Diagnosis and treatment of late-onset myoclonic epilepsy in Down syndrome (LOMEDS): a systematic review with individual patients ’ data analysis

Down syndrome (DS), caused by chromosome 21 trisomy, is the most common cause of genetic-related intellectual disability. According to recent epidemiological studies, almost 1 in 400-1500 newborns every year is diagnosed with DS. Individuals with DS may present heterogenous clinical pictures, including congenital heart diseases, hypothyroidism, diabetes, obstructive sleep apnea, hearing loss, vision problems, and developmental and behavioral disorders. Several neurological comorbidities can be associated with DS including movement disorders (e.g., myoclonus, parkinsonism, chorea), Alzheimer's Disease (AD), cerebrovascular disease (e.g., Moya-Moya disease), and epilepsy.

Source: Seizure: European Journal of Epilepsy - May 20, 2023 Category: Neurology Authors: Clarissa Corniello, Fedele Dono, Giacomo Evangelista, Stefano Consoli, Sibilla De Angelis, Sara Cipollone, Davide Liviello, Gaetano Polito, Sara Melchiorre, Mirella Russo, Alberto Granzotto, Francesca Anzellotti, Marco Onofrj, Astrid Thomas, Stefano L. Se Tags: Review Source Type: research