The Clinical Characteristics and Outcomes of Infantile Seizures in the First Year of Life: A Single-Center Study
Epilepsy has a high incidence among infants during their first year of life, yet the prognosis can vary significantly. While considerable research has been conducted on infantile spasms, studies examining infantile-onset epilepsy, excluding infantile spasms, remain limited, particularly concerning the factors influencing outcomes. Therefore, our study aims to elucidate seizure control, developmental outcomes, and prognostic factors in infants with epilepsy during their first year of life, within a single-center study in Malaysia. (Source: Pediatric Neurology)
Source: Pediatric Neurology - October 16, 2023 Category: Neurology Authors: Muhamad Azamin Anuar, Muhammad ‘Adil Zainal Abidin, Soo Hong Tan, Cai Fong Yeap, Nor Azni Yahaya Tags: Research Paper Source Type: research
Transverse Myelitis in the Setting of Enterobius Vermicularis (Pinworm) Infection: Case Report
Myelitis is a rare inflammatory myelopathy and known associated etiologies only account for a small number of causes. A significant percentage of cases have an unknown etiology and are considered idiopathic. With 64-68% of cases fitting into the idiopathic category, helminth infections, and specifically pinworm para-infections should be considered in cases which would otherwise be classified as idiopathic. This case report outlines a pediatric patient diagnosed with myelitis given her progressive weakness, fussiness, refusal to bear weight as well as MRI demonstrating T2 hyperintense signal and/or T1 gadolinium enhancement...
Source: Pediatric Neurology - October 13, 2023 Category: Neurology Authors: Amy C. Buck, Sapna Khemka, Kailey A. Remien, Francesca Carra, Ian Rossman, Kelsey Merison Tags: Short Communication Source Type: research
Neuroinfectious Diseases in Children: Pathophysiology, Outcomes, and Global Challenges
Pathogens with affinity for the central nervous system (CNS) in children are diverse in their mechanisms of infecting and attacking the brain. Infections can reach the CNS via hematogenous routes, transneurally thereby avoiding the blood-brain barrier, and across mucosal or skin surfaces. Once transmission occurs, pathogens can wreak havoc both by direct action on host cells and via an intricate interplay between the protective and pathologic actions of the host's immune system. Pathogen prevalence varies depending on region, and susceptibility differs based on epidemiologic factors such as age, immune status, and genetics...
Source: Pediatric Neurology - October 10, 2023 Category: Neurology Authors: Hanalise V. Huff, Molly Wilson-Murphy Tags: Research Paper Source Type: research
Neuroinfectious Diseases in Children: Pathophysiology, Outcomes and Global Challenges
Pathogens with affinity for the central nervous system (CNS) in children are diverse in their mechanisms of infecting and attacking the brain. Infections can reach the CNS via hematogenous routes, trans-neurally thereby avoiding the blood brain barrier, and across mucosal or skin surface. Once transmission occurs, pathogens can wreak havoc both by direct action on host cells as well as via an intricate interplay between the protective and pathologic actions of the host ’s immune system. Pathogen prevalence varies depending on region, and susceptibility differs based on epidemiologic factors such as age, immune status and...
Source: Pediatric Neurology - October 10, 2023 Category: Neurology Authors: Hanalise V. Huff, Molly Wilson-Murphy Source Type: research
Factors Associated with Underutilization of Genetic Testing in Autism Spectrum Disorders
To identify patient and provider factors associated with low completion of genetic testing for autism spectrum disorder (ASD). (Source: Pediatric Neurology)
Source: Pediatric Neurology - October 9, 2023 Category: Neurology Authors: Nicolas J. Abreu, Madeline Chiujdea, Shanshan Liu, Bo Zhang, Sarah J. Spence Tags: Research Paper Source Type: research
Editorial Board and Masthead
(Source: Pediatric Neurology)
Source: Pediatric Neurology - October 5, 2023 Category: Neurology Source Type: research
Table of Contents
(Source: Pediatric Neurology)
Source: Pediatric Neurology - October 5, 2023 Category: Neurology Source Type: research
Pediatric Neurology in the Post-Roe Era
Dismantling the precedent previously established by Roe v Wade has had far-reaching consequences. Since the Supreme Court ’s ruling in Dobbs v Jackson Women’s Health Organization, abortion bans or restrictions have been enacted across half of the country [1,2]. The purpose of this editorial is to discuss the practical implications of the Dobbs decision for pediatric neurologists, our patients, and their families/ca regivers. As a microcosm of our polarized society, the pediatric neurology community likely contains a multitude of views on abortion and its regulation. (Source: Pediatric Neurology)
Source: Pediatric Neurology - October 5, 2023 Category: Neurology Authors: Dawn Gano, Sonika Agarwal, Yasmin Khakoo Tags: Editorial Source Type: research
Moyamoya Angiopathy: An underdiagnosed cause of ischemic stroke in a Tunisian pediatric cohort
Moyamoya angiopathy is a rare cerebral vasculopathy and an underdiagnosed cause of arterial ischemic stroke in children. We aim to report the clinical and radiological presentations in a Tunisian pediatric cohort. (Source: Pediatric Neurology)
Source: Pediatric Neurology - October 4, 2023 Category: Neurology Authors: Wafa Bouchaala, Sirine Laroussi, Yosra Mzid, Imen Maaloul, Olfa Jallouli, Salma Zouari, Sihem Ben Nsir, Zeineb Mnif, Fatma Kammoun, Chahnez Triki Tags: Short Communication Source Type: research
Role of Perampanel in the Management of Pediatric Epilepsies in Asia: Expert Opinion
Management of pediatric epilepsies poses unique challenges around diagnosis, treatment options, comorbidities, and the potential for these factors to interact with processes in the developing brain. In pediatric patients, broad-spectrum antiseizure medications (ASMs) with minimal potential for adverse events (AEs) and limited impact on cognition and behavior are preferred. Perampanel is a first-in-class ASM with broad-spectrum efficacy, a tolerable safety profile, minimal negative impact on cognitive function, and other features that make it a viable treatment option in this patient population. (Source: Pediatric Neurology)
Source: Pediatric Neurology - October 3, 2023 Category: Neurology Authors: Wang-Tso Lee, Derrick Wei Shih Chan, Sheffali Gulati, Surachai Likasitwattanakul, Byung Chan Lim, Akihisa Okumura, Benilda Sanchez-Gan, Yi Wang, Kam Tim Liu Tags: Review Article Source Type: research
Role of perampanel in the management of paediatric epilepsies in Asia: expert opinion
Management of paediatric epilepsies poses unique challenges around diagnosis, treatment options, comorbidities and the potential for these factors to interact with processes in the developing brain. In paediatric patients, broad-spectrum anti-seizure medications (ASMs) with minimal potential for adverse events (AEs) and limited impact on cognition and behaviour are preferred. Perampanel is a first-in-class ASM with broad-spectrum efficacy, a tolerable safety profile, minimal negative impact on cognitive function and other features that make it a viable treatment option in this patient population. (Source: Pediatric Neurology)
Source: Pediatric Neurology - October 3, 2023 Category: Neurology Authors: Wang-Tso Lee, Derrick Wei Shih Chan, Sheffali Gulati, Surachai Likasitwattanakul, Byung Chan Lim, Akihisa Okumura, Benilda Sanchez-Gan, Yi Wang, Kam Tim Liu Tags: Review Article Source Type: research
Epilepsy outcome and pathology analysis for ganglioglioma: A series of 51 pediatric patients
The overall outcome of GG and epilepsy in children is optimistic, and the outcome is not closely related to the presence of BRAF V600E mutation and CD34 (+). The FCD surrounding GG could be type I or type II. Incomplete resection of surrounding FCD has the risk of unsatisfactory control of epilepsy. Children with the BRAF V600E mutation may be prone to early-onset epilepsy. The expression of CD34 is more likely to be detected in children with older age and a long duration of epilepsy. (Source: Pediatric Neurology)
Source: Pediatric Neurology - October 2, 2023 Category: Neurology Authors: Qingzhu Liu, Lixin Cai, Yu Sun, Yao Wang, Hao Yu, Chang Liu, Hui Wang, Shuang Zhang, Jian Gong Tags: Research Paper Source Type: research
Lacosamide for the Treatment of Seizures in Neonates and Infants: A Retrospective Assessment of Efficacy and Tolerability
A retrospective study was conducted to assess the safety and efficacy of lacosamide in children less than 24 months of age. Patients were included if they were50% reduction in seizure burden. (Source: Pediatric Neurology)
Source: Pediatric Neurology - September 30, 2023 Category: Neurology Authors: Abdullah B. Shoaib, Michelle Machie, Jennifer M. Thomas, Alison Dolce Tags: Research Paper Source Type: research
Epilepsy and Encephalopathy
Epilepsy encompasses more than the predisposition to unprovoked seizures. In children, epileptic activity during (ictal) and between (interictal) seizures has the potential to disrupt normal brain development. The term “epileptic encephalopathy (EE)” refers to the concept that such abnormal activity may contribute to cognitive and behavioral impairments beyond that expected from the underlying cause of the epileptic activity. (Source: Pediatric Neurology)
Source: Pediatric Neurology - September 28, 2023 Category: Neurology Authors: Tristan T. Sands, Jennifer N. Gelinas Tags: Articles from the Special Issue on “Neurological Diseases Affect the Developing Brain”, Edited by Grace Gombolay and Melissa Walker Source Type: research
“Epilepsy & Encephalopathy ”
Epilepsy is defined by the International League Against Epilepsy (ILAE) as “an enduring predisposition to generate epileptic seizures and by the neurobiologic, cognitive, psychological, and social consequences of this condition.”1 As the definition recognizes, the neurophysiological dysfunction that leads to unprovoked seizures in persons with epilepsy (PWE) often occu rs not in isolation but alongside other functional impairments. Indeed, these comorbidities can be the main drivers of quality of life for PWE. (Source: Pediatric Neurology)
Source: Pediatric Neurology - September 28, 2023 Category: Neurology Authors: Tristan T. Sands, Jennifer N. Gelinas Source Type: research
