Ali Al-Otaibi, Lamyaa Jad, Asma Almadhi, Fahad Bashiri, Amal Kentab, Muddathir H Hamad, Duaa Baarmah, Mohamme Source Type: research

Analysing patient-generated data to understand behaviours and characteristics of women with epilepsy of childbearing years: A prospective cohort study
Approximately 40% of all women with epilepsy (WWE) are of childbearing age and WWE account for 0.5% of all pregnancies [1,2]. Consequently, epilepsy is often considered as the most common neurological disorder requiring medical treatment during pregnancy [1,3,4]. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - April 11, 2023 Category: Neurology Authors: Shang-Ming Zhou, Brendan McLean, Elis Roberts, Rebecca Baines, Peter Hannon, Samantha Ashby, Craig Newman, Arjune Sen, Ellen Wilkinson, Richard Laugharne, Rohit Shankar Source Type: research

Minimum effective sodium valproate dose in genetic generalized epilepsies
Sodium valproate (VPA) is usually regarded as the best available antiseizure medication (ASM) in generalized genetic epilepsies (GGEs), such as juvenile myoclonic epilepsy (JME), juvenile absence epilepsy (JAE), epilepsy with generalized tonic ‒clonic seizures alone (GTCA), and epilepsy with eyelid myoclonia (EEM), with the potential to control all seizure types present in these epilepsy syndromes [1,2,3]. Compared with currently used ASMs, VPA showed superiority in controlling myoclonic (MS) and generalized tonic‒clonic seizures (GTC S) and a reasonable effect in absence seizures (AS) [2,3,4]. (Source: Seizure: Europe...
Source: Seizure: European Journal of Epilepsy - April 7, 2023 Category: Neurology Authors: Vanessa Dinis Marques, B árbara Amorim Hackbart, Laura Maria Guilhoto, Jeana Torres Corso Duarte, Jose Eduardo Peixoto-Santos, Elza Márcia Targas Yacubian, Mirian S. Bittar Guaranha Source Type: research

Automated spike and seizure detection: are we ready for implementation?
: Automated detection of spikes and seizures has been a subject of research for several decades now. There have been important advances, yet automated detection in EMU (Epilepsy Monitoring Unit) settings has not been accepted as standard practice. We intend to implement this software at our EMU and so carried out a qualitative study to identify factors that hinder ( ‘barriers’) and facilitate (‘enablers’) implementation. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - April 7, 2023 Category: Neurology Authors: E.E.M. Reus, G.H. Visser, M.P.J. Sommers-Spijkerman, J.G. van Dijk, F.M.E. Cox Source Type: research

‘A Rollercoaster of Emotions’: Reflections on Growing Up with Epilepsy in Ireland
Childhood epilepsy has life-long effects that extend beyond the disruption attributed to seizure activity [1,2]. These effects have been investigated using proxy reports typically from parents [3], quantitative assessments of quality of life [4 –6] and qualitative methods eliciting children's self-reported lived experience [7–14]. These studies evidence the negative impact epilepsy has on children's independence, school performance and relationships with peers. Retrospective qualitative research has captured the experiences of adults w ith epilepsy coming to terms with their diagnosis, some during childhood [15] but, t...
Source: Seizure: European Journal of Epilepsy - April 6, 2023 Category: Neurology Authors: Clara Sherlock, Christine Linehan, Cathy Madigan, Michelle Downes Source Type: research

EA2 and temporal lobe epilepsy associated with a novel variant in CACNA1A
A 19-year-old man was born at term after an unremarkable pregnancy and had nearly normal psychomotor development, but he had a history of poor school performance with mild learning difficulties in elementary school. He had no family history of neurological disease. He had suffered from episodes of mild dizziness and gait disturbance for a few minutes monthly since 13 years of age, but no abnormalities were found on brain MRI at the age of 14 years (Supplementary Figure 1A). At 17 years of age, he was hospitalized for recurrent focal impaired awareness seizures. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - April 5, 2023 Category: Neurology Authors: Xi Lu, Xufang Xie Tags: Clinical letter Source Type: research

Neurocysticercosis-related Seizures: Imaging Biomarkers
Neurocysticercosis (NCC) —a parasitic CNS infection endemic to developing nations—has been called the leading global cause of acquired epilepsy yet remains understudied. It is currently unknown why a large proportion of patients develop recurrent seizures, often following the presentation of acute seizures. Furthermore, the presentation of NCC is heterogenous and the features that predispose to the development of an epileptogenic state remain uncertain. Perilesional factors (such as oedema and gliosis) have been implicated in NCC-related ictogenesis, but the effects of cystic factors, including lesion load and loc atio...
Source: Seizure: European Journal of Epilepsy - April 5, 2023 Category: Neurology Authors: Corey Ratcliffe, Guleed Adan, Anthony Marson, Tom Solomon, Jitender Saini, Sanjib Sinha, Simon S. Keller Tags: Review Source Type: research