The Scanner as the Stimulus: Deficient Gamma-BOLD Coupling in Schizophrenia at Rest
AbstractFunctional magnetic resonance imaging (fMRI) scanners are unavoidably loud and uncomfortable experimental tools that are necessary for schizophrenia (SZ) neuroscience research. The validity of fMRI paradigms might be undermined by well-known sensory processing abnormalities in SZ that could exert distinct effects on neural activity in the presence of scanner background sound. Given the ubiquity of resting-state fMRI (rs-fMRI) paradigms in SZ research, elucidating the relationship between neural, hemodynamic, and sensory processing deficits during scanning is necessary to refine the construct validity of the MR neur...
Source: Schizophrenia Bulletin - April 25, 2023 Category: Psychiatry Source Type: research
Development and Validation of the Negative Symptom Inventory-Psychosis Risk
ConclusionsThese findings support the psychometric properties of the NSI-PR and guided the creation of a new 11-item NSI-PR that will be validated in the next phase of this multi-site scale development project. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - April 25, 2023 Category: Psychiatry Source Type: research
Sleep Problems, Suicidal Ideation, and Psychopathology in First-Episode Psychosis
ConclusionsSleep problems are highly prevalent and associated with suicidal ideation and greater psychopathology in first-episode psychosis. Formal assessment and treatment of insomnia appear relevant to the clinical care of patients with psychosis as a predictor of suicidal ideation and symptom severity. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - April 22, 2023 Category: Psychiatry Source Type: research
Abnormalities of Regional Brain Activity in Patients With Schizophrenia: A Longitudinal Resting-State fMRI Study
ConclusionsThese findings provide novel evidence for the abnormal functional activity hypothesis of SZ, suggesting that abnormality of right SFGmed can be used as a biomarker of treatment response in SZ. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - April 21, 2023 Category: Psychiatry Source Type: research
Macroscale Thalamic Functional Organization Disturbances and Underlying Core Cytoarchitecture in Early-Onset Schizophrenia
ConclusionsThese findings provide mechanistic evidence for disrupted thalamocortical system in schizophrenia, suggesting a unitary pathophysiological framework. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - April 20, 2023 Category: Psychiatry Source Type: research
Evidence of Neurovascular Water Exchange and Endothelial Vascular Dysfunction in Schizophrenia: An Exploratory Study
ConclusionsThis study provides initial evidence of neurovascular water exchange abnormalities, which appeared clinically associated, especially with negative symptoms, in schizophrenia. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - April 20, 2023 Category: Psychiatry Source Type: research
Quantitative Susceptibility Mapping MRI in Deep-Brain Nuclei in First-Episode Psychosis
ConclusionsReduction in QSM and R2* suggests a decreased iron concentration in the GPe of patients. Susceptibility reduction in putamen cannot be associated with iron changes. Since changes observed in putamen and GPe were not associated with symptoms, dose, and treatment duration, we hypothesize that susceptibility may be a trait marker rather than a state marker, but this must be verified with long-term studies. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - April 8, 2023 Category: Psychiatry Source Type: research
Shared and Disorder-Specific Alterations of Brain Temporal Dynamics in Obsessive-Compulsive Disorder and Schizophrenia
ConclusionsOur study provides evidence of transdiagnostic and clinically relevant functional brain abnormalities across OCD and schizophrenia in neocortex, as well as functional dynamic alterations in the cerebellum specific to schizophrenia. These findings add to the recognition of overlap in neocortical alterations in the 2 disorders, and indicate that cerebellar alterations in schizophrenia may be specifically important in schizophrenia pathophysiology via impact on cerebellar thalamocortical circuitry. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - April 8, 2023 Category: Psychiatry Source Type: research
Correction to: Listening to and Believing Derogatory and Threatening Voices
Higher Education EnglandNational Institute for Health and Care Research10.13039/501100000272ICA-CDRF-2017-03-088 (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - March 27, 2023 Category: Psychiatry Source Type: research
Correction to: Schizophrenia Polygenic Risk and Experiences of Childhood Adversity: A Systematic Review and Meta-analysis
Medical Research Council CentreMR/L010305/1G0800509MR/L011794/1MC_PC_17212 (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - March 16, 2023 Category: Psychiatry Source Type: research
The Difficulties of Grandiose Delusions: Harms, Challenges, and Implications for Treatment Engagement
ConclusionsActing on grandiose delusions, including harmful behaviors and excessive thinking about grandiose delusions, may be routes for clinicians to engage patients in treatment. This could be a starting point for targeted psychological interventions for grandiose delusions. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - March 14, 2023 Category: Psychiatry Source Type: research
Dissecting Schizotypy and Its Association With Cognition and Polygenic Risk for Schizophrenia in a Nonclinical Sample
AbstractSchizotypy is a multidimensional construct that captures a continuum of risk for developing schizophrenia-spectrum psychopathology. Existing 3-factor models of schizotypy, consisting of positive, negative, and disorganized dimensions have yielded mixed evidence of genetic continuity with schizophrenia using polygenic risk scores. Here, we propose an approach that involves splitting positive and negative schizotypy into more specific subdimensions that are phenotypically continuous with distinct positive symptoms and negative symptoms recognized in clinical schizophrenia. We used item response theory to derive high-...
Source: Schizophrenia Bulletin - March 3, 2023 Category: Psychiatry Source Type: research
Correction to: Psychotic Like Experiences in Healthy Adolescents are Underpinned by Lower Fronto-Temporal Cortical Gyrification: a Study from the IMAGEN Consortium
This is a correction to: Raka Maitra, Charlotte M Horne, Owen O ’Daly, Evangelos Papanastasiou, Christian Gaser, IMAGEN list of authors, IMAGEN Consortium, Psychotic Like Experiences in Healthy Adolescents are Underpinned by Lower Fronto-Temporal Cortical Gyrification: a Study from the IMAGEN Consortium,Schizophrenia Bulletin, 2022;, sbac132,https://doi.org/10.1093/schbul/sbac132. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - November 17, 2022 Category: Psychiatry Source Type: research
My Strategies for Dealing With Radical Psychotic Doubt: A Schizo-Something Philosopher ’s Tale
I am a 45-year-old Swedish philosopher with “schizo-something”: I have never been given a precise diagnostic label, but a psychiatrist once said that although I do not tick enough boxes for schizophrenia, I am somewhere in the ballpark. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - June 30, 2022 Category: Psychiatry Source Type: research
Schizophrenia in Translation: Why the Eye?
AbstractSchizophrenia is increasingly recognized as a systemic disease, characterized by dysregulation in multiple physiological systems (eg, neural, cardiovascular, endocrine). Many of these changes are observed as early as the first psychotic episode, and in people at high risk for the disorder. Expanding the search for biomarkers of schizophrenia beyond genes, blood, and brain may allow for inexpensive, noninvasive, and objective markers of diagnosis, phenotype, treatment response, and prognosis. Several anatomic and physiologic aspects of the eye have shown promise as biomarkers of brain health in a range of neurologic...
Source: Schizophrenia Bulletin - May 28, 2022 Category: Psychiatry Source Type: research
