Google cardboard indirect ophthalmoscopy
No abstract available (Source: RETINA)
Source: RETINA - July 21, 2017 Category: Opthalmology Tags: New Instruments Source Type: research

Diagnostic and Therapeutic Challenges
No abstract available (Source: RETINA)
Source: RETINA - July 21, 2017 Category: Opthalmology Tags: Diagnostic and Therapeutic Challenges Source Type: research

A New Method of Subretinal Injection of Tissue Plasminogen Activator and Air in Patients With Submacular Hemorrhage
No abstract available (Source: RETINA)
Source: RETINA - July 21, 2017 Category: Opthalmology Tags: Surgical Technique Source Type: research

Sticky silicone oil
Objective: To report and analyze the phenomenon of sticky silicone oil on the retina at the time of its removal. Background: Silicone oil has been used for more than 25 years as a long-term retinal tamponade in the surgical management of patients with complex retinal detachments. When a decision to remove silicone oil was made at the end of the tamponade period, the system involved a number of different materials: silicone oil, aqueous solution with or without remnants of perfluorocarbon liquid plus the material of the cannula used to aspirate Silicone oil. This, in effect, may lead to an abnormal adherence of large bubbl...
Source: RETINA - July 21, 2017 Category: Opthalmology Tags: Original Study Source Type: research

SUBFOVEAL NODULE IN COATS' DISEASE: Toward an Updated Classification Predicting Visual Prognosis
Purpose: To determine the prevalence, clinical characteristics and nature of subfoveal nodules in Coats' disease and the associated impact on the long-term visual outcome. Methods: Consecutive cases of Coats' disease with foveal exudation were retrospectively reviewed. The presence of a subfoveal nodule or macular fibrosis was recorded. Clinical characteristics, retinal imaging, and outcome were analyzed by comparative analysis. The histopathological description of an enucleated eye with subfoveal nodule was performed. Results: Among 40 patients presenting unilateral Stage 2B or 3A1 Coats' disease, a subfoveal nodule was...
Source: RETINA - July 21, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Clinical presentation and disease course of usher syndrome because of mutations in myo7a or ush2a
Conclusion: The current study confirmed a more severe progression of the retinal disease in USH1 patients rather than in USH2 patients. Furthermore, most visual symptoms (i.e., night blindness, visual acuity worsening) occurred at an earlier age in USH1 patients carrying mutations in MYO7A. (Source: RETINA)
Source: RETINA - July 21, 2017 Category: Opthalmology Tags: Original Study Source Type: research

TOPICAL APRACLONIDINE REDUCES PAIN AFTER INTRAVITREAL INJECTIONS: A Double-Blind Randomized Controlled Trial
Purpose: To evaluate the efficacy of topical apraclonidine in reducing pain and subconjunctival hemorrhage (SCH) after intravitreal injections (IViT). Methods: A prospective, randomized, double-blinded study. Thirty-nine patients were examined twice, at each monthly IViT of 1.25 mg/0.05 mL bevacizumab. Patients were randomly assigned to receive either topical apraclonidine 0.5% or placebo to the treated eye, 30 minutes before the first IViT. At their second IViT, the intervention was switched. Thirty minutes after the injection, SCH size was measured by a slit lamp, and pain was assessed by the numerical rating scale (NRS...
Source: RETINA - July 21, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Assessment of the retinal structure in children with incontinentia pigmenti
Conclusion: Hand-held SDOCT imaging of the retina has brought to light additional retinal structural defects that were not previously reported or visualized via routine clinical ophthalmic examination including retinal photography. Despite a normal foveal structure and visual acuity, we identified inner and outer retinal thinning on SDOCT which may benefit from future functional assessment such as visual field testing. (Source: RETINA)
Source: RETINA - July 21, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Choroidal thickness of central serous chorioretinopathy secondary to corticosteroid use
Conclusion: The choroidal status in the acute phase of secondary CSC after corticosteroid use might be different from that of idiopathic CSC, which suggests a complex mechanism for CSC. (Source: RETINA)
Source: RETINA - July 21, 2017 Category: Opthalmology Tags: Original Study Source Type: research

USE OF A CARBONIC ANHYDRASE INHIBITOR IN X-LINKED RETINOSCHISIS: Effect on Cystic-Appearing Macular Lesions and Visual Acuity
Purpose: To evaluate changes in cystic-appearing macular lesions and visual acuity in patients with X-linked retinoschisis while being treated with a carbonic anhydrase inhibitor. Methods: A retrospective analysis of 68 eyes from 36 patients between the ages of 5 years and 61 years with X-linked retinoschisis were monitored while on a carbonic anhydrase inhibitor. Macular cystic-appearing lesions were monitored with optical coherence tomography. Snellen visual acuity measurements were converted to logarithm of the minimum angle of resolution equivalent Early Treatment Diabetic Retinopathy Study letters for analysis. Analy...
Source: RETINA - July 21, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Choroidal changes associated with serous macular detachment in eyes with staphyloma, dome-shaped macula or tilted disk syndrome
Purpose: To study the relationship of choroidal abnormalities with serous retinal detachment (SRD) in eyes with staphyloma, dome-shaped macula, or tilted disk syndrome. Methods: Group 1, 28 eyes of 20 patients with staphyloma/dome-shaped macula/tilted disk syndrome associated with SRD was compared with Group 2, 30 eyes of 20 patients, with staphyloma/dome-shaped macula/tilted disk syndrome but without SRD. Radial and en-face optical coherence tomography and choroidal analysis were performed. Results: Group 1 had a thicker mean subfoveal choroidal thickness (161 μm vs. 92 μm, P 0.05) compared with eyes of Group 2. F...
Source: RETINA - July 21, 2017 Category: Opthalmology Tags: Original Study Source Type: research

DIFFERENT SURGICAL MODALITIES FOR MANAGEMENT OF PERSISTENT GLAUCOMA AFTER SILICONE OIL REMOVAL IN VITRECTOMIZED EYES: One Year Comparative Study
Conclusion: For controlling persistent glaucoma after silicone oil removal in our work, Ex-Press minishunt had the highest complete success rate with no postoperative complications. (Source: RETINA)
Source: RETINA - July 21, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Long-term results of total retinectomy in cases with advanced proliferative vitreoretinopathy
Conclusion: Total retinectomy may be a last option to preserve the eyeball in cases with massive fibrosis and rhegmatogenous retinal detachment, despite previous complex surgical treatments. (Source: RETINA)
Source: RETINA - July 21, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Incomplete repair of retinal structure after vitrectomy with internal limiting membrane peeling
Conclusion: The ultrastructural studies showed that most of ILM peeling area was covered with glial cells during wound healing processes. Retinal changes were found comparable with dissociated optic nerve fiber layer appearance or dimple sign, which were clinically observed with optical coherence tomography. (Source: RETINA)
Source: RETINA - July 21, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Choroidal thickness and chorioretinal atrophy in myopic choroidal neovascularization with anti–vascular endothelial growth factor therapy
Conclusion: Chorioretinal atrophy progression was associated with a poor long-term prognosis. Relative thinning of the subfoveal choroid about the inferior choroid and subfoveal CNV location may predispose eyes with myopic CNV to develop CRA progression after anti–vascular endothelial growth factor therapy. (Source: RETINA)
Source: RETINA - July 21, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Recurrence in patients with type 3 neovascularization (retinal angiomatous proliferation) after intravitreal ranibizumab
Conclusion: Recurrence did not occur in 23.8% of the patients with Type 3 neovascularization who were initially treated with 3 monthly ranibizumab injections. Close follow-up examination may be needed 4 months to 6 months after the third ranibizumab injection. The close follow-up or continuous injection may also be required for patients with early first recurrences. (Source: RETINA)
Source: RETINA - July 21, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Clinical and electrophysiological evaluation after intravitreal ziv-aflibercept for exudative age-related macular degeneration
Purpose: To evaluate the 6-month safety and efficacy of ziv-aflibercept intravitreal injections for treating exudative age-related macular degeneration. Methods: Fifteen patients with unilateral exudative age-related macular degeneration were enrolled. The best-corrected visual acuity was measured and spectral domain optical coherence tomography was performed at baseline and monthly. Full-field electroretinography and multifocal electroretinography were obtained at baseline and 4, 13, and 26 weeks after the first injection. All patients received three monthly intravitreal injections of ziv-aflibercept (1.25 mg) followed b...
Source: RETINA - July 21, 2017 Category: Opthalmology Tags: Original Study Source Type: research

SEMIAUTOMATED QUANTITATIVE APPROACH TO CHARACTERIZE TREATMENT RESPONSE IN NEOVASCULAR AGE-RELATED MACULAR DEGENERATION: A Real-World Study
Conclusion: The semiautomated vessel segmentation software provides an objective and quantitative approach for choroidal neovascularization characterization. The consistently nonsignificant outcomes between the groups may provide evidence to support the “normalization hypothesis.” This would suggest that regardless of treatment interval, individualized therapy in these eyes established vessel stability. (Source: RETINA)
Source: RETINA - July 21, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Duration of prone positioning after macular hole surgery determined by swept-source optical coherence tomography
Purpose: To compare the closure rate of macular hole closure and duration of the prone positioning after macular hole (MH) surgery with two protocols for halting the prone positioning. Methods: The authors studied 129 eyes of 125 consecutive patients with MH who had undergone vitrectomy. In 60 eyes of 59 patients, the prone positioning was halted after detecting an MH closure in the swept-source optical coherence tomographic images (SS group). In 69 eyes of 66 patients, the prone position was halted by the surgeon's decision (conventional group). The MH closure rate and duration of the prone positioning were compared. Re...
Source: RETINA - July 21, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Reproducibility of vessel density measurement with optical coherence tomography angiography in eyes with and without retinopathy
Conclusion: The evidence presented here demonstrates good reproducibility of optical coherence tomography angiography for measurement of superficial macula vessel density in both healthy eyes and eyes with diabetic retinopathy without diabetic macular edema. (Source: RETINA)
Source: RETINA - July 21, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Characterization and differentiation of polypoidal choroidal vasculopathy using swept source optical coherence tomography angiography
Conclusion: Swept-source optical coherence tomography angiography is effective at detecting vascular network that correlate to conventional angiography in eyes with t-AMD and PCV. Swept-source optical coherence tomography angiography is inferior to indocyanine green angiography in detecting polyps and cannot replace indocyanine green angiography for differentiating PCV from t-AMD; however, SS-OCT-A may be more sensitive than SD-OCT in detecting early recurrence. (Source: RETINA)
Source: RETINA - July 21, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Optical coherence tomography angiography of chorioretinal lesions due to idiopathic multifocal choroiditis
Conclusion: Optical coherence tomography angiography may be a useful imaging modality for understanding the pathophysiology of multifocal choroiditis and monitoring its clinical course. (Source: RETINA)
Source: RETINA - July 21, 2017 Category: Opthalmology Tags: Original Study Source Type: research

RHEGMATOGENOUS RETINAL DETACHMENT AFTER INTRAARTERIAL CHEMOTHERAPY FOR RETINOBLASTOMA: The 2016 Founders Award Lecture
Conclusion: After IAC for retinoblastoma, RRD occurs in 6%, mostly in advanced eyes with extensive endophytic tumor and generally from atrophic retinal hole after rapid tumor regression. (Source: RETINA)
Source: RETINA - July 21, 2017 Category: Opthalmology Tags: Original Study Source Type: research

BRUCH MEMBRANE AND THE MECHANISM OF MYOPIZATION: A New Theory
Conclusions: It led to the hypothesis that axial elongation occurs by production of BM in the retro-equatorial region leading to a decreased RPE density and retinal thinning in that region and a more tube-like than spherical enlargement of the globe, without compromise in the density of the macular RPE cells and in macular retinal thickness. The increased disc-fovea distance in axially myopic eyes is caused by the development and enlargement of parapapillary, BM free, gamma zone while the length of macular BM, and indirectly macular RPE cell density and macular retinal thickness, remain constant. The target tissue for medi...
Source: RETINA - July 21, 2017 Category: Opthalmology Tags: Review Source Type: research

High Visual Acuity Retinal Prosthesis: Understanding Limitations and Advancements Toward Functional Prosthetic Vision
No abstract available (Source: RETINA)
Source: RETINA - July 21, 2017 Category: Opthalmology Tags: Editorial Source Type: research

Reply
No abstract available (Source: RETINA)
Source: RETINA - June 23, 2017 Category: Opthalmology Tags: Correspondence Source Type: research

Correspondence
No abstract available (Source: RETINA)
Source: RETINA - June 23, 2017 Category: Opthalmology Tags: Correspondence Source Type: research

Localized Bilateral Juxtafoveal Photoreceptor Loss in POEMS: A New Association
No abstract available (Source: RETINA)
Source: RETINA - June 23, 2017 Category: Opthalmology Tags: Photo Essay Source Type: research

Experience using a 3d head-mounted display system in ophthalmic surgery
No abstract available (Source: RETINA)
Source: RETINA - June 23, 2017 Category: Opthalmology Tags: New Instruments Source Type: research

Diagnostic and Therapeutic Challenges
No abstract available (Source: RETINA)
Source: RETINA - June 23, 2017 Category: Opthalmology Tags: Diagnostic and Therapeutic Challenges Source Type: research

Three-Dimensional Head-Mounted Display System for Ophthalmic Surgical Procedures
No abstract available (Source: RETINA)
Source: RETINA - June 23, 2017 Category: Opthalmology Tags: Surgical Technique Source Type: research

A Surgical Technique for the Management of Retinal Detachment Associated With Severe Proliferative Vitreoretinopathy
No abstract available (Source: RETINA)
Source: RETINA - June 23, 2017 Category: Opthalmology Tags: Surgical Technique Source Type: research

Ultrasound measurements of the distance between limbus and retinal break in eyes with media opacities
Conclusion: This study suggests relevant accuracy and reliability of US readings and provides the possibility of using this technique for localizing tears in eyes with media opacities by identifying the meridian and corneoscleral limbus-retinal break distance. (Source: RETINA)
Source: RETINA - June 23, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Comparison of the retinal blood flow velocity between laser speckle flowgraphy and the retinal function imager
This study included a total of 15 eyes of 15 healthy Japanese subjects (mean age, 41.7 ± 17.0 years). The retinal blood flow velocities were separately measured in arteries and veins around the optic disc using LSFG and an RFI. Linear regression analyses were used to analyze possible correlations of retinal blood flow velocities between the devices. Results: The average blood flow velocities using LSFG as the mean blur rate were 18.6 ± 4.8 in arteries and 18.3 ± 5.5 in veins. The average blood flow velocities using the RFI were 3.4 ± 1.1 mm/second in arteries and 2.9 ± 0.9 mm/second in v...
Source: RETINA - June 23, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Optical coherence tomography and infrared images of astrocytic hamartomas not revealed by funduscopy in tuberous sclerosis complex
Conclusion: The combined imaging with spectral-domain OCT and infrared images improves the detection of hamartomas if compared with the spectral-domain OCT technique alone. Moreover, a new subtype of hamartoma is proposed to complete a previous classification based on OCT. (Source: RETINA)
Source: RETINA - June 23, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Vitrectomy-assisted biopsy for molecular prognostication of choroidal melanoma 2 mm or less in thickness with a 27-gauge cutter
Conclusion: Tumor sampling of small choroidal melanoma with a 27-gauge vitreous cutter is safe and offers excellent biopsy yield for molecular prognostication when cancer prognosis is desired by patients. (Source: RETINA)
Source: RETINA - June 23, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Outcomes of an intravitreal injection clinic
Conclusion: An injection-only clinic may provide a reasonable approach to streamline retina practices to ensure that patients receive timely injections. (Source: RETINA)
Source: RETINA - June 23, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Functional and anatomical outcomes of choroidal neovascularization complicating best1-related retinopathy
Conclusion: There is a high rate of spontaneous recovery of BEST1-related choroidal neovascular membrane, and overall the authors observed a gain in visual acuity associated with a reduction in central macular thickness. Active treatment, here with intravitreal bevacizumab, is associated with better functional outcomes than observation alone. (Source: RETINA)
Source: RETINA - June 23, 2017 Category: Opthalmology Tags: Original Study Source Type: research

SAFETY OF INTRAVITREAL DEXAMETHASONE IMPLANT (OZURDEX): The SAFODEX study. Incidence and Risk Factors of Ocular Hypertension
Purpose: To analyze the incidence, risk factors, and time course of intraocular pressure elevation after intravitreal dexamethasone implant (Ozurdex). Methods: The medical charts of 421 consecutive eyes (361 patients) receiving one or more Ozurdex implant between October 2010 and February 2015 were reviewed retrospectively. Ocular hypertension was defined as intraocular pressure of at least 25 mmHg or an increase of at least 10 mmHg from baseline. The main indications for treatment were retinal vein occlusion (34%), diabetic macular edema (30%), postsurgical macular edema (17%), uveitis (14%), and other etiologies (5%). ...
Source: RETINA - June 23, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Ocular hypertension after intravitreal dexamethasone (ozurdex) sustained-release implant
Conclusion: Patients (26.9%) who received Ozurdex developed OHT. Glaucoma or glaucoma-suspicion factors were present in all patients who required invasive surgery for glaucoma. A greater proportion of patients who received multiple injections had an intraocular pressure elevation, but the relative intraocular pressure increase was not significant. (Source: RETINA)
Source: RETINA - June 23, 2017 Category: Opthalmology Tags: Original Study Source Type: research

INTRAVITREAL DEXAMETHASONE IMPLANT AS ADJUVANT TREATMENT FOR BEVACIZUMAB- AND RANIBIZUMAB-RESISTANT NEOVASCULAR AGE-RELATED MACULAR DEGENERATION: A Prospective Pilot Study
Purpose: To study the benefit of intravitreal dexamethasone implant in the management of neovascular age-related macular degeneration resistant to bevacizumab and ranibizumab. Methods: Patients with persistent macular fluid on optical coherence tomography despite monthly treatment with at least three consecutive bevacizumab injections followed by at least three ranibizumab injections were prospectively enrolled. A single dexamethasone implant was administered followed by intravitreal ranibizumab 1 week later. Ranibizumab was continued afterward on an as-needed basis. Main outcomes were improvement in central retinal thick...
Source: RETINA - June 23, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Association between visual function and subretinal drusenoid deposits in normal and early age-related macular degeneration eyes
Conclusion: In a study specifically focused on eyes in normal macular health and in the earliest phases of AMD, early AMD eyes with SDDs have slower dark adaptation, largely attributable to the older ages of eyes with SDD; they did not exhibit deficits in other visual functions. Subretinal drusenoid deposits in older eyes in normal macular health are not associated with any visual functions evaluated. (Source: RETINA)
Source: RETINA - June 23, 2017 Category: Opthalmology Tags: Original Study Source Type: research

INCIDENCE AND CAUSES OF VISION LOSS DURING AFLIBERCEPT TREATMENT FOR NEOVASCULAR AGE-RELATED MACULAR DEGENERATION: One-Year Follow-up
Conclusion: The incidence rate of vision loss during aflibercept treatment was relatively low. Identifying high-risk patients, those with a high PED height and disruption of the external limiting membrane, would be helpful in ensuring appropriate informed consent before treatment. Further studies are needed to establish optimal treatment for these patients. (Source: RETINA)
Source: RETINA - June 23, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Effect of intravitreal ranibizumab on ganglion cell complex and peripapillary retinal nerve fiber layer in neovascular age-related macular degeneration using spectral domain optical coherence tomography
Purpose: To analyze the changes in ganglion cell complex and peripapillary retinal nerve fiber layer thickness, in central macular thickness and choroidal thickness on spectral domain optical coherence tomography in patients with neovascular age-related macular degeneration treated with intravitreal ranibizumab injections. Methods: All consecutive patients with untreated neovascular age-related macular degeneration received loading phase of three monthly intravitreal ranibizumab, followed by retreatments on a pro re nata protocol for 12 months. Primary outcome: changes in ganglion cell complex and retinal nerve fiber laye...
Source: RETINA - June 23, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Analysis of age-related choroidal layers thinning in healthy eyes using swept-source optical coherence tomography
Conclusion: Choroidal and Haller's layer thickness profiles are similar between different age groups. Age-related choroidal thinning is mostly at the expense of Haller's layer. (Source: RETINA)
Source: RETINA - June 23, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Quantitative analysis of pigment epithelial detachment response to different anti–vascular endothelial growth factor agents in wet age-related macular degeneration
Purpose: To assess whether best-corrected visual acuity and pigment epithelial detachment (PED) height, volume, and reflectivity in patients with wet age-related macular degeneration are influenced by baseline anatomical and functional parameters, including quantifiable metrics of PED morphology and choice of treatment. Methods: One hundred two consecutive, treatment-naive wet age-related macular degeneration patients with PED (>50 μm) treated with aflibercept (52) or ranibizumab (50) were retrospectively included. Pigment epithelial detachment height, horizontal and vertical dimensions, and volume were recorded at ...
Source: RETINA - June 23, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Tomographic relationships between retinal neovascularization and the posterior vitreous in proliferative diabetic retinopathy
Conclusion: Tomographic analysis of diabetic NVCs showed that most NVCs arise and grow along the posterior hyaloid face and that vitreoschisis is more prevalent than what has been found in ultrasound studies. The wolf's jaw configuration does not seem to result from the invasion of the bursa, as previously suggested. (Source: RETINA)
Source: RETINA - June 23, 2017 Category: Opthalmology Tags: Original Study Source Type: research

COMBINED INTRAVITREAL RANIBIZUMAB AND ORAL SUPPLEMENTATION WITH DOCOSAHEXAENOIC ACID AND ANTIOXIDANTS FOR DIABETIC MACULAR EDEMA: Two-Year Randomized Single-Blind Controlled Trial Results
Conclusion: Intravitreal ranibizumab combined with DHA supplementation reduced central subfield macular thickness after 2 years of follow-up as compared with ranibizumab alone in patients with diabetic macular edema. This anatomical improvement was accompanied by a trend for an amelioration of vision. (Source: RETINA)
Source: RETINA - June 23, 2017 Category: Opthalmology Tags: Original Study Source Type: research

HIGH MYOPIA AND DIABETIC RETINOPATHY: A Contralateral Eye Study in Diabetic Patients With High Myopic Anisometropia
Purpose: To examine an association between high myopia and diabetic retinopathy (DR) in diabetic patients with high myopic anisometropia. Methods: A total of 116 white diabetic patients (232 eyes) with high myopia (spherical equivalent> −5.00 diopters, D) anisometropia (difference ≥ −6 D) were enrolled in this cross-sectional, contralateral eye study. The frequency of DR was compared between the high myopic and the contralateral eyes. Results: Compared with the fellow eyes, DR was significantly less frequent in high myopic side (27.6% vs. 100%, P (Source: RETINA)
Source: RETINA - June 23, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Gore-tex vascular graft for macular buckling in high myopia eyes
Conclusion: The initial pilot results from this series using a Gore-Tex graft for macular buckling is promising. Throughout the follow-up period, the Gore-Tex was well tolerated in the highly myopic eyes. Large scale and long-term follow-up is warranted. (Source: RETINA)
Source: RETINA - June 23, 2017 Category: Opthalmology Tags: Original Study Source Type: research