FLOW AND GEOMETRICAL ALTERATIONS IN RETINAL MICROVASCULATURE CORRELATED WITH THE OCCURRENCE OF DIABETIC RETINOPATHY: Evidence from a Longitudinal Study
Purpose:
To assess the relationship between flow and geometric parameters in optical coherence tomography angiography images and the risk of incident diabetic retinopathy (DR).
Methods:
This prospective, observational cohort study recruited patients with Type 2 diabetes without DR in Guangzhou, China, and followed up annually. A commercially available optical coherence tomography angiography device (DRI OCT Triton; Topcon Inc, Tokyo, Japan) was used to obtain a variety of flow (foveal avascular zone area, vessel density, and vessel length density) and geometric (fractal dimension and blood vessel tortuosity) par...
Source: RETINA - August 23, 2022 Category: Opthalmology Tags: Original Study Source Type: research
RETINAL THICKNESS AND FOVEAL HYPOPLASIA IN ADULTS BORN PRETERM WITH AND WITHOUT RETINOPATHY OF PREMATURITY: The Gutenberg Prematurity Eye Study
This study analyses whether prematurity, retinopathy of prematurity (ROP), and associated factors lead to altered foveal shape in adulthood and whether these alterations are associated with visual acuity.
Methods:
The Gutenberg Prematurity Eye Study is a German cohort study with a prospective ophthalmologic examination (participants aged 18–52 years) of individuals born preterm and full-term that were examined with spectral domain optical coherence tomography. Participants were grouped according to gestational age (GA) and postnatal ROP status. Multivariable linear regression analyses for foveolar retinal thicknes...
Source: RETINA - August 23, 2022 Category: Opthalmology Tags: Original Study Source Type: research
Cytomegalovirus retinitis screening using machine learning technology
Conclusion:
This study demonstrated the benefit of the machine learning model VGG16, which provided high sensitivity and specificity for detecting sight-threatening CMVR in HIV-positive patients. This model is a useful tool for ophthalmologists in clinical practice for preventing blindness from CMVR, especially during the Coronavrus Disease 2019 pandemic. (Source: RETINA)
Source: RETINA - August 23, 2022 Category: Opthalmology Tags: Original Study Source Type: research
EFFICIENCY OF LASER PHOTOCOAGULATION ON THE PREVENTION OF RETINAL DETACHMENT IN ACUTE RETINAL NECROSIS: A Systematic Review and Meta-Analysis
Background:
Retinal detachment is a severe complication of acute retinal necrosis, threatening vision. The published articles on the effectiveness of laser in preventing retinal detachment in acute retinal necrosis are controversial. Therefore, we aim to evaluate whether prophylactic laser is effective for retinal detachment after acute retinal necrosis.
Methods:
PubMed, Embase, and Cochrane databases were searched, and the retrieved records were screened. Each included study has well-defined laser-treated group and control group without laser treatment or with enough data for manual grouping. The quality of the...
Source: RETINA - August 23, 2022 Category: Opthalmology Tags: Original Study Source Type: research
DELAYED FOLLOW-UP IN PATIENTS WITH NEOVASCULAR AGE-RELATED MACULAR DEGENERATION TREATED UNDER UNIVERSAL HEALTH COVERAGE: Risk Factors and Visual Outcomes
Background/Purpose:
To report the rate of delayed follow-up visits (DFU), to identify risk factors of DFU, and to assess the impact of DFU on outcomes in neovascular age-related macular degeneration.
Methods:
This retrospective study included all patients with neovascular age-related macular degeneration (n = 1,291) treated with antivascular endothelial growth factor injections between January 2013 and December 2020 in 2 centers in Quebec, Canada. A DFU was defined as a delay of ≥4 weeks than scheduled. Visual outcomes, especially ≥15 letters loss, were reported.
Results:
A total of 351 patients (27.2...
Source: RETINA - August 23, 2022 Category: Opthalmology Tags: Original Study Source Type: research
Baseline sattler layer–choriocapillaris complex thickness cutoffs associated with age-related macular degeneration progression
Purpose:
To assess the relationship between choroidal overall and sublayer thickness and age-related macular degeneration (AMD) stage progression.
Methods:
A prospective, observational case series was performed. Two hundred and sixty-two eyes of 262 patients with different stages of AMD were imaged by optical coherence tomography. Age-related macular degeneration stage, choroidal thickness, Sattler layer–choriocapillaris complex thickness (SLCCT), and Haller layer thickness were determined at the baseline visit, at a 1-year follow-up visit, at a 2-year follow up visit, and at a final visit (performed after a m...
Source: RETINA - August 23, 2022 Category: Opthalmology Tags: Original Study Source Type: research
Validation of an automated fluid algorithm on real-world data of neovascular age-related macular degeneration over five years
Conclusion:
The Vienna Fluid Monitor can precisely quantify fluid volumes in optical coherence tomography images from clinical routine over 5 years. Automated tools will introduce precision medicine based on fluid guidance into real-world management of exudative disease, improving clinical outcomes while saving resources. (Source: RETINA)
Source: RETINA - August 23, 2022 Category: Opthalmology Tags: Original Study Source Type: research
Predicting lesion shrinkage in eyes with myopic choroidal neovascularization from features on optical coherence tomography angiography
Purpose:
To identify baseline morphological predictors of lesion shrinkage in eyes with myopic choroidal neovascularization (mCNV) treated with anti-vascular endothelial growth factor.
Methods:
This retrospective study included 46 eyes (41 consecutive patients) with active mCNV receiving anti–vascular endothelial growth factor treatment. Optical coherence tomography angiography was performed at baseline and 1 year after treatment. Quantitative features were obtained from optical coherence tomography angiography images using AngioTool software. Eyes were classified as “high shrinkage” or “low shrinkage”...
Source: RETINA - August 23, 2022 Category: Opthalmology Tags: Original Study Source Type: research
Anomalies of choroidal venous structure in highly myopic eyes
Purpose:
To identify anomalies of choroidal venous structure in highly myopic (HM) eyes.
Methods:
Widefield indocyanine green angiographic images of 175 HM eyes (refractive error ≤ –6.0D diopters or axial length>26.5 mm) and 100 control eyes taken between January 2014 and December 2018 were reviewed.
Results:
There were no significant differences in age and gender between HM patients and controls. Three types of changes of large choroidal veins were found in 103 HM eyes (58.86%): Asymmetry of vortex veins in 44 eyes (25.14%), isolated long vein across the macula in 58 eyes (33.14%), and intervortex an...
Source: RETINA - August 23, 2022 Category: Opthalmology Tags: Original Study Source Type: research
Swept-source optical coherence tomography detection of bruch membrane and choriocapillaris abnormalities in sorsby macular dystrophy
Conclusion:
Swept-source optical coherence tomography angiography imaging can detect BM and CC abnormalities in vivo in subjects unaware of their TIMP3 status in a family with SMD. (Source: RETINA)
Source: RETINA - August 23, 2022 Category: Opthalmology Tags: Original Study Source Type: research
Sausaging and bulbosities of the choroidal veins in central serous chorioretinopathy
Purpose:
To evaluate the caliber of the choroidal veins in central serous chorioretinopathy, a disease proposed to be associated with overloading of choroidal venous outflow.
Methods:
Widefield indocyanine green angiograms of eyes with central serous chorioretinopathy were graded for sausaging defined as three or more contiguous fusiform dilations that vary by at least 50% from the narrowest to largest diameters. A bulbosity was defined as a focal 2X dilation of a blood vessel as compared with the diameter of the surrounding host vessel. The data underwent statistical analysis including the use of generalized es...
Source: RETINA - August 23, 2022 Category: Opthalmology Tags: Original Study Source Type: research
A CONSENSUS ON RISK MITIGATION FOR BROLUCIZUMAB IN NEOVASCULAR AGE-RELATED MACULAR DEGENERATION: Patient Selection, Evaluation, and Treatment
Conclusion:
Careful patient selection, patient education, assessment for inflammation, and intensive treatment of possible inflammation are important when using brolucizumab in patients with neovascular age-related macular degeneration. (Source: RETINA)
Source: RETINA - August 23, 2022 Category: Opthalmology Tags: Review Source Type: research
Sibling concordance in symptom onset and atrophy growth rates in stargardt disease using ultra-widefield fundus autofluorescence
Conclusion:
There was significant discordance in age-matched best-corrected visual acuity and DAF beyond the expected limits of interocular asymmetry. Lack of significant intersibling differences in GR warrants further investigation. (Source: RETINA)
Source: RETINA - August 1, 2022 Category: Opthalmology Tags: Original Study Source Type: research
Age-related retentional avascular pigment epithelial detachment viewed with indocyanine green angiography
Conclusion:
Most age-related avascular serous PEDs are retentional PEDs. The location and area of retentional PEDs are consistent with the distribution of ASHS-LIA. These findings suggest that the hydrophobic neutral lipid deposits in the Bruch membrane might be involved in the pathogenesis and be a therapeutic target in age-related retentional avascular PED. (Source: RETINA)
Source: RETINA - August 1, 2022 Category: Opthalmology Tags: Original Study Source Type: research
Foldable capsular vitreous body implantation for complicated retinal detachment caused by severe ocular trauma
Purpose:
To explore the effectiveness, safety and psychological impact of foldable capsular vitreous body (FCVB) implantation for complicated retinal detachment caused by severe ocular trauma.
Methods:
This was a prospective, single-arm, surgical interventional case series study. A standard 3-port 23-gauge pars plana vitrectomy was performed, and the FCVB was implanted into the vitreous cavity. Observed indicators, including the best-corrected visual acuity, intraocular pressure (IOP), retinal reattachment, complications, and patient satisfaction, were analyzed to evaluate the study.
Results:
A total of 2...
Source: RETINA - August 1, 2022 Category: Opthalmology Tags: Original Study Source Type: research
