Gaps in Care Following First Time Seizure in an Underserved Region: A Retrospective Analysis
Epilepsy, one of the most common neurological diseases globally, affects around 50 million persons worldwide. [1] Approximately 80% of persons with epilepsy (PWE) live in low- or middle-income countries. [2] Current practice guidelines from the United Kingdom (UK) state that adult patients presenting with a single seizure should be seen by an epileptologist within four weeks of a first time seizure (FTS), which may be logistically challenging to implement in the United States. [3] The period following the initial seizure is time-sensitive, given that the length of seizure freedom following a FTS is inversely proportional t...
Source: Seizure: European Journal of Epilepsy - April 19, 2023 Category: Neurology Authors: Christopher Jenkins, Andrew Cabrera, Daniel M. Goldenholz, Travis Losey, Nancy A. Baker, Molly Estes, Charles M. Casassa Source Type: research

Circadian rhythm of blood pressure in patients with drug-resistant mesial temporal lobe epilepsy
Interictal autonomic dysfunction in patients with epilepsy (PWE) has been evaluated mainly at the cardiovascular level, with heart rate variability being the most studied parameter and alterations observed mainly in patients with temporal lobe epilepsy (TLE), Dravet syndrome and drug-resistant epilepsies [1]. Despite the fact that there have been some studies that have evaluated ictal and periictal blood pressure (BP) in PWE [2 –4], interictal BP and the possible alteration of its central control have not been widely evaluated: the prevalence of hypertension in PWE is similar to that in the general population [5]. (Sourc...
Source: Seizure: European Journal of Epilepsy - April 13, 2023 Category: Neurology Authors: Alejandro Viloria-Alebesque, Elena Bellosta-Diago, Mar ía Pilar Navarro-Pérez, Sonia Santos-Lasaosa, José Ángel Mauri-Llerda Source Type: research

Personalized seizure detection using logistic regression machine learning based on wearable ECG-monitoring device.
Wearable seizure detection devices alerting patients, caregivers and family of patients with epilepsy represent a vital asset for patients with intractable epilepsy, who have uncontrolled and unpredictable seizures[1]. In clinical practice reporting of the seizure frequency of the individual patient relies on seizure diaries logged by the patients or caregivers, however these are highly unreliable as more than half of seizures go unnoticed by the patients[2]. The erroneous seizure counts both leads to under and over prescription of anti-seizure drugs and furthermore bias clinical assessment of efficacy of anti-seizure drug...
Source: Seizure: European Journal of Epilepsy - April 13, 2023 Category: Neurology Authors: Jesper Jeppesen, Jakob Christensen, Peter Johansen, S ándor Beniczky Source Type: research

Developmental and/or Epileptic Encephalopathy with Spike-and-Wave Activation in Sleep in Saudi Arabia: Electroclinical, Etiologic, Genetic, and Outcome Multicenter Study
As per the International League Against Epilepsy (ILAE), the continuum of developmental and/or epileptic encephalopathy with spike-and-wave activation in sleep (D/EE-SWAS) is characterized by seizures, specific electroencephalogram (EEG) patterns with dominant slow-sleep activation of interictal discharges, and marked stagnation or regression of neuropsychological function. [1] The EEG pattern associated with D/EE-SWAS was first qualified as electrical status epilepticus during sleep and was studied by selecting patients with at least 85% spike and wave index (SWI) during non-rapid eye movement (REM) sleep. (Source: Seizur...
Source: Seizure: European Journal of Epilepsy - April 13, 2023 Category: Neurology Authors: Hanin Alsini, Abdulaziz Alghamdi, Shatha Alshafi, Khalid Hundallah, Sameer Almehmadi, Daad Alsowat, Suad Al-Yamani, Hanin Almuzaini, Ali Alwadie, Ali Al-Otaibi, Lamyaa Jad, Asma Almadhi, Fahad Bashiri, Amal Kentab, Muddathir H Hamad, Duaa Baarmah, Mohamme Source Type: research

Analysing patient-generated data to understand behaviours and characteristics of women with epilepsy of childbearing years: A prospective cohort study
Approximately 40% of all women with epilepsy (WWE) are of childbearing age and WWE account for 0.5% of all pregnancies [1,2]. Consequently, epilepsy is often considered as the most common neurological disorder requiring medical treatment during pregnancy [1,3,4]. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - April 11, 2023 Category: Neurology Authors: Shang-Ming Zhou, Brendan McLean, Elis Roberts, Rebecca Baines, Peter Hannon, Samantha Ashby, Craig Newman, Arjune Sen, Ellen Wilkinson, Richard Laugharne, Rohit Shankar Source Type: research