Increased Belief Instability in Psychotic Disorders Predicts Treatment Response to Metacognitive Training
ConclusionsOur results point towards increased belief instability as a key computational mechanism underlying probabilistic reasoning in psychotic disorders. We provide a proof-of-concept that this computational approach may be useful to help identify suitable treatments for individual patients with psychotic disorders. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - May 26, 2022 Category: Psychiatry Source Type: research
Hierarchical Symptom Components in Early Psychosis
ConclusionsThe hierarchical structure of psychotic symptomatology and its external validity have been robustly established in independent, longitudinal first-episode psychosis samples. The established model incorporates multiple levels of granularity that can be flexibly applied based on the level that offers the greatest predictive utility for external validators. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - May 26, 2022 Category: Psychiatry Source Type: research
Probiotics Plus Dietary Fiber Supplements Attenuate Olanzapine-Induced Weight Gain in Drug-Na ïve First-Episode Schizophrenia Patients: Two Randomized Clinical Trials
ConclusionsThese results provide support for the efficacy and safety of probiotics plus dietary fiber in attenuating antipsychotic-induced weight gain in drug-na ïve, first-episode schizophrenia patients. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - May 15, 2022 Category: Psychiatry Source Type: research
Comparative Effectiveness of Antipsychotics in Preventing Readmission for First-Admission Schizophrenia Patients in National Cohorts From 2001 to 2017 in Taiwan
ConclusionsThe use of LAIs after the first admission for schizophrenia has notable advantages in preventing readmission. Such formulations should be offered earlier in the course of illness. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - May 15, 2022 Category: Psychiatry Source Type: research
Graph Convolutional Networks Reveal Network-Level Functional Dysconnectivity in Schizophrenia
ConclusionsThe present study demonstrates that GCN allows classification of schizophrenia at the individual level with high accuracy, indicating a promising direction for detection of individual patients with schizophrenia. Functional topological deficits of striatal areas may represent a focal neural deficit of negative symptomatology in schizophrenia. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - May 15, 2022 Category: Psychiatry Source Type: research
Maintenance Treatment With Antipsychotic Drugs in Schizophrenia: A Cochrane Systematic Review and Meta-analysis
AbstractAntipsychotic drugs are the mainstay of treatment of schizophrenia, and are known to reduce acute symptoms of the disorder. An original version of the current review, published in 2012, examined whether antipsychotics are effective for relapse prevention, compared to withdrawing these agents for people with schizophrenia or schizophrenia-like psychoses, based on evidence from randomized trials. The current report of the update of the review is focused on some newly investigated outcomes: rates of remission and recovery, change in social functioning and in quality of life. The updated review included 75 randomized c...
Source: Schizophrenia Bulletin - May 12, 2022 Category: Psychiatry Source Type: research
Comparison of Acute Followed by Maintenance ECT vs Clozapine on Psychopathology and Regional Cerebral Blood Flow in Treatment-Resistant Schizophrenia: A Randomized Controlled Trial
ConclusionsAcute followed by M-ECT was more effective than clozapine over 6 months in reducing the positive and negative symptoms, general psychopathology, illness-severity, and improving the global functionality in TRS [clinicaltrials.gov: NCT03807882]. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - May 12, 2022 Category: Psychiatry Source Type: research
Choosing an Optimal Antipsychotic Dose for Relapse Prevention
Taipale et al.1 (this issue) investigated optimal antipsychotic dose for the maintenance treatment of schizophrenia by linking the Hospital Discharge registry of Finland with the prescription register 1995 to 2017 from which they estimated dose for each prescribing period classified in the WHO Defined Daily Dose (DDD) categories<0.6, 0.6 –0.9, 0.9–1.1, 1.1–1.4, 1.4–1.6, ≥1.6. The DDD was developed as a tool for drug utilization research that reflects common doses used to treat schizophrenia with 1 DDD unit being an average dose (eg, 10 mg olanzapine is 1 DDD unit, 0.6 DDD is 6 mg, 1.6 DDD is 16 mg). The DDD co...
Source: Schizophrenia Bulletin - May 10, 2022 Category: Psychiatry Source Type: research
Optimal Doses of Specific Antipsychotics for Relapse Prevention in a Nationwide Cohort of Patients with Schizophrenia
ConclusionsFor most antipsychotics, the risk of severe relapse was the lowest during use of standard dose. Our results suggest that olanzapine LAI is highly effective in dose ranges>0.9 DDD/day, and especially at 1.4 –<1.6 DDDs/day (405 mg/4 weeks) associated with substantially lower risk of rehospitalization than any dose of any other antipsychotic. The current WHO standard dose definitions appear to be clearly too high for perphenazine and somewhat too high for risperidone. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - May 7, 2022 Category: Psychiatry Source Type: research
The Important Role of Motivation and Pleasure Deficits on Social Functioning in Patients With Schizophrenia: A Network Analysis
This study is among the few which used network analysis and the CAINS to examine the interrelationship between negative symptoms and social functioning. Our findings supported the pivotal role of the MAP factor to determine SCZ patients’ social functioning, and as a potential intervention target for improving functional outcomes of SCZ. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - May 7, 2022 Category: Psychiatry Source Type: research
Correction to: Anandamide Hydrolysis Inhibition Reverses the Long-Term Behavioral and Gene Expression Alterations Induced by MK-801 in Male Rats: Differential CB1 and CB2 Receptor-Mediated Effects
Correction to “Anandamide Hydrolysis Inhibition Reverses the Long-Term Behavioral and Gene Expression Alterations Induced by MK-801 in Male Rats: Differential CB1 and CB2 Receptor-Mediated Effects” by Bauminger et al., Schizophr Bull, 2022, sbab153, doi:10.1093/schbul/sbab153 (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - May 6, 2022 Category: Psychiatry Source Type: research
Deletion of Schizophrenia Susceptibility Gene Ulk4 Leads to Abnormal Cognitive Behaviors via Akt-GSK-3 Signaling Pathway in Mice
ConclusionsOur data identified potential downstream signaling pathway of Ulk4, which plays important roles in the cognitive functions and when defective, may promote SCZ-like pathogenesis and behavioral phenotypes in mice. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - May 6, 2022 Category: Psychiatry Source Type: research
Movement Disorders and Mortality in Severely Mentally Ill Patients: The Curacao Extrapyramidal Syndromes Study XIV
ConclusionsParkinsonism may be an important risk factor for mortality in SMI patients. This finding calls for more follow-up and intervention studies to confirm this finding and to explore whether treatment or prevention of parkinsonism can reduce excess mortality. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - April 29, 2022 Category: Psychiatry Source Type: research
The Time is Ripe for a Consensus Definition of Clinical Recovery in First-episode Psychosis: Suggestions Based on a 10-Year Follow-up Study
ConclusionsFindings suggest that clinical recovery is common in FEP, although more in bipolar than in schizophrenia spectrum disorders, also when altering the recovery criteria. We call for a future consensus definition of clinical recovery for FEP, and suggest it should include affective symptom remission and more reasonable criteria for functioning that are more in line with the general population. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - April 14, 2022 Category: Psychiatry Source Type: research
Central Oxidative Stress and Early Vocational Outcomes in First Episode Psychosis: A 7-Tesla Magnetic Resonance Spectroscopy Study of Glutathione
ConclusionOur observations support a key role for the central antioxidant tone in the functional outcomes of early psychosis. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - March 21, 2022 Category: Psychiatry Source Type: research
