Risk for low visual acuity after 1 and 2 years of treatment with ranibizumab or bevacizumab for patients with neovascular age-related macular degeneration
Conclusion:Treatment with anti-vascular endothelial growth factor intravitreal injections mainly maintains the visual acuity level, and only approximately 20% and 40% of the patients required vision rehabilitation after 1 year and 2 years, respectively. (Source: RETINA)
Source: RETINA - October 25, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Foveal exudate and choroidal neovascularization in atypical cases of multiple evanescent white dot syndrome
Conclusion:A subset of patients with atypical MEWDS may develop persistent poor vision due to subfoveal exudation and secondary Type 2 neovascularization. Patients showing increased choroidal thickness at presentation may be more susceptible to this unusual presentation. (Source: RETINA)
Source: RETINA - October 25, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Integrity of outer retinal layers after resolution of central involved diabetic macular edema
Purpose:To evaluate the integrity of outer retina layers after resolution of central involved diabetic macular edema (DME) and to demonstrate the effect of various baseline factors for the final vision and final external limiting membrane (ELM) integrity. Methods:Fifty-nine eyes of 48 patients with resolved DME were included. Several optical coherence tomography parameters including central subfield thickness, maximum foveal thickness, foveal center point thickness, and the extent of the ellipsoidal (ISe) layer and ELM damage were assessed at the time of DME and after resolution of DME. Eyes having laser scars near the fo...
Source: RETINA - October 25, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Choriocapillaris signal voids in maternally inherited diabetes and deafness and in pseudoxanthoma elasticum
Purpose:To evaluate the pattern of choriocapillaris signal voids in maternally inherited diabetes and deafness and in pseudoxanthoma elasticum in eyes before the development of any geographic atrophy. Methods:The choriocapillaris under the central macula was imaged with the Optovue RTVue XR Avanti using a 10 μm slab thickness. Automatic local thresholding of the resultant raw data extracted areas of absent flow signal, called signal voids, and these were counted and logarithmically binned. The signal void patterns were analyzed in four eyes of two patients with maternally inherited diabetes and deafness and four eyes o...
Source: RETINA - October 25, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Assessment of retinal blood flow in diabetic retinopathy using doppler fourier-domain optical coherence tomography
Conclusion:Total retinal blood flow was significantly lower in eyes with severe NPDR and PDR compared with normal eyes. Retinal blood flow determined by Doppler OCT may be a useful parameter for evaluating patients with DR. (Source: RETINA)
Source: RETINA - October 25, 2017 Category: Opthalmology Tags: Original Study Source Type: research

RISK OF SILICONE OIL AS VITREOUS TAMPONADE IN PARS PLANA VITRECTOMY: A Systematic Review and Meta-Analysis
Conclusion:Based on the available studies, the authors conclude that there is no significant difference in the risk of poor outcomes between pars plana vitrectomy with silicone oil and that with other vitreous tamponades with different surgical histories. (Source: RETINA)
Source: RETINA - October 25, 2017 Category: Opthalmology Tags: Review Source Type: research

Reply
No abstract available (Source: RETINA)
Source: RETINA - September 27, 2017 Category: Opthalmology Tags: Correspondence Source Type: research

Correspondence
No abstract available (Source: RETINA)
Source: RETINA - September 27, 2017 Category: Opthalmology Tags: Correspondence Source Type: research

Reply
No abstract available (Source: RETINA)
Source: RETINA - September 27, 2017 Category: Opthalmology Tags: Correspondence Source Type: research

Correspondence
No abstract available (Source: RETINA)
Source: RETINA - September 27, 2017 Category: Opthalmology Tags: Correspondence Source Type: research

Reply
No abstract available (Source: RETINA)
Source: RETINA - September 27, 2017 Category: Opthalmology Tags: Correspondence Source Type: research

Correspondence
No abstract available (Source: RETINA)
Source: RETINA - September 27, 2017 Category: Opthalmology Tags: Correspondence Source Type: research

Circumscribed White Retinal Mass
No abstract available (Source: RETINA)
Source: RETINA - September 27, 2017 Category: Opthalmology Tags: Photo Essay Source Type: research

Multimodal Imaging of Presumed Ocular Manifestations in End-Stage Diffuse Large B-Cell Lymphoma
No abstract available (Source: RETINA)
Source: RETINA - September 27, 2017 Category: Opthalmology Tags: Photo Essay Source Type: research

Scleral Surgery for Uveal Effusion
No abstract available (Source: RETINA)
Source: RETINA - September 27, 2017 Category: Opthalmology Tags: Surgical Technique Source Type: research

Construct and face validity of the eyesi indirect ophthalmoscope simulator
Purpose: To evaluate construct and face validity of the Eyesi Binocular Indirect Ophthalmoscope Simulator. Methods: The performance of 25 medical students (Group A) was compared with that of 17 ophthalmology and optometry trainees (Group B) on the Eyesi Binocular Indirect Ophthalmoscope Simulator. During the course of a single session, each participant viewed an orientation module followed by an instruction session and a demonstration case, and performed 6 cases of progressively increasing difficulty (4 levels) and a 10-question face validity questionnaire. Outcomes included total score, total examination time, percent re...
Source: RETINA - September 27, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Repeatability and longitudinal assessment of foveal cone structure in cngb3-associated achromatopsia
Conclusion: Foveal cone structure showed little or no change in this group of subjects with CNGB3-associated achromatopsia. Over the time scales investigated (6–26 months), achromatopsia seems to be a structurally stable condition, although longer-term follow-up is needed. These data will be useful in assessing foveal cone structure after therapeutic intervention. (Source: RETINA)
Source: RETINA - September 27, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Vitreous incarceration in sclerotomies after valved 23-, 25-, or 27-gauge and nonvalved 23- or 25-gauge macular surgery
Conclusion: In 23- and 25-gauge macular surgeries, postoperative vitreous incarceration does not seem to be reduced using valved cannulas and was similar to that observed in 27-gauge surgery. (Source: RETINA)
Source: RETINA - September 27, 2017 Category: Opthalmology Tags: Original Study Source Type: research

SURGICAL OUTCOMES AND COMPLICATIONS OF RHEGMATOGENOUS RETINAL DETACHMENT IN EYES WITH CHORIORETINAL COLOBOMA: The Results of the KKESH International Collaborative Retina Study Group
Conclusion: The optimal option for managing retinal detachment in eyes with chorioretinal colobomas is pars plana vitrectomy with long-acting tamponade (silicone oil or octafluoropropane) and retinopexy to the edge of the coloboma and the primary breaks. Cryotherapy is associated with poor anatomical outcomes. An encircling band does not seem to affect the final anatomical outcome. (Source: RETINA)
Source: RETINA - September 27, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Factors influencing visual acuity in patients receiving anti-vascular endothelial growth factor for myopic choroidal neovascularization
Conclusion: Ranibizumab/bevacizumab therapy was effective in improving and maintaining visual acuity in myopic choroidal neovascularization. Early diagnosis, better baseline BCVA, and hyperfundus autofluorescence CNV pattern were strongly associated with better functional outcomes. Moreover, CNV distinguished by its small size and low CMT responded more favorably, achieving a better visual outcome. (Source: RETINA)
Source: RETINA - September 27, 2017 Category: Opthalmology Tags: Original Study Source Type: research

INVERTED INTERNAL LIMITING MEMBRANE FLAP TECHNIQUE VERSUS COMPLETE INTERNAL LIMITING MEMBRANE REMOVAL IN MYOPIC MACULAR HOLE SURGERY: A Comparative Study
Purpose: To compare the results of vitrectomy with complete internal limiting membrane (ILM) removal and inverted ILM flap in the treatment of myopic macular hole (MMH). Methods: Seventy eyes of 68 patients with MMH undergone pars-plana vitrectomy (PPV) with either complete ILM removal (n = 36, Group 1) or inverted ILM flap technique (n = 34, Group 2) were included in the study. Outcomes measured were the rate of MMH closure assessed by optical coherence tomography (OCT) and visual acuity (BCVA) at six months. Results: Closure of MMH was achieved in 22 cases of Group 1 (61%) and in 32 cases of Group 2 (94%). Surgical fai...
Source: RETINA - September 27, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Outcomes of pars plana vitrectomy in the management of refractory aqueous misdirection syndrome
Conclusion: The PPV was effective for managing aqueous misdirection refractory to medical therapy. Two-port or three-port PPV did not change the success rate but early surgery improved both anatomical and functional outcomes. (Source: RETINA)
Source: RETINA - September 27, 2017 Category: Opthalmology Tags: Original Study Source Type: research

ACUTE CENTRAL SEROUS CHORIORETINOPATHY: Factors Influencing Episode Duration
Conclusion: Older age, higher subfoveal choroidal thickness, and higher degree of retinal pigment epithelium alteration at leakage sites are independent factors of longer acute central serous chorioretinopathy episodes. (Source: RETINA)
Source: RETINA - September 27, 2017 Category: Opthalmology Tags: Original Study Source Type: research

ASSOCIATIONS BETWEEN MACULAR EDEMA AND CIRCULATORY STATUS IN EYES WITH RETINAL VEIN OCCLUSION: An Adaptive Optics Scanning Laser Ophthalmoscopy Study
Conclusion: Using adaptive optics scanning laser ophthalmoscopy in eyes with retinal vein occlusion macular edema, we could quantitatively evaluate the parafoveal AEV. A reduction or an increase in parafoveal AEV may be a clinical marker for the resolution or development/progression of macular edema respectively. (Source: RETINA)
Source: RETINA - September 27, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Outer retinal layer changes after dexamethasone implant for central retinal vein occlusion
Purpose: To analyze the outer retinal layer changes on spectral-domain optical coherence tomography after dexamethasone implant for the treatment of macular edema secondary to central retinal vein occlusions (CRVO). Methods: Thirty patients affected by macular edema related to CRVO (8 patients less than 50 years of age with nonischemic CRVO [50-niCRVO], and 10 patients with ischemic CRVO [iCRVO]) were included in a prospective study. After a comprehensive ophthalmologic examination, including best-corrected visual acuity, fluorescein angiography, and spectral-domain optical coherence tomography, each patient received a fi...
Source: RETINA - September 27, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Association of drusen volume with choroidal parameters in nonneovascular age-related macular degeneration
Conclusion: Choroidal intensity, but not choroidal thickness, seems to be associated with drusen volume in Amish and non-Amish populations. These observations suggest that choroidal parameters beyond thickness warrant further study in the setting of age-related macular degeneration. (Source: RETINA)
Source: RETINA - September 27, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Optical coherence tomography angiography changes in early type 3 neovascularization after anti-vascular endothelial growth factor treatment
Conclusion: Optical coherence tomography angiography showed that the tuft-shaped abnormal outer retinal lesion, frequently associated with a small clew-like flow signal in the choriocapillaris, after 1 year of anti–vascular endothelial growth factor therapy, either becomes undetectable or develops sub–retinal pigment epithelium neovascularization. (Source: RETINA)
Source: RETINA - September 27, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Choroidal thickness as a prognostic factor of photodynamic therapy with aflibercept or ranibizumab for polypoidal choroidal vasculopathy
Purpose: To investigate factors associated with visual improvement and retreatment 12 months after a combination therapy of intravitreal injection of ranibizumab or aflibercept followed by photodynamic therapy for polypoidal choroidal vasculopathy. Methods: Changes in the best-corrected visual acuity and the subfoveal thickness of the retina and choroid were studied in 56 consecutive eyes with polypoidal choroidal vasculopathy treated initially with a combination therapy of either intravitreal ranibizumab injection (n = 23) or intravitreal aflibercept injection (n = 33) followed by photodynamic therapy. Factors associated...
Source: RETINA - September 27, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Short-term safety of 2 mg intravitreal ziv-aflibercept
Conclusion: Single intravitreal injections of 2 mg ziv-aflibercept (0.08 mL) appear to be safe through 1 month. (Source: RETINA)
Source: RETINA - September 27, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Systemic pharmacokinetics and pharmacodynamics of intravitreal aflibercept, bevacizumab, and ranibizumab
Conclusion: The three anti-VEGF treatments examined in this analysis demonstrated notable differences in systemic PKs. Generally, the reduction in plasma free-VEGF levels correlated with elevated levels of circulating anti-VEGF agents, with the reduction in free-VEGF levels greatest with aflibercept and least with ranibizumab. (Source: RETINA)
Source: RETINA - September 27, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Imaging and measurement of the preretinal space in vitreomacular adhesion and vitreomacular traction by a new spectral domain optical coherence tomography analysis
Conclusion: Our study provides evidence of significant differences in preretinal space volume between eyes with VMA and those with VMT. This may be useful not only in the investigation of preretinal space properties in VMA and VMT, but also in other conditions, such as age-related macular degeneration, diabetic retinopathy, and central retinal vein occlusion. (Source: RETINA)
Source: RETINA - September 27, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Longitudinal microperimetry evaluation after intravitreal ocriplasmin injection for vitreomacular traction
Purpose: To determine whether improvements in microperimetry testing are associated with anatomic resolution after ocriplasmin treatment in patients with symptomatic vitreomacular adhesion (VMA)/vitreomacular traction and relatively preserved baseline best-corrected visual acuity (BCVA). Methods: Patients with vitreomacular traction received a single 125-μg intravitreal ocriplasmin injection and were followed longitudinally for 6 months with optical coherence tomography, BCVA testing, and microperimetry. Visual function changes were compared between eyes with and without VMA resolution on optical coherence tomography. ...
Source: RETINA - September 27, 2017 Category: Opthalmology Tags: Original Study Source Type: research

Pneumatic vitreolysis for relief of vitreomacular traction
Purpose: To evaluate the outcome of perfluoropropane (C3F8) gas injection for symptomatic vitreomacular traction (VMT) with or without Stage 2 macular hole (MH). Methods: A retrospective review of eyes with VMT treated with 0.3 mL of C3F8 gas was performed. Patients avoided the supine position until gas resolution. Patients with small MH maintained partial face-down positioning. Results: Forty-nine consecutive patients (50 eyes) with symptomatic VMT underwent pneumatic vitreolysis between 2010 and 2016. A posterior vitreous detachment developed in 43 eyes (86.0%) after a single gas injection, at a median of 3.0 weeks. Tw...
Source: RETINA - September 27, 2017 Category: Opthalmology Tags: Original Study Source Type: research

EFFECTS OF INTERNAL LIMITING MEMBRANE PEELING COMBINED WITH REMOVAL OF IDIOPATHIC EPIRETINAL MEMBRANE: A Systematic Review of Literature and Meta-Analysis
Purpose: To evaluate the effects on postoperative prognosis of internal limiting membrane (ILM) peeling in conjunction with removal of idiopathic epiretinal membranes (ERMs). Methods: MEDLINE, Cochrane Central Register of Controlled Trials (CENTRAL), and EMBASE were systematically searched for studies that compared ILM peeling with no ILM peeling in surgery to remove idiopathic ERM. Outcome measures were best-corrected visual acuity, central macular thickness, and ERM recurrence. Studies that compared ILM peeling with no ILM peeling for the treatment of idiopathic ERM were selected. Results: Sixteen studies that included...
Source: RETINA - September 27, 2017 Category: Opthalmology Tags: Review Source Type: research

Considerations in the Understanding of Venous Outflow in the Retinal Capillary Plexus
No abstract available (Source: RETINA)
Source: RETINA - September 27, 2017 Category: Opthalmology Tags: Editorial Source Type: research

Reply
No abstract available (Source: RETINA)
Source: RETINA - August 24, 2017 Category: Opthalmology Tags: Correspondence Source Type: research

Correspondence
No abstract available (Source: RETINA)
Source: RETINA - August 24, 2017 Category: Opthalmology Tags: Correspondence Source Type: research

Reply
No abstract available (Source: RETINA)
Source: RETINA - August 24, 2017 Category: Opthalmology Tags: Correspondence Source Type: research

Correspondence
No abstract available (Source: RETINA)
Source: RETINA - August 24, 2017 Category: Opthalmology Tags: Correspondence Source Type: research

Reply
No abstract available (Source: RETINA)
Source: RETINA - August 24, 2017 Category: Opthalmology Tags: Correspondence Source Type: research

Correspondence
No abstract available (Source: RETINA)
Source: RETINA - August 24, 2017 Category: Opthalmology Tags: Correspondence Source Type: research

Reply
No abstract available (Source: RETINA)
Source: RETINA - August 24, 2017 Category: Opthalmology Tags: Correspondence Source Type: research

Correspondence
No abstract available (Source: RETINA)
Source: RETINA - August 24, 2017 Category: Opthalmology Tags: Correspondence Source Type: research

Reply
No abstract available (Source: RETINA)
Source: RETINA - August 24, 2017 Category: Opthalmology Tags: Correspondence Source Type: research

Correspondence
No abstract available (Source: RETINA)
Source: RETINA - August 24, 2017 Category: Opthalmology Tags: Correspondence Source Type: research

Treatment of Postvitrectomy Fibrin Using Intravitreal Tissue Plasminogen Activator
No abstract available (Source: RETINA)
Source: RETINA - August 24, 2017 Category: Opthalmology Tags: Photo Essay Source Type: research