ULTRASOUND IN VITRECTOMY: An Alternative Approach to Traditional Vitrectomy Techniques
Conclusion: Ultrasound-based vitrectomy may represent an important alternative to traditional vitrectomy. Such a tool, capable of liquefying and excising the vitreous body using ultrasound, could overcome all the limits of the guillotine-based technique (GV). Knowledge of the physical phenomena underlying ultrasound-based technology is a necessary prerequisite for further development of this new technology. (Source: RETINA)
Source: RETINA - December 20, 2019 Category: Opthalmology Tags: Original Study Source Type: research

First-in-human clinical study to investigate the effectiveness and safety of pars plana vitrectomy surgery using a new hypersonic technology
Conclusion: This first-in-human study suggests that this new hypersonic vitrector technology is a promising alternative to commercially available guillotine vitrectors. The hypersonic vitrector was effective in core vitreous removal in all cases. Larger-scale studies are required to expand on our initial findings for induction of a posterior vitreous detachment or peripheral vitrectomy. (Source: RETINA)
Source: RETINA - December 20, 2019 Category: Opthalmology Tags: Original Study Source Type: research

FIRST FAILED MACULAR HOLE SURGERY OR REOPENING OF A PREVIOUSLY CLOSED HOLE: Do We Gain by Reoperating?—A Systematic Review and Meta-analysis
Purpose: To evaluate repeated surgery for idiopathic full-thickness macular hole that failed to close (FTC) after first surgery or reopened (RO) once originally closed. Methods: Systematic review and meta-analysis. Pubmed.gov and Cochrane Library were searched for studies in English presenting outcomes of idiopathic full-thickness macular hole that FTC or RO (case reports/series of (Source: RETINA)
Source: RETINA - December 20, 2019 Category: Opthalmology Tags: Review Source Type: research

Reply
No abstract available (Source: RETINA)
Source: RETINA - November 27, 2019 Category: Opthalmology Tags: Correspondence Source Type: research

Correspondence
No abstract available (Source: RETINA)
Source: RETINA - November 27, 2019 Category: Opthalmology Tags: Correspondence Source Type: research

Reply
No abstract available (Source: RETINA)
Source: RETINA - November 27, 2019 Category: Opthalmology Tags: Correspondence Source Type: research

Correspondence
No abstract available (Source: RETINA)
Source: RETINA - November 27, 2019 Category: Opthalmology Tags: Correspondence Source Type: research

Reply
No abstract available (Source: RETINA)
Source: RETINA - November 27, 2019 Category: Opthalmology Tags: Correspondence Source Type: research

Correspondence
No abstract available (Source: RETINA)
Source: RETINA - November 27, 2019 Category: Opthalmology Tags: Correspondence Source Type: research

Reply
No abstract available (Source: RETINA)
Source: RETINA - November 27, 2019 Category: Opthalmology Tags: Correspondence Source Type: research

Correspondence
No abstract available (Source: RETINA)
Source: RETINA - November 27, 2019 Category: Opthalmology Tags: Correspondence Source Type: research

Reply
No abstract available (Source: RETINA)
Source: RETINA - November 27, 2019 Category: Opthalmology Tags: Correspondence Source Type: research

Correspondence
No abstract available (Source: RETINA)
Source: RETINA - November 27, 2019 Category: Opthalmology Tags: Correspondence Source Type: research

Reply
No abstract available (Source: RETINA)
Source: RETINA - November 27, 2019 Category: Opthalmology Tags: Correspondence Source Type: research

Correspondence
No abstract available (Source: RETINA)
Source: RETINA - November 27, 2019 Category: Opthalmology Tags: Correspondence Source Type: research

Bilateral Ocular Injury From Lightning Strike
No abstract available (Source: RETINA)
Source: RETINA - November 27, 2019 Category: Opthalmology Tags: Photo Essay Source Type: research

Diagnostic and Therapeutic Challenges
No abstract available (Source: RETINA)
Source: RETINA - November 27, 2019 Category: Opthalmology Tags: Diagnostic and Therapeutic Challenges Source Type: research

Clinical course of paraneoplastic retinopathy with anti-trpm1 autoantibody in japanese cohort
Conclusion: Paraneoplastic retinopathy patients with retinal ON-bipolar cell dysfunction possess autoantibodies against TRPM1 at the onset of the disease process; however, the clinical course of these eyes can be different. (Source: RETINA)
Source: RETINA - November 27, 2019 Category: Opthalmology Tags: Original Study Source Type: research

Correlations between choroidal structures and visual functions in eyes with retinitis pigmentosa
Purpose: To investigate the choroidal structures in the enhanced depth imaging optical coherence tomographic images in eyes with retinitis pigmentosa (RP) and to determine correlations between the choroidal structures and visual functions. Methods: The enhanced depth imaging optical coherence tomographic images of 100 eyes with typical RP and 60 age-, sex-, and axial length–matched normal eyes were binarized using ImageJ. The cross-sectional luminal and stromal areas of the inner and outer subfoveal choroid of 1,500-µm width were measured. The inner choroid included the choriocapillaris and medium vessel l...
Source: RETINA - November 27, 2019 Category: Opthalmology Tags: Original Study Source Type: research

Subclinical macular changes and disease laterality in pediatric coats disease determined by quantitative optical coherence tomography angiography
Conclusion: The findings support the unilaterality of Coats disease and show that vascular changes on optical coherence tomography angiography precede clinical staging of the condition. (Source: RETINA)
Source: RETINA - November 27, 2019 Category: Opthalmology Tags: Original Study Source Type: research

Assessment of macular vasculature of children with sickle cell disease compared to that of healthy controls using optical coherence tomography angiography
Conclusion: The foveal vascular density was significantly reduced and area of the foveal avascular zone was significantly increased in the eyes of patients with SCD. Consistent architectural changes in the perifoveal capillaries were also observed in the pediatric patients with SCD. (Source: RETINA)
Source: RETINA - November 27, 2019 Category: Opthalmology Tags: Original Study Source Type: research

Scotopic and fast mesopic microperimetry in eyes with drusen and reticular pseudodrusen
Purpose: To evaluate the feasibility in the clinical practice of a fast and simple mesopic microperimetry examination comparing the retinal sensitivity in eyes with drusen and reticular pseudodrusen by scotopic and mesopic testing. Methods: In eyes with only drusen and only reticular pseudodrusen, retinal sensitivity was assessed by mesopic testing and after 35 minutes of dark adaptation by scotopic testing using 2 grids of 6 and 10 stimulus points. Results: Fifteen eyes with drusen and 14 eyes with reticular pseudodrusen were enrolled with mean best-corrected visual acuity of 20/20. In mesopic and scotopic examina...
Source: RETINA - November 27, 2019 Category: Opthalmology Tags: Original Study Source Type: research

RANIBIZUMAB IN PIGMENT EPITHELIAL TEARS SECONDARY TO AGE-RELATED MACULAR DEGENERATION: A Prospective Study
Conclusion: In retinal pigment epithelium tears secondary to age-related macular degeneration, monthly intravitreal ranibizumab therapy results in stabilization of visual acuity over 12 months. (Source: RETINA)
Source: RETINA - November 27, 2019 Category: Opthalmology Tags: Original Study Source Type: research

Changes in optical coherence tomography findings in patients with chronic renal failure undergoing dialysis for the first time
Conclusion: Macular edema and central subfield thickness significantly decreased after initiation of dialysis in patients with diabetic chronic renal failure without any ocular treatment. This may be related to the improvement in uremia and volume overload after the initiation of dialysis. (Source: RETINA)
Source: RETINA - November 27, 2019 Category: Opthalmology Tags: Original Study Source Type: research

FACEDOWN POSITIONING AFTER VITRECTOMY WILL NOT FACILITATE MACULAR HOLE CLOSURE BASED ON SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY IMAGING IN GAS-FILLED EYES: A Prospective, Randomized Comparative Interventional Study
Conclusion: The nFD protocol neither delayed the MH closure nor decreased the final closure rate after vitrectomy surgery. Therefore, postoperative prone position seems to be unnecessary for all MH repair procedures. (Source: RETINA)
Source: RETINA - November 27, 2019 Category: Opthalmology Tags: Original Study Source Type: research

ASSESSMENT OF ANATOMICAL AND FUNCTIONAL OUTCOMES WITH OCRIPLASMIN TREATMENT IN PATIENTS WITH VITREOMACULAR TRACTION WITH OR WITHOUT MACULAR HOLES: Results of OVIID-1 Trial
Conclusion: Ocriplasmin is effective for resolution of VMT without or with MH (≤400 μm); treatment outcomes can be optimized with patient selection. (Source: RETINA)
Source: RETINA - November 27, 2019 Category: Opthalmology Tags: Original Study Source Type: research

INNER MACULAR CHANGES AFTER VITRECTOMY WITH INTERNAL LIMITING MEMBRANE PEELING FOR RHEGMATOGENOUS RETINAL DETACHMENT: Similarity With Alport Syndrome
This study aimed to investigate the effect of ILM loss on the retina. Methods: We used optical coherence tomography to retrospectively evaluate retinal changes in 26 eyes (11 ILM-peeled and 15 ILM-unpeeled eyes) of 26 patients after vitrectomy for retinal detachment. In addition, we studied six eyes of three patients with Alport syndrome, in which ILM is genetically impaired. Results: We observed significant inner retinal displacement of the foveal pit toward the optic disk with inner retinal thickening in the nasal area (fellow, 191.9 ± 24.3 μm vs. affected, 210.3 ± 31.4 μm; P = 0.048), inner ret...
Source: RETINA - November 27, 2019 Category: Opthalmology Tags: Original Study Source Type: research

FIVE-YEAR FUNCTIONAL OUTCOMES AFTER EPIRETINAL MEMBRANE SURGERY: A Prospective, Controlled Study
Purpose: To evaluate 5-year functional outcomes involving the inner retina after epiretinal membrane (ERM) surgery. Methods: The study eye (SE) and fellow eye (FE) of 20 patients undergoing ERM surgery were examined preoperatively and at 3, 12, 24, 36, 48, and 60 months postoperatively. Retinal nerve fiber layer and ganglion cell–inner plexiform layer (GC-IPL) thicknesses were analyzed using spectral domain optical coherence tomography. Humphrey visual field mean deviation, pattern SD, and qualitative changes were assessed and compared over time. Results: Mean GC-IPL thickness in SEs was less than that of FEs...
Source: RETINA - November 27, 2019 Category: Opthalmology Tags: Original Study Source Type: research

CLINICAL CHARACTERIZATION OF STARGARDT DISEASE PATIENTS WITH THE p.N1868I ABCA4 MUTATION
Conclusion: This study demonstrates the consistency of foveal sparing, the variation in age at onset, the intrafamilial variability, and the prognosis with regard to visual acuity in p.N1868I-associated Stargardt disease. (Source: RETINA)
Source: RETINA - November 27, 2019 Category: Opthalmology Tags: Original Study Source Type: research

Genetic risk factors in acute central serous chorioretinopathy
Conclusion: Three variants in the CFH gene and copy number variations in C4B were found to be significantly associated with the risk of aCSC development. Despite the differences in clinical presentation, acute and chronic CSC may share a similar genetic predisposition based on our present analysis. Other genetic and/or nongenetic risk factors may be more influential in the differentiation toward an acute or a chronic phenotype of CSC. (Source: RETINA)
Source: RETINA - November 27, 2019 Category: Opthalmology Tags: Original Study Source Type: research

Peripapillary neurovascular coupling in the early stages of diabetic retinopathy
Purpose: To study radial peripapillary capillary (RPC) density in the early stages of diabetic retinopathy (DR), using optical coherence tomography angiography. Methods: A cross-sectional evaluation of RPCs was performed using optical coherence tomography angiography (Avanti RTVue-XR 100, Optovue Inc, Fremont, CA). Annular RPC density was the primary outcome. Global density and retinal nerve fiber layer thickness were secondary outcomes. Diabetic eyes were divided into three groups: no DR, mild nonproliferative DR (mild NPDR), and moderate NPDR. Multilevel mixed-effects univariate and multivariate linear regression mo...
Source: RETINA - November 27, 2019 Category: Opthalmology Tags: Original Study Source Type: research

Optical coherence tomography biomarkers to distinguish diabetic macular edema from pseudophakic cystoid macular edema using machine learning algorithms
Conclusion: Confirming a diabetic etiology for edema in cases with uncertainty between diabetic cystoid ME and pseudophakic ME was possible using few spectral domain optical coherence tomography parameters with high accuracy. We propose a clinical decision flowchart for cases with uncertainty, which may support the decision for intravitreal injections rather than topical treatment. (Source: RETINA)
Source: RETINA - November 27, 2019 Category: Opthalmology Tags: Original Study Source Type: research

INTRAVITREAL ANTI–VASCULAR ENDOTHELIAL GROWTH FACTOR FOR THE MANAGEMENT OF NEOVASCULARIZATION IN RETINOBLASTOMA AFTER INTRAVENOUS AND/OR INTRAARTERIAL CHEMOTHERAPY: Long-Term Outcomes in a Series of 35 Eyes
Conclusion: Intravitreal anti–vascular endothelial growth factor contributed to a globe salvage rate of 51% by providing conditions to continue conservative treatment. (Source: RETINA)
Source: RETINA - November 27, 2019 Category: Opthalmology Tags: Original Study Source Type: research

OPHTHALMIC VASCULAR EVENTS AFTER INTRA‐ARTERIAL CHEMOTHERAPY FOR RETINOBLASTOMA: Real-World Comparison Between Primary and Secondary Treatments
Conclusion: Ophthalmic vascular events after IAC for retinoblastoma affect only 5% of eyes per infusion (17% of treated eyes). Vascular event risk per eye is similar when using IAC as primary or secondary treatment. (Source: RETINA)
Source: RETINA - November 27, 2019 Category: Opthalmology Tags: Original Study Source Type: research

Management of retinal hemangioblastoma in von hippel–lindau disease
Conclusion: Ocular outcomes can be gratifying in many cases with appropriate management. Improved understanding of the molecular basis for the disease creates an opportunity for rational design of better therapies. (Source: RETINA)
Source: RETINA - November 27, 2019 Category: Opthalmology Tags: Review Source Type: research

VON HIPPEL–LINDAU DISEASE: Update on Pathogenesis and Systemic Aspects
Conclusion: The ophthalmologist plays a key role in VHL disease diagnosis, as retinal hemangioblastoma is frequently the first disease manifestation. Screening guidelines for individuals with known VHL disease, and those at risk of VHL disease, help to ensure early detection of potentially vision-threatening and life-threatening disease. (Source: RETINA)
Source: RETINA - November 27, 2019 Category: Opthalmology Tags: Review Source Type: research

Reply
No abstract available (Source: RETINA)
Source: RETINA - October 24, 2019 Category: Opthalmology Tags: Correspondence Source Type: research

Correspondence
No abstract available (Source: RETINA)
Source: RETINA - October 24, 2019 Category: Opthalmology Tags: Correspondence Source Type: research

Reply
No abstract available (Source: RETINA)
Source: RETINA - October 24, 2019 Category: Opthalmology Tags: Correspondence Source Type: research

Correspondence
No abstract available (Source: RETINA)
Source: RETINA - October 24, 2019 Category: Opthalmology Tags: Correspondence Source Type: research

Diagnostic and Therapeutic Challenges
No abstract available (Source: RETINA)
Source: RETINA - October 24, 2019 Category: Opthalmology Tags: Diagnostic and Therapeutic Challenges Source Type: research

Visual function and optical coherence tomography angiography features in children born preterm
Purpose: Preterm children have an increased risk of impaired vision from retinopathy, strabismus, and high refractive error. The aim of this study was to investigate the relationship between foveal parameters generated by optical coherence tomography angiography and visual function in preterm children. Methods: Eighty eyes (32 eyes of former preterm infants and 48 age-matched full-term control eyes) were analyzed. Subjects underwent complete eye examinations including best-corrected visual acuity and retinal imaging with the Optovue XR Avanti optical coherence tomography angiography device. Foveal morphologic paramete...
Source: RETINA - October 24, 2019 Category: Opthalmology Tags: Original Study Source Type: research

Preoperative vitreoretinal interface abnormalities on spectral domain optical coherence tomography as risk factor for pseudophakic cystoid macular edema after phacoemulsification
Conclusion: In this cohort, preoperative detection of epiretinal membrane by spectral domain OCT was a risk factor for PCME after cataract extraction. It is recommended to perform a spectral domain OCT before cataract surgery because the presence of an epiretinal membrane may be passed unnoticed by fundus examination. (Source: RETINA)
Source: RETINA - October 24, 2019 Category: Opthalmology Tags: Original Study Source Type: research

Dilute povidone-iodine prophylaxis maintains safety while improving patient comfort after intravitreal injections
Conclusion: Application of dilute PI solution to the conjunctiva at the time of IVT is an effective alternative to 5% PI for endophthalmitis prophylaxis in betadine-sensitive patients. (Source: RETINA)
Source: RETINA - October 24, 2019 Category: Opthalmology Tags: Original Study Source Type: research

Increased complement levels in human vitreous aspirates of proliferative diabetic retinopathy and retinal detachment eyes
Conclusion: Elevated complement factors, particularly of the alternative pathway, were noted in PDR and RD eyes compared with controls. One potential explanation for this is that the oxidative stress in RD and PDR eyes leads to complement dysregulation and alternative complement upregulation. (Source: RETINA)
Source: RETINA - October 24, 2019 Category: Opthalmology Tags: Original Study Source Type: research

Retinal arterial dilation is impaired in eyes with drusen and reticular pseudodrusen
Conclusion: Dynamic vessel analysis in eyes with drusen and RPD revealed an impaired retinal arterial dilation in response to flicker light stimulation, which further supports the relationship between cardiovascular risk and age-related macular degeneration. (Source: RETINA)
Source: RETINA - October 24, 2019 Category: Opthalmology Tags: Original Study Source Type: research

How to measure the largest basal dimension of choroidal melanoma: a mathematical study
Purpose: To identify the most accurate ultrasonographic technique to measure the largest basal dimension (LBD) of choroidal melanoma. Methods: B-scan ultrasound images were retrospectively reviewed in 99 eyes of 99 choroidal melanoma patients. The LBD was measured using one, two, and three straight lines along the inner and outer sclera. Theoretical arc length, calculated using trigonometry formulas based on the spherical model with the axial length as the sphere diameter, was used for comparisons with the actual measurements using straight lines. Results: For straight-line measurements in the inner sclera, the low...
Source: RETINA - October 24, 2019 Category: Opthalmology Tags: Original Study Source Type: research

Adalimumab therapy for refractory birdshot chorioretinopathy
Conclusion: The results suggest that adalimumab is effective at improving visual acuity and at tapering concomitant immunomodulatory therapy, in patients with refractory birdshot chorioretinopathy. However, complete remission is rarely achieved. (Source: RETINA)
Source: RETINA - October 24, 2019 Category: Opthalmology Tags: Original Study Source Type: research

PATTERNS OF CHORIOCAPILLARIS FLOW SIGNAL VOIDS IN CENTRAL SEROUS CHORIORETINOPATHY: An Optical Coherence Tomography Angiography Study
Purpose: To investigate choriocapillaris flow signal void distribution on optical coherence tomography (OCT) angiography in central serous chorioretinopathy (CSCR) and its correlation to choroidal vessel morphology. Methods: Fifty-three CSCR eyes (48 patients) and 34 healthy control eyes were included, retrospectively. Exclusion criteria were refractive error>2D, previous laser or photodynamic therapy, low-quality OCT angiography, or excessive shadowing artifacts. Choriocapillaris OCT angiography scans were processed by local-threshold binarization to identify signal voids, and extract their cumulative area. The lo...
Source: RETINA - October 24, 2019 Category: Opthalmology Tags: Original Study Source Type: research

Fractal dimension and optical coherence tomography angiography features of the central macula after repair of rhegmatogenous retinal detachments
This study was performed to evaluate the retinal microvasculature in subjects undergoing surgery for RRD using optical coherence tomography angiography. Methods: In this case–control study, the analysis of optical coherence tomography angiography findings of 19 eyes of 19 patients (15 men) who underwent RRD surgery at a tertiary institute were compared with 19 eyes of 19 age- and sex-matched healthy subjects with no known ocular disease. 3 × 3-mm optical coherence tomography angiography scans were obtained at 3 months postoperatively and analyzed. Optical coherence tomography angiography images of patients w...
Source: RETINA - October 24, 2019 Category: Opthalmology Tags: Original Study Source Type: research