Seizure Recurrence in Children after Stopping Antiepileptic Medication: 5-Year Follow-Up
We wanted to identify in children with epilepsy the factors associated with seizure control and recurrence after a 2-year remission. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - January 10, 2017 Category: Perinatology & Neonatology Authors: Inn-Chi Lee, Shuan-Yow Li, Yung-Jung Chen Tags: Original article Source Type: research

Fetal Primary Cardiac Tumors During Perinatal Period
Fetal primary cardiac tumors are rare, but they may cause complications, which are sometimes life threatening, including arrhythmias, hydrops fetalis, ventricular outflow/inflow obstruction, cardiac failure, and even sudden death. Among fetal primary cardiac tumors, rhabdomyomas are most common, followed by teratomas, fibromas, hemangiomas, and myxomas. Everolimus, a mammalian target of rapamycin inhibitor, has been reported to be an effective drug to cause tumor remission in three neonates with multiple cardiac rhabdomyomas. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - December 31, 2016 Category: Perinatology & Neonatology Authors: Shi-Min Yuan Tags: Review article Source Type: research

Leukocyte Adhesion Deficiency III: Report of Two Siblings
Leukocyte adhesion deficiencies (LADs) are autosomal recessive immunodeficiency disorders characterized by a blockage in the process of leukocyte emigration to sites of inflammation.1 There are three types of this disease, each affecting a different phase of the leukocyte adhesion cycle. LAD III is caused by a defect in leukocyte integrin activation due to a mutation in the FERMT3 gene.2 The structure and expression of an integrin expression level in LAD III is normal in contrast to that in LAD I. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - December 31, 2016 Category: Perinatology & Neonatology Authors: Deniz Aygun, Serdar Nepesov, Ruth Gershoni, Y ıldız Camcıoglu Tags: Letter to the Editor Source Type: research

Ebstein's Anomaly: Genetics, Clinical Manifestations, and Management
Ebstein's anomaly is uncommon. Genetic bases of this congenital heart defect may be related to the mutations in myosin heavy chain 7 and NKX2.5, among others. Asymptomatic patients with Ebstein's anomaly can be conservatively treated and kept under close follow-up, whereas surgical operation is indicated for those patients with evidence of right heart dilation and progressively impaired ventricular systolic function. A biventricular repair consisting of the reconstruction of a competent monocuspid tricuspid valve, right ventriculorrhaphy, subtotal atrial septal defect closure, and aggressive reduction atrioplasty is suitab...
Source: Pediatrics and Neonatology - December 23, 2016 Category: Perinatology & Neonatology Authors: Shi-Min Yuan Tags: Review article Source Type: research

Surgical Management of Complicated Necrotizing Pneumonia in Children
This study presents our experience regarding this challenging topic. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - December 16, 2016 Category: Perinatology & Neonatology Authors: Jin-Yao Lai, Wendy Yang, Yung-Ching Ming Tags: Original article Source Type: research

Exome Sequencing is a Valuable Approach in Critically Ill Patients with Suspected Monogenic Disease: Diagnosis of X-linked Centronuclear Myopathy in Preterm Twins
X-linked centronuclear myopathy (CNMX) is a severe congenital myopathy resulting from mutations in the myotubularin (MTM1) gene.1 Patients with CNMX usually present with profound weakness, muscular hypotonia, and respiratory failure in the neonatal period.2 Diagnosis is based on characteristic histopathological findings in skeletal muscle specimens from males with suggestive clinical features and the identification of supporting genetic defects.3 However, muscle biopsy requiring general anesthesia can be a high-risk procedure in premature infants or in patients with a poor general condition. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - December 16, 2016 Category: Perinatology & Neonatology Authors: Jessika Johannsen, Maja Hempel, Thilo Diehl, Tobias B. Haack, Jonas Denecke Tags: Brief communication Source Type: research

Foreign Body Mimicking a Granuloma in the Ear in an Asymptomatic Child
A 3-year-old boy presented to the hospital without any symptoms such as ear pain, itch, hearing loss, sensation of fullness, otorrhea, fever, or rhinorrhea. He was transferred to the pediatric emergency department of Chang Gung Memorial Hospital under the impression of an external auditory canal (EAC) tumor detected via otoscopy by a local doctor. The clinical otoscopic examination revealed a granuloma from an edge on the wall of the ear canal (Figure  1A). The patient's white blood cell count was 23,800/μL with 61.5% segment. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - December 14, 2016 Category: Perinatology & Neonatology Authors: Hao-Yuan Lee, Chyi-Liang Chen, Chang-Teng Wu Tags: Pediatric images Source Type: research

Biomarkers of Myocardial Injury in Congenital Heart Disease: More Questions than Answers
Since the first study of a biochemical marker in myocardial injury was published in Science in 1954,1 numerous circulating marker proteins have been identified as valuable biomarkers of acute myocardial injury. Currently, creatine kinase (CK)-MB mass (heart type), myoglobin, and troponin I are widely used in the diagnosis and risk stratification of myocardial ischemia in adults. Although this type of myocardial insult rarely occurs in patients with congenital heart disease (CHD), several studies have indicated that hemodynamic overload in CHD results in elevated levels of cardiac injury biomarkers, suggesting that myocardi...
Source: Pediatrics and Neonatology - December 2, 2016 Category: Perinatology & Neonatology Authors: Chun-An Chen Tags: Editorial Source Type: research

A Diagnostic Dilemma for the Pediatrician: Radiolucent Tracheobronchial Foreign Body
The purpose of this study is to determine the role of clinical history, physical examinations, and radiological findings in the evaluation of patients with suspected radiolucent foreign body aspiration. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - November 19, 2016 Category: Perinatology & Neonatology Authors: Hakan Ta şkınlar, Gökhan Berktuğ Bahadır, Cankat Erdoğan, Doğakan Yiğit, Dinçer Avlan, Ali Naycı Tags: Original article Source Type: research

Developmental Changes in Aortic Mechanical Properties in Normal Fetuses and Fetuses with Cardiovascular Disease
We hypothesized that fetal aortic mechanical properties assessed by aortic diameter (AoD) and flow show maturational changes during the gestational period, and that these properties are different in fetuses with congenital heart diseases and fetuses with normal development. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - November 2, 2016 Category: Perinatology & Neonatology Authors: Mio Taketazu, Masaya Sugimoto, Hirofumi Saiki, Hirotaka Ishido, Satoshi Masutani, Hideaki Senzaki Tags: Original article Source Type: research

Current Genetic Testing Tools in Neonatal Medicine
With the growing understanding of the magnitude of genetic diseases in newborns and equally rapid advancement of tools used for genetic diagnoses, healthcare providers must have a sufficient knowledge base to both recognize and evaluate genetic diseases in the neonatal period. Genetic assessment has become an essential aspect of medicine, and professionals need to know when genetic evaluation is indispensable. Much progress has been made in recent years in utilizing massively parallel sequencing for rapid diagnosis of genetic conditions in neonates. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - October 26, 2016 Category: Perinatology & Neonatology Authors: Seema R. Lalani Tags: Review article Source Type: research

Probiotics Prevent Candida Colonization and Invasive Fungal Sepsis in Preterm Neonates: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
To investigate whether probiotic supplementation could reduce the risk of fungal infection in preterm neonates in neonatal intensive care units (NICUs), we systematically searched PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials databases for randomized controlled trials (RCTs) focusing on the effect of probiotics on fungal infection in preterm neonates. The outcomes of interest were Candida colonization and invasive fungal sepsis. Seven trials involving 1371 preterm neonates were included. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - October 25, 2016 Category: Perinatology & Neonatology Authors: Hua-Jian Hu, Guo-Qiang Zhang, Qiao Zhang, Shristi Shakya, Zhong-Yue Li Tags: Review article Source Type: research

Bone Mineral Density According to Dual Energy X-ray Absorptiometry is Associated with Serial Serum Alkaline Phosphatase Level in Extremely Low Birth Weight Infants at Discharge
To examine bone mineral density in extremely low birth weight infants at discharge and investigate whether serial measurements of serum alkaline phosphatase (ALP) and phosphate can predict bone mineralization. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - October 22, 2016 Category: Perinatology & Neonatology Authors: Jin Lee, Hyun-Kyung Park, Ja Hye Kim, Yun Young Choi, Hyun Ju Lee Tags: Original article Source Type: research

Diagnosis and Risk Factors of Acute Kidney Injury in Very Low Birth Weight Infants
Acute kidney injury (AKI) is common in critically ill premature infants. There is a lack of consensus on the diagnostic definition of AKI in very low birth weight (VLBW) infants. The primary aim of this study was to determine the incidence and risk factors for AKI in VLBW infants using the AKI network (AKIN) and pRIFLE (pediatric Risk, Injury, Failure, Loss, End-Stage) criteria and to evaluate whether Clinical Risk Index for Babies (CRIB II) score is a predictor of AKI. The secondary objective was to determine the extent of agreement between the AKIN and pRIFLE criteria in the diagnosis of AKI in VLBW infants. (Source: Ped...
Source: Pediatrics and Neonatology - October 20, 2016 Category: Perinatology & Neonatology Authors: Ankana Daga, Fredrick Dapaah-Siakwan, Sharina Rajbhandari, Cassandra Arevalo, Agnes Salvador Tags: Original article Source Type: research

Caffeine Toxicity in a Preterm Neonate
Apnea of prematurity is a common complication in premature infants. The first-line pharmacotherapeutic agent for this condition is caffeine, a methylxanthine. Caffeine is preferred over theophylline because it has fewer adverse effects and a wider therapeutic window.1 Measuring the serum caffeine concentration is not required in preterm neonates because most of these infants can tolerate therapeutic levels.2 In this paper, we present the first report of a preterm neonate in whom the serum caffeine concentration exceeded therapeutic levels, which resulted in rhabdomyolysis. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - October 11, 2016 Category: Perinatology & Neonatology Authors: Sachiko Nakaoka, Yukako Kawasaki, Satomi Inomata, Masami Makimoto, Taketoshi Yoshida Tags: Brief communication Source Type: research

Axillary Skin Ulcers in Infants with Juvenile Dermatomyositis
A 1-year-old Japanese boy (Case 1) was referred to our hospital because of muscle weakness and skin ulcers. At the age of 1  year, he lost the ability to walk, although he had started to walk at 11 months. The patient exhibited proximal muscle weakness and muscle grasping pain. The serum creatine kinase level was increased to 136 IU/L (reference range, 41–123 IU/L), erythrocyte sedimentation rate was elevated to 36  mm/h (reference range, 1–10 mm/h), and anti-Jo-1 antibody was positive; magnetic resonance imaging indicated possible myositis of both the femoral muscles. (Source: Ped...
Source: Pediatrics and Neonatology - October 9, 2016 Category: Perinatology & Neonatology Authors: Hiroyuki Wakiguchi, Syuji Takei, Yoshifumi Kawano Tags: Pediatric images Source Type: research

Acute Myeloid Leukemia Presenting with Sweet Syndrome: A Case Report and Review of the Literature
We report a case of a 15-year-old girl with AML who initially had MASS as a paraneoplastic syndrome. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - October 6, 2016 Category: Perinatology & Neonatology Authors: Shu-Huey Chen, Yung-Ting Kuo, Yen-Lin Liu, Bo-Jung Chen, Yuan-Chieh Lu, James S. Miser Tags: Brief communication Source Type: research

Quality Improvement of Nasal Continuous Positive Airway Pressure Therapy in Neonatal Intensive Care Unit
Nasal continuous positive airway pressure (NCPAP) therapy is widely used in neonates, but the clinical practice varies. However, nursing practice differs among individuals, and an inappropriate application method may delay the respiratory therapy, influence the beneficial effect of NCPAP, and increase complications. We introduced a quality improvement project to expedite the application of NCPAP therapy and decrease the incidence of nasal trauma. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - September 22, 2016 Category: Perinatology & Neonatology Authors: Chien-Yi Chen, An-Kuo Chou, Yu-Lien Chen, Hung-Chieh Chou, Po-Nien Tsao, Wu-Shiun Hsieh Tags: Original article Source Type: research

5-aza-2 ′-deoxycytidine Inhibits the Proliferation of Lung Fibroblasts in Neonatal Rats Exposed to Hyperoxia
This study investigated the effects of 5-aza-CdR on LFs in vitro from a hyperoxia-induced lung fibrosis model in newborn rats. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - September 20, 2016 Category: Perinatology & Neonatology Authors: Shimeng Zhao, Meiling Cao, Hongmin Wu, Yu Hu, Xindong Xue Tags: Original article Source Type: research

Imaging Findings of Intraluminal Duodenal Duplication Cyst in a Pediatric Patient
A 10-year-old girl was admitted with complaints of abdominal discomfort episodes. Physical examination was unremarkable, and laboratory findings were within normal limits, which were as follows: hemoglobin, 13.5  g/dL; white cell count, 6×103/μL; platelet count, 280×103/μL; blood urea nitrogen, 11 mg/dL; creatinine, 0.6 mg/dL; aspartate aminotransferase, 15 U/L; alanine aminotransferase, 17 U/L; alkaline phosphatase, 60 U/L; total bilirubin, 0.5 mg/dL; and amylase, 35 U/L. Abdominal ultrasonogra phy and computed tomography exhibited an intraluminal cyst in the secon...
Source: Pediatrics and Neonatology - September 20, 2016 Category: Perinatology & Neonatology Authors: Mehmet S. Dogan, Selim Doganay, Gonca Koc, Sureyya B. Gorkem, Saliha Ciraci, Abdulhakim Coskun Tags: PEDIATRIC IMAGES Source Type: research

Inguinal Hernia in a Preterm Neonate Complicated by Strangulation and Subcutaneous Hernia Sac Rupture
We report a unique case of an extremely premature neonate with an enlarging right inguinal hernia that progressed to incarceration, bowel strangulation with necrosis, and subcutaneous rupture of the hernia sac on the 21st day of life requiring urgent laparotomy for reduction and resection of the necrotic small bowel and ostomy creation. The potential morbidity of a missed incarcerated inguinal hernia is high. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - September 16, 2016 Category: Perinatology & Neonatology Authors: Jessica A. Naiditch, David T. Schindel Tags: Brief communication Source Type: research

Is Pneumococcal Serotype Replacement Impending?
Widespread use of pneumococcal conjugate vaccines (PCVs) has substantially decreased the incidence of pneumococcal diseases, such as pneumonia, meningitis, and acute otitis media in several parts of the world. The absolute number of cases of Streptococcus pneumoniae bacteremia and its proportion among all bacteremia cases in children has also significantly decreased. Routine PCV7 implementation has reduced 84% of S. pneumoniae bacteremia in Northern California, USA, and 57.5% of occult bacteremia caused by S. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - September 15, 2016 Category: Perinatology & Neonatology Authors: Chun-Yi Lu, Li-Min Huang Tags: Editorial Source Type: research

Familial Mediterranean Fever Presenting with Recurrent Aseptic Meningitis: A Case Report
Familial Mediterranean fever (FMF) is an autoinflammatory disorder that is inherited in an autosomal recessive pattern and primarily affects people of specific ethnicities such as Jews, Turks, Arabs, and Armenians.1 It usually presents as periodic fever associated with serositis (predominantly peritonitis, pleuritis, and arthritis).1 Central nervous system (CNS) manifestations in patients with FMF are rarely reported, and are associated with optic neuritis, pseudotumor cerebri, multiple sclerosis, and aseptic meningitis. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - September 9, 2016 Category: Perinatology & Neonatology Authors: Dawood Yusef, Wasim Khasawneh Tags: Brief communication Source Type: research

Longitudinal Effects of Self-Report Pubertal Timing and Menarcheal Age on Adolescent Psychological and Behavioral Outcomes in Female Youths from Northern Taiwan
Early puberty is linked to adverse developmental outcomes in adolescents in Western societies. However, little is known about this relationship in an East Asian context. In addition, whether the impact of subjective pubertal timing (PT) and menarcheal age (MA) on adolescent psychosocial development persists into early adulthood remains unclear and is worthy of investigation. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - September 3, 2016 Category: Perinatology & Neonatology Authors: Chih-Ting Lee, Meng-Che Tsai, Chung-Ying Lin, Carol Strong Tags: Original article Source Type: research

Maternal and Placental Factors Associated with Congenital Hearing Loss in Very Preterm Neonates
Sensorineural hearing loss (SNHL) is a multifactorial disease that more frequently affects preterm newborns. Although a number of maternal conditions have been reported to be associated with preterm birth, little information is available concerning maternal risk factors for the development of SNHL. We aimed to identify maternal and placental risk factors associated with a “refer” result on the newborn hearing screening (NHS) test and subsequently confirmed SNHL in very preterm neonates. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - August 30, 2016 Category: Perinatology & Neonatology Authors: Shin Hye Kim, Byung Yoon Choi, Jaehong Park, Eun Young Jung, Soo-Hyun Cho, Kyo Hoon Park Tags: Original article Source Type: research

Congenital Microvillus Inclusion Disease in the Differential Diagnosis of Intractable Metabolic Acidosis
This report presents the case of a 3-day-old girl with secretory diarrhea, which was originally thought to be urine, caused by MVID. She presented with severe weight loss, hypernatremic dehydration, and metabolic acidosis. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - August 27, 2016 Category: Perinatology & Neonatology Authors: Nilufer Guzoglu, Didem Aliefendioglu, Fulya Gulerman, Safak Gucer, Figen Kaymaz Tags: Brief communication Source Type: research

Kayser –Fleisher Ring and Sunflower Cataract in a Child with Wilson's Disease
Wilson's disease (WD) is characterized by excessive accumulation of copper in the central nervous system, liver, kidneys, cornea, and other organs, leading to damage of the liver and brain.1 A Kayser –Fleischer (KF) ring, a brownish coloration of the outer margin of the cornea in the Descemet's membrane, is characteristic of WD.2 Another rare ophthalmic manifestation of WD is sunflower cataract.3 Both KF rings and sunflower cataracts are best observed with an ophthalmic microscope. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - August 27, 2016 Category: Perinatology & Neonatology Authors: Chiang Ling Koay, Mimiwati Zahari, Way Seah Lee Tags: Pediatric images Source Type: research

How to Simplify the Diagnostic Criteria of Metabolic Syndrome in Adolescents
This study evaluated the feasibility and accuracy of the height-corrected definition for identifying metabolic syndrome (MS). (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - August 18, 2016 Category: Perinatology & Neonatology Authors: Chun-Ming Ma, Fu-Zai Yin, Xiao-Li Liu, Rui Wang, Dong-Hui Lou, Qiang Lu Tags: Original article Source Type: research

Risk Factors for Necrotizing Enterocolitis in Neonates: A Retrospective Case-Control Study
This study aimed to evaluate risk factors for NEC in different gestational age (GA) groups. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - August 16, 2016 Category: Perinatology & Neonatology Authors: Qi Lu, Shupeng Cheng, Min Zhou, Jialin Yu Tags: Original article Source Type: research

Immunization Status in Childhood Cancer Survivors: A Hidden Risk Which Could be Prevented
A limited number of studies have examined the vaccine-specific antibody status of children with cancer. There are disagreements over the guidelines for postcancer immunization strategy. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - August 16, 2016 Category: Perinatology & Neonatology Authors: Najwa Yahya Fayea, Ashraf Elsayed Fouda, Shaimaa Mohamed Kandil Tags: Original article Source Type: research

Prenatal Dexamethasone Exposure Programs the Development of the Pancreas and the Secretion of Insulin in Rats
There is increasing epidemiological evidence indicating that many chronic diseases originate during early life, even before birth, through what are termed fetal programming effects. Prenatal glucocorticoid is frequently used clinically to accelerate the maturation of the lung, but its long-term effects remain unclear. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - August 13, 2016 Category: Perinatology & Neonatology Authors: Yu-Chieh Chen, Ying-Hua Huang, Jiunn-Ming Sheen, You-Lin Tain, Hong-Ren Yu, Chih-Cheng Chen, Miao-Meng Tiao, Ho-Chang Kuo, Li-Tung Huang Tags: Original article Source Type: research

Proinflammatory Cytokines, Enolase and S-100 as Early Biochemical Indicators of Hypoxic-Ischemic Encephalopathy Following Perinatal Asphyxia in Newborns
Estimation of the neurological prognosis of infants suffering from perinatal asphyxia and signs of hypoxic-ischemic encephalopathy is of great clinical importance; however, it remains difficult to satisfactorily assess these signs with current standard medical practices. Prognoses are typically based on data obtained from clinical examinations and neurological tests, such as electroencephalography (EEG) and neuroimaging, but their sensitivities and specificities are far from optimal, and they do not always reliably predict future neurological sequelae. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - August 10, 2016 Category: Perinatology & Neonatology Authors: Ver ónica Chaparro-Huerta, Mario Eduardo Flores-Soto, Mario Ernesto Merin Sigala, Juan Carlos Barrera de León, María de Lourdes Lemus-Varela, Blanca Miriam de Guadalupe Torres-Mendoza, Carlos Beas-Zárate Tags: Original article Source Type: research

Red Blood Cell Transfusion and Clinical Outcomes in Extremely Low Birth Weight Preterm Infants
Red blood cell (RBC) transfusion is often considered a life-saving measure in critically ill neonates. The smallest and least mature infants tend to receive the largest amount of transfusions. RBC transfusion itself has also been suggested as an independent risk factor of poor clinical outcome in critical patients. Our aim is to study if there are associations between RBC transfusion and in-hospital mortality, short-term morbidities, and late neurodevelopmental outcome in extremely low birth weight (ELBW) preterm infants. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - August 8, 2016 Category: Perinatology & Neonatology Authors: Yu-Cheng Wang, Oi-Wa Chan, Ming-Chou Chiang, Peng-Hong Yang, Shih-Ming Chu, Jen-Fu Hsu, Ren-Huei Fu, Reyin Lien Tags: Original article Source Type: research

Risk Factors and Outcome Analysis in Children with Carbon Monoxide Poisoning
Carbon monoxide (CO) poisoning is one of the common causes of poisoning in patients and can result in significant morbidity and mortality. However, few studies have focused on the pediatric group. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - August 5, 2016 Category: Perinatology & Neonatology Authors: Yu-Ching Chang, Hao-Yuan Lee, Jing-Long Huang, Cheng-Hsun Chiu, Chyi-Liang Chen, Chang-Teng Wu Tags: Original article Source Type: research

Risk Factors for Prolonged Hospitalization in Pediatric Appendicitis Patients with Medical Treatment
With effective antibiotics against enteric flora and computed tomography-guided drainage for abscesses, the initial use of nonoperative therapy for children with appendicitis has increased both in recent reports and at our hospital. However, it has been reported that these patients have a relatively longer hospital stay and that their treatment is more expensive than those who undergo aggressive surgical intervention. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - July 29, 2016 Category: Perinatology & Neonatology Authors: Ching-Lun Chen, Hsun-Chin Chao, Man-Shan Kong, Shih-Yen Chen Tags: Original article Source Type: research

Lotus Birth Associated With Idiopathic Neonatal Hepatitis
“Lotus Birth” (LB) is a holistic practice in which the umbilical cord is not cut after birth.1 Drying and mummification of the umbilical cord usually leads to detachment from the baby's navel a few days after birth. The UK Royal College of Obstetricians and Gynecologists in 2013 warned of the po tential risks of LB practice.2 It is unknown whether LB practice can increase the risks of the postpartum period or can lead to neonatal complications. Infections could spread to the baby, because at the postdelivery stage, the placenta has no circulation and is especially prone to infection. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - July 13, 2016 Category: Perinatology & Neonatology Authors: Antonella Tricarico, Valentina Bianco, Anna Rita Di Biase, Lorenzo Iughetti, Fabrizio Ferrari, Alberto Berardi Tags: Brief communication Source Type: research

Lotus Birth Associated With Idiopathic Neonatal Hepatitis
“Lotus Birth” (LB) is a holistic practice in which the umbilical cord is not cut after birth.1 Drying and mummification of the umbilical cord usually leads to detachment from the baby's navel a few days after birth. The UK Royal College of Obstetricians and Gynecologists in 2013 warned of the potential risks of LB practice.2 It is unknown whether LB practice can increase the risks of the postpartum period or can lead to neonatal complications. Infections could spread to the baby, because at the postdelivery stage, the placenta has no circulation and is especially prone to infection. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - July 13, 2016 Category: Perinatology & Neonatology Authors: Antonella Tricarico, Valentina Bianco, Anna Rita Di Biase, Lorenzo Iughetti, Fabrizio Ferrari, Alberto Berardi Tags: Brief communication Source Type: research

Fetal Valproate Syndrome
There have been several reports of congenital malformations in the offspring of mothers who took valproic acid (VPA) during pregnancy as a treatment for epilepsy. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - July 12, 2016 Category: Perinatology & Neonatology Authors: Hatice Mutlu-Albayrak, Cahide Bulut, H üseyin Çaksen Tags: Original article Source Type: research

Effects of Breast Milk and Vanilla Odors on Premature Neonates ’ Heart Rate and Blood Oxygen Saturation During and After Venipuncture
We read with great interest the current study by Neshat et  al1 on the effects of breast milk odor, but not vanilla odor, in decreasing the variability of heart rate and blood-oxygen saturation when administering painful procedures to premature neonates. The author concluded that breast-milk odor has a significant calming effect on premature neonates durin g certain painful procedures. It was inspirational to us to learn that premature neonates could actually be calmed by breast-milk odor as compared with results observed in full-term infants. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - July 4, 2016 Category: Perinatology & Neonatology Authors: Yu-Chien Wei, Po-Nien Tsao Tags: Letter to the Editor Source Type: research

Effects of Breast Milk and Vanilla Odors on Premature Neonates’ Heart Rate and Blood Oxygen Saturation During and After Venipuncture
We read with great interest the current study by Neshat et al1 on the effects of breast milk odor, but not vanilla odor, in decreasing the variability of heart rate and blood-oxygen saturation when administering painful procedures to premature neonates. The author concluded that breast-milk odor has a significant calming effect on premature neonates during certain painful procedures. It was inspirational to us to learn that premature neonates could actually be calmed by breast-milk odor as compared with results observed in full-term infants. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - July 4, 2016 Category: Perinatology & Neonatology Authors: Yu-Chien Wei, Po-Nien Tsao Tags: Letter to the Editor Source Type: research

Albuminuria in Childhood is a Risk Factor for Chronic Kidney Disease and End-Stage Renal Disease
Emerging studies have shown that albuminuria, which is traditionally viewed as a marker of renal damage, has a direct lethal effect on the kidney tissue; this leads to a progressive loss of renal function.1 Multiple mechanisms have been proposed to explain the effect of increased albuminuria on renal damage. Nonetheless, all these pathways result in tubulointerstitial damage. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - July 1, 2016 Category: Perinatology & Neonatology Authors: Chi-Hui Cheng Tags: Editorial Source Type: research

Combined Transarterial Embolization and Propranolol as Effective Treatment for Hepatic Hemangioma with Kasabach –Merritt Syndrome and Heart Failure in a Neonate
While hepatic hemangiomas are the most common hepatic tumors in children, giant hepatic hemangiomas with clinical symptoms in neonates are rare.1 Accompanying complications, such as Kasabach –Merritt syndrome and cardiac failure, result in a high mortality rate in affected neonates.2 There is no consensus on the treatment for critical hepatic hemangiomas. Besides medical treatment, local treatment such as endovascular intervention is an alternative. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - June 30, 2016 Category: Perinatology & Neonatology Authors: Wan-Chen Shen, Po-Chin Liang, Jia-Feng Wu, Chien-Ting Hsu, Ho-Sheng Chen, Huey-Ling Chen Tags: Brief communication Source Type: research

Combined Transarterial Embolization and Propranolol as Effective Treatment for Hepatic Hemangioma with Kasabach–Merritt Syndrome and Heart Failure in a Neonate
While hepatic hemangiomas are the most common hepatic tumors in children, giant hepatic hemangiomas with clinical symptoms in neonates are rare.1 Accompanying complications, such as Kasabach–Merritt syndrome and cardiac failure, result in a high mortality rate in affected neonates.2 There is no consensus on the treatment for critical hepatic hemangiomas. Besides medical treatment, local treatment such as endovascular intervention is an alternative. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - June 30, 2016 Category: Perinatology & Neonatology Authors: Wan-Chen Shen, Po-Chin Liang, Jia-Feng Wu, Chien-Ting Hsu, Ho-Sheng Chen, Huey-Ling Chen Tags: Brief communication Source Type: research

Rebound Thymic Hyperplasia after Chemotherapy in Children with Lymphoma
Development of mediastinal masses after completion of chemotherapy in pediatric patients with malignant lymphoma is worrisome and challenging to clinicians. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - June 27, 2016 Category: Perinatology & Neonatology Authors: Chih-Ho Chen, Chih-Chen Hsiao, Yu-Chieh Chen, Sheung-Fat Ko, Shu-Hua Huang, Shun-Chen Huang, Kai-Sheng Hsieh, Jiunn-Ming Sheen Tags: Original article Source Type: research

Factors Determining Bone Mineral Density in Patients with Biliary Atresia after a Successful Kasai Operation
Hepatic osteodystrophy is a common complication in patients with chronic liver disease, however, bone mineral status in patients with biliary atresia has rarely been investigated. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - June 27, 2016 Category: Perinatology & Neonatology Authors: Ming-Huei Chen, Jiaan-Der Wang, Chia-Man Chou, Chieh-Chung Lin Tags: Original article Source Type: research

Risk Factors and Management of Urinary Tract Infections in Children Aged 3 Months to 2 Years
Pediatric urinary tract infections (UTIs) include a range of asymptomatic bacteriuria, lower UTIs (i.e., cystitis), acute pyelonephritis, acute lobar nephronia, and severe renal abscess formation. If not properly treated, pediatric UTIs can result in renal scar formation and subsequently, a deterioration of renal function. Hence, pediatric UTIs have attracted wide attention, both from the clinical and general viewpoints.1,2 To provide a clinically consistent and cost-effective practice for the diagnosis, treatment, and further management of pediatric UTIs, the British National Institute for Health and Clinical Excellence, ...
Source: Pediatrics and Neonatology - June 27, 2016 Category: Perinatology & Neonatology Authors: Chi-Hui Cheng, Yhu-Chering Huang Tags: Editorial Source Type: research

Rebound Thymic Hyperplasia after Chemotherapy in Children with Lymphoma
Development of mediastinal masses after completion of chemotherapy in pediatric patients with malignant lymphoma is worrisome and challenging to clinicians. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - June 27, 2016 Category: Perinatology & Neonatology Authors: Chih-Ho Chen, Chih-Chen Hsiao, Yu-Chieh Chen, Sheung-Fat Ko, Shu-Hua Huang, Shun-Chen Huang, Kai-Sheng Hsieh, Jiunn-Ming Sheen Tags: Original article Source Type: research