Mechanisms of Coronary Artery Spasm
The ISCHEMIA and REVIVED-BCIS2 trials have highlighted that percutaneous coronary intervention (PCI) in patients with stable coronary syndrome provides limited additional prognostic benefits when used on top of optimal medical therapy.1,2 This has led to much attention being paid to coronary vasomotion abnormalities regardless of the presence or absence of obstructive coronary artery disease. Coronary vasomotion is regulated by multiple me... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - May 29, 2023 Category: Cardiology Authors: dbarot525787 Source Type: research
Artificial Intelligence in Ventricular Arrhythmias and Sudden Death
Ventricular Arrhythmias and Sudden Death: What Are the Knowledge Gaps and How Can Artificial Intelligence Address These?
Sudden cardiac arrest (SCA) is a major public health problem worldwide. In the US alone, ~360,000 individuals have SCA every year.1,2 SCA is a mostly lethal event, and despite the developments in acute management, at least 90% of the cases still lead to death (i.e. sudden cardiac death [S... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - May 29, 2023 Category: Cardiology Authors: dbarot525787 Source Type: research
Ventricular Arrhythmia in Cancer Patients: Mechanisms, Treatment Strategies and Future Avenues
Cardiovascular diseases and cancer pose a significant morbidity and mortality burden on a global scale.1 –5 Advances in cancer therapeutics and treatment strategies have resulted in improved cancer outcomes, leading to a growing cancer survivor population. However, there has been a concerning uptrend of cardiovascular diseases, including ventricular arrhythmias (VA), in cancer patie... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - May 29, 2023 Category: Cardiology Authors: dbarot525787 Source Type: research
Contemporary Left Main Percutaneous Coronary Intervention: A State-of-the-art Review
Significant left main coronary artery (LMCA) disease is observed in 4 –5% of patients undergoing coronary angiographies.1 Major adverse cardiac events (MACE) are more common because LMCA disease substantially affects myocardial supply. Until recently, coronary artery bypass surgery (CABG) has been the standard of care for most patients with LMCA disease because of i ts established mortality be... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - May 26, 2023 Category: Cardiology Authors: dbarot525787 Source Type: research
Contemporary Left Main Percutaneous Coronary Intervention: A State-of-the-art Review
Contemporary Left Main Percutaneous Coronary Intervention: A State-of-the-art Review
Significant left main coronary artery (LMCA) disease is observed in 4 –5% of patients undergoing coronary angiographies.1 Major adverse cardiac events (MACE) are more common because LMCA disease substantially affects myocardial supply. Until recently, coronary artery bypass surgery (CABG) has been the standard of care for most patients with LMCA disease because of i ts established mortality b... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - May 26, 2023 Category: Cardiology Authors: dbarot525787 Source Type: research
Percutaneous Transcatheter Closure of Post-infarction Ventricular Septal Defect: An Alternative to Surgical Intervention
Post-infarction ventricular septal defect (PIVSD) is a rare mechanical complication of acute MI (AMI) associated with very high acute mortality. It is a rupture between the left and right ventricle caused by infarction and necrosis of the muscular intraventricular septum. The incidence of PIVSD is approximately 0.2% in the era of primary percutaneous coron... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - May 26, 2023 Category: Cardiology Authors: dbarot525787 Source Type: research
Percutaneous Transcatheter Closure of Post-infarction Ventricular Septal Defect: An Alternative to Surgical Intervention
Percutaneous Transcatheter Closure of Post-infarction Ventricular Septal Defect: An Alternative to Surgical Intervention
Post-infarction ventricular septal defect (PIVSD) is a rare mechanical complication of acute MI (AMI) associated with very high acute mortality. It is a rupture between the left and right ventricle caused by infarction and necrosis of the muscular intraventricular septum. The incidence of PIVSD is approximately 0.2% in the era of primary percutaneous coro... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - May 26, 2023 Category: Cardiology Authors: dbarot525787 Source Type: research
Lead Cap Use in Interventional Cardiology: Time to Protect Our Head in the Cardiac Catheterisation Laboratory?
Since the evolution of interventional procedures from the first right heart catheterisation in 1929, the use of catheter-based interventions has grown exponentially due to new technologies and an increase in coronary artery disease prevalence.1 The risk of radiation injury in a cardiac catheterisation laboratory has always been a topic of debate. American College of... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - May 26, 2023 Category: Cardiology Authors: dbarot525787 Source Type: research
Management of Coronary Artery Spasm
The most typical and well-defined clinical condition caused by coronary artery spasm (CAS) is Prinzmetal or variant angina.1 Variant angina is characterised by recurrent angina attacks that usually last 5 –10 min, but sometimes only 30–60 s, and occur at rest, frequently at night, and usually in the absence of apparent triggering factors. However, exercise may trigger CAS in approximately 25% of patients.2 The ECG recorded during angina att... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - May 17, 2023 Category: Cardiology Authors: dbarot525787 Source Type: research
The Novel Biomarker Growth Differentiation Factor-15 in Patients with Chronic Heart Failure at a Heart Failure Clinic in the Asia-Pacific Region: A Prospective Observational Study
Growth differentiation factor-15 (GDF-15) is a member of the transforming growth factor β cytokine superfamily. It is weakly expressed in healthy individuals, with normal values in healthy elderly people reported to be (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - May 17, 2023 Category: Cardiology Authors: dbarot525787 Source Type: research
Two Holes in One: A Rare Case of Congenital Mitral Valve Anomaly
Double orifice mitral valve (DOMV), which was initially described by Greenfield in 1876, is a rare congenital malformation that occurs in about 0.05% of the general population.1,2 It is characterised by a mitral valve with a single fibrous annulus, resulting in two orifices.1 Since its discovery, around 200 cases have been reported.2
Its embryonic development, as with most cardiac lesions, is incompletely unde... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - May 17, 2023 Category: Cardiology Authors: dbarot525787 Source Type: research
Pregnancy and Congenital Heart Disease: Moving Beyond the Current Risk Stratification Tools
Pregnancy and Congenital Heart Disease: Moving Beyond the Current Risk Stratification Tools
The specialty of pregnancy and heart disease (or cardio-obstetrics) has established itself as an important sub-specialty in cardiology and maternal medicine. Although covering all cardiovascular disease in pregnancy, most patients attending specialty cardio-obstetric antenatal clinics have congenital heart disease (CHD), at least in high-income countries.1
It is imperative that mult... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - May 16, 2023 Category: Cardiology Authors: dbarot525787 Source Type: research
Transcatheter Left Atrial Appendage Closure: Devices Available, Pitfalls, Advantages, and Future Directions
Transcatheter left atrial appendage (LAA) closure has emerged as a non-pharmacological alternative to long-term anticoagulation for stroke prevention in appropriately selected patients with AF.
Over the past decade, multiple devices have been developed for transcatheter LAA closure, with continuous refinement in design and peri-procedural techniques. Watchman FIx and ... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - May 16, 2023 Category: Cardiology Authors: dbarot525787 Source Type: research
Role of Imaging in Cardiomyopathies
Imaging and Cardiomyopathy Phenotype
Cardiomyopathies (CMPs) are a group of diseases affecting the cardiac muscle, heterogeneous in terms of aetiology and clinical presentation. In 2008, a European Society of Cardiology (ESC) position statement defined CMPs as myocardial disorders “in which the heart muscle is structurally and functionally abnormal, in the absence of coronary artery disease, hypertension, valvular disease and congenital h... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - May 16, 2023 Category: Cardiology Authors: dbarot525787 Source Type: research
Effects of Sacubitril/Valsartan on Exercise Capacity in Patients with Heart Failure with Reduced Ejection Fraction and the Role of Percentage of Delayed Enhancement Measured by Cardiac Magnetic Resonance in Predicting Therapeutic Response: A Multicentre S
Sacubitril/valsartan (S/V) therapy in patients with heart failure (HF) with reduced ejection fraction (HFrEF) has been shown to be superior to enalapril in reducing the risk of death and hospitalisation for HF.1 Cardiopulmo... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - May 15, 2023 Category: Cardiology Authors: dbarot525787 Source Type: research
