Reversal of Retinal Vascular Leakage and Arrest of Progressive Retinal Nonperfusion With Monthly Anti–Vascular Endothelial Growth Factor Therapy for Proliferative Diabetic Retinopathy
No abstract available (Source: RETINA)
Source: RETINA - August 23, 2018 Category: Opthalmology Tags: Photo Essay Source Type: research

Diagnostic and Therapeutic Challenges
No abstract available (Source: RETINA)
Source: RETINA - August 23, 2018 Category: Opthalmology Tags: Diagnostic and Therapeutic Challenges Source Type: research

INTRAOPERATIVE AND POSTOPERATIVE COMPLICATIONS IN PHACOVITRECTOMY FOR EPIRETINAL MEMBRANE AND MACULAR HOLE: A Clinical Audit of 1,000 Consecutive Eyes
Purpose: The aim of this study was to report the intraoperative and postoperative complications of phacovitrectomy for epiretinal membrane (ERM) and macular hole (MH). Methods: This was a retrospective audit of 1,052 phacovitrectomy operations (410 for ERM and 642 for MH) by the same surgical team between 1998 and 2017. Outcome measures included rates of intraoperative anterior segment and posterior segment complications such as posterior capsule rupture and retinal breaks. A subgroup analysis of 189 procedures in which postoperative complications were rigorously recorded was also undertaken. Results: The rate of p...
Source: RETINA - August 23, 2018 Category: Opthalmology Tags: Original Study Source Type: research

Blindness related to presumed retinal toxicity after using perfluorocarbon liquid during vitreoretinal surgery
Conclusion: Presumed toxic batches of perfluorocarbon liquid may cause massive retinal toxicity. A rapid suspicion, a correct traceability of surgical products, and informing health authorities are fundamental to prevent further cases of toxicity. (Source: RETINA)
Source: RETINA - August 23, 2018 Category: Opthalmology Tags: Original Study Source Type: research

ENDOPHTHALMITIS AFTER PARS PLANA VITRECTOMY: Efficacy of Intraoperative Subconjunctival Antibiotics
Conclusion: Prophylactic subconjunctival antibiotics were not associated with a significantly reduced rate of post-PPV endophthalmitis. With consideration of emerging multidrug-resistant bacteria, routine prophylactic subconjunctival antibiotics may not be justified. (Source: RETINA)
Source: RETINA - August 23, 2018 Category: Opthalmology Tags: Original Study Source Type: research

Temporal vascular arcade width and angle in high axial myopia
Purpose: Axial myopia is associated with elongation of the posterior ocular segment. The authors measured posterior fundus landmarks and assessed their associations with axial length. Methods: Using fundus photographs, the authors measured the vertical distance between the temporal superior and temporal inferior arterial arcade (VDA) and the angle kappa between the temporal arterial arcades among other morphometric variables. Results: The study included 456 eyes with a mean age of 61.2 ± 14.2 years (range: 13–88 years) and mean axial length of 29.4 ± 2.1 mm (range: 23.2–35.3 mm). Mean angl...
Source: RETINA - August 23, 2018 Category: Opthalmology Tags: Original Study Source Type: research

TREATMENT PATTERNS AND 2-YEAR VISION OUTCOMES WITH BEVACIZUMAB IN DIABETIC MACULAR EDEMA: An Analysis From a Large U.S. Integrated Health Care System
Conclusion: This is the largest U.S. clinical practice–based study of bevacizumab use in diabetic macular edema. Consistent with national studies, the frequency of injection was low. Average BCVA improvement was lower than in anti–vascular endothelial growth factor trials. Significant BCVA improvement was achieved in approximately 30% of patients with newly diagnosed diabetic macular edema. (Source: RETINA)
Source: RETINA - August 23, 2018 Category: Opthalmology Tags: Original Study Source Type: research

Impact of long-term intravitreal anti–vascular endothelial growth factor on preexisting microstructural alterations in diabetic macular edema
Purpose: Evaluation of the influence of long-term intravitreal anti–vascular endothelial growth factor treatment on preexisting retinal microstructural alterations in patients with diabetic macular edema. Methods: Eyes with diabetic macular edema and a history of ≥ 20 intravitreal anti–vascular endothelial growth factor (aflibercept and/or ranibizumab) injections were included in this retrospective study. Primary outcome was the extent of disorganization of retinal inner layers, alterations at the outer plexiform layer/Henle fiber layer junction, disruption of external limiting membrane/ellipsoid zone, ...
Source: RETINA - August 23, 2018 Category: Opthalmology Tags: Original Study Source Type: research

Value of fractal analysis of optical coherence tomography angiography in various stages of diabetic retinopathy
Conclusion: The optical coherence tomography angiography FD is significantly lower in both superficial and deep capillary plexuses in eyes with all stages studied of diabetic retinopathy. The results were more often significant for the deep capillary plexus. The use of fractal analysis provides an objective criterion to assess microvascular disease burden in diabetic retinopathy. (Source: RETINA)
Source: RETINA - August 23, 2018 Category: Opthalmology Tags: Original Study Source Type: research

Asymmetric diabetic retinopathy progression in patients with axial anisometropia
Purpose: To investigate the differences in the progression of diabetic retinopathy (DR) in both eyes of patients with axial anisometropia. Methods: A retrospective review was conducted on diabetic patients who had different axial lengths (difference greater than 1 mm) in each eye. The primary objective of this study was to analyze the differences in the progression of DR in both eyes of patients with axial anisometropia. Fundus images (fluorescein angiography and photographs of the fundus covering the Early Treatment Diabetic Retinopathy Study seven fields) were graded using the Early Treatment Diabetic Retinopathy St...
Source: RETINA - August 23, 2018 Category: Opthalmology Tags: Original Study Source Type: research

Changes in plasma vascular endothelial growth factor level after intravitreal injection of bevacizumab, aflibercept, or ranibizumab for diabetic macular edema
Purpose: The aim of this study was to investigate the changes in plasma vascular endothelial growth factor (VEGF) level depending on the severity of diabetic retinopathy (DR) or diabetic macular edema (DME) and after intravitreal injection of bevacizumab, aflibercept, or ranibizumab for treatment of DME. Methods: Plasma VEGF level was evaluated in 72 patients with DR and changes were measured in 42 patients with DME receiving intravitreal injections of bevacizumab, aflibercept, or ranibizumab at the initial injection. Results: There were no correlations between plasma VEGF level and the severity of DME or DR. Basel...
Source: RETINA - August 23, 2018 Category: Opthalmology Tags: Original Study Source Type: research

Efficacy and frequency of intravitreal aflibercept versus bevacizumab for macular edema secondary to central retinal vein occlusion
Purpose: To compare the safety, efficacy, and frequency of intravitreal injection of aflibercept and bevacizumab for treatment of macular edema secondary to central retinal vein occlusion. Design: Prospective, comparative, randomized, interventional study. Patients and Methods: Eyes with macular edema secondary to central retinal vein occlusion were randomized between two groups according to the intravitreal injection used. Group A included eyes treated with intravitreal aflibercept, and Group B included eyes treated with intravitreal bevacizumab injections. The inclusion criteria were macular edema secondary to ce...
Source: RETINA - August 23, 2018 Category: Opthalmology Tags: Original Study Source Type: research

Foveal avascular zone area after internal limiting membrane peeling for epiretinal membrane and macular hole compared with that of fellow eyes and healthy controls
Purpose: To measure the foveal avascular zone (FAZ) area after internal limiting membrane (ILM) peeling and to determine the factors significantly correlated with the FAZ area. Methods: This was a retrospective, observational, and cross-sectional study. The affected and normal fellow eyes of 102 patients with unilateral macular diseases and 169 healthy subjects were studied. The patients underwent successful vitrectomy with internal limiting membrane peeling for an epiretinal membrane (n = 56) or a macular hole (n = 46). The superficial FAZ area and average foveal (within 1 mm) thickness were measured. The main outcom...
Source: RETINA - August 23, 2018 Category: Opthalmology Tags: Original Study Source Type: research

Arcuate nerve fiber layer changes after internal limiting membrane peeling in idiopathic epiretinal membrane
Purpose: To analyze the relationship between swelling of the arcuate nerve fiber layer (SANFL) and long-term decrease of retinal nerve fiber layer thickness after internal limiting membrane peeling for idiopathic epiretinal membrane, and to investigate if SANFL is related to a mechanical surgical damage. Methods: Prospective, interventional consecutive case series of 46 eyes that underwent combined epiretinal membrane/internal limiting membrane peeling for idiopathic epiretinal membrane. Infrared, blue autofluorescence, color fundus imaging and measurement of retinal nerve fiber layer thickness in six peripapillary se...
Source: RETINA - August 23, 2018 Category: Opthalmology Tags: Original Study Source Type: research

Comparative analysis of retinal reattachment surgery with or without internal limiting membrane peeling to prevent postoperative macular pucker
Conclusion: Internal limiting membrane peeling during pars plana vitrectomy for rhegmatogenous retinal detachment significantly reduces ERM formation in the postoperative period and is associated with better visual and anatomical outcomes. (Source: RETINA)
Source: RETINA - August 23, 2018 Category: Opthalmology Tags: Original Study Source Type: research

Imaging of pigment epithelial detachments with optical coherence tomography angiography
Conclusion: Our proposed two-step approach of OCTA interpretation, first using cross-sectional OCTA and then en face OCTA, may allow the detection of vascularization within PEDs and, in some cases, reduce the need for conventional angiography. Increased awareness about potential artifacts and limitations of OCTA may help clinicians interpret OCTA more accurately. (Source: RETINA)
Source: RETINA - August 23, 2018 Category: Opthalmology Tags: Original Study Source Type: research

IDENTIFYING FEATURES OF EARLY AND LATE AGE-RELATED MACULAR DEGENERATION: A Comparison of Multicolor Versus Traditional Color Fundus Photography
Conclusion: Multicolor retinal imaging allowed for improved detection and definition of AMD features. (Source: RETINA)
Source: RETINA - August 23, 2018 Category: Opthalmology Tags: Original Study Source Type: research

Macular atrophy and macular morphology in aflibercept-treated neovascular age-related macular degeneration
Conclusion: Macular atrophy developed in about 10% of eyes with neovascular age-related macular degeneration during 12 months of treatment with a fixed regimen of aflibercept. Intraretinal fluid and subfoveal choroidal thickness seem to be predictors for development of macular atrophy after anti-vascular endothelial growth factor (VEGF) therapy. (Source: RETINA)
Source: RETINA - August 23, 2018 Category: Opthalmology Tags: Original Study Source Type: research

The natural history of full-field stimulus threshold decline in choroideremia
Purpose: To evaluate full-field sensitivity thresholds (FSTs) across a wide range of choroideremia (CHM) disease stages and to determine their applicability as functional endpoints for CHM clinical trials. Methods: Thirty CHM subjects (60 eyes) and 50 healthy controls (50 eyes) underwent FST testing under dark-adapted conditions to determine rod- and cone-mediated FSTs. Central retinal structure and function were assessed using fundus autofluorescence and microperimetry. Correlation and regression analyses were performed to compare FST responses with the residual area of retinal pigment epithelium in the peri- and par...
Source: RETINA - August 23, 2018 Category: Opthalmology Tags: Original Study Source Type: research

SCLERAL PITS IN CHOROIDEREMIA: Implications for Retinal Gene Therapy
We report a novel finding on spectral domain optical coherence tomography in patients with choroideremia, which we describe as scleral pits (SCPs). Methods: Cross-sectional observational case series of 36 patients with choroideremia, who underwent ophthalmic examination and multimodal imaging, including optical coherence tomography of the macula. Optical coherence tomography images were reviewed for SCP, which were defined as discrete tracts of hyporeflectivity that traverse the sclera with or without the involvement of Bruch membrane, retinal pigment epithelium, and retina. Unpaired two-tailed t-test with Welch correct...
Source: RETINA - August 23, 2018 Category: Opthalmology Tags: Original Study Source Type: research

Long-term follow-up of patients with choroideremia with scleral pits and tunnels as a novel observation
Conclusion: Choroideremia is a severely debilitating disease showing a rapid decline of visual acuity generally after the age of 35, but a more gradual decline for other abnormalities. (Source: RETINA)
Source: RETINA - August 23, 2018 Category: Opthalmology Tags: Original Study Source Type: research

Prophylactic preoperative laser retinopexy does not reduce the occurrence of rhegmatogenous retinal complications in macular surgery
Conclusion: Preoperative prophylactic peripheral laser retinopexy does not seem to offer an added benefit in the prevention of intraoperative and postoperative rhegmatogenous events. (Source: RETINA)
Source: RETINA - August 23, 2018 Category: Opthalmology Tags: Original Study Source Type: research

Prevalence of foveolar lucency with different gas tamponades in surgically closed macular holes assessed by spectral domain optical coherence tomography
Conclusion: Temporary FL is a highly prevalent feature in successfully closed macular holes. Eyes treated with C3F8 gas had lower rates of FL at Month 1 than C2F6 and SF6-treated eyes. The presence of FL in closed holes does not seem to have any effect on the visual outcomes. (Source: RETINA)
Source: RETINA - August 23, 2018 Category: Opthalmology Tags: Original Study Source Type: research

Lean six sigma techniques to improve ophthalmology clinic efficiency
Conclusion: Manufacturing industry techniques, such as Lean and Six Sigma, can be used to improve patient care, minimize waste, and enhance patient and staff satisfaction in outpatient clinics. (Source: RETINA)
Source: RETINA - August 23, 2018 Category: Opthalmology Tags: Original Study Source Type: research

Comparison of optical coherence tomography angiographic changes after anti–vascular endothelial growth factor therapy alone or in combination with photodynamic therapy in polypoidal choroidal vasculopathy
Conclusion: Longitudinal optical coherence tomography angiography demonstrates more significant reduction in lesion flow and pachyvessels in the short term after combination therapy than after monotherapy, although visual and structural OCT showed similar improvement. (Source: RETINA)
Source: RETINA - August 23, 2018 Category: Opthalmology Tags: Original Study Source Type: research

Indocyanine green angiography of pachychoroid pigment epitheliopathy
Purpose: To compare choroidal hyperpermeability and vessel density between eyes with central serous chorioretinopathy (CSC), those with pachychoroid pigment epitheliopathy (PPE) and those with uncomplicated pachychoroid (UCP). Methods: We retrospectively reviewed indocyanine green angiography images of 60 patients with unilateral active CSC who had PPE (36 eyes) or UCP (24 eyes) in their fellow eyes. We used color thresholding of indocyanine green angiography images to determine choroidal vessel density. Results: The mean choroidal thickness of eyes with CSC was greater than that of eyes with PPE or UCP, but this d...
Source: RETINA - August 23, 2018 Category: Opthalmology Tags: Original Study Source Type: research

Peripapillary pachychoroid syndrome
Purpose: To describe the features of peripapillary pachychoroid syndrome (PPS), a novel pachychoroid disease spectrum (PDS) entity. Methods: Medical records of 31 eyes (16 patients) with choroidal thickening associated with intraretinal and/or subretinal fluid in the nasal macula extending from the disk were reviewed (patients with PPS). Choroidal thickness was compared with 2 age-matched cohorts: typical PDS (17 eyes with central serous chorioretinopathy or pachychoroid neovasculopathy) and 19 normal eyes. Results: The patients with PPS were 81% men aged 71 ± 7 years. Peripapillary pachychoroid syndrome eye...
Source: RETINA - August 23, 2018 Category: Opthalmology Tags: Original Study Source Type: research

ASSOCIATION OF OBSTRUCTIVE SLEEP APNEA WITH CENTRAL SEROUS CHORIORETINOPATHY AND CHOROIDAL THICKNESS: A Systematic Review and Meta-Analysis
Conclusion: In summary, our results suggest that patients with CSCR are more likely to have OSA, and that moderate/severe OSA is associated with smaller subfoveal choroidal measurements on enhanced depth imaging optical coherence tomography. (Source: RETINA)
Source: RETINA - August 23, 2018 Category: Opthalmology Tags: Review Source Type: research

Is It Time to Abandon Subconjunctival Antibiotics following Pars Plana Vitrectomy?
No abstract available (Source: RETINA)
Source: RETINA - August 23, 2018 Category: Opthalmology Tags: Editorial Source Type: research

Reply
No abstract available (Source: RETINA)
Source: RETINA - August 1, 2018 Category: Opthalmology Tags: Correspondence Source Type: research

Correspondence
No abstract available (Source: RETINA)
Source: RETINA - August 1, 2018 Category: Opthalmology Tags: Correspondence Source Type: research

Reply
No abstract available (Source: RETINA)
Source: RETINA - August 1, 2018 Category: Opthalmology Tags: Correspondence Source Type: research

Correspondence
No abstract available (Source: RETINA)
Source: RETINA - August 1, 2018 Category: Opthalmology Tags: Correspondence Source Type: research

Reply
No abstract available (Source: RETINA)
Source: RETINA - August 1, 2018 Category: Opthalmology Tags: Correspondence Source Type: research

Correspondence
No abstract available (Source: RETINA)
Source: RETINA - August 1, 2018 Category: Opthalmology Tags: Correspondence Source Type: research

Reply
No abstract available (Source: RETINA)
Source: RETINA - August 1, 2018 Category: Opthalmology Tags: Correspondence Source Type: research

Correspondence
No abstract available (Source: RETINA)
Source: RETINA - August 1, 2018 Category: Opthalmology Tags: Correspondence Source Type: research

Reply
No abstract available (Source: RETINA)
Source: RETINA - August 1, 2018 Category: Opthalmology Tags: Correspondence Source Type: research

Correspondence
No abstract available (Source: RETINA)
Source: RETINA - August 1, 2018 Category: Opthalmology Tags: Correspondence Source Type: research

Branch Retinal Artery Ischemia
No abstract available (Source: RETINA)
Source: RETINA - August 1, 2018 Category: Opthalmology Tags: Photo Essay Source Type: research

Diagnostic and Therapeutic Challenges
No abstract available (Source: RETINA)
Source: RETINA - August 1, 2018 Category: Opthalmology Tags: Diagnostic and Therapeutic Challenges Source Type: research

Changes in choroidal thickness in clinically significant pseudophakic cystoid macular edema
Purpose: To investigate choroidal thickness in eyes with clinically significant pseudophakic cystoid macular edema (PCME) during the acute phase and following resolution of the edema, using enhanced depth imaging spectral domain optical coherence tomography (EDI-OCT). Methods: This is a retrospective, observational clinical study. Patients' records were reviewed for cases of clinically significant PCME after uneventful phacoemulsification surgery. Choroidal thickness was measured at time of PCME diagnosis in both eyes and after CME resolution in the affected eye using enhanced depth imaging spectral domain optical coh...
Source: RETINA - August 1, 2018 Category: Opthalmology Tags: Original Study Source Type: research

Interocular asymmetry in choroidal thickness and retinal sensitivity in high myopia
Purpose: To investigate the normal range of interocular asymmetry in choroidal thickness and retinal sensitivity in high myopia without ocular fundus manifestations and to determine the relationship between interocular asymmetry and refractive error. Methods: Forty-three patients (35.07 ± 13.31 years) with high myopia and 45 healthy participants (39.9 ± 14.1 years) were administered an ocular coherence tomography and a microperimetry examination to determine choroidal thickness and retinal sensitivity at the foveal region and at 1, 2, and 3 mm, nasally, temporally, superiorly, and inferiorly. Absolute in...
Source: RETINA - August 1, 2018 Category: Opthalmology Tags: Original Study Source Type: research

The relationship between foveal avascular zone area, vessel density, and cystoid changes in diabetic retinopathy: an optical coherence tomography angiography study
Conclusion: The FAZ area and vessel density at the superficial capillary plexus level are reproducible and independent of the presence of cystoid edema. (Source: RETINA)
Source: RETINA - August 1, 2018 Category: Opthalmology Tags: Original Study Source Type: research

Atypical form of retinopathy of prematurity with severe fibrovascular proliferation in the optic disk region
Conclusion: An atypical and severe form of ROP, in which fibrovascular proliferation grew mainly from the optic disk region, needs further investigation for treatment in addition to laser photocoagulation and vitreous surgery. (Source: RETINA)
Source: RETINA - August 1, 2018 Category: Opthalmology Tags: Original Study Source Type: research

Short-term outcomes after intravitreal injections of conbercept versus ranibizumab for the treatment of retinopathy of prematurity
Conclusion: Both conbercept and ranibizumab are effective choice for the treatment of ROP. Conbercept is a novel effective treatment strategy for ROP providing a new treatment option for ophthalmologists. (Source: RETINA)
Source: RETINA - August 1, 2018 Category: Opthalmology Tags: Original Study Source Type: research

Handheld spectral domain optical coherence tomography imaging through the undilated pupil in infants born preterm or with hypoxic injury or hydrocephalus
Conclusion: Undilated, handheld SDOCT imaging is a potential alternative method to evaluate the retina and optic nerve in patients with relative contraindication to pharmacological pupil dilation. This approach will enable the study of the eye–brain connection and ocular manifestations of neurologic diseases. (Source: RETINA)
Source: RETINA - August 1, 2018 Category: Opthalmology Tags: Original Study Source Type: research

Time course of changes in metamorphopsia following intravitreal ranibizumab injection for branch retinal vein occlusion
Purpose: To evaluate the effects of intravitreal ranibizumab injection (IVR) on metamorphopsia in patients with branch retinal vein occlusion (BRVO) and to assess the relationship between retinal microstructure and metamorphopsia. Methods: Subjects were 39 eyes of 39 patients with branch retinal vein occlusion. The severity of metamorphopsia was quantified using the M-CHARTS before and 1, 2, 3, 4, 5, and 6 months after treatment. Based on optical coherence tomography (OCT) images, we assessed central retinal thickness (CRT) and status of the external limiting membrane (ELM) and ellipsoid zone (EZ). The association bet...
Source: RETINA - August 1, 2018 Category: Opthalmology Tags: Original Study Source Type: research

EVALUATION OF MACULAR ISCHEMIA IN EYES WITH CENTRAL RETINAL VEIN OCCLUSION: An Optical Coherence Tomography Angiography Study
Conclusion: Optical coherence tomography angiography is a novel technique that enables segmented evaluation of the macular perfusion status in eyes with central retinal vein occlusion and provides visual prognostic information. Enlargement of the macular NPA in the superficial and deep layers was significantly correlated with impaired visual acuity and with decreased macular sensitivity in patients with aflibercept-treated central retinal vein occlusion and resolved macular edema. (Source: RETINA)
Source: RETINA - August 1, 2018 Category: Opthalmology Tags: Original Study Source Type: research