ASSOCIATIONS BETWEEN MACULAR EDEMA AND CIRCULATORY STATUS IN EYES WITH RETINAL VEIN OCCLUSION: An Adaptive Optics Scanning Laser Ophthalmoscopy Study
Conclusion: Using adaptive optics scanning laser ophthalmoscopy in eyes with retinal vein occlusion macular edema, we could quantitatively evaluate the parafoveal AEV. A reduction or an increase in parafoveal AEV may be a clinical marker for the resolution or development/progression of macular edema respectively. (Source: RETINA)
Source: RETINA - September 27, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Outer retinal layer changes after dexamethasone implant for central retinal vein occlusion
Purpose: To analyze the outer retinal layer changes on spectral-domain optical coherence tomography after dexamethasone implant for the treatment of macular edema secondary to central retinal vein occlusions (CRVO). Methods: Thirty patients affected by macular edema related to CRVO (8 patients less than 50 years of age with nonischemic CRVO [50-niCRVO], and 10 patients with ischemic CRVO [iCRVO]) were included in a prospective study. After a comprehensive ophthalmologic examination, including best-corrected visual acuity, fluorescein angiography, and spectral-domain optical coherence tomography, each patient received a fi...
Source: RETINA - September 27, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Association of drusen volume with choroidal parameters in nonneovascular age-related macular degeneration
Conclusion: Choroidal intensity, but not choroidal thickness, seems to be associated with drusen volume in Amish and non-Amish populations. These observations suggest that choroidal parameters beyond thickness warrant further study in the setting of age-related macular degeneration. (Source: RETINA)
Source: RETINA - September 27, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Optical coherence tomography angiography changes in early type 3 neovascularization after anti-vascular endothelial growth factor treatment
Conclusion: Optical coherence tomography angiography showed that the tuft-shaped abnormal outer retinal lesion, frequently associated with a small clew-like flow signal in the choriocapillaris, after 1 year of anti–vascular endothelial growth factor therapy, either becomes undetectable or develops sub–retinal pigment epithelium neovascularization. (Source: RETINA)
Source: RETINA - September 27, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Choroidal thickness as a prognostic factor of photodynamic therapy with aflibercept or ranibizumab for polypoidal choroidal vasculopathy
Purpose: To investigate factors associated with visual improvement and retreatment 12 months after a combination therapy of intravitreal injection of ranibizumab or aflibercept followed by photodynamic therapy for polypoidal choroidal vasculopathy. Methods: Changes in the best-corrected visual acuity and the subfoveal thickness of the retina and choroid were studied in 56 consecutive eyes with polypoidal choroidal vasculopathy treated initially with a combination therapy of either intravitreal ranibizumab injection (n = 23) or intravitreal aflibercept injection (n = 33) followed by photodynamic therapy. Factors associated...
Source: RETINA - September 27, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Short-term safety of 2 mg intravitreal ziv-aflibercept
Conclusion: Single intravitreal injections of 2 mg ziv-aflibercept (0.08 mL) appear to be safe through 1 month. (Source: RETINA)
Source: RETINA - September 27, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Systemic pharmacokinetics and pharmacodynamics of intravitreal aflibercept, bevacizumab, and ranibizumab
Conclusion: The three anti-VEGF treatments examined in this analysis demonstrated notable differences in systemic PKs. Generally, the reduction in plasma free-VEGF levels correlated with elevated levels of circulating anti-VEGF agents, with the reduction in free-VEGF levels greatest with aflibercept and least with ranibizumab. (Source: RETINA)
Source: RETINA - September 27, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Imaging and measurement of the preretinal space in vitreomacular adhesion and vitreomacular traction by a new spectral domain optical coherence tomography analysis
Conclusion: Our study provides evidence of significant differences in preretinal space volume between eyes with VMA and those with VMT. This may be useful not only in the investigation of preretinal space properties in VMA and VMT, but also in other conditions, such as age-related macular degeneration, diabetic retinopathy, and central retinal vein occlusion. (Source: RETINA)
Source: RETINA - September 27, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Longitudinal microperimetry evaluation after intravitreal ocriplasmin injection for vitreomacular traction
Purpose: To determine whether improvements in microperimetry testing are associated with anatomic resolution after ocriplasmin treatment in patients with symptomatic vitreomacular adhesion (VMA)/vitreomacular traction and relatively preserved baseline best-corrected visual acuity (BCVA). Methods: Patients with vitreomacular traction received a single 125-μg intravitreal ocriplasmin injection and were followed longitudinally for 6 months with optical coherence tomography, BCVA testing, and microperimetry. Visual function changes were compared between eyes with and without VMA resolution on optical coherence tomography. ...
Source: RETINA - September 27, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Pneumatic vitreolysis for relief of vitreomacular traction
Purpose: To evaluate the outcome of perfluoropropane (C3F8) gas injection for symptomatic vitreomacular traction (VMT) with or without Stage 2 macular hole (MH). Methods: A retrospective review of eyes with VMT treated with 0.3 mL of C3F8 gas was performed. Patients avoided the supine position until gas resolution. Patients with small MH maintained partial face-down positioning. Results: Forty-nine consecutive patients (50 eyes) with symptomatic VMT underwent pneumatic vitreolysis between 2010 and 2016. A posterior vitreous detachment developed in 43 eyes (86.0%) after a single gas injection, at a median of 3.0 weeks. Tw...
Source: RETINA - September 27, 2017 Category: Opthalmology Tags: Original Study Source Type: research

EFFECTS OF INTERNAL LIMITING MEMBRANE PEELING COMBINED WITH REMOVAL OF IDIOPATHIC EPIRETINAL MEMBRANE: A Systematic Review of Literature and Meta-Analysis
Purpose: To evaluate the effects on postoperative prognosis of internal limiting membrane (ILM) peeling in conjunction with removal of idiopathic epiretinal membranes (ERMs). Methods: MEDLINE, Cochrane Central Register of Controlled Trials (CENTRAL), and EMBASE were systematically searched for studies that compared ILM peeling with no ILM peeling in surgery to remove idiopathic ERM. Outcome measures were best-corrected visual acuity, central macular thickness, and ERM recurrence. Studies that compared ILM peeling with no ILM peeling for the treatment of idiopathic ERM were selected. Results: Sixteen studies that included...
Source: RETINA - September 27, 2017 Category: Opthalmology Tags: Review Source Type: research

Considerations in the Understanding of Venous Outflow in the Retinal Capillary Plexus
No abstract available (Source: RETINA)
Source: RETINA - September 27, 2017 Category: Opthalmology Tags: Editorial Source Type: research

Reply
No abstract available (Source: RETINA)
Source: RETINA - August 24, 2017 Category: Opthalmology Tags: Correspondence Source Type: research

Correspondence
No abstract available (Source: RETINA)
Source: RETINA - August 24, 2017 Category: Opthalmology Tags: Correspondence Source Type: research

Reply
No abstract available (Source: RETINA)
Source: RETINA - August 24, 2017 Category: Opthalmology Tags: Correspondence Source Type: research

Correspondence
No abstract available (Source: RETINA)
Source: RETINA - August 24, 2017 Category: Opthalmology Tags: Correspondence Source Type: research

Reply
No abstract available (Source: RETINA)
Source: RETINA - August 24, 2017 Category: Opthalmology Tags: Correspondence Source Type: research

Correspondence
No abstract available (Source: RETINA)
Source: RETINA - August 24, 2017 Category: Opthalmology Tags: Correspondence Source Type: research

Reply
No abstract available (Source: RETINA)
Source: RETINA - August 24, 2017 Category: Opthalmology Tags: Correspondence Source Type: research

Correspondence
No abstract available (Source: RETINA)
Source: RETINA - August 24, 2017 Category: Opthalmology Tags: Correspondence Source Type: research

Reply
No abstract available (Source: RETINA)
Source: RETINA - August 24, 2017 Category: Opthalmology Tags: Correspondence Source Type: research

Correspondence
No abstract available (Source: RETINA)
Source: RETINA - August 24, 2017 Category: Opthalmology Tags: Correspondence Source Type: research

Treatment of Postvitrectomy Fibrin Using Intravitreal Tissue Plasminogen Activator
No abstract available (Source: RETINA)
Source: RETINA - August 24, 2017 Category: Opthalmology Tags: Photo Essay Source Type: research

Diagnostic and Therapeutic Challenges
No abstract available (Source: RETINA)
Source: RETINA - August 24, 2017 Category: Opthalmology Tags: Diagnostic and Therapeutic Challenges Source Type: research

The Ophthalmology Surgical Competency Assessment Rubric for Vitrectomy
No abstract available (Source: RETINA)
Source: RETINA - August 24, 2017 Category: Opthalmology Tags: Surgical Technique Source Type: research

Change of choroidal volume in untreated central serous chorioretinopathy
This study aimed to investigate the change in choroidal thickness and volume in eyes with untreated CSC. Methods: The authors retrospectively analyzed 27 eyes with treatment-naïve CSC (25 patients), who had a follow-up of 4 to 6 weeks. Retinal and choroidal volume and SRF were segmented manually and calculated using the Spectralis OCT built-in software (Spectralis; Heidelberg Engineering). Results: In treatment-naïve eyes with CSC, an increase in SRF was significantly associated with an increase in choroidal thickness and volume (rho = 0.93, P (Source: RETINA)
Source: RETINA - August 24, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Ocular manifestations and treatment outcomes in chinese patients with poems syndrome
Purpose: To evaluate the relationship of serum vascular endothelial growth factor (VEGF) levels and ocular manifestations in Chinese patients with POEMS syndrome. Methods: This is a prospective study. Forty-one treatment-naive patients were enrolled from April 2014 to November 2014. Among the 41 patients, 40 had complete ocular examination, spectral domain optical coherence tomography scan, and serum VEGF measurement before treatment and every 3-month interval after lenalidomide and dexamethasone treatment. Results: Twenty-seven (67.5%) patients had optic disk edema (ODE) at baseline. Retinal manifestations included reti...
Source: RETINA - August 24, 2017 Category: Opthalmology Tags: Original Study Source Type: research

CLINICAL OUTCOMES OF INTRAVITREAL BEVACIZUMAB VERSUS PHOTODYNAMIC THERAPY WITH OR WITHOUT BEVACIZUMAB FOR MYOPIC CHOROIDAL NEOVASCULARIZATION: A 7-Year Follow-up Study
Conclusion: IVB resulted in superior long-term functional and anatomical outcomes compared with PDT. In particular, PDT resulted in a greater BCVA decrease and CRA increase compared with IVB in eyes with preoperative diffuse CRA. However, the clinical outcomes were not different in eyes with preoperative tessellated fundi. (Source: RETINA)
Source: RETINA - August 24, 2017 Category: Opthalmology Tags: Original Study Source Type: research

EFFECTS OF A MODIFIED VITRECTOMY PROBE IN SMALL-GAUGE VITRECTOMY: An Experimental Study on the Flow and on the Traction Exerted on the Retina
Conclusion: The modified probe could be useful in vitreoretinal surgery. It allows for faster vitreous removal while minimizing tractional forces on the retina. Moreover, any available probe can be modified by creating a hole in the inner duct. (Source: RETINA)
Source: RETINA - August 24, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Long-term anatomical and functional outcomes following vitrectomy for advanced coats disease
Conclusion: Pars plana vitrectomy combined with cryotherapy, laser photocoagulation, and intraocular tamponade could be an effective treatment option for advanced Coats disease. Despite surgery, disease-related complications remained high, but the main aim of management in these young patients is functional and anatomical stability. (Source: RETINA)
Source: RETINA - August 24, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Air tamponade combined with nonsupine positioning in macular hole surgery for pseudophakic eyes
Purpose: To investigate the closure rate of primary full-thickness macular hole, following intraocular air tamponade combined with a nonsupine positioning regimen. Methods: A prospective study of patients with full-thickness macular hole, who underwent pars plana vitrectomy with internal limiting membrane peeling and intraocular air tamponade followed by 3 days of nonsupine positioning. Outcome measures were primary full-thickness macular hole closure and improvement in best-corrected visual acuity after 6 months. Results: A total of 34 eyes were included. In the group of full-thickness macular hole ≤400 μm, primar...
Source: RETINA - August 24, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Minimal endoillumination levels and display luminous emittance during three-dimensional heads-up vitreoretinal surgery
Purpose: To determine minimal endoillumination levels required to perform 3-dimensional heads-up vitreoretinal surgery and to correlate endoillumination levels used for measurements of heads-up display (HUD) luminous emittance. Methods: Prospective, observational surgical case series of 10 patients undergoing vitreoretinal surgery. Endoillumination levels were set to 40% of maximum output and were decreased at set intervals until the illumination level was 0%. Corresponding luminous emittance (lux) of the HUD was measured 40 cm from the display using a luxmeter (Dr. Meter, Model #LX1010BS). Results: In 9 of 10 cases, the...
Source: RETINA - August 24, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Association between the vitreomacular interface and optical coherence tomography characteristics in wet age-related macular degeneration
Conclusion: In conclusion, the vitreomacular interface does seem to be associated with an increased choroidal thickness in cases of wet AMD. Furthermore, the association between the vitreomacular interface and wet AMD is more significant for Type 1 CNV. (Source: RETINA)
Source: RETINA - August 24, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Association between parafoveal capillary nonperfusion and macular function in eyes with branch retinal vein occlusion
Purpose: To investigate the parafoveal perfusion status of the superficial and deep capillary layer in eyes with resolved branch retinal vein occlusion, and to study its effects on retinal sensitivity. Methods: In 27 enrolled eyes (27 patients) with resolved branch retinal vein occlusion, superficial and deep capillaries in the macular area (3- × 3-mm, centered on the fovea) were examined with optical coherence tomography angiography. Retinal sensitivity was examined with fundus-monitored microperimetry. Results: Optical coherence tomography angiography clearly showed the parafoveal superficial and deep capillaries...
Source: RETINA - August 24, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Efficacy and safety of intravitreal conbercept injections in macular edema secondary to retinal vein occlusion
Conclusion: Intravitreal injections of conbercept demonstrated a generally favorable safety and tolerability profile as well as efficacy in the treatment of macular edema due to RVO. (Source: RETINA)
Source: RETINA - August 24, 2017 Category: Opthalmology Tags: Original Study Source Type: research

CAPILLARY NONPERFUSION AND PHOTORECEPTOR LOSS IN BRANCH RETINAL VEIN OCCLUSION: Spatial Correlation and Morphologic Characteristics
Conclusion: En face OCT reconstruction and subsequent representation of ellipsoid zone revealed a close association between capillary nonperfusion and photoreceptor disruption in eyes with branch retinal vein occlusion. It seems that the deep capillary plexus plays an important role on the metabolic demands of outer retina and, consequently, an ischemia at the level of deep capillary plexus has significant impact on the integrity of the photoreceptors. (Source: RETINA)
Source: RETINA - August 24, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Correlation of microvascular structures on optical coherence tomography angiography with visual acuity in retinal vein occlusion
Purpose: To analyze the correlation of superficial and deep capillary plexuses using optical coherence tomography (OCT) angiography with visual acuity in eyes with retinal vein occlusion (RVO). Methods: We retrospectively reviewed the medical records of 33 patients with retinal vein occlusion (RVO; branch retinal vein occlusion in 21 patients, central retinal vein occlusion in 12 patients) and included 33 healthy subjects as a control group, who were evaluated by OCT angiography. The OCT angiography was performed on a 3 mm × 3-mm region centered on the fovea and parafoveal area. The foveal avascular zone (FAZ), and ...
Source: RETINA - August 24, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Prospective evaluation of a sustained-release dexamethasone intravitreal implant for cystoid macular edema in quiescent uveitis
Conclusion: Dexamethasone intravitreal implant may be an effective treatment for patients with persistent cystoid macular edema in quiescent uveitis. (Source: RETINA)
Source: RETINA - August 24, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Optical coherence tomography angiography in patients with behÇet uveitis
Purpose: To describe optical coherence tomography angiography (OCTA) findings in eyes with Behçet uveitis (BU) and to compare these findings with those of fluorescein angiography (FA). Methods: Prospective, comparative, cross-sectional study. Patients presenting with clinically active BU involving the posterior segment were evaluated using FA, spectral domain optical coherence tomography (SD-OCT), and OCTA. Optical coherence tomography angiograms were reviewed and analyzed. Foveal avascular zone areas and vessel densities were also reported. Results: Twenty-five patients (44 eyes) were included. Perifoveal microva...
Source: RETINA - August 24, 2017 Category: Opthalmology Tags: Original Study Source Type: research

TWENTY-FIVE-GAUGE CANNULA–ASSISTED FINE-NEEDLE ASPIRATION BIOPSY OF CHOROIDAL MELANOMA: Cytopathological Analysis
Conclusion: Use of a 25-G valved cannula offers potential advantages by isolating the needle tract and by allowing retrieval of the contaminating cells without affecting the prognostic yield of the fine-needle aspiration biopsy sample. (Source: RETINA)
Source: RETINA - August 24, 2017 Category: Opthalmology Tags: Original Study Source Type: research

IMAGE QUALITY AND ARTIFACTS ON OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY: Comparison of Pathologic and Paired Fellow Eyes in 65 Patients With Unilateral Choroidal Melanoma Treated With Plaque Radiotherapy
Purpose: To study image quality and artifacts seen on optical coherence tomography angiography (OCTA). Methods: Sixty-five consecutive patients with unilateral posterior uveal melanoma treated with plaque radiotherapy had OCTA during follow-up. Optical coherence tomography angiography was performed on both the affected and fellow eye. Signal strength and frequency of image artifacts on en face images were compared between affected and fellow eyes. Results: A total of 130 eyes in 65 patients were analyzed, the mean age at time of OCTA was 55 years (median: 56, range: 12–81 years), and 39 (39/65, 60%) were female. Ma...
Source: RETINA - August 24, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Novel findings on optical coherence tomography angiography in patients with tubercular serpiginous-like choroiditis
Conclusion: The OCTA images provide high-resolution structural information of the retinochoroidal vasculature in tubercular serpiginous-like choroiditis. Morphologic information obtained from OCTA images correlates well with and supplements other imaging techniques such as indocyanine green angiography and enhanced-depth imaging OCT. (Source: RETINA)
Source: RETINA - August 24, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Short-term effects of exercise on optic nerve and macular perfusion measured by optical coherence tomography angiography
Purpose: To evaluate the effects of exercise on optic nerve and macular perfusion using optical coherence tomography angiography. Methods: Thirteen eyes of 13 healthy volunteers were examined using a high-speed and high-resolution spectral-domain optical coherence tomography XR Avanti with a split-spectrum amplitude-decorrelation angiography algorithm. Blood pressure, heart rate, the mean area of the foveal avascular zone , and flow density on the optic nerve head and macula, before and after exercise were measured and analyzed. Results: Mean patient age was 27.3 ± 3.5 years. Heart rate, systolic and diastolic blo...
Source: RETINA - August 24, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Reproducibility and reliability of optical coherence tomography angiography for foveal avascular zone evaluation and measurement in different settings
Conclusion: AngioVue OCTA Imaging System produces highly reproducible FAZ images with a high interoperators concordance level. Optical coherence tomography angiography capability to detect FAZ area seems not to be influenced by any of the vasoactive stimuli considered in the current study. Nonflow areas seem to be larger when measured automatically than manually. (Source: RETINA)
Source: RETINA - August 24, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Macular degeneration and aspirin use
Conclusion: Overall, the number, size, and quality of the cardiovascular studies recommending aspirin use are far superior to the fewer, smaller and conflicting studies suggesting a possible adverse effect of aspirin use in relation to AMD. The benefits of aspirin usage include preserving the duration and quality of life by decreasing stroke and heart attack risk. These benefits seem to far outweigh the theoretical risks of possibly exacerbating wet AMD, which can be reasonably controlled with anti-VEGF therapy. (Source: RETINA)
Source: RETINA - August 24, 2017 Category: Opthalmology Tags: Review Source Type: research

Imaging of Exudative Age-Related Macular Degeneration: Toward a Shift in the Diagnostic Paradigm?
No abstract available (Source: RETINA)
Source: RETINA - August 24, 2017 Category: Opthalmology Tags: Editorial Source Type: research

Later Development of Posterior Staphyloma in Choroidal Osteoma With Choroidal Neovascularization
No abstract available (Source: RETINA)
Source: RETINA - July 21, 2017 Category: Opthalmology Tags: Photo Essay Source Type: research

Clinicopathologic correlation of retinal angiomatous proliferation treated with ranibizumab
Conclusion: In a patient with ARMD extensively treated with ranibizumab, color fundus photography, fluorescein angiography and SD-OCT images of RAP correlated histopathologically with a paucicellular intraretinal vascular complex. (Source: RETINA)
Source: RETINA - July 21, 2017 Category: Opthalmology Tags: Clinicopathologic Correlation Source Type: research