Haemodynamic Effects of Sildenafil on Subpulmonic Morphological Left Ventricle in Congenitally Corrected Transposition of Arteries After Left Ventricular Assist Device Implantation
Postoperative right ventricular failure is a major cause of postoperative mortality and morbidity after implantation of a left ventricular assist device (LVAD).1 The morphological right ventricle (RV) is more sensitive to afterload than the morphological left ventricle (LV). In patients with conco... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - June 9, 2023 Category: Cardiology Authors: dbarot525787 Source Type: research
Cardioneuroablation for Treating Vasovagal Syncope: Current Status and Future Directions
Vasovagal syncope (VVS) is one of the most common types of syncope. By the age 60 years, 42% of women and 32% of men already had at least one episode of syncope.1 Although the outcome of VVS is generally benign, it can result in injury and it can affect quality of life.2,3 The underlying pathophysiology of VVS results from a reflex causing hypotension and bradycardia, which is mediated t... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - June 9, 2023 Category: Cardiology Authors: dbarot525787 Source Type: research
A Survey of Drug-coated Balloon Usage Patterns in the Asia-Pacific Region
Drug-coated balloons (DCBs) represent a method of revascularisation of coronary artery disease without requiring a permanent stent implant, which could induce an inflammatory response and delayed healing. Following on from studies demonstrating the inferiority of bioresorbable scaffolds as compared with drug-eluting stents (DESs) in terms of safety and major adverse cardiac events (MACE), DCBs represen... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - June 7, 2023 Category: Cardiology Authors: dbarot525787 Source Type: research
Coronary Spasm: Ethnic and Sex Differences
Coronary spasm (CS) represents an important functional cardiac disorder, characterised by exaggerated vasoconstriction of the coronary arteries leading to transient myocardial ischaemia and anginal chest pain. Attilio Maseri ’s work was pioneering in demonstrating the clinical relevance of CS as a functional vasomotor disorder, which is associated with an increased risk of non-fatal cardiovascular events and substantial morbidity due... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - June 7, 2023 Category: Cardiology Authors: dbarot525787 Source Type: research
Pre-eclampsia and Cardiovascular Disease: From Pregnancy to Postpartum
Hypertensive disorders of pregnancy (HDP) include a spectrum of complications, such as gestational hypertension (GH) and pre-eclampsia/toxaemia (PET), which affect 5 –10% and 3–5% of pregnancies, respectively.1 The incidence of HDP has increased during the past two decades, and they still account for 10–22% of maternal mortality worldwide.2,3 Systemic cardiovascular impairment is a pathognomonic feature of... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - June 7, 2023 Category: Cardiology Authors: dbarot525787 Source Type: research
When Should We Start Sodium –Glucose Co-transporter Inhibitors in Patients with Heart Failure? The Importance of Early Intervention
Sodium–glucose co-transporter (SGLT2) inhibitors were primarily developed as anti-diabetic drugs to increase the excretion of glucose in the urine. However, SGLT2 inhibitor s have been reported to have multifactorial effects, such as renal protection and improvement of myocardial energy metabolism and anaemia symptoms, which may exert protection a... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - June 7, 2023 Category: Cardiology Authors: dbarot525787 Source Type: research
Nuclear Factor- κB is a Prime Candidate for the Diagnosis and Control of Inflammatory Cardiovascular Disease
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) was discovered in 1986 by Sen and Baltimore.1 NF-κB is a dimeric transcription factor, originally found as an ind ucible B cell-specific factor that binds to the κB motif in the enhancer of the immunoglobulin light chain.2 NF-κB plays a crucial role in the regulation of immune responses and inflammat... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - June 7, 2023 Category: Cardiology Authors: dbarot525787 Source Type: research
Defining Heart Failure Based on Imaging the Heart and Beyond
Heart failure is an umbrella term for a variety of common and serious problems that are often overlooked in clinical practice.1 Two universal definitions of heart failure have recently been proposed; both highlight the central role of congestion in the pathophysiology and presentation of heart failure.2,3 One definition requires symptoms (such as exertional breathlessness) and clinical signs (such as peripheral oed... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - June 5, 2023 Category: Cardiology Authors: dbarot525787 Source Type: research
Pathophysiological Rationale and Clinical Evidence for Neurohormonal Modulation in Heart Failure with Preserved Ejection Fraction
Heart failure (HF) with preserved ejection fraction (HFpEF) is defined as ‘a clinical syndrome characterised by prior or current symptoms and/or signs secondary to a cardiac structural or functional abnormality, corroborated by the presence of elevated natriuretic peptides (NPs) levels or objective evidence of cardiogenic pulmonary or systemic con... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - June 5, 2023 Category: Cardiology Authors: dbarot525787 Source Type: research
Complicated Mycotic Thoracic Aortic Aneurysm Secondary to Staphylococcus aureus Endocarditis
Staphylococcus aureus is a Gram-positive bacteria that normally colonises the skin and mucous membranes. Multiple skin punctures and the presence of vascular access catheters common among patients undergoing haemodialysis, compounded by an immunocompromised state due to their general medical condition, increase the likelihood of bloodstream contamination leading to bacteraemia and in... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - May 31, 2023 Category: Cardiology Authors: dbarot525787 Source Type: research
Preparing for the European Examination in Core Cardiology (Asian Pacific Society of Cardiology Exit Examinations)
The European Examination in Core Cardiology (EECC) is an annual examination that provides a broad, balanced and up-to-date test of the core knowledge required by cardiology speciality trainees for independent practice.1 It assesses knowledge from the European Society of Cardiology (ESC) Core Curriculum for the Cardiologist.2
The Asian Pacific Society of Cardiolo... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - May 30, 2023 Category: Cardiology Authors: dbarot525787 Source Type: research
How Can We Survive the Heart Failure Pandemic Era? Basic Research for Understanding the Pathophysiology of Heart Failure and Development of Novel Therapies
Heart failure (HF) is a clinical syndrome that represents the final manifestation of many underlying cardiovascular disorders and is the most common cause of hospitalisation in the elderly population.1 The number of patients with HF has been increasing rapidly over the past few decades in Japan, mainly because of the agei... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - May 30, 2023 Category: Cardiology Authors: dbarot525787 Source Type: research
Mechanisms of Coronary Artery Spasm
The ISCHEMIA and REVIVED-BCIS2 trials have highlighted that percutaneous coronary intervention (PCI) in patients with stable coronary syndrome provides limited additional prognostic benefits when used on top of optimal medical therapy.1,2 This has led to much attention being paid to coronary vasomotion abnormalities regardless of the presence or absence of obstructive coronary artery disease. Coronary vasomotion is regulated by multiple me... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - May 29, 2023 Category: Cardiology Authors: dbarot525787 Source Type: research
Artificial Intelligence in Ventricular Arrhythmias and Sudden Death
Ventricular Arrhythmias and Sudden Death: What Are the Knowledge Gaps and How Can Artificial Intelligence Address These?
Sudden cardiac arrest (SCA) is a major public health problem worldwide. In the US alone, ~360,000 individuals have SCA every year.1,2 SCA is a mostly lethal event, and despite the developments in acute management, at least 90% of the cases still lead to death (i.e. sudden cardiac death [S... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - May 29, 2023 Category: Cardiology Authors: dbarot525787 Source Type: research
Ventricular Arrhythmia in Cancer Patients: Mechanisms, Treatment Strategies and Future Avenues
Cardiovascular diseases and cancer pose a significant morbidity and mortality burden on a global scale.1 –5 Advances in cancer therapeutics and treatment strategies have resulted in improved cancer outcomes, leading to a growing cancer survivor population. However, there has been a concerning uptrend of cardiovascular diseases, including ventricular arrhythmias (VA), in cancer patie... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - May 29, 2023 Category: Cardiology Authors: dbarot525787 Source Type: research
