Visual function scale for identification of infants with low respiratory compliance
Precise estimation of respiratory function is essential to optimise neonatal respiratory care. However, current clinical scores have not been validated with quantitative measures of respiratory function. The aim of this study was to develop a physiological scoring system to predict low respiratory dynamic compliance of (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - March 21, 2019 Category: Perinatology & Neonatology Authors: Eimei Harada, Masahiro Kinoshita, Sachiko Iwata, Mamoru Saikusa, Kennosuke Tsuda, Ryota Shindou, Takeshi Sahashi, Shin Kato, Yasumasa Yamada, Shinji Saitoh, Osuke Iwata Tags: Original Article Source Type: research

Clinical significance of asymmetric skin folds in the medial thigh for the infantile screening of developmental dysplasia of the hip
The presence of asymmetric skin folds in the medial thigh (ASM) is often used as one of the screening items for developmental dysplasia of the hip (DDH). However, few studies have evaluated the clinical relevance of ASM in DDH. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - March 20, 2019 Category: Perinatology & Neonatology Authors: Michael Seungcheol Kang, Geun Won Han, Minjae Kam, Soo-Sung Park Tags: Original Article Source Type: research

How to predict serious bacterial infections in young febrile infants in the emergency department?
Fever is the most common reason for young infants (age (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - March 20, 2019 Category: Perinatology & Neonatology Authors: Ting-Yu Yen Tags: Editorial Source Type: research

Endoscopic balloon dilatation in pediatric patients with esophageal strictures: From the past to the future
Following its first successful use in re-opening an artery with stenosis by Dr. Andreas Gr üntzig in 1974,1 balloon catheter was applied to not only angioplasty but also dilatation of esophageal strictures under fluoroscope in two adults in 1981 and under fiberesophagoscope in seven patients, including a child with caustic stricture complicated twice with perforation in 1984.2,3 Balloon catheters can pass thorough severe, lengthy, irregular esophageal strictures with a bendable guide wire with subsequent balloon catheter dilatation for patients who had failed treatment with conventional bougienage techniques. (Source:...
Source: Pediatrics and Neonatology - March 20, 2019 Category: Perinatology & Neonatology Authors: Shiuh-Bin Fang Tags: Editorial Source Type: research

Single strain versus multispecies probiotic on necrotizing enterocolitis and faecal IgA levels in very low birth weight preterm neonates: A randomized clinical trial
The objective of this study was to compare single strain (Lactobacillus acidophilus boucardii) versus multispecies probiotics on NEC incidence and faecal secretory Immunoglobulin A (sIgA) levels in very low preterm newborns. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - March 18, 2019 Category: Perinatology & Neonatology Authors: Guadalupe G ómez–Rodríguez, Norma Amador-Licona, Leonel Daza-Benítez, Gloria Barbosa-Sabanero, Deyanira Carballo-Magdaleno, Rodrigo Aguilar-Padilla, Eduardo González-Ramirez Tags: Original Article Source Type: research

Dynamics of concomitant therapy in children with juvenile idiopathic arthritis treated with etanercept and methotrexate
Both the steroid- and NSAID-sparing effects of biologics in juvenile idiopathic arthritis (JIA) treatment are key aspects of the dynamics of patient ’s condition. The proper selection of biologics enables maximum treatment effectiveness and reduction of the dosage of concomitant therapy. Our aim was to study the dynamics of concomitant therapy during etanercept (ETA) and methotrexate (MTX) treatment in patients with JIA. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - March 15, 2019 Category: Perinatology & Neonatology Authors: Ekaterina Alexeeva, Tatyana Dvoryakovskaya, Rina Denisova, Tatyana Sleptsova, Kseniya Isaeva, Alexandra Chomahidze, Anna Fetisova, Anna Mamutova, Alina Alshevskaya, Victor Gladkikh, Andrey Moskalev Tags: Original Article Source Type: research

Penetrating craniocerebral injury by chopsticks in a Japanese boy confirmed by combined brain computed tomography and magnetic resonance imaging
Penetrating craniofacial injuries by chopsticks rarely occur in children living in Oriental societies.1 –3 In many cases, the penetrating accident is caused by accidentally holding chopsticks in their hands and can be identified based on the stab wound in their face.1–3 Here we report a case with the difficult diagnosis of a transorbital penetrating intracranial injury in a child because of a mino r stab wound. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - March 1, 2019 Category: Perinatology & Neonatology Authors: Hiromune Narusawa, Keiichi Koizumi, Fumikazu Sano, Hideaki Yagasaki, Takaya Nakane Tags: Short Communication Source Type: research

Effect of packed red blood cell transfusion on IL-8 and sICAM-1 in premature neonates at different postnatal ages
This study aimed to monitor changes in IL-8, sICAM-1 as markers for TRIM in premature infants at different postnatal ages. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - February 26, 2019 Category: Perinatology & Neonatology Authors: Lamiaa Mohsen, Hala Youssef, Hala Abdelrahman, Rabab El Hawary, Abeer Selim, Safwat Aly, Mustafa Nada, Hany Aly Tags: Original Article Source Type: research

Secular trends of birthweight in boys from 1950 to 2010
Birthweight is an indicator of fetal development and intrauterine conditions and is associated with future health outcomes. Secular birthweight trends prior to the 1970s are mostly unknown. Our aim was to explore secular birthweight trends in Swedish boys from 1950 to 2010. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - February 23, 2019 Category: Perinatology & Neonatology Authors: Jimmy C élind, Marie Hedlund, Maria Bygdell, Arvid Sondén, Anders Elfvin, Jenny M. Kindblom Tags: Original Article Source Type: research

Early diagnosis of necrotizing enterocolitis by plasma RELM β and thrombocytopenia in preterm infants: A pilot study
As the inflammatory regulators, Resistin-like molecule β (RELMβ) and Resistin might be potential biomarkers of necrotizing enterocolitis (NEC), while thrombocytopenia is often related to the severity of NEC, clinical observation suggests that thrombocytopenia might be an early biomarker of NEC. The aim of this study was to evaluate whether RELMβ, Res istin and thrombocytopenia could be biomarkers for early diagnosis of NEC in preterm infants. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - February 21, 2019 Category: Perinatology & Neonatology Authors: Jun Luo, Hong ping Li, Fen Xu, Ben qing Wu, Hung Chih Lin Tags: Original Article Source Type: research

Acute pancreatitis in a patient with glycogen storage disease type 1a
A female child, 13 months of age, presented to our institution and was of short stature (68.2  cm;–2.5 standard deviation [SD]) and low weight (7655 g,–1.5 SD). She had hypertriglyceridemia (triglyceride (TG): 1100 mg/dL, total cholesterol (TC): 237 mg/dL) with mild hepatomegaly and did not present with hypoglycemia. We initially suspected a lipid metabolism disorder. At 19 months, t he child was admitted to our institution again because of a viral infection. She had hypoglycemia (64 mg/dL), hyperlactatemia (84.7 mg/dL), hyperuricemia (13.5 mg/dL), hypertriglyceridemia (1124&n...
Source: Pediatrics and Neonatology - February 19, 2019 Category: Perinatology & Neonatology Authors: Kaname Hirashima, Jun Kido, Shirou Matsumoto, Kimitoshi Nakamura Tags: Letter to the Editor Source Type: research

Complementary and alternative medicine use in treating pediatric surgical diseases including inflammatory bowel disease
We read with great interest the paper by Ong et  al.1 and agree with their conclusion. As they have reported, the prevalence of inflammatory bowel diseases (IBDs) and the use of complementary and alternative medicine (CAM) are increasing among pediatric patients with IBD. Defining the term CAM is very difficult as it includes a broad spectrum o f alternative medical systems, biologically based therapies, mind–body interventions, manipulative and body-based methods, and energy therapies. Various types of CAM are used by individuals according to their nationality and locality. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - February 18, 2019 Category: Perinatology & Neonatology Authors: Keiichi Uchida, Mikihiro Inoue, Yuhki Koike, Masato Kusunoki Tags: Letter to the Editor Source Type: research

Inguinal hernia containing uterus in a newborn: What to do?
A preterm newborn of 31 weeks of gestation was admitted because of hyaline membrane disease and apnea-bradycardia syndrome. On day 3 of life, a left inguinal hernia was detected, but was not painful and reducible. Sonographically, a homogeneous and hypoechoic mass containing a hyperecoic line was observed in the hernia sac, corresponding to a uterus with the endometrium. Besides the uterus, one of the ovaries could be seen. Color Doppler ultrasonography revealed no vascular compromise (Figs. 1 and 2). (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - February 6, 2019 Category: Perinatology & Neonatology Authors: Beatriz Pemart ín Comella, Paula Ortolá Fortes, Roberto Llorens Salvador Tags: Images Source Type: research

Abscess and symptoms duration upon presentation should guide decision algorithms for early versus interval appendectomy in children
To compare outcomes for complicated appendicitis treated with early versus interval appendectomy and to identify which patients would likely benefit from early appendectomy. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - February 5, 2019 Category: Perinatology & Neonatology Authors: Faidah Badru, Nicholas Piening, Armando Salim Munoz Abraham, Hector Osei, Jose Greenspon, Kaveer Chatoorgoon, Colleen Fitzpatrick, Gustavo A. Villalona Tags: Original Article Source Type: research

Cesarean section predominantly affects right ventricular diastolic function during the early transitional period
Although the mode of delivery is well known to affect pulmonary function, the effects of a cesarean delivery on postnatal changes in cardiac mechanics have not been clearly defined. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - January 31, 2019 Category: Perinatology & Neonatology Authors: Katsuo Tao, Yoshikazu Hara, Yasunori Ishihara, Yusei Ohshima Tags: Original Article Source Type: research

Neonatal gastric perforation enclosed by the lesser sac
A female preterm infant was born by cesarean delivery at a gestational age of 244/7 weeks with a birth weight of 523  g. On Day 8, mild abdominal distention and bilious gastric residuals were noted. Pneumoperitoneum was not evident in the plain abdominal radiographs. On Day 9, a round, 4-cm translucent structure was observed in the left upper quadrant (Fig. 1). Pneumoperitoneum was not evident in the lateral dec ubitus view. On Day 10, the translucent structure was still present; however, an upper gastrointestinal series did not delineate the structure (Fig. 2). (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - January 30, 2019 Category: Perinatology & Neonatology Authors: Hiroyuki Ichiba, Naohiro Yamamoto Tags: Images Source Type: research

Fat-soluble vitamin deficiency in pediatric patients with chronic liver disease
Nutritional deficiencies have become a common problem among patients with chronic liver disease (CLD) and may easily be underestimated by clinical appearance alone; they negatively impact the neurocognitive development and growth. CLD is defined as the process of long-term progressive destruction and regeneration of liver parenchyma leading to fibrosis and cirrhosis. Children with CLD are more at risk than adults for severe malnutrition and feature lower reserves. In the United States, the overall incidence of liver disease in neonates is approximately 1 in every 2500 live births1 with extrahepatic biliary atresia (BA), me...
Source: Pediatrics and Neonatology - January 29, 2019 Category: Perinatology & Neonatology Authors: Chun-Yan Yeung Tags: Editorial Source Type: research

Editorial Board
(Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - January 29, 2019 Category: Perinatology & Neonatology Source Type: research

Maternal HBeAg positivity and viremia associated with umbilical cord blood hepatitis B viremia
Hepatitis B (HBV) transmission may result from in utero transmission. We aimed to determine the correlation between maternal serum and umbilical cord blood HBV DNA levels in infants delivered by chronic HBV-infected mothers and to describe the effect of cord blood viremia on vertical transmission. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - January 22, 2019 Category: Perinatology & Neonatology Authors: Le Ye Lee, Guan Huei Lee, Citra Mattar, Sharon Saw, Marion Aw Tags: Original Article Source Type: research

DNA methylation of the Rtl1 promoter in the placentas with fetal growth restriction
Small for gestational age (SGA) babies experience fetal growth restriction because of placental insufficiency, and aberrant fetal growth has been linked to DNA methylation in the placenta. An imprinted gene encoding retrotransposon-like protein 1 (RTL1) is regulated by DNA methylation in the promoter region and plays a key role in placental development. We therefore investigated the DNA methylation status of RTL1 in the placenta of infants with severe SGA. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - January 21, 2019 Category: Perinatology & Neonatology Authors: Kazumichi Fujioka, Kosuke Nishida, Mariko Ashina, Shinya Abe, Sachiyo Fukushima, Toshihiko Ikuta, Shohei Ohyama, Ichiro Morioka, Kazumoto Iijima Tags: Original Article Source Type: research

Cortisol production in preterm infants with or without late-onset adrenal insufficiency of prematurity: A prospective observational study
The objective of this study is to compare cortisol production in preterm infants with and without late-onset AOP. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - January 19, 2019 Category: Perinatology & Neonatology Authors: Kenichi Masumoto, Noriko Tagawa, Yoshiharu Kobayashi, Satoshi Kusuda Tags: Original Article Source Type: research

Array-CGH increased the diagnostic rate of developmental delay or intellectual disability in Taiwan
This study aimed to investigate and compare the d iagnosis rate for DD/ID using array-CGH and conventional chromosome study in DD/ID patients in Taiwan. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - December 20, 2018 Category: Perinatology & Neonatology Authors: Chung-Lin Lee, Chen-Hao Lee, Chih-Kuang Chuang, Huei-Ching Chiu, Yen-Jiun Chen, Chao-Ling Chou, Peih-Shan Wu, Chih-Ping Chen, Hsiang-Yu Lin, Shuan-Pei Lin Tags: Original Article Source Type: research

Clinical significance of detecting serum melatonin and SBDPs in brain injury in preterm infants
To investigate the clinical values of serum melatonin and αII spectrin cleavage products (SBDPs) in assessing the severity of brain injury in preterm infants. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - December 14, 2018 Category: Perinatology & Neonatology Authors: Caixia Yan, Binghong Zhang Tags: Original Article Source Type: research

Different degrees of maternal Ureaplasma colonization and its correlation with bronchopulmonary dysplasia in < 32 weeks' preterm infants
Ureaplasma spp. is a known risk factor for bronchopulmonary dysplasia (BPD). However, little is known about the effect of different degrees of maternal Ureaplasma colonization and their adverse outcomes. Hence, the aim of this study was to determine the effects of different degrees of maternal Ureaplasma colonization on BPD. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - December 14, 2018 Category: Perinatology & Neonatology Authors: Jiyoung Chun, Sang Hoon Chun, Yea Seul Han, Tae-Jung Sung Tags: Original Article Source Type: research

Editorial Board
(Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - November 29, 2018 Category: Perinatology & Neonatology Source Type: research

What is the exact mechanism underlying periventricular echogenicity?
The anterior fontanelle is a fantastic window that nature has left us for viewing the neonatal brain. Using a brain echo, the structure problems in the neonatal brain, especially in preterm infants, can be assessed. This technique can easily detect intraventricular hemorrhage, hydrocephalus, and periventricular leukomalacia (PVL) through brain sonography. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - November 29, 2018 Category: Perinatology & Neonatology Authors: Hung-Chieh Chou Tags: Editorial Source Type: research

Intrauterine volvulus that had been misunderstood as an antenatal mesenteric cyst
A 29-year-old mother gave birth to a full-term boy. He was hospitalized in our clinic due to suckling difficulty, bilious vomiting, and a mesenteric cyst diagnosed via antenatal ultrasonography at the 12th week of intrauterine life. In the prenatal period, there was no history of polyhydramnios or fetal distress. His first physical examination and all the laboratory tests were normal. The appearance of a hyperechoic cystic mass that measured 46  × 41 mm in size with a thick wall, and fluid level in its lumen on abdominal ultrasonography, was compatible with a mesenteric cyst. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - November 29, 2018 Category: Perinatology & Neonatology Authors: Nazl ı Dilay Gultekin, Ozgul Salihoglu, Ahmet Alptekin, Fatma Hilal Yılmaz, Huseyin Altunhan Tags: Images Source Type: research

Primary intracranial meningeal melanoma mimicking chronic meningitis: A case report
A 6-year -8-month-old girl was presented with headache, vomiting, and unstable gait. Neurologic examination revealed dysmetria, positive tandem gait, and negative Romberg test. Computed tomography of the brain showed mild ventriculomegaly (Fig.  1A). Cerebrospinal fluid (CSF) analysis revealed negative findings. However, there was a suspicion of cerebellitis. She was discharged with clinical improvement. However, the headache and vomiting recurred after 6 months. Magnetic resonance imaging (MRI) of the brain revealed marked dilatation of all ventricles with prominent leptomeningeal contrast enhancement. (Source: Pedia...
Source: Pediatrics and Neonatology - November 27, 2018 Category: Perinatology & Neonatology Authors: Po-Cheng Hung, Yu-Ching Chang, Meng-Ying Hsieh, Chieh-Tsai Wu Tags: Images Source Type: research

Effect of postnatal hydrocortisone on 18-month neurodevelopmental outcomes in  very-low-birth-weight infants
Potential neurodevelopmental impairments following postnatal corticosteroid therapy in preterm infants are a  concern. Although hydrocortisone has been more commonly used than dexamethasone, its long-term neurodevelopmental impact remains debatable.1–3 In addition, hydrocortisone exposure for longer than 7 days has been associated with poor performance in fine motor skills during the first year of life .4 Moreover, the safety range of dose and the duration of hydrocortisone still remain undetermined; therefore, we investigated the effect of cumulative dose and treatment duration of hydrocortisone on neurode...
Source: Pediatrics and Neonatology - November 27, 2018 Category: Perinatology & Neonatology Authors: Yosuke Ono, Kentaro Tamura, Satomi Inomata, Takeshi Futatani, Shigeru Saito, Taketoshi Yoshida Tags: Short Communication Source Type: research

Comparison of HbA1c and OGTT for the diagnosis of type 2 diabetes in children at risk of diabetes
The aim of this study was to evaluate the correlation between plasma glucose and HbA1c and the diagnostic accuracy of HbA1c as a screening tool to identify asymptomatic diabetes mellitus in children and adolescents with obesity or asymptomatic glucosuria. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - November 26, 2018 Category: Perinatology & Neonatology Authors: Min Sun Kim, Dae Sun Jo, Dae-Yeol Lee Tags: Original Article Source Type: research

Retrospective evaluation of children with immune thrombocytopenic purpura and factors contributing to chronicity
Immune thrombocytopenic purpura (ITP) is the most common cause of acquired thrombocytopenia children. The aim of this retrospective study is to describe presenting features and clinical characteristics of ITP and evaluate clinical course, treatment modalities, and complications and determine the effects of preceding infection history, age, gender, treatment modality, and admission platelet count on chronicity. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - November 20, 2018 Category: Perinatology & Neonatology Authors: T ülin Güngör, Özlem Arman Bilir, Vildan Koşan Çulha, Ali Güngör, Abdurrahman Kara, Fatih Mehmet Azık, Hüsniye Neşe Yaralı Tags: Original Article Source Type: research

The presentation of proteinuria in an adolescent with new-onset diabetes after heart transplantation
A 14-year-old girl presented with new-onset noninsulin-dependent diabetes mellitus for 5 years after a heart transplantation that was performed 7 years ago. The immunosuppressive agents that she received initially were tacrolimus, everolimus, and prednisolone, and she was maintained with cyclosporine and everolimus for the past 5 years. Treatment for her diabetes initially included oral hypoglycemic agents (OHAs), which was then switched to insulin therapy due to OHA-induced gastrointestinal upset. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - November 20, 2018 Category: Perinatology & Neonatology Authors: Chin Yee Ho, Gwo-Tsann Chuang, Wei-Chou Lin, I-Jung Tsai Tags: Letter to the Editor Source Type: research

Effect of rewarming in oxygenation and respiratory condition after neonatal exposure to moderate therapeutic hypothermia
To assess changes in clinical condition and oxygenation in neonates after rewarming following moderate therapeutic hypothermia (MTH) for neonatal encephalopathy. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - November 17, 2018 Category: Perinatology & Neonatology Authors: Itamar Nitzan, Shmuel Goldberg, Cathy Hammerman, Alona Bin-Nun, Ruben Bromiker Tags: Original Article Source Type: research

Heparin-binding epidermal growth factor-like growth factor (HB-EGF) protected intestinal ischemia-reperfusion injury through JNK and p38/MAPK-dependent pathway for anti-apoptosis
In this study, we intended to examine whether HB-EGF exerts its protective effects through MAPK dependent anti-apoptosis after intestinal I/R injury. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - November 16, 2018 Category: Perinatology & Neonatology Authors: Yung-Ching Ming, Hsun-Chin Chao, Shih-Ming Chu, Chih-Cheng Luo Tags: Original Article Source Type: research

Immunotherapy for anti-NMDA receptor encephalitis: Experience from a single center in Taiwan
Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis is an anti-neuronal antibody-mediated inflammatory brain disease that causes severe psychiatric and neurological deficits in previously healthy patients. The aims of this study were to demonstrate the clinical characteristics of patients diagnosed with anti-NMDA receptor encephalitis and to compare the different treatment strategies among these patients. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - November 15, 2018 Category: Perinatology & Neonatology Authors: Shu-Sing Kong, Yun-Ju Chen, I-Chen Su, Jainn-Jim Lin, I-Jun Chou, Min-Liang Chou, Po-Cheng Hung, Meng-Ying Hsieh, Yi-Shan Wang, Cheng-Che Chou, Huei-Shyong Wang, Kuang-Lin Lin, the CHEESE Study Group Tags: Original Article Source Type: research

Partial liquid ventilation for bronchopulmonary dysplasia: Visualizing ventilation patterns on chest radiographs
Despite the advances in neonatal intensive care, bronchopulmonary dysplasia (BPD) still remains a major cause of mortality and morbidity in many preterm infants. A definitive treatment still does not exist, and BPD has serious consequences, including poor cardiopulmonary function and development. Hence, to address this  need, a randomized clinical trial (NCT03041740) is currently underway to assess the safety and feasibility of partial liquid ventilation (PLV) in preterm infants with severe BPD. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - November 14, 2018 Category: Perinatology & Neonatology Authors: Andrew J. Degnan, William W. Fox, Huayan Zhang, David Saul Tags: Images Source Type: research

Characteristics and outcome of primary sclerosing cholangitis associated with inflammatory bowel disease in Asian children
We described the presenting features and natural history of primary sclerosing cholangitis-inflammatory bowel disease seen in a cohort of Southeast Asian children. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - October 26, 2018 Category: Perinatology & Neonatology Authors: Way Seah Lee, Sivaramakrishnan Venkatesh Karthik, Ruey Terng Ng, Sik Yong Ong, Christina Ong, Fang K. Chiou, Shin Yee Wong, Seng Hock Quak, Marion Margaret Aw Tags: Original Article Source Type: research

Emergency room visits and admission rates of children with neuromuscular disorders: A 10-year experience in a medical center in Taiwan
No previous studies have explored emergency medical care for children with chronic neuromuscular disorders (NMDs). We aimed to determine the major reasons for the emergency room (ER) readmission of pediatric patients with NMDs and suggest changes to the care plan to decrease readmissions. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - October 25, 2018 Category: Perinatology & Neonatology Authors: Wei-Tsun Kao, Yung-Hao Tseng, Yuh-Jyh Jong, Tai-Heng Chen Tags: Original Article Source Type: research

Prognostic parameters of pediatric acute liver failure and the role of plasma exchange
This study investigated the prognostic parameters and beneficial effects of repeat plasma exchange in children with acute liver failure (ALF). (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - October 22, 2018 Category: Perinatology & Neonatology Authors: Mu-Ming Chien, Mei-Hwei Chang, Kai-Chi Chang, Fang-Ting Lu, Yu-Chun Chiu, Huey-Ling Chen, Yen-Hsuan Ni, Hong-Yuan Hsu, Jia-Feng Wu Tags: Original Article Source Type: research

A case of bowel perforation in a newborn exposed to cocaine in utero
A full-term male neonate without perinatal problems presented with irritability, tremors, and episodes of clonus of the limbs in the first days of life. He was treated with phenobarbital. The mother was a cocaine abuser; the toxicological screen test of the newborn's urine was positive for cocaine and opiates. On the 10th day of life, the infant started presenting stools with abundant red blood and an increase in CRP levels and developed a sudden clinical deterioration with tense abdomen and sore. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - October 18, 2018 Category: Perinatology & Neonatology Authors: Sara Dal Bo, Francesca Curr ò, Alberto Ratta, Simona Straziuso, Federico Marchetti Tags: Images Source Type: research

New features of aplasia cutis congenita type 5 – Skin atrophy associated with respiratory insufficiency and multiple intestinal atresia caused by the early death of twin fetus
A 1-day-old female infant was transferred to our NICU with a diagnosis of a congenital skin defect. She was born from a twin pregnancy complicated with intrauterine twin death in week 12 of pregnancy. Two previous pregnancies had ended early in spontaneous miscarriages. The infant presented hypersensitivity to stimuli, symmetrical skin defects covering 30% of the body, most widely distributed in a butterfly/H-pattern on the trunk, with thigh and elbow marks, and a single horizontal lesion underneath the clavicles and upon the sagittal suture. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - October 11, 2018 Category: Perinatology & Neonatology Authors: Alina Sobczak, Tomasz Tomasik, Andrzej Zaj ąc, Barbara Klasa, Piotr Kruczek, Przemko Kwinta Tags: Images Source Type: research

The clinical value of plasma hepcidin levels in predicting bacterial infections in febrile children
In this study, we examined the plasma hepcidin levels in febrile children. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - October 10, 2018 Category: Perinatology & Neonatology Authors: Jia-Huei Yan, Xin-Yuan Cai, Ying-Hsien Huang Tags: Original Article Source Type: research

Chemokine levels predict progressive liver disease in Down syndrome patients with transient abnormal myelopoiesis
The objective is to search for biomarkers predicting the development of hepatic failure in DS infants with TAM. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - October 9, 2018 Category: Perinatology & Neonatology Authors: Tadamune Kinjo, Hirosuke Inoue, Takeshi Kusuda, Junko Fujiyoshi, Masayuki Ochiai, Yasushi Takahata, Satoshi Honjo, Yuhki Koga, Toshiro Hara, Shouichi Ohga Tags: Original Article Source Type: research

Positive end-expiratory pressure during resuscitation at birth in very-low-birth-weight infants: A randomized controlled pilot trial
Very-low-birth-weight (VLBW) premature infants show a high risk of developing surfactant deficiency, respiratory difficulty, or apnea after birth. The neonatal resuscitation guideline recommends resuscitation in the delivery room by  positive pressure ventilation (PPV) to rescue high-risk newborns suffering from apnea, gasping, or a heart rate of less than 100/min.1,2 Positive end-expiratory pressure (PEEP) using 5 cm H2O is recommended while applying PPV in neonatal resuscitation; however, there is still a lack of strong ev idence of the beneficial significance of PEEP in VLBW infants through clinically ran...
Source: Pediatrics and Neonatology - October 1, 2018 Category: Perinatology & Neonatology Authors: Mei-Jy Jeng Tags: Editorial Source Type: research

Editorial Board
(Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - October 1, 2018 Category: Perinatology & Neonatology Source Type: research

Spondylocarpotarsal synostosis syndrome: “Bat wings” spinal fusions and “ladybug” carpal coalitions
A pediatrician noticed a hump in a 1-year-old girl during a chest examination for cough and fever. The girl had suffered from intrauterine growth retardation and had been born preterm at 34 weeks, through a caesarean section, in the context of preeclampsia. The child's weight was 1.88  kg at birth. Growth rate was slower than expected for age (at 2 years and 6 months, height was on the 2.9th percentile and weight was on the 1.8th percentile; at 3 years and 6 months, there was slowing in growth with height on the 0.4th percentile and weight on the 1.8th percentile; and at 4 year s and 6 months, there was further s...
Source: Pediatrics and Neonatology - September 20, 2018 Category: Perinatology & Neonatology Authors: Alberto Bazzocchi, Paolo Spinnato, Maria Pilar Aparisi G ómez, Daniele Mercatelli, Ugo Albisinni Tags: Images Source Type: research

Long-term effects of enzyme replacement therapy for Taiwanese patients with mucopolysaccharidosis IVA
Mucopolysaccharidosis IVA (MPS IVA; Morquio A syndrome; OMIM 253000) is a rare autosomal-recessive inherited disorder caused by N-acetylgalactosamine-6-sulfatase (GALNS) deficiency which leads to excessive lysosomal storage of glycosaminoglycans (GAGs), keratan sulfate (KS) and chondroitin-6-sulfate in various tissues and organs. The clinical manifestations include corneal clouding, hearing loss, valvular heart disease, systemic skeletal chondrodysplasia, malformation of the thorax that impairs respiratory function, short stature, joint abnormalities with limitations in mobility and endurance, odontoid hypoplasia and ligam...
Source: Pediatrics and Neonatology - September 18, 2018 Category: Perinatology & Neonatology Authors: Hsiang-Yu Lin, Chih-Kuang Chuang, Yu-Yuan Ke, Chia-Chi Hsu, Pao Chin Chiu, Dau-Ming Niu, Fuu-Jen Tsai, Wuh-Liang Hwu, Ju-Li Lin, Shuan-Pei Lin Tags: Short Communication Source Type: research

Conventional MRI combined with DTI for neonatal hyperbilirubinemia; Methodological issues on diagnostic value
We read with interest the article by Yan R and colleagues published in the April 2018 issue of Pediatr Neonatol.1 Increased signal intensity in the globus pallidus on MR T1WI is an important sign of neonatal bilirubin encephalopathy. Brain diffusion tensor imaging (DTI) has not been used extensively to study hyperbilirubinemia (HB). The purpose of the authors was to evaluate the diagnostic value of conventional magnetic resonance imaging (MRI) combined with DTI (MRI-DTI) in neonatal hyperbilirubinemia. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - September 15, 2018 Category: Perinatology & Neonatology Authors: Siamak Sabour, Hadis Batari Tags: Letter to the Editor Source Type: research

Regarding platelets and ductus: Is it platelet function rather than number that matters for ductal closure?
I read with great interest the recent article by Dr Kahvecioglu and her colleagues in which the authors provide further evidence for an association between platelets and  closure of ductus arteriosus. They identified longer collagen-ADP duration as a risk factor for ductal closure, although there were no differences in platelet count, mean platelet volume (MPV), and platelet mass index between the open and closed ductus groups.1 (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - September 12, 2018 Category: Perinatology & Neonatology Authors: Defne Engur Tags: Letter to the Editor Source Type: research

The equations of the inserted length of percutaneous central venous catheters on neonates in NICU
In neonatal intensive care units, a percutaneous central venous catheter (PCVC) is inserted peripherally and threaded into a central venous location, when intravenous access is anticipated for an extended period of time. The tip location of PCVCs should be checked by an X-ray after the procedure. The present study aimed to determine an equation to estimate the optimal insertion length of PCVCs in neonates prior to the procedure. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - September 11, 2018 Category: Perinatology & Neonatology Authors: I-Lun Chen, Mei-Chen Ou-Yang, Feng-Shun Chen, Mei-Yung Chung, Chih-Cheng Chen, Yu-Chen Liu, Kuan-Hung Lin, Hsin-Chun Huang Tags: Original Article Source Type: research