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Real-world experience with cannabidiol as add-on treatment in drug-resistant epilepsy
To evaluate the efficacy and safety of cannabidiol (CBD) for the treatment of epilepsy in a real-world setting. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - July 15, 2023 Category: Neurology Authors: Vicino Walter, Muccioli Lorenzo, Pondrelli Federica, Licchetta Laura, Stipa Carlotta, Mostacci Barbara, Di Vito Lidia, Ferri Lorenzo, Cancellerini Chiara, Sold à Martina, Tinuper Paolo, Bisulli Francesca Source Type: research

Focus disconnection of the SEEG-identified epileptic network by radiofrequency thermal coagulation
Coagulating much of the epileptogenic lesion (EL) is a favorable prognostic factor for radiofrequency thermocoagulation (RFTC) for focal epilepsy [1]. However, trajectory limitations exist due to the risk of brain tissue and vascular injury around coagulated lesions. It is sometimes challenging to coagulate the entire focus when the EL is large and/or extends over the eloquent area. We propose an RFTC focal disconnection technique that minimizes the number of lesions and trajectories through stereoelectroencephalography (SEEG) monitoring and cortical stimulation mapping (CSM) to estimate the abnormal network consisting of ...
Source: Seizure: European Journal of Epilepsy - July 13, 2023 Category: Neurology Authors: Tomotaka Ishizaki, Satoshi Maesawa, Hiroyuki Yamamoto, Miki Hashida, Manabu Mutoh, Yoshiki Ito, Takafumi Tanei, Jun Natsume, Ryuta Saito Source Type: research

Physical exercise for children and adolescents with epilepsy: what have we learned?
A growing number of studies has demonstrated the beneficial effect of regular exercise in individuals with epilepsy, including reduction in seizure frequency and severity, as well as better health and psychosocial benefits [1 –3]. To date, clinical and experimental investigations have shown the mechanisms of these positive effects. A previous review highlights the impact of physical activity on epilepsy in both human and animal studies [4]. However, there is no extensive literature demonstrating the impact of physical exercise or sport activities in children/adolescents with epilepsy. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - July 11, 2023 Category: Neurology Authors: Ricardo Mario Arida, Lavinia Teixeira-Machado Tags: Review Source Type: research

Mortality among persons with epilepsy in onchocerciasis-endemic and non-endemic areas of sub-Saharan Africa: A systematic review and meta-analysis
Epilepsy is among the most prevalent neurological diseases globally, with a greater burden of disease in low- and middle-income countries (LMICs) compared to high-income countries (HICs) [1]. Mortality among persons with epilepsy (PWE) is also significantly higher than in the general population, with standardised mortality ratios (SMRs) reaching 3.0 in HICs and19.8 in LMICs [1]. Although sub-Saharan Africa (SSA) is particularly affected by epilepsy, data on epilepsy mortality remain scarce in most SSA countries. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - July 10, 2023 Category: Neurology Authors: Joseph Nelson Siewe Fodjo, Gilles Van Cutsem, Lu ís-Jorge Amaral, Robert Colebunders Source Type: research

A case-control evaluation of Spasm control and Tolerability of the Modified Atkins diet versus classic ketogenic diet in Chinese Children with infantile epileptic spasms syndrome
Infantile epileptic spasms syndrome, as an age- specific epileptic encephalopathy, is characterized by clustering spasms, electrographic hypsarrhythmia, and frequent developmental regression [1]. However, there are limited available therapies that have proven to be beneficial for this medical condition. The proposed first-line treatment options are adrenocorticotropic hormone (ACTH), oral corticosteroids, or vigabatrin, while any other treatments are less effective or lack proper evidence for their use [1 –3]. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - July 6, 2023 Category: Neurology Authors: Xiangjun Dou, Shanshan Jia, Zhijing Wang, Yan Wang, Fang Wu, Yan Wu, Mengmeng Niu, Xia Li, Dong Wang Source Type: research

Efficacy and safety of perampanel monotherapy in patients with focal-onset seizures:a real-world experience in eastern China
Epilepsy is one of the most common neurological diseases which affects approximately 70 million people worldwide each year. So far, the anti-seizure medications (ASMs) are still the first choice for epilepsy. In the last few years, more and more epileptologists chose newer ASMs such as perampanel (PER) monotherapy for prescription in patients with focal-onset seizure. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - July 5, 2023 Category: Neurology Authors: Sha Xu, Zheng-yan-ran Xu, Yuanyuan Zheng, Pu Miao, Jianhua feng, Yi Guo Source Type: research

Ipsilateral preictal alpha rhythm attenuation (IPARA): an EEG sign of side of seizure onset in temporal lobe epilepsy
Identification of the seizure onset zone is critically important for outlining the surgical plan in the treatment of pharmacoresistant focal epilepsy. In patients with temporal lobe epilepsy (TLE), bilateral ictal scalp EEG changes frequently occur and can make lateralization of the seizure onset zone difficult. We investigated the incidence and clinical utility of unilateral preictal alpha rhythm attenuation as a lateralizing sign of seizure onset in TLE. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - July 5, 2023 Category: Neurology Authors: Arezoo Rezazadeh, Esther Bui, Richard A Wennberg Source Type: research

Real-world safety of Lacosamide: A pharmacovigilance study based on spontaneous reports in the FDA Adverse Event Reporting System
One of the most prevalent neurological disorders, epilepsy is a temporary brain malfunctioning condition that poses a major risk to people's health and quality of life. It is defined by varying degrees of sensory, motor, behavioral, and autonomic nerve seizure abnormalities [1]. According to statistics, epilepsy affects more than 50 million people worldwide, including tens of millions of sufferers in China [2]. A number of factors, including genetics, blood-brain barrier damage, gene alterations, cellular pathway activation or inhibition, and immunological dysregulation, may contribute to the complex pathophysiology of epi...
Source: Seizure: European Journal of Epilepsy - July 4, 2023 Category: Neurology Authors: Pengcheng Liu, Mengjiao He, Xiaoli Xu, Yun He, Wenbing Yao, Bin Liu Source Type: research

Genetics and SUDEP: Challenges and Future Directions
Sudden unexpected death in epilepsy (SUDEP) is an important cause of premature mortality in persons living with epilepsy (PWE) [1 –2]. The incidence of SUDEP in children and adults is equal, approximately 1.2 per 1000-person years [3–5]. SUDEP is the leading cause of epilepsy-related deaths in children and adults with epilepsy [1–2]. Furthermore, next to stroke, SUDEP is the second leading cause of total years of potenti al life lost [6–7]. Although inroads have been made in our understanding of SUDEP, its pathophysiology remains unknown. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - July 2, 2023 Category: Neurology Authors: Robyn Whitney, Suvasini Sharma, Kevin C. Jones, Rajesh RamachandranNair Tags: Review Source Type: research

Changes in awake and sleep electroencephalography characteristics after 1-year treatment for childhood and juvenile absence epilepsy
Childhood absence epilepsy (CAE) and juvenile absence epilepsy (JAE) are well-defined syndromes with absence seizures being the predominant type among the four idiopathic generalized epilepsies (IGEs).[1] CAE and JAE show some degree of overlap regarding age at onset, electroencephalography (EEG) features, and seizure types; however, they are considered distinct IGE subgroups with different prognostic and therapeutic implications.[2,3] They are characterised by typical absence seizures in otherwise healthy children. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - June 30, 2023 Category: Neurology Authors: Selvinaz Edizer, Bahar Toklu Baysal, Aycan Ünalp, Ünsal Yılmaz Source Type: research

Use of video alone for differentiation of epileptic seizures from non-epileptic spells: A Systematic Review and Meta-analysis
Epilepsy is one of the most common neurological disorders, with an estimated prevalence of 45.9 million worldwide.[1] Non-epileptic spells (NES) are episodic events that can present with symptoms similar to epileptic seizures (ES) but are not associated with abnormal electrical activity.[2,3] NES often refers to all events that are not epileptic seizures, including functional seizures (psychogenic non-epileptic spells, PNES) and other non-functional events such as syncope, migraine, sleep abnormalities, movement disorders. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - June 29, 2023 Category: Neurology Authors: Cemal Karakas, Liam D. Ferreira, Zulfi Haneef Source Type: research

Disparities in Adherence and Emergency Department Utilization Among People with Epilepsy: A Machine Learning Approach
Epilepsy is a complex neurological condition with a wide array of health and social complications including several comorbid health conditions, lower education and income, and an overall lower reported quality of life. [1 –7] Ultimately, these complications contribute to an increased risk for poor health outcomes. [8–17] While these outcomes are documented across all people living with epilepsy, there are also disparities for specific populations of people with epilepsy, including racial and ethnic minoritized po pulations. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - June 27, 2023 Category: Neurology Authors: Wyatt P. Bensken, Guadalupe Fernandez-Baca Vaca, Scott M. Williams, Omar I. Khan, Barbara C. Jobst, Kurt C. Stange, Martha Sajatovic, Siran M. Koroukian Source Type: research

Dissociation in Patients with Epilepsy and Functional Seizures: A Narrative Review of the Literature
Historically, dissociation has been difficult to describe and assess. In the late 1800 ’s, functional seizures, dissociative phenomena, ictal symptoms, as well as other difficult-to-explain presentations were grouped together under the term “hysteria” and were famously studied by French neurologist Jean- Martin Charcot [1]. Today, what was formerly called hysteria is seen as dis tinct disorders ranging from DSM-5 dissociative disorders and functional neurological symptom disorder (conversion disorder) to complex sensory changes now recognized as ictal phenomena. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - June 24, 2023 Category: Neurology Authors: Maureen Cassady, Gaston Baslet Tags: Review Source Type: research

The photoparoxysmal response belongs to the spectrum of electroencephalographic findings in patients with triple X syndrome and epilepsy
Dear Editor, (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - June 23, 2023 Category: Neurology Authors: E. Bartolini, L Baldini, F Casolaro, A Perruzza, R Pieri, AR Ferrari Tags: Letter to the editor Source Type: research

“The photoparoxysmal response belongs to the spectrum of electroencephalographic findings in patients with triple X syndrome and epilepsy”
Dear Editor, (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - June 23, 2023 Category: Neurology Authors: E. Bartolini, L Baldini, F Casolaro, A Perruzza, R Pieri, AR Ferrari Source Type: research