Development and validation of an explainable artificial intelligence framework for macular disease diagnosis based on optical coherence tomography images
Conclusion:
The integrated method achieved high accuracy and interpretability in retinal lesion classification and macular disease diagnosis in optical coherence tomography images and could have the potential to facilitate the clinical diagnosis. (Source: RETINA)
Source: RETINA - February 22, 2022 Category: Opthalmology Tags: Original Study Source Type: research
Denoising swept source optical coherence tomography volumetric scans using a deep learning model
Purpose:
To evaluate the use of a deep learning noise reduction model on swept source optical coherence tomography volumetric scans.
Methods:
Three groups of images including single-line highly averaged foveal scans (averaged images), foveal B-scans from volumetric scans using no averaging (unaveraged images), and deep learning denoised versions of the latter (denoised images) were obtained. We evaluated the potential increase in the signal-to-noise ratio by evaluating the contrast-to-noise ratio of the resultant images and measured the multiscale structural similarity index to determine whether the unaveraged a...
Source: RETINA - February 22, 2022 Category: Opthalmology Tags: Original Study Source Type: research
Associations between dysglycemia, retinal neurodegeneration, and microalbuminuria in prediabetes and type 2 diabetes
Purpose:
To explore the association between retinal neurodegeneration and metabolic parameters in progressive dysglycemia.
Method:
A cross-sectional study was performed on 68 participants: normal glucose tolerance (n = 23), prediabetes (n = 25), and Type 2 diabetes without diabetic retinopathy (n = 20). Anthropometric assessment and laboratory sampling for HbA1c, fasting glucose, insulin, c-peptide, lipid profile, renal function, and albumin-to-creatinine ratio were conducted. Central and pericentral macular thicknesses on spectral domain optical coherence tomography were compared with systemic parameters.
Re...
Source: RETINA - February 22, 2022 Category: Opthalmology Tags: Original Study Source Type: research
Correlation of photoreceptor integrity with retinal vessel density and choriocapillaris in eyes with diabetic retinopathy
Conclusion:
The size of the foveal avascular zone and ischemia at the deep capillary plexus may play an important role in maintaining foveal photoreceptor integrity in eyes with diabetic retinopathy. Considering optical coherence tomography angiography artifacts, such as projection and shadowing, future studies are required to reveal the correlation between ellipsoid zone disruption and the VD of the choriocapillaris. (Source: RETINA)
Source: RETINA - February 22, 2022 Category: Opthalmology Tags: Original Study Source Type: research
NEW BIOMARKER QUANTIFYING THE EFFECT OF ANTI-VEGF THERAPY IN EYES WITH PROLIFERATIVE DIABETIC RETINOPATHY ON ULTRAWIDE FIELD FLUORESCEIN ANGIOGRAPHY: RECOVERY Study
Purpose:
To quantify changes of the retinal vascular bed area (RVBA) in mm2 on stereographically projected ultrawide field fluorescein angiography images in eyes with proliferative diabetic retinopathy after antivascular endothelial growth factor injection.
Methods:
This is a prospective, observational study. The early-phase ultrawide field fluorescein angiography images (Optos 200Tx) of 40 eyes with proliferative diabetic retinopathy and significant nonperfusion obtained at baseline and after six months (NCT02863354) were stereographically projected by correcting peripheral distortion. The global retinal vascul...
Source: RETINA - February 22, 2022 Category: Opthalmology Tags: Original Study Source Type: research
