Role of Right Ventricle Reserve Assessment and Left Ventricular Unloading to Predict Right Heart Failure After Left Ventricular Assist Device Implantation
Dr Tedford opened his talk with a patient case: a 62-year-old man with non-ischaemic cardiomyopathy with a left ventricular (LV) end-diastolic diameter of 7.7 cm and a LV ejection fraction of 25%. The patient had severe mitral regurgitation and a dilated right ventricle (RV) with mild to moderate dysfunction and moderate t... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - February 14, 2024 Category: Cardiology Authors: dbarot525787 Source Type: research
Selected Talk: Left Ventricular Unloading Acutely Reduces Right Ventricular Preload in Patients with Acute Decompensated Heart Failure and Cardiogenic Shock
Acute decompensated heart failure (ADHF) and cardiogenic shock (CS) are signs of deterioration in patients experiencing heart failure (HF). The proportion of patients with CS who also have ADHF is increasing, and mortality rates have remained high over the past few decades at 30 –50%.1 Unfortunately, right ventricular (RV... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - February 14, 2024 Category: Cardiology Authors: dbarot525787 Source Type: research
Selected Talk: A Novel Fluoroscopic Approach to Impella Percutaneous Ventricular Assist Device Positioning
Dr Baldetti ’s talk covered the importance of the correct positioning of Impella implantation to avoid device-related complications and to optimise its function. In his presentation, Dr Baldetti discussed how correct positioning is best achieved, and presented results from his study to improve assessment of I mpella malrotation.Dr Baldetti set out the three conditions tha... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - February 14, 2024 Category: Cardiology Authors: dbarot525787 Source Type: research
Panel Discussion: Targeting Heart Recovery in a Real-world Setting
Discussion: Targeting Heart Recovery in a Real-world Setting
Dr Bobbi Chapman from Abiomed welcomed everyone to this interactive panel discussion and introduced the panellists, starting with Dr Jane Wilcox, Chief of the Section of Heart Failure Treatment and Recovery at Northwestern University Feinberg School of Medicine in Chicago, US, and principal investigator of the Impella BTR ™ Early Feasibility Study (BTR EFS), and then Dr Manreet Kanwar, Section Head of the AGH ... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - February 14, 2024 Category: Cardiology Authors: dbarot525787 Source Type: research
Decompensated Heart Failure: Taking the Acute Out of Decompensation
Dr Bozkurt is one of the world ’s leaders in heart failure (HF). She gave a groundbreaking talk on the trajectory she would like to see the field move towards, including reconsideration of the definition of decompensated HF, a vision of how to target success for treating decompensated HF and how to create phenotypical types to tailor treatment strategy to phenotype.Dr Bozkurt started her talk by providing the... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - February 14, 2024 Category: Cardiology Authors: dbarot525787 Source Type: research
UNLOAD-HF Randomised Controlled Trial for Left Ventricular Unloading in Acute Heart Failure
Acute heart failure (AHF) is a common but serious condition associated with high morbidity and mortality. Unfortunately, the number of patients presenting with AHF is increasing, and most of these patients present with acute decompensated heart failure (ADHF) or acute on chronic heart failure (HF). Following diuretic treatment, most patients are discharged, but there are some patients... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - February 14, 2024 Category: Cardiology Authors: dbarot525787 Source Type: research
CERAMICS Trial: Best Practices for Mechanical Circulatory Support Escalation and Management in Acute MI –Cardiogenic Shock
The National Cardiogenic Shock Initiative (NCSI) was assembled to assess the impact of early mechanical circulatory support (MCS) in patients with acute MI (AMI) and cardiogenic shock (CS) treated with percutaneous coronary intervention (PCI). Before establis hment of the NCSI in 2016, there was significant variability in the use of MCS in AMI-CS. There we... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - February 14, 2024 Category: Cardiology Authors: dbarot525787 Source Type: research
UNLOAD-ECMO Randomised Controlled Trial for Left Ventricular Unloading with Veno-arterial Extracorporeal Membrane Oxygenation in Severe Cardiogenic Shock
Dr Schrage opened his presentation by recapping that veno-arterial extracorporeal membrane oxygenation (VA-ECMO) provides circulatory support for cardiogenic shock (CS), but also increases left ventricular (LV) afterload, which can hamper myocardial recovery. In a recent multinational multicentre retrospective registry stud... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - February 14, 2024 Category: Cardiology Authors: dbarot525787 Source Type: research
Automatic Left Ventricular Unloading Using a Percutaneous Transvalvular Microaxial Flow Pump During Veno-arterial Extracorporeal Membrane Oxygenation Support
Dr Schrage opened his presentation by recapping the use of mechanical circulatory support (MCS) devices to prevent patients from deteriorating into cardiogenic shock (CS) by supporting the patient and providing end organ perfusion. Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is one such device increasing... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - February 14, 2024 Category: Cardiology Authors: dbarot525787 Source Type: research
PROTECT-Kidney Randomised Controlled Trial: MRI Pilot Study
The PROTECT-Kidney trial was designed to address the important clinical issue of contrast-induced acute kidney injury (CI-AKI), which was shown to be associated with higher mortality in patients after percutaneous coronary intervention (PCI).1 CI-AKI ranks second among all causes of acute kidney injury (AKI) and contributes to inappropriately low rates of coronary angiography in patients with chronic kidney disease.... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - February 13, 2024 Category: Cardiology Authors: dbarot525787 Source Type: research
From Door to Balloon to Unload: The STEMI Door-to-Unload (DTU) Clinical Trial Programme
Dr Kapur opened with a case study of a 70-year-old active man who experienced chest pain during exercise. Electrocardiogram confirmed anterior ST-elevation MI (STEMI) with sum of ST elevation greater than 20 mm in leads V2 –V5. The patient was admitted 1 hour from symptom onset. He consented to entry into the STEMI Door-to-Unload (DTU) clinical trial and was randomised to the control arm t... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - February 13, 2024 Category: Cardiology Authors: dbarot525787 Source Type: research
Is Unloading the Left Ventricle the Key to Improving Survival in Anterior Wall Acute MI?
The concept of myocardial salvage has been described since the 1970s. Acute MI is survivable but its impact is time dependent because the ‘wavefront’ of tissue necrosis begins to spread from a small area of infarct after 40 minutes of coronary occlusion, plateauing at around 96 hours.1 Dr O’Neill commented on the difficulty researchers faced at the time to accurately measure infarct size... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - February 13, 2024 Category: Cardiology Authors: dbarot525787 Source Type: research
Mechanical Left Ventricular Unloading Increases Coronary Flow by Prolonging the Diastolic Phase
Dr Sakata was awarded the Best in Research Award by the A-CURE Faculty as the author of the highest-scoring abstract from all abstract submissions.At the 6th Annual A-CURE Symposium, Dr Sakata showed preclinical evidence that mechanical left ventricular (LV) unloading increases coronary perfusion of the infarct area.1 Study data suggested that mechanical LV unloading is more benef... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - February 13, 2024 Category: Cardiology Authors: dbarot525787 Source Type: research
Transvalvular Unloading Reduces Anaerobic Glycolysis Before Reperfusion and Preserves Energy Substrate Utilisation After Reperfusion in Models of Acute Myocardial Infarction
Dr Swain is the recipient of the Young Investigator Award awarded by the A-CURE Faculty for the scientific merit and innovation of her research.A previous study showed that mechanical preconditioning with left ventricular (LV) unloading with a mechanical circulatory support device reduces infarct size an... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - February 13, 2024 Category: Cardiology Authors: dbarot525787 Source Type: research
Selected Talk: An Analysis of Extracellular Matrix Proteins Involved in the Loaded and Unloaded Heart After Myocardial Infarction
In acute heart failure, unloading the left ventricle (LV) by percutaneous LV assist devices (pLVAD) reduces LV filling pressures and volumes, as well as cardiac workload and wall stress, which, in turn, reduces myocardial oxygen demand and increases coronary perfusion. Dr Mavropoulos shared previous mechanistic studies that examined the effects of... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - February 13, 2024 Category: Cardiology Authors: dbarot525787 Source Type: research
