Erratum to: A Matter of Choice?
Erratum to “A Matter of Choice?” by Robert Francis. Schizophr Bull. 2020; doi:10.1093/schbul/sbaa050. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - April 30, 2020 Category: Psychiatry Source Type: research
Evidence for Altered Metabolism of Sphingosine-1-Phosphate in the Corpus Callosum of Patients with Schizophrenia
AbstractThe disturbed integrity of myelin and white matter, along with dysregulation of the lipid metabolism, may be involved in schizophrenia pathophysiology. Considering the crucial role of sphingolipids in neurodevelopment, particularly in oligodendrocyte differentiation and myelination, we examined the role of sphingolipid dynamics in the pathophysiology of schizophrenia. We performed targeted mass spectrometry-based analysis of sphingolipids from the cortical area and corpus callosum of postmortem brain samples from patients with schizophrenia and controls. We observed lower sphingosine-1-phosphate (S1P) levels, speci...
Source: Schizophrenia Bulletin - April 29, 2020 Category: Psychiatry Source Type: research
Striatal Dopamine and Reward Prediction Error Signaling in Unmedicated Schizophrenia Patients
In this study, we investigated striatal dopamine synthesis capacity, reward prediction errors, and their association in unmedicated schizophrenia patients (n = 19) and healthy controls (n = 23). They took part in FDOPA-PET and underwent functional magnetic resonance imaging (fMRI) scanning, where they performed a reversal-learning paradigm. The groups were compared regarding dopamine synthesis capacity (Kicer), fMRI neural prediction error signals, and the correlation of both. Patients did not differ from controls with respect to striatal Kicer. Taking into account, comorbid alcohol abuse revealed that patients without suc...
Source: Schizophrenia Bulletin - April 22, 2020 Category: Psychiatry Source Type: research
Sex Differences in Verbal Memory Predict Functioning Through Negative Symptoms in Early Psychosis
This study highlights the importance of investigating sex effects for understanding VM deficits in early psychosis and suggests that sex may be a disease-modifying variable with important treatment implications. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - April 20, 2020 Category: Psychiatry Source Type: research
Real-World Clinical Outcomes Two Years After Transition to Psychosis in Individuals at Clinical High Risk: Electronic Health Record Cohort Study
The objective of this study is to describe the 2-year real-world clinical outcomes after transition to psychosis in patients at clinical high-risk. The study used the clinical electronic health record cohort study including all patients receiving a first index primary diagnosis of nonorganic International Classification of Diseases (ICD)-10 psychotic disorder within the early psychosis pathway in the South London and Maudsley (SLaM) National Health Service (NHS) Trust from 2001 to 2017. Outcomes encompassed: cumulative probability (at 3, 6, 12, and 24 months) of receiving a first (1) treatment with antipsychotic, (2) infor...
Source: Schizophrenia Bulletin - April 18, 2020 Category: Psychiatry Source Type: research
Overlapping but Asymmetrical Relationships Between Schizophrenia and Autism Revealed by Brain Connectivity
In conclusion, using the 2 biological dimensions based on resting-state functional connectivity enabled us to discover the quantified relationships between SSD and ASD. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - April 17, 2020 Category: Psychiatry Source Type: research
Identifying 5 Common Psychiatric Disorders Associated Chemicals Through Integrative Analysis of Genome-Wide Association Study and Chemical-Gene Interaction Datasets
This study aims to systematically explore the potential relationships between 5 major psychiatric disorders and more than 11 000 chemicals. The genome-wide association studies (GWAS) datasets of attention deficiency/hyperactive disorder (ADHD), autism spectrum disorder (ASD), bipolar disorder (BD), major depression disorder (MDD), and schizophrenia (SCZ) were driven from the Psychiatric GWAS Consortium and iPSYCH website. The chemicals related gene sets were obtained from the comparative toxicogenomics database (CTD). First, transcriptome-wide association studies (TWAS) were performed by FUSION to calculate the expression ...
Source: Schizophrenia Bulletin - April 15, 2020 Category: Psychiatry Source Type: research
Ethnicity-Dependent Effects of Schizophrenia Risk Variants of the OLIG2 Gene on OLIG2 Transcription and White Matter Integrity
AbstractPrevious studies have indicated associations between severalOLIG2 gene single-nucleotide polymorphisms (SNPs) and susceptibility to schizophrenia among Caucasians. Consistent with these findings, postmortem brain and diffusion tensor imaging studies have indicated that the schizophrenia-risk-associated allele (A) in theOLIG2 SNP rs1059004 predicts lowerOLIG2 gene expression in the dorsolateral prefrontal cortex (DLPFC) of schizophrenia patients and reduced white matter (WM) integrity of the corona radiata in normal brains among Caucasians. In an effort to replicate the association between this variant and WM integr...
Source: Schizophrenia Bulletin - April 14, 2020 Category: Psychiatry Source Type: research
A Matter of Choice?
The day was off to a terrific start. I got a lot of things done this morning, important things too, and an emotional distill of satisfaction and ease now are my byproducts. But today has just begun. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - April 6, 2020 Category: Psychiatry Source Type: research
Altered Signaling in CB1R-5-HT2AR Heteromers in Olfactory Neuroepithelium Cells of Schizophrenia Patients is Modulated by Cannabis Use
AbstractSchizophrenia (SCZ) has been associated with serotonergic and endocannabinoid systems dysregulation, but difficulty in obtaining in vivo neurological tissue has limited its exploration. We investigated CB1R-5-HT2AR heteromer expression and functionality via intracellular pERK and cAMP quantification in olfactory neuroepithelium (ON) cells of SCZ patients non-cannabis users (SCZ/nc), and evaluated whether cannabis modulated these parameters in patients using cannabis (SCZ/c). Results were compared vs healthy controls non-cannabis users (HC/nc) and healthy controls cannabis users (HC/c). Further, antipsychotic effect...
Source: Schizophrenia Bulletin - April 6, 2020 Category: Psychiatry Source Type: research
Anatomical Dysconnectivity in Psychosis Across the Illness Course: Expanding and Extending the Functional Dysconnectivity Literature
“Thalamocortical anatomical connectivity in schizophrenia and psychotic bipolar disorder” by Sheffield et al1 is a welcome addition to the growing literature on thalamocorticalfunctional dysconnectivity in schizophrenia. Using diffusion-weighted imaging, Sheffield et al1 give anatomical teeth to the functional findings. Furthermore, they expand on the functional literature by studying people with schizophrenia and psychotic bipolar disorder, and go even further, by studying patients who are in the early stages of the disorders. In a set of findings that nicely parallel the functional connectivity data, the authors repo...
Source: Schizophrenia Bulletin - April 1, 2020 Category: Psychiatry Source Type: research
Is Early Blindness Protective of Psychosis or Are We Turning a Blind Eye to the Lack of Statistical Power?
schizophreniablindnessvisioncortical blindnesscongenital blindnesspsychotic disorders (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - March 31, 2020 Category: Psychiatry Source Type: research
Identification of Reproducible BCL11A Alterations in Schizophrenia Through Individual-Level Prediction of Coexpression
This study demonstrates that machine learning can capture gene-specific coexpression differences at the individual subject level for SCZ and identify novel biomarker candidates. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - March 31, 2020 Category: Psychiatry Source Type: research
Thalamocortical Anatomical Connectivity in Schizophrenia and Psychotic Bipolar Disorder
ConclusionsAltered thalamocortical anatomical connectivity, especially reduced PFC-thalamic connectivity, is a transdiagnostic feature of psychosis detectable in the early stage of illness. Further work is required to elucidate the functional consequences of the full spectrum of thalamocortical connectivity abnormalities in psychosis. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - March 27, 2020 Category: Psychiatry Source Type: research
Higher Serum C-Reactive Protein Levels in Catatonic Patients: A Comparison to Non-catatonic Patients and Healthy Controls
AbstractCatatonia is a psychomotor syndrome defined by a constellation of predominantly motor symptoms. The aim of the present study was to determine whether recently admitted psychiatric patients with catatonia exhibited higher serum C-reactive protein (hs-CRP) levels compared to non-catatonic psychiatric patients and healthy controls (HCs). Recently admitted psychiatric patients were screened and evaluated for the catatonia syndrome using the Bush-Francis Catatonia Rating Scale and the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). The study sample was formed by 150 individuals (39 male and...
Source: Schizophrenia Bulletin - March 27, 2020 Category: Psychiatry Source Type: research
