The effect of SPARK on social and motor skills of children with autism
This study aimed to evaluate the effectiveness of a selected group exercise known as Sports, Play and Active Recreation for Kids (SPARK) on the motor and behavioral skills of children with autism spectrum disorder (ASD) using a quasi-experimental design with repeated measures. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - February 2, 2018 Category: Perinatology & Neonatology Authors: Mahboubeh Ghayour Najafabadi, Mahmood Sheikh, Rasoul Hemayattalab, Mehran Amir, Maryam Rezaii, Sina Hafizi Tags: Original Article Source Type: research

Level of maternal triglycerides is a predictor of fetal macrosomia in non-obese pregnant women with gestational diabetes mellitus
The role of maternal serum triglycerides (TGs) in the development of fetal macrosomia in different subgroups of body mass index (BMI) has received little attention. The aim of this study was to determine the association between the level of maternal TGs and fetal macrosomia in Iranian pregnant women of different BMI subgroups with gestational diabetes mellitus (GDM). (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - February 2, 2018 Category: Perinatology & Neonatology Authors: Sima Hashemipour, Ezzatalsadat Haji Seidjavadi, Firoozeh Maleki, Neda Esmailzadehha, Farideh Movahed, Zohreh Yazdi Tags: Original Article Source Type: research

The effect of SPARK on social and motor skills of children with autism
This study aimed to evaluate the effectiveness of a selected group exercise known as Sports, Play and Active Recreation for Kids (SPARK) on the motor and behavioral skills of children with autism spectrum disorder (ASD) using a quasi-experimental design with repeated measures. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - February 2, 2018 Category: Perinatology & Neonatology Authors: Mahboubeh Ghayour Najafabadi, Mahmood Sheikh, Rasoul Hemayattalab, Mehran Amir, Maryam Rezaii, Sina Hafizi Tags: Original Article Source Type: research

Level of maternal triglycerides is a predictor of fetal macrosomia in non-obese pregnant women with gestational diabetes mellitus
The role of maternal serum triglycerides (TGs) in the development of fetal macrosomia in different subgroups of body mass index (BMI) has received little attention. The aim of this study was to determine the association between the level of maternal TGs and fetal macrosomia in Iranian pregnant women of different BMI subgroups with gestational diabetes mellitus (GDM). (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - February 2, 2018 Category: Perinatology & Neonatology Authors: Sima Hashemipour, Ezzatalsadat Haji Seidjavadi, Firoozeh Maleki, Neda Esmailzadehha, Farideh Movahed, Zohreh Yazdi Tags: Original Article Source Type: research

Current practice of iron prophylaxis in preterm and low birth weight neonates: A  survey among Italian Neonatal Units
Preterm babies are at high risk of iron deficiency. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - February 1, 2018 Category: Perinatology & Neonatology Authors: Emilia Parodi, Anna Ferrero, Barbara Perrone, Paola Saracco, Maria Teresa Giraudo, Daniela Regoli Tags: Original Article Source Type: research

Identification of the largest homozygous glycine decarboxylase gene deletion in a Turkish infant
Nonketotic hyperglycinemia (NKH) is an autosomal recessive inborn error of metabolism caused by a defect in the glycine cleavage complex.1 Progressive lethargy, hypotonia, feeding difficulties, hiccups, and recurrent apnea are usually observed during the first few days of life. Subsequent severe neurologic dysfunction may occur, including intractable seizures, motor and cognitive impairments.2 NKH is characterized biochemically by increased cerebrospinal fluid (CSF) and plasma glycine levels and an increased CSF-to-plasma glycine ratio. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - February 1, 2018 Category: Perinatology & Neonatology Authors: Semra G ürsoy, Esra Ataman, Özlem Giray Bozkaya, Engin Köse, Müge Ayanoğlu, Ayşe İpek Polat, Nur Arslan, Semra Hız Kurul, Derya Erçal Tags: Short Communication Source Type: research

Prevalence of airway hyperresponsiveness and its seasonal variation in children with asthma
This study evaluated the prevalence of AHR to methacholine and its seasonal variation in asthmatic children in Taiwan, a subtropical country. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - February 1, 2018 Category: Perinatology & Neonatology Authors: Shu-Jung Huang, Li-Lun Lin, Li-Chen Chen, Liang-Shiou Ou, Tsung-Chieh Yao, Kuo-Chien Tsao, Kuo-Wei Yeh, Jing-Long Huang Tags: Original Article Source Type: research

Clinical presentation of PTEN mutations
We describe the case of a 6-year-old girl who presented with  macrocephaly and multiple lipomatous lesions. She was the fifth child of nonconsanguineous parents of Pakistani origin with no significant family history. At birth, her head circumference was above the 97th percentile and she had normal body weight and length. Brain scans showed normal results. Sh e also displayed regular psychomotor development. At the age of 3 years, she developed left tibial swelling accompanied by pain and limping, but there was neither fever nor changes in the levels of inflammatory markers. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - February 1, 2018 Category: Perinatology & Neonatology Authors: Vanna Graziani, Sara Dal Bo, Michela Giovannini, Federico Marchetti Tags: Images Source Type: research

Current practice of iron prophylaxis in preterm and low birth weight neonates: A  survey among Italian Neonatal Units
Preterm babies are at high risk of iron deficiency. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - February 1, 2018 Category: Perinatology & Neonatology Authors: Emilia Parodi, Anna Ferrero, Barbara Perrone, Paola Saracco, Maria Teresa Giraudo, Daniela Regoli Tags: Original Article Source Type: research

Identification of the largest homozygous glycine decarboxylase gene deletion in a Turkish infant
Nonketotic hyperglycinemia (NKH) is an autosomal recessive inborn error of metabolism caused by a defect in the glycine cleavage complex.1 Progressive lethargy, hypotonia, feeding difficulties, hiccups, and recurrent apnea are usually observed during the first few days of life. Subsequent severe neurologic dysfunction may occur, including intractable seizures, motor and cognitive impairments.2 NKH is characterized biochemically by increased cerebrospinal fluid (CSF) and plasma glycine levels and an increased CSF-to-plasma glycine ratio. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - February 1, 2018 Category: Perinatology & Neonatology Authors: Semra G ürsoy, Esra Ataman, Özlem Giray Bozkaya, Engin Köse, Müge Ayanoğlu, Ayşe İpek Polat, Nur Arslan, Semra Hız Kurul, Derya Erçal Tags: Short Communication Source Type: research

Prevalence of airway hyperresponsiveness and its seasonal variation in children with asthma
This study evaluated the prevalence of AHR to methacholine and its seasonal variation in asthmatic children in Taiwan, a subtropical country. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - February 1, 2018 Category: Perinatology & Neonatology Authors: Shu-Jung Huang, Li-Lun Lin, Li-Chen Chen, Liang-Shiou Ou, Tsung-Chieh Yao, Kuo-Chien Tsao, Kuo-Wei Yeh, Jing-Long Huang Tags: Original Article Source Type: research

Clinical presentation of PTEN mutations
We describe the case of a 6-year-old girl who presented with  macrocephaly and multiple lipomatous lesions. She was the fifth child of nonconsanguineous parents of Pakistani origin with no significant family history. At birth, her head circumference was above the 97th percentile and she had normal body weight and length. Brain scans showed normal results. Sh e also displayed regular psychomotor development. At the age of 3 years, she developed left tibial swelling accompanied by pain and limping, but there was neither fever nor changes in the levels of inflammatory markers. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - February 1, 2018 Category: Perinatology & Neonatology Authors: Vanna Graziani, Sara Dal Bo, Michela Giovannini, Federico Marchetti Tags: Images Source Type: research

Renal replacement therapy in the neonatal intensive care unit
Renal replacement therapy (RRT) is becoming increasingly necessary for supporting critically ill neonates. Few studies have reported the use of RRT in the neonatal intensive care unit (NICU). Therefore, we performed a retrospective study to describe the use of RRT in our NICU and its associated efficacy, complications, and outcomes. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - January 23, 2018 Category: Perinatology & Neonatology Authors: Tze Yee Diane Mok, Min-Hua Tseng, Ming-Chou Chiang, Ju-Li Lin, Shih Ming Chu, Jen-Fu Hsu, Reyin Lien Tags: Original Article Source Type: research

Two novel mutations in the BCKDHB gene that cause maple syrup urine disease
Maple syrup urine disease (MSUD) is a rare metabolic disorder of autosomal recessive inheritance caused by decreased activity of branched-chain α-ketoacid dehydrogenase complex (BCKD). Mutations in the three genes (BCKDHA, BCKDHB and DBT) are associated with MSUD. Here, we describe the presenting symptoms, clinical course and gene mutation analysis of a Chinese boy with MSUD. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - January 22, 2018 Category: Perinatology & Neonatology Authors: Bingjuan Han, Bingchao Han, Bin Guo, Yingxia Liu, Zhiyang Cao Tags: Original Article Source Type: research

An atlantoaxial rotatory subluxation secondary to a parapharyngeal abscess
Grisel's syndrome secondary to deep neck infection is rare with only four cases secondary to retropharyngeal abscess in the posterior pharyngeal space reported.1 –3 However, no cases secondary to parapharyngeal abscess in the lateral pharyngeal space have been reported. Here we describe a case of Grisel's syndrome with non-traumatic atlantoaxial rotatory subluxation (AARS) due to hematogenous spread of a parapharyngeal space infection to the cervical spine , with hyperemia and abnormal relaxation of the transverse ligament of the atlantoaxial joint. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - January 21, 2018 Category: Perinatology & Neonatology Authors: Hao-Yuan Lee, Chyi-Liang Chen, Cheng-Hsun Chiu Tags: Images Source Type: research

Schizencephaly in children: A single medical center retrospective study
The aim of this study was to evaluate the clinical, and neuroimaging features, outcomes, and other associated systemic disorders in children with schizencephaly at a single medical center in Taiwan. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - January 19, 2018 Category: Perinatology & Neonatology Authors: Po-Cheng Hung, Huei-Shyong Wang, Ming-Liang Chou, Kuang-Lin Lin, Meng-Ying Hsieh, I-Jun Chou, Alex M-C. Wong Tags: Original Article Source Type: research

Bacilli-containing granuloma with subsequent granuloma annulare-like eruptions following Bacillus Calmette –Guérin vaccination
Bacille Calmette-Guerin (BCG), an attenuated strain of Mycobacterium bovis, is currently the only licensed tuberculosis vaccine in use. BCG vaccination is routinely given at birth to billions of children globally,1 including those born in Taiwan since 1981 (Taiwan Centers for Disease Control website: https://goo.gl/4FDNLg). Cutaneous manifestations after BCG inoculation into the dermis may provide an important sign of the host immune response. Here we report a male infant who developed a bacilli-containing granuloma over the vaccination site and subsequent granuloma annulare (GA)-like eruptions over the arm and back. (Sour...
Source: Pediatrics and Neonatology - January 18, 2018 Category: Perinatology & Neonatology Authors: Shiang-Yu Yang, Chung-Hsing Chang Tags: Short Communication Source Type: research

Hyperechogenicity of lenticulostriate vessels: A poor prognosis or a normal variant? A seven year retrospective study
Lenticulostriate vasculopathy (LSV) is a hyperechogenicity of the lenticulostriate branches of the basal ganglia and/or thalamus' middle cerebral arteries and is frequently seen in neonatology. Our study primarily describes the perinatal data and long-term follow-up of newborns with lenticulostriate vessel hyperechoic degeneration. Secondly, it describes the cerebral imaging data as a function of perinatal factors and neurodevelopmental follow-up of these newborns. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - January 18, 2018 Category: Perinatology & Neonatology Authors: Candice Fabre, Barth élémy Tosello, Estelle Pipon, Catherine Gire, Kathia Chaumoitre Tags: Original Article Source Type: research

Bacilli-containing granuloma with subsequent granuloma annulare-like eruptions following Bacillus Calmette –Guérin vaccination
Bacille Calmette-Guerin (BCG), an attenuated strain of Mycobacterium bovis, is currently the only licensed tuberculosis vaccine in use. BCG vaccination is routinely given at birth to billions of children globally,1 including those born in Taiwan since 1981 (Taiwan Centers for Disease Control website: https://goo.gl/4FDNLg). Cutaneous manifestations after BCG inoculation into the dermis may provide an important sign of the host immune response. Here we report a male infant who developed a bacilli-containing granuloma over the vaccination site and subsequent granuloma annulare (GA)-like eruptions over the arm and back. (Sour...
Source: Pediatrics and Neonatology - January 18, 2018 Category: Perinatology & Neonatology Authors: Shiang-Yu Yang, Chung-Hsing Chang Tags: Short Communication Source Type: research

Hyperechogenicity of lenticulostriate vessels: A poor prognosis or a normal variant? A seven year retrospective study
Lenticulostriate vasculopathy (LSV) is a hyperechogenicity of the lenticulostriate branches of the basal ganglia and/or thalamus' middle cerebral arteries and is frequently seen in neonatology. Our study primarily describes the perinatal data and long-term follow-up of newborns with lenticulostriate vessel hyperechoic degeneration. Secondly, it describes the cerebral imaging data as a function of perinatal factors and neurodevelopmental follow-up of these newborns. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - January 18, 2018 Category: Perinatology & Neonatology Authors: Candice Fabre, Barth élémy Tosello, Estelle Pipon, Catherine Gire, Kathia Chaumoitre Tags: Original Article Source Type: research

Complementary and alternative medicine (CAM) practices and dietary patterns in children with inflammatory bowel disease in Singapore and Malaysia
The use of complementary and alternative medicine (CAM) has been associated with adverse effects and self-imposed dietary restrictions. The prevalence of its use in Asian children with inflammatory bowel disease (IBD) is unknown. We aimed to determine the prevalence, types, and factors associated with the use of CAM among children with IBD from Singapore and Malaysia, and to ascertain if dietary restriction was prevalent in patients who used CAM. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - January 15, 2018 Category: Perinatology & Neonatology Authors: Fangyi Ong, Way Seah Lee, Charlotte Lin, Ruey Terng Ng, Shin Yee Wong, Su Lin Lim, Seng Hock Quak, Marion Aw Tags: Original Article Source Type: research

Genotype and homology analysis of pathogenic and colonization strains of Candida albicans from hospitalized neonates
To detect the genotypes of pathogenic and colonization Candida albicans strains and to reveal whether there was a homologous relationship between these strains. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - January 12, 2018 Category: Perinatology & Neonatology Authors: Jin-Zhen Su, Yu-Lan Yang, Rong Rong, Ben-Qing Wu Tags: Original Article Source Type: research

An unusual GFAP mutation in a Taiwanese child with infantile Alexander disease
Alexander disease (AD) is a rare progressive leukoencephalopathy which typically involves the frontal lobes. The disease spectrum comprises macrocephaly, progressive pyramidal signs, and seizures. It can be divided into infantile, juvenile, and adult subtypes according to the age of clinical presentation. AD is a not a primary disease of myelin, oligodendrocytes, or axons, but a disease of astrocytes. The disease is caused by mutations in the glial fibrillary acidic protein (GFAP) gene, which encodes a type III intermediate filament predominantly found in astrocytes in the central nervous system. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - January 12, 2018 Category: Perinatology & Neonatology Authors: Jao-Shwann Liang, Li-Ju Lin, Haung-Chi Lin, Ming-Tao Yang, Jinn-Shyan Wang, Jyh-Feng Lu Tags: Short Communication Source Type: research

Genotype and homology analysis of pathogenic and colonization strains of Candida albicans from hospitalized neonates
To detect the genotypes of pathogenic and colonization Candida albicans strains and to reveal whether there was a homologous relationship between these strains. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - January 12, 2018 Category: Perinatology & Neonatology Authors: Jin-Zhen Su, Yu-Lan Yang, Rong Rong, Ben-Qing Wu Tags: Original Article Source Type: research

An unusual GFAP mutation in a Taiwanese child with infantile Alexander disease
Alexander disease (AD) is a rare progressive leukoencephalopathy which typically involves the frontal lobes. The disease spectrum comprises macrocephaly, progressive pyramidal signs, and seizures. It can be divided into infantile, juvenile, and adult subtypes according to the age of clinical presentation. AD is a not a primary disease of myelin, oligodendrocytes, or axons, but a disease of astrocytes. The disease is caused by mutations in the glial fibrillary acidic protein (GFAP) gene, which encodes a type III intermediate filament predominantly found in astrocytes in the central nervous system. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - January 12, 2018 Category: Perinatology & Neonatology Authors: Jao-Shwann Liang, Li-Ju Lin, Haung-Chi Lin, Ming-Tao Yang, Jinn-Shyan Wang, Jyh-Feng Lu Tags: Short Communication Source Type: research

Neonatal solid tumors: A therapeutic challenge
The incidence of neonatal cancer has been estimated to be one in every 12,500 –27,500 live births, comprising 2% of pediatric cancer.1 Cancer occurring in the neonatal period and cancer occurring in children younger than 18 years of age can be different in terms of incidence, anatomical site, histological features, clinical behavior, and treatment. Neonatal solid tumors enc ompass a group of heterogeneous neoplasms and are unique due to their origin from embryonic and immature tissues. Although the majority of neonatal solid tumors are benign, they can be fatal based on their size and location. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - January 12, 2018 Category: Perinatology & Neonatology Authors: Shih-Hsiang Chen Tags: Editorial Source Type: research

Serum lactate dehydrogenase isoenzymes 4 plus 5 is a better biomarker than total lactate dehydrogenase for refractory Mycoplasma pneumoniae pneumonia in children
Although usually self-limiting, Mycoplasma pneumoniae pneumonia (MPP) may lead to clinical or radiological deterioration despite macrolide antibiotic therapy, resulting in the development of refractory MPP (RMPP). Corticosteroids have been used to treat RMPP with beneficial effects. Serum lactate dehydrogenase (LDH) is a suggested biomarker for the use of steroid therapy. Since serum LDH is a non-specific marker and elevated in many inflammatory processes, this study investigates the predicting level of LDH isoenzymes for RMPP. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - January 11, 2018 Category: Perinatology & Neonatology Authors: Ta-Yu Liu, Wei-Ju Lee, Chih-Min Tsai, Kuang-Che Kuo, Chen-Hsiang Lee, Kai-Sheng Hsieh, Chin-Hao Chang, Yu-Tsun Su, Chen-Kuang Niu, Hong-Ren Yu Tags: Original Article Source Type: research

Successful catheter ablation of atrioventricular reentrant tachycardia with left lateral bypass tract in a patient with unroofed coronary sinus atrial septal defect
An unroofed coronary sinus (CS) type atrial septal defect (ASD) is a rare congenital heart disease, in which the common wall between the left atrium (LA) and CS is partially or completely absent.1 This condition is often difficult to diagnose because the clinical signs and symptoms are nonspecific. Most of the reported cases were found incidentally.2 Unroofed CS type ASD have been associated with atrial tachycardia, atrioventricular nodal reentrant tachycardia and accessory pathway related tachycardia. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - January 10, 2018 Category: Perinatology & Neonatology Authors: Ji-Eun Ban, Woo-Hyeuk Choi, So-Young Bak Tags: Short Communication Source Type: research

Effect of oral propranolol on periocular Capillary Hemangiomas of Infancy
To assess the safety and efficacy of oral propranolol in the management of periocular Capillary Hemangiomas of Infancy (CHI). (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - January 2, 2018 Category: Perinatology & Neonatology Authors: Kirthi Koka, Bipasha Mukherjee, Sumita Agarkar Tags: Original Article Source Type: research

Analysis of individual-level and community-level effects on childhood undernutrition in Malawi
Undernutrition is a major global public health problem among children under the age of 5 years. We aimed to untangle the effects of a wide range of individual- and community-level socioeconomic factors on the risks of childhood undernutrition in Malawi. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - December 30, 2017 Category: Perinatology & Neonatology Authors: Peter Austin Morton Ntenda, Ying-Chih Chuang Tags: Original Article Source Type: research

Carcinoid tumor arising from a retroperitoneal mature cystic teratoma
We report a case of a teenage girl with TMT into a carcinoid tumor presenting with abdominal pain and a huge retroperitoneal mass. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - December 30, 2017 Category: Perinatology & Neonatology Authors: Po-Wei Huang, Yen-Lin Liu, James S. Miser, Chii-Hong Lee, Chun-Yu Kao, Shu-Huey Chen Tags: Short Communication Source Type: research

Analysis of individual-level and community-level effects on childhood undernutrition in Malawi
Undernutrition is a major global public health problem among children under the age of 5 years. We aimed to untangle the effects of a wide range of individual- and community-level socioeconomic factors on the risks of childhood undernutrition in Malawi. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - December 30, 2017 Category: Perinatology & Neonatology Authors: Peter Austin Morton Ntenda, Ying-Chih Chuang Tags: Original Article Source Type: research

Carcinoid tumor arising from a retroperitoneal mature cystic teratoma
We report a case of a teenage girl with TMT into a carcinoid tumor presenting with abdominal pain and a huge retroperitoneal mass. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - December 30, 2017 Category: Perinatology & Neonatology Authors: Po-Wei Huang, Yen-Lin Liu, James S. Miser, Chii-Hong Lee, Chun-Yu Kao, Shu-Huey Chen Tags: Short Communication Source Type: research

Role of Th22 and IL-22 in pathogenesis of allergic airway diseases: Pro-inflammatory or anti-inflammatory effect?
A new population of T cells known as Th22 was described for the first time in 2009. These cells are usually identified by the production of IL-22. However, this cytokine is also secreted by other cells such as Th1, Th2, Th17, natural killers, and innate lymphoid cells. Th22 is known as a pro-inflammatory agent in allergic skin diseases. Recently, more evidence has emerged showing associations between these cells and other diseases. The role of Th22 in asthma and allergic rhinitis is controversial: some authors suggest that Th22 has a pro-inflammatory effect, while others state that Th22 has anti-inflammatory properties. (S...
Source: Pediatrics and Neonatology - December 29, 2017 Category: Perinatology & Neonatology Authors: Laura Tamasauskiene, Brigita Sitkauskiene Tags: Review Article Source Type: research

Positive end-expiratory pressure during resuscitation at birth in very-low birth weight infants: A randomized-controlled pilot trial
The objective of this study was to evaluate the short term respiratory outcomes after positive pressure ventilation (PPV) with PEEP in preterm infants at birth. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - December 27, 2017 Category: Perinatology & Neonatology Authors: Ratchada Kitsommart, Kittaya Nakornchai, Buranee Yangthara, Ratchada Jiraprasertwong, Bosco Paes Tags: Original Article Source Type: research

Intestinal tight junctions are severely altered in NEC preterm neonates
Necrotizing Enterocolitis (NEC) is a severe inflammatory disorder of the intestine endangering the health and survival of preterm infants. It is well established that the gut barrier is severely damaged in NEC patients, nonetheless an in depth investigation of modifications at the transcriptional and translational levels of tight junction genes and proteins during NEC are still missing. The aim of this study was to investigate changes in the expression of tight junctions and other associated proteins during NEC and determine their correlation to the disease severity. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - December 21, 2017 Category: Perinatology & Neonatology Authors: Amir Bein, Smadar Eventov-Friedman, Dan Arbell, Betty Schwartz Tags: Original Article Source Type: research

Linear IgA dermatosis: An atypical manifestation of a rare disease
A 7-year-old girl was evaluated in the Pediatric Dermatology Department for pruritic skin lesions with one week duration. The lesions began in the neck region progressing to the trunk and upper limbs, sparing the lower body. There were no other symptoms associated. Contact with animals and sick people and trips to endemic sites were denied. Physical examination showed an erythematous and confluent urticariform rash, predominantly in the trunk (Fig.  1 – Panel A). Face and retroauricular region also revealed agglomerated vesicles and small bullous lesions with serous content(Fig. 1 – Panel B). (Source:...
Source: Pediatrics and Neonatology - December 21, 2017 Category: Perinatology & Neonatology Authors: Helena Ferreira, Catarina Vilarinho Tags: Images Source Type: research

Intestinal tight junctions are severely altered in NEC preterm neonates
Necrotizing Enterocolitis (NEC) is a severe inflammatory disorder of the intestine endangering the health and survival of preterm infants. It is well established that the gut barrier is severely damaged in NEC patients, nonetheless an in depth investigation of modifications at the transcriptional and translational levels of tight junction genes and proteins during NEC are still missing. The aim of this study was to investigate changes in the expression of tight junctions and other associated proteins during NEC and determine their correlation to the disease severity. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - December 21, 2017 Category: Perinatology & Neonatology Authors: Amir Bein, Smadar Eventov-Friedman, Dan Arbell, Betty Schwartz Tags: Original Article Source Type: research

Linear IgA dermatosis: An atypical manifestation of a rare disease
A 7-year-old girl was evaluated in the Pediatric Dermatology Department for pruritic skin lesions with one week duration. The lesions began in the neck region progressing to the trunk and upper limbs, sparing the lower body. There were no other symptoms associated. Contact with animals and sick people and trips to endemic sites were denied. Physical examination showed an erythematous and confluent urticariform rash, predominantly in the trunk (Fig.  1 – Panel A). Face and retroauricular region also revealed agglomerated vesicles and small bullous lesions with serous content(Fig. 1 – Panel B). (Source:...
Source: Pediatrics and Neonatology - December 21, 2017 Category: Perinatology & Neonatology Authors: Helena Ferreira, Catarina Vilarinho Tags: Images Source Type: research

The effect of nesting positions on pain, stress and comfort during heel lance in premature infants
Nesting positions are commonly used in procedural analgesic administration in premature neonates. The effectiveness of nesting positions is questioned. The aim of the this study was to assess the pain, stress, comfort and salivary cortisol and melatonin values in nesting positions during the heel lance procedure in premature infants at the NICU. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - December 13, 2017 Category: Perinatology & Neonatology Authors: Ay şe Kahraman, Zümrüt Başbakkal, Mehmet Yalaz, Eser Y. Sözmen Tags: Original Article Source Type: research