An Early Developmental Marker of Deficit versus Nondeficit Schizophrenia
AbstractPeople with schizophrenia and primary negative symptoms (deficit schizophrenia) differ from those without such symptoms (nondeficit schizophrenia) on risk factors, course of illness, other signs and symptoms, treatment response, and biological correlates. These differences suggest that the 2 groups may also have developmental differences. A previous study found that people with schizophrenia have a wider palate than comparison subjects. We tested the hypothesis that those with deficit and nondeficit schizophrenia would differ on palate width. A dentist made blinded measurements of palate shape in deficit (N = 21) a...
Source: Schizophrenia Bulletin - August 19, 2019 Category: Psychiatry Source Type: research
Delusional
(Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - July 29, 2019 Category: Psychiatry Source Type: research
Estimating Exposome Score for Schizophrenia Using Predictive Modeling Approach in Two Independent Samples: The Results From the EUGEI Study
AbstractExposures constitute a dense network of the environment: exposome. Here, we argue for embracing the exposome paradigm to investigate the sum of nongenetic “risk” and show how predictive modeling approaches can be used to construct an exposome score (ES; an aggregated score of exposures) for schizophrenia. The training dataset consisted of patients with schizophrenia and controls, whereas the independent validation dataset consisted of patients, th eir unaffected siblings, and controls. Binary exposures were cannabis use, hearing impairment, winter birth, bullying, and emotional, physical, and sexual abuse along...
Source: Schizophrenia Bulletin - July 23, 2019 Category: Psychiatry Source Type: research
The Hyperfocusing Hypothesis: A New Account of Cognitive Dysfunction in Schizophrenia
AbstractImpairments in basic cognitive processes such as attention and working memory are commonly observed in people with schizophrenia and are predictive of long-term outcome. In this review, we describe a new theory —thehyperfocusing hypothesis—which provides a unified account of many aspects of impaired cognition in schizophrenia. This hypothesis proposes that schizophrenia involves an abnormally narrow but intense focusing of processing resources. This hyperfocusing impairs the ability of people with schizophrenia to distribute attent ion among multiple locations, decreases the number of representations that can s...
Source: Schizophrenia Bulletin - July 18, 2019 Category: Psychiatry Source Type: research
The Prehistory of Schneider ’s First-Rank Symptoms: Texts From 1810 to 1932
Conclusions and RelevanceFrom the beginning of Western descriptive psychopathology in the early 19th century, symptoms have been observed later described as first-rank by Schneider. A term “delusion of unseen agency”—closely related to Schneider’s first-rank concept—was popular in the second half of the 19th century and described in publications as prominent as the Encyclopedia Britannica and New England Journal of Medicine. The descriptions of these specific symptoms, with substantial continuity, over more than 2 centuries and many countries, suggest that an understanding of their etiology would teach us somethi...
Source: Schizophrenia Bulletin - June 17, 2019 Category: Psychiatry Source Type: research
