Present and Future Perspectives on the Role of Biomarkers in Atherosclerotic Cardiovascular Disease Risk Stratification
Atherosclerotic cardiovascular diseases (ASCVD) remain the leading cause of death in Europe, with more than 4 million deaths in 2017.1 Ischaemic heart disease and stroke account for 82% of disability-adjusted life years (DALYs) in European Society of Cardiology member countries, even though ASCVD incidence has declined during the past 27 years.1
ASCVDs are... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - April 18, 2023 Category: Cardiology Authors: c242508f1d9059bc0f2aa9bdd5421ba2 Source Type: research
Epicardial Fat in Heart Failure with Preserved Ejection Fraction: Bad Actor or Just Lying Around?
Heart failure with preserved ejection fraction (HFpEF) is becoming the most common cause of heart failure worldwide, in part, driven by a rising prevalence of obesity.1 Since the first description of obesity-related HFpEF, there has been widespread recognition of this being a unique phenotype with its pathophysiology driven directly by excess adiposity.2 –4 Notably, obesity is th... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - April 15, 2023 Category: Cardiology Authors: c242508f1d9059bc0f2aa9bdd5421ba2 Source Type: research
Treatment of Persistent Left Atrial Appendage Thrombus in Patients with Atrial Fibrillation on Adequate Oral Anticoagulation: Pathways of Care for All-comers and Heart Failure Patients
Non-valvular AF is the most prevalent sustained cardiac arrhythmia linked to a high risk of stroke, systemic embolism (SE), heart failure (HF) and all-cause death.1 Without oral anticoagulation, the age-adjusted risk of AF-related stroke increases fivefold.2 For decades, oral anticoagulants (O... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - April 15, 2023 Category: Cardiology Authors: c242508f1d9059bc0f2aa9bdd5421ba2 Source Type: research
Pulsed Field Ablation for Atrial Fibrillation
Pulsed field ablation (PFA) leading to non-thermal irreversible electroporation has been increasingly investigated as an energy source in the field of catheter ablation over the last few years. This review discusses our own clinical findings and current literature focusing on the safety and efficacy of pulmonary vein isolation (PVI) with PFA. Additionally, an overview of PFA targets beyond PVI is provided.
Technology
General Bi... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - April 14, 2023 Category: Cardiology Authors: c242508f1d9059bc0f2aa9bdd5421ba2 Source Type: research
Defibrillation Threshold Testing for Right-sided Device Implants: A Review to Inform Shared Decision-making, in Association with the British Heart Rhythm Society
The use of ICDs for the prevention of sudden cardiac death relies on the ability to deliver a shock to successfully terminate VF. During early adoption of these devices, induction of ventricular fibrillation with defibrillation testing was routinely used at implant to identify the defibrillation threshold. However, ... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - April 14, 2023 Category: Cardiology Authors: c242508f1d9059bc0f2aa9bdd5421ba2 Source Type: research
Leadless Pacing: Therapy, Challenges and Novelties
Leadless devices are the next frontier in the field of cardiac pacing. While conventional pacing systems have a long history of widespread use and a robust evidence base, leadless technology is attractive in its potential to subvert the long-term issues inherent to transvenous leads, such as fracture (1 –4%), tricuspid regurgitation (5%) and infection (1–2%).1 The first leadless right ventricular (RV) pacing device, the Nanos... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - April 13, 2023 Category: Cardiology Authors: c242508f1d9059bc0f2aa9bdd5421ba2 Source Type: research
Hypersensitivity Reactions to Components of Cardiac Implantable Electronic Devices and Their Treatment: A Systematic Review
Cardiac implantable electronic device (CIED) implantation is increasing worldwide. In 2013, in the EU, the implantation rate for cardiac pacemakers was 532/million population and for ICD was 100/million population; furthermore, more than 51,000 CRT devices were implanted.1 In the US, pacemaker implantation rates increased by more than 50% between 1993 a... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - April 13, 2023 Category: Cardiology Authors: c242508f1d9059bc0f2aa9bdd5421ba2 Source Type: research
Machine Learning and the Conundrum of Stroke Risk Prediction
Stroke is a leading cause of death and permanent disability worldwide.1 Ischaemic stroke is the most common stroke variety, comprising more than 80% of strokes in the US.2 One mechanism of ischaemic stroke is atherosclerosis in the extracranial and intracranial arteries, with plaque rupture leading to thrombosis. The second major category is embolic stroke, in which thrombi form in the heart or the arterial/venous ... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - April 12, 2023 Category: Cardiology Authors: c242508f1d9059bc0f2aa9bdd5421ba2 Source Type: research
Managing Complex Coronary Access After Transcatheter Aortic Valve Implantation
Randomised controlled trials have shown the safety and efficiency of transcatheter aortic valve implantation (TAVI) for the treatment of severe symptomatic aortic stenosis (AS) in patients across all surgical risks, even in those with low risk for open surgery.1,2 Consequently, the number of patients treated with TAVI has increased exponentially in recent times, including patients who are younger ... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - April 11, 2023 Category: Cardiology Authors: c242508f1d9059bc0f2aa9bdd5421ba2 Source Type: research
Asian Pacific Society of Cardiology Consensus Statements on the Diagnosis and Management of Chronic Heart Failure
In the Asia-Pacific region, heart failure (HF) is associated with significant health and socioeconomic burdens. Despite registry and epidemiological data indicating that HF patients in the Asia-Pacific are younger and have more severe signs and symptoms compared with their counterparts in Western countries, most local guidelines draw their evidence from clinical ... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - April 11, 2023 Category: Cardiology Authors: c242508f1d9059bc0f2aa9bdd5421ba2 Source Type: research
The First Malaysian Multidisciplinary Team Heart Failure Clinic: A Tertiary Cardiac Centre Experience
Approximately 25% of patients hospitalised for acute decompensated heart failure (ADHF) are at risk of future re-hospitalisation or mortality within 1 month of discharge.1 Rates of mortality and hospitalisation are equally poor in Malaysia, with 30-day mortality and rehospitalisation reaching levels as high as 13.1–15.7% and 4.1–11.2%, respectively, based on local data.2,3 O... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - April 10, 2023 Category: Cardiology Authors: c242508f1d9059bc0f2aa9bdd5421ba2 Source Type: research
An Update on Anti-thrombotic Therapy Following Transcatheter Aortic Valve Implantation: Expert Cardiologist Opinion from a UK and Ireland Delphi Group
Transcatheter aortic valve implantation (TAVI) is a well-established treatment strategy for symptomatic and severe aortic stenosis, supported by multiple randomised controlled trials across the spectrum of surgical risk.1,2 However, thromboembolic and bleeding complications remain a major concern following the procedure, exace... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - April 10, 2023 Category: Cardiology Authors: c242508f1d9059bc0f2aa9bdd5421ba2 Source Type: research
Myval: A Novel Transcatheter Heart Valve for the Treatment of Severe Aortic Stenosis
Transcatheter aortic valve implantation (TAVI) via femoral arterial access has become the treatment of choice for elderly patients with severe calcific aortic stenosis (AS) who are at intermediate or high risk for surgical aortic valve replacement (SAVR).1,2 More recently, randomised trials have led to the approval of TAVI for patients at lower surgical risk, thereby expanding its applicabil... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - April 10, 2023 Category: Cardiology Authors: c242508f1d9059bc0f2aa9bdd5421ba2 Source Type: research
ESC Congress 2022 Imaging Highlights
Cardiac imaging is an ever-evolving area, with imaging parameters and application in constant re-evaluation. This was reflected in many imaging debates and by the increased number of scientific contributions at ESC Congress 2022.
The Danish-NICAD2 study, presented in the Hot Line Sessions, evaluated the role of stress cardiac magnetic resonance (CMR) and PET in patients with coronary lesions of unclear significance on CT.1 The performanc... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - April 6, 2023 Category: Cardiology Authors: c242508f1d9059bc0f2aa9bdd5421ba2 Source Type: research
Streptococcus mitis Tricuspid Valve Infective Endocarditis Accompanied by Haematological Management Challenges
Tricuspid valve infective endocarditis (TVIE) is strongly associated with IV drug use (IVDU); device implants also represent significant risk factors. Congenital anomalies, including ventricular septal defect (VSD), predispose patients to TVIE.1 Streptococcus mitis is a mesophilic alfa-haemolytic germ inhabiting the oro- and nasopharyngeal cavities and has been impl... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - April 6, 2023 Category: Cardiology Authors: c242508f1d9059bc0f2aa9bdd5421ba2 Source Type: research
