Boots
I prefer square-toed cowboy boots. But that morning I chose the less agreeable pointed toes. I ’m not a martyr; I did it out of respect. Why is it that when someone dies we amble around muttering things like, “I think he would have wanted that” or “I’m pretty sure that would have meant something to her.” It helps to mollify the pain, to circumvent losing touch. Only God knows the way grief-logic works as we slog through the labyrinth. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - February 20, 2020 Category: Psychiatry Source Type: research
Psychotic Experiences Are Associated With Paternal Age But Not With Delayed Fatherhood in a Large, Multinational, Community Sample
AbstractAdvanced paternal age has been consistently associated with an increased risk of schizophrenia. It is less known if such an association also exists with subclinical/attenuated forms of psychosis. Additionally, it has been suggested that it is not paternal age per se, but rather delayed fatherhood, as a marker of a genetic liability of psychosis, that is the cause of the association. The aim of the current study was to examine whether paternal age and/or delayed fatherhood (paternity age) predict self-reported positive, negative, and/or depressive dimensions of psychosis in a large sample from the general population...
Source: Schizophrenia Bulletin - February 12, 2020 Category: Psychiatry Source Type: research
Cognitive Impairment and Diminished Neural Responses Constitute a Biomarker Signature of Negative Symptoms in Psychosis
AbstractThe treatment of negative symptoms (NS) in psychosis represents an urgent unmet medical need given the significant functional impairment it contributes to psychosis syndromes. The lack of progress in treating NS is impacted by the lack of known pathophysiology or associated quantitative biomarkers, which could provide tools for research. This current analysis investigated potential associations between NS and an extensive battery of behavioral and brain-based biomarkers in 932 psychosis probands from the B-SNIP database. The current analyses examined associations between PANSS-defined NS and (1) cognition, (2) pro-...
Source: Schizophrenia Bulletin - February 11, 2020 Category: Psychiatry Source Type: research
Cacna1c Hemizygosity Results in Aberrant Fear Conditioning to Neutral Stimuli
In this study, we utilize auditory-cued fear memory paradigms in order to investigate whether associative learning is altered in rats hemizygous for theCacna1c gene.Cacna1c hemizygous (Cacna1c+/ −) rats and their wild-type littermates were exposed to either delay, trace, or unpaired auditory fear conditioning. All rats received a Context Recall (24 h post-conditioning) and a Cue Recall (48 h post-conditioning) to test their fear responses. In the delay condition, which results in strong conditioning to the cue in wild-type animals,Cacna1c+/ − rats showed increased fear responses to the context. In the trace condition, ...
Source: Schizophrenia Bulletin - January 7, 2020 Category: Psychiatry Source Type: research
Differences in Functional Connectivity Networks Related to the Midbrain Dopaminergic System-Related Area in Various Psychiatric Disorders
ConclusionsThe results suggest that altered brain functional connectivity related to VTA networks could be associated with the distinctive pathophysiologies of psychiatric disorders, especially affective disorders. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - January 5, 2020 Category: Psychiatry Source Type: research
One-Year Stability of Frontoparietal Cognitive Control Network Connectivity in Recent Onset Schizophrenia: A Task-Related 3T fMRI Study
In this study, we examined the 1-year stability of the frontoparietal control network during the AX-Continuous Performance Task (AX-CPT) from a new baseline sample of 153 participants scanned at 3T, of which 29 recent onset individuals with SZ and 42 healthy control (HC) participants had follow-up data available for analysis. Among individuals that had both baseline and follow-up data, reduced functional connectivity in SZ was observed between the dorsolateral prefrontal cortex (DLPFC) and superior parietal cortex (SPC) during the high control (B cue) condition. Furthermore, this deficit was stable over time, as no signifi...
Source: Schizophrenia Bulletin - January 5, 2020 Category: Psychiatry Source Type: research
Second Chance
Erratum to “Second Chance” by E. Fuller Torrey. Schizophr Bull. 2017; doi:10.1093/schbul/sbw188. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - October 24, 2019 Category: Psychiatry Source Type: research
Erratum to: Second Chance
Erratum to “Second Chance” by E. Fuller Torrey. Schizophr Bull. 2017; doi:10.1093/schbul/sbw188. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - October 24, 2019 Category: Psychiatry Source Type: research
On Delusion and Self-recognition: A Phenomenological Perspective From the Diagnosed (and Functional)
When does a cognitive occupancy officially translate to a “belief?” When I say occupancy, I am referring to my experiences, as denominated by temporal delineation. I refer to such temporally delineated experiences as my “episodes.” Such episodes entail myen vivo interpretations regarding my ongoing reality. But because I have schizophrenia, trying to interpret my reality comes with its challenges. As I can attest, schizophrenia is the ultimate metaphysical experiment. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - October 14, 2019 Category: Psychiatry Source Type: research
Monitoring My Journey From Doctor, to Patient, to Doctor With Lived Experience
As a medical student, and thereafter as a psychiatry resident, I (J.L.) spent more than 10 years studying diagnosis, treatment, and prevention of mental, emotional, and behavioral disorders. After several years of clinical experience, I thought I had gained some insight into what mental suffering is about. However, as I found out, nothing out there can prepare you for what it is really like. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - October 13, 2019 Category: Psychiatry Source Type: research
Blindness, Psychosis, and the Visual Construction of the World
AbstractThe relationship between visual loss and psychosis is complex: congenital visual loss appears to be protective against the development of a psychotic disorder, particularly schizophrenia. In later life, however, visual deprivation or visual loss can give rise to hallucinosis, disorders of visual insight such as blindsight or Anton syndrome, or, in the context of neurodegenerative disorders, more complex psychotic presentations. We draw on a computational psychiatric approach to consider the foundational role of vision in the construction of representations of the world and the effects of visual loss at different de...
Source: Schizophrenia Bulletin - October 11, 2019 Category: Psychiatry Source Type: research
GABA and Negative Affect —Catatonia as Model of RDoC-Based Investigation in Psychiatry
We were very pleased to read the excellent article by Taylor and colleagues,1 which has highlighted the central role of the GABAergic system in determining stress vulnerability and modulation of negative affect (NA) in schizophrenia. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - September 18, 2019 Category: Psychiatry Source Type: research
Major Announcement: Schizophrenia Bulletin Open
Schizophrenia Bulletin was launched in 1969 by the National Institute of Mental Health (NIMH) to provide the scientific, clinical, and education communities with a reputable source for following the science and illuminating the experience of persons afflicted with this mental disorder. In 2005, responsibility for theBulletin moved from the NIMH to a joint collaboration between Oxford University Press (OUP) and the Maryland Psychiatric Research Center (MPRC). Two hallmark features of theBulletin, the cover artwork and First Person Accounts contributed by people with lived experiences, help foster awareness and understanding...
Source: Schizophrenia Bulletin - September 18, 2019 Category: Psychiatry Source Type: research
Ideology and Scientific Progress: First-Rank Symptoms
This is a psychopathology story of some importance. Kurt Schneider described symptoms associated with schizophrenia and referred to a small group as first rank based on a unique relationship to schizophrenia.1 Kendler2 reviews the history of concept development leading to Schneider ’s influential formulation. This psychopathology was influential in English-speaking psychiatry made accessible in Fish’s little blue book3 and Mellor ’s description of 11 first-rank symptoms (FRS).4 FRS were central to Wing ’s concept of nuclear schizophrenia and the algorithm used in Catego5 and Langfeldt ’s distinction of true from ...
Source: Schizophrenia Bulletin - September 10, 2019 Category: Psychiatry Source Type: research
On Loneliness
I ’ve sat down several times over the past few weeks attempting to work out what I would tell you about loneliness and being a mental health family carer of someone with severe mental illness. You see; I’m not used to telling my story because mine is an invisible one, I have obligations to meet at work, and also at home caring for my husband and family. I have many roles and responsibilities to others. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - August 23, 2019 Category: Psychiatry Source Type: research
