Social Motivation in Schizophrenia: What ’s Effort Got to Do With It?
ConclusionsEBDM is an especially promising framework of social motivation that goes beyond the current focus on social reward processing to include a focus on effort. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - June 24, 2023 Category: Psychiatry Source Type: research

Correction to: The Difficulties of Grandiose Delusions: Harms, Challenges, and Implications for Treatment Engagement
National Institute for Health and Care Research10.13039/501100000272Health Education EnglandICA-CDRF-2016-02-069 (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - June 24, 2023 Category: Psychiatry Source Type: research

Correction to: Heightened COVID-19 Mortality in People With Severe Mental Illness Persists After Vaccination: A Cohort Study of Greater Manchester Residents
ConclusionsPeople with SMI, notably schizophrenia and bipolar disorder, were at greater risk of COVID-19 mortality compared to matched controls. Despite population vaccination efforts that have prioritised people with SMI, disparities still remain in COVID-19 mortality for people with SMI. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - June 20, 2023 Category: Psychiatry Source Type: research

Tracing the Roots of Dementia Praecox: Charles Las ègue and his 1852 Essay “Du Délire De Persécutions” (On Persecutory Delusions)For Submission to Schizophrenia Bulletin
AbstractWhile the evolution of our modern concepts of mania and melancholia over the 19th century is relatively well-understood, no such clear narrative exists for the nonaffective psychotic syndromes that culminated in Kraepelin ’s concept of dementia praecox in 1899. These narratives were relatively distinct in Germany and France. An important milestone in the French literature is the 1852 essay by the alienist and polymath Charles Lasègue which contained the first detailed modern description of a persecutory delusional syndrome. Lasègue was a careful clinical observer who emphasized a symptomatic approach to psychia...
Source: Schizophrenia Bulletin - June 15, 2023 Category: Psychiatry Source Type: research

Shared Genetic Loci Between Schizophrenia and White Blood Cell Counts Suggest Genetically Determined Systemic Immune Abnormalities
ConclusionsOur results suggest that genetic factors involved in WBC counts are associated with the risk of SCZ, indicating a role of immune mechanisms in subgroups of SCZ with potential for stratification of patients for immune targeted treatment. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - June 15, 2023 Category: Psychiatry Source Type: research

Familiality of the Intelligence Quotient in First Episode Psychosis: Is the Degree of Family Resemblance Associated With Different Profiles?
ConclusionsThe deviation from the familial cognitive performance may be related to a particular pathological process in SSD. Individuals with low IQ who do not reach their cognitive familial potential show difficulties in adjustment since childhood, probably influenced by environmental factors. Instead, FEP patients with high phenotypic family resemblance might have a more significant genetic burden for the disorder. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - June 14, 2023 Category: Psychiatry Source Type: research

Pleiotropic Association of CACNA1C Variants With Neuropsychiatric Disorders
ConclusionIntegrating multiple levels of analyses, we identifiedCACNA1C variants associated with multiple psychiatric disorders, and schizophrenia and bipolar disorder were most strongly implicated.CACNA1C variants may contribute to shared risk and pathophysiology in these conditions. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - June 12, 2023 Category: Psychiatry Source Type: research

The Cost-Effectiveness of a Novel Online Social Therapy to Maintain Treatment Effects From First-Episode Psychosis Services: Results From the Horyzons Randomized Controlled Trial
ConclusionsThe Horyzons intervention offers a cost-effective approach for improving social functioning in young people with FEP after discharge from early intervention services. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - June 1, 2023 Category: Psychiatry Source Type: research

Psychometric Properties and Diagnostic Associations of the Short-Form Community Assessment of Psychic Experiences in a Population-Based Sample of 29 021 Adult Men
ConclusionsCAPE-9 showed good psychometric properties in this large population-based adult male sample, and PEs were more clearly associated with psychotic disorders after controlling for current emotional symptoms. These results support the use of the short CAPE-9 as a cost-effective tool for informing public health initiatives and advancing our understanding of the dimensionality of psychosis. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - June 1, 2023 Category: Psychiatry Source Type: research

False Responses From Artificial Intelligence Models Are Not Hallucinations
Novo Nordisk Foundation10.13039/501100009708NNF20SA0062874Lundbeck Foundation10.13039/501100003554R358-2020-2341R344-2020-1073Danish Cancer Society10.13039/100008363R283-A16461Central Denmark Region Fund for Strengthening of Health Science1-36-72-4-20Danish Agency for Digitisation Investment Fund for New Technologies2020-6720 (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - May 23, 2023 Category: Psychiatry Source Type: research

Compositional and Functional Alterations in Intestinal Microbiota in Patients with Psychosis or Schizophrenia: A Systematic Review and Meta-analysis
ConclusionsThe microbiome may play a role in the etiology and symptomatology of schizophrenia. Understanding how the implications of alterations in microbial genes for symptomatic expression and clinical outcomes may contribute to the development of microbiome targeted interventions for psychosis. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - May 20, 2023 Category: Psychiatry Source Type: research

Turning the Spotlight on Apathy: Identification and Treatment in Schizophrenia Spectrum Disorders
AbstractAmong negative symptoms, apathy is central to the impairments in real-life functioning in schizophrenia spectrum disorders (SSD). Thus, optimizing treatment for apathy appears key to improve outcomes. In treatment research, however, negative symptoms are typically studied as a unifactorial construct. We, therefore, aim to shed necessary light on the status of apathy identification and treatment in SSD. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - May 17, 2023 Category: Psychiatry Source Type: research

Measures of Social and Occupational Function in Early Psychosis: A Systematic Review and Meta-analysis
AbstractDeficits in social and occupational function are widely reported in psychosis, yet no one measure of function is currently agreed upon as a gold standard in psychosis research. The aim of this study was to carry out a systematic review and meta-analysis of functioning measures to determine what measures were associated with largest effect sizes when measuring between-group differences, changes over time, or response to treatment. Literature searches were conducted based on PsycINFO and PubMed to identify studies for inclusion. Cross-sectional and longitudinal observational and intervention studies of early psychosi...
Source: Schizophrenia Bulletin - May 13, 2023 Category: Psychiatry Source Type: research

Incidence and Risk Profiles for Suicide Mortality in Patients With Schizophrenia Receiving Homecare Case Management in Taiwan
We examined the demographic and medical utilization profile for suicide and then performed a nested case–control study and multivariate regression to identify independent risk factors for suicide mortality. Among the 13 317 patients who received homecare CM intervention, 1766 died during the study period, of whom 213 died by suicide, which is the leading cause of unnatural death. Jumping from a high place, self-poisoning, and hanging were the top 3 suicide methods. Increased medical utiliza tion was noted for both psychiatric and non-psychiatric services within 3 months of suicide mortality. Comorbidities of depressive d...
Source: Schizophrenia Bulletin - May 10, 2023 Category: Psychiatry Source Type: research

Correction to: Effects of a Novel, Transdiagnostic Ecological Momentary Intervention for Prevention, and Early Intervention of Severe Mental Disorder in Youth (EMIcompass): Findings From an Exploratory Randomized Controlled Trial
Deutsche Forschungsgemeinschaft10.13039/501100001659389626655DFG Heisenberg professorship389624707 (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - May 6, 2023 Category: Psychiatry Source Type: research