Epilepsy & Encephalopathy
Epilepsy is defined by the International League Against Epilepsy (ILAE) as “an enduring predisposition to generate epileptic seizures and by the neurobiologic, cognitive, psychological, and social consequences of this condition.”1 As the definition recognizes, the neurophysiological dysfunction that leads to unprovoked seizures in persons with epilepsy (PWE) often occu rs not in isolation but alongside other functional impairments. Indeed, these comorbidities can be the main drivers of quality of life for PWE. (Source: Pediatric Neurology)
Source: Pediatric Neurology - September 28, 2023 Category: Neurology Authors: Tristan T. Sands, Jennifer N. Gelinas Source Type: research
Visual acuity outcomes in children with optic nerve hypoplasia and septo-optic-pituitary dysplasia
To investigate best-corrected visual acuity (BCVA) outcomes in patients with optic nerve hypoplasia (ONH)/Septo-optic-pituitary dysplasia (SOD). Our primary hypothesis was that BCVA in patients with ONH/SOD does not change significantly over time. (Source: Pediatric Neurology)
Source: Pediatric Neurology - September 28, 2023 Category: Neurology Authors: Michael S. Salman, Shakhawat Hossain, Elizabeth Carson, Chelsea A. Ruth, Ian H. Clark Tags: Research Paper Source Type: research
The Effect of Disease on the Developing Nervous System: Challenges and Opportunities.
Epilepsy is defined by the International League Against Epilepsy (ILAE) as “an enduring predisposition to generate epileptic seizures and by the neurobiologic, cognitive, psychological, and social consequences of this condition.”1 As the definition recognizes, the neurophysiological dysfunction that leads to unprovoked seizures in persons with epilepsy (PWE) often occu rs not in isolation but alongside other functional impairments. Indeed, these comorbidities can be the main drivers of quality of life for PWE. (Source: Pediatric Neurology)
Source: Pediatric Neurology - September 28, 2023 Category: Neurology Authors: Tristan T. Sands, Jennifer N. Gelinas Source Type: research
Neurological Symptoms Due To Severe Acute Respiratory Syndrome Coronavirus 2 Infection Require Thorough Evaluation and Assignment to a Diagnosis
We read with interest the article by Bildik et al. about a retrospective, single-center study in 342 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive pediatric patients with neurological manifestations.1 In 322 patients nonspecific symptoms (ageusia, anosmia, parosmia, headache, dizziness, myalgia) were noted, and specifi c symptoms (seizure, cranial nerve palsy, Guillain-Barré syndrome [GBS], acute disseminated encephalomyelitis, cerebral vasculitis) were noted in the rest.1 It was concluded that neurological manifestations differ by age groups and that physicians should remain vigilant to detect ...
Source: Pediatric Neurology - September 26, 2023 Category: Neurology Authors: Josef Finsterer Tags: Correspondence Source Type: research
Neurological symptoms due to SARS-CoV-2 infection require thorough work-up and assignment to a diagnosis
We read with interest the article by Bildik et al. about a retrospective, single center study in 342 SARS-CoV-2 positive pediatric patients with neurological manifestations [1]. In 322 patients, non-specific symptoms (ageusia, anosmia, parosmia, headache, dizziness, myalgia), and specific symptoms (seizure, cranial nerve palsy, Guillain-Barre syndrome (GBS), acute disseminated encephalomyelitis (ADEM), cerebral vasculitis) were noted in the rest [1]. It was concluded that neurological manifestations differ between by age groups and that physicians should remain vigilant to detect neurological manifestations of SARS-CoV-2 [...
Source: Pediatric Neurology - September 26, 2023 Category: Neurology Authors: Josef Finsterer Tags: Correspondence Source Type: research
A Mixed Methods Study of Practice Variation in Selective Dorsal Rhizotomy: A Study by the Cerebral Palsy Research Network
Selective dorsal rhizotomy (SDR) is an established procedure for the treatment of spasticity associated with cerebral palsy (CP). With the indications for the procedure expanding, we aimed to investigate provider perception about SDR candidates against the characteristics of those undergoing SDR in the CP Research Network (CPRN) registry. (Source: Pediatric Neurology)
Source: Pediatric Neurology - September 25, 2023 Category: Neurology Authors: Ziyad Makoshi, Jeffrey Raskin, Robert Bollo, Brandon Rocque, Susan Zickmund, Patrick Galyean, Grace Perry, Samuel Browd, Paul Gross, Kristie Bjornson, Jeffrey Leonard Tags: Research Paper Source Type: research
Intracranial Hemorrhage, Cerebral Venous Thrombosis, and Hypereosinophilia
We presented a rare pediatric case with diffuse intracranial thrombosis and bleeding, followed by mesenteric , portal, and pulmonary thrombosis, with severe eosinophilia. (Source: Pediatric Neurology)
Source: Pediatric Neurology - September 25, 2023 Category: Neurology Authors: Elif Habibe Aktekin, Ay şe Erbay, Semra Saygı, Nalan Yazici Tags: Correspondence Source Type: research
Electroencephalographic Patterns in Pediatric Patients With Multisystem Inflammatory Syndrome in Children and Coronavirus Disease 2019 Coinfection
Children with recent or acute coronavirus disease 2019 (COVID-19) infections are susceptible to a number of neurological complications, including encephalopathy and seizures. Within the phenomenon of multisystem inflammatory syndrome in children (MIS-C), patients may be encephalopathic or have other nervous system sequelae. The electroencephalographic (EEG) patterns accompanying neurological complications of COVID-19 infection have been reported but primarily in case reports or small case series. (Source: Pediatric Neurology)
Source: Pediatric Neurology - September 25, 2023 Category: Neurology Authors: Alejandra Martinez-Valderrama, Kenneth A. Myers Tags: Research Paper Source Type: research
A Mixed-Methods Study of Practice Variation in Selective Dorsal Rhizotomy: A Study by the Cerebral Palsy Research Network (CPRN)
Selective dorsal rhizotomy (SDR) is an established procedure for the treatment of spasticity associated with cerebral palsy (CP). With the indications for the procedure expanding, we aimed to investigate provider perception about SDR candidates against the characteristics of those undergoing SDR in the CP Research Network (CPRN) registry. Methods: This was a mixed methods study. Descriptive data on 2486 individuals in the CPRN registry is reported, and results of semi-structured interviews with 41 providers about the effect of age, GMFCS level, and dystonia on consideration for SDR. (Source: Pediatric Neurology)
Source: Pediatric Neurology - September 25, 2023 Category: Neurology Authors: Ziyad Makoshi, Jeffrey Raskin, Robert Bollo, Brandon Rocque, Susan Zickmund, Patrick Galyean, Grace Perry, Samuel Browd, Paul Gross, Kristie Bjornson, Jeffrey Leonard Tags: Research Paper Source Type: research
Lissencephaly with cerebellar hypoplasia due to a new RELN mutation
We report on a case of LCH whose clinical and neuroradiological features led to the identification of a homozygous pathogenic variant in RELN gene that has not been previously reported in the scientific literature. (Source: Pediatric Neurology)
Source: Pediatric Neurology - September 25, 2023 Category: Neurology Authors: Liliana Igreja, Catarina Menezes, Pedro S. Pinto, Jo ão Parente Freixo, Rui Chorão Tags: Short Communication Source Type: research
Intracranial hemorrhage, cerebral venous thrombosis and hypereosinophilia
We presented a rare pediatric case with diffuse intracranial thrombosis and bleeding, followed by mesenteric, portal and pulmonary thrombosis, with severe eosinophilia. (Source: Pediatric Neurology)
Source: Pediatric Neurology - September 25, 2023 Category: Neurology Authors: Elif Habibe Aktekin, Ay şe Erbay, Semra Saygi, Nalan Yazici Tags: Correspondence Source Type: research
EEG Patterns in Pediatric Patients with Multisystem Inflammatory Syndrome in Children or COVID-19 Co-infection
Children with recent or acute COVID-19 infections are susceptible to a number of neurological complications, including encephalopathy and seizures. Within the phenomenon of multisystem inflammatory syndrome in children (MIS-C), patients may be encephalopathic or have other nervous system sequelae. The EEG patterns accompanying neurologic complications of COVID-19 infection have been reported, but primarily in case reports or small case series. (Source: Pediatric Neurology)
Source: Pediatric Neurology - September 25, 2023 Category: Neurology Authors: Alejandra Martinez, Kenneth A. Myers Tags: Research Paper Source Type: research
Epilepsy Frequency and Risk Factors Three Years After Neonatal Seizures
In this study, we aimed to determine the frequency of and the risk factors for the development of epilepsy in patients with neonatal seizures. (Source: Pediatric Neurology)
Source: Pediatric Neurology - September 25, 2023 Category: Neurology Authors: Pelin Alt ınbezer, Rüya Çolak, Şebnem Çalkavur, Ünsal Yılmaz Tags: Research Paper Source Type: research
Subpial Hemorrhage in Extremely Premature Neonate: A Rare Finding in a Rare Cohort
Subpial hemorrhage is a rare form of intracranial hemorrhage in which blood accumulates in the potential space between the pia mater and the glia limitans. Subpial hemorrhage may be caused by injury to the glial limitans and rupture of vessels inserting into the tissue layer. The hemorrhage in the subpial space is thought to compress the subpial veins and obstruct cortical venous outflow, increasing risk of focal cortical and subcortical hemorrhage and infarction1. (Source: Pediatric Neurology)
Source: Pediatric Neurology - September 23, 2023 Category: Neurology Authors: Nathan Kattapuram, Sotonye Bobojama, Arash R. Zandieh, Paola Pergami, Earn-Chun Christabel Lee Tags: Short Communication Source Type: research
Diagnostic Algorithm for Pediatric Headaches: a clinical improvement initiative
The widespread variation diagnosing primary headache disorders in children and adolescents results in reduced quality and high costs. Defining an algorithm for primary headache diagnoses in children and adolescents is part of a larger initiative to standardize and improve care. The aim of this algorithm was to increase the accuracy of headache diagnosis by formal criteria to more than 80% of patient encounters. (Source: Pediatric Neurology)
Source: Pediatric Neurology - September 22, 2023 Category: Neurology Authors: Daniel N. Lax, Shannon White, Paula Manning, Marielle Kabbouche Samaha Tags: Research Paper Source Type: research
