Docosahexaenoic Acid Plus Piracetam Versus Piracetam Alone for Treatment of Breath-Holding Spells in Children: A Randomized Clinical Trial
This study aimed to compare the efficacy of docosahexaenoic acid (DHA) plus piracetam versus piracetam alone in reducing the frequency and severity of BHS in infants and preschool children. (Source: Pediatric Neurology)
Source: Pediatric Neurology - August 8, 2023 Category: Neurology Authors: Abeer Salamah, Amira Hamed Darwish Tags: Research Paper Source Type: research

Early surgery for Ohtahara syndrome associated with cortical dysplasia
Ohtahara syndrome, also known as early infantile epileptic encephalopathy with suppression-burst, is characterized by intractable seizures and severe neurodevelopmental retardation. This electroclinical syndrome is often associated with structural brain lesions, whereas surgical treatment has been infrequently employed. Here we report an infant with Ohtahara syndrome associated with posterior quadrant cortical dysplasia, in whom early epilepsy surgery brought about immediate seizure remission and subsequent developmental progress. (Source: Pediatric Neurology)
Source: Pediatric Neurology - August 8, 2023 Category: Neurology Authors: Wei-Chen Lee, Hsin-Hung Chen, Tsui-Fen Yang, Tse-Hao Lee, Ting-Rong Hsu, Chien Chen, Kai-Ping Chang, Shang-Yeong Kwan, Wei-Sheng Lin Tags: Short Communication Source Type: research

Deep Brain Stimulation for Dystonia: Experience of a Moroccan University Hospital
In this study, we aim to report the experience of Ibn Rochd University Hospital in the treatment of dystonia using DBS of the globus pallidus internus, which represents an exceptional challenge for a developing country such as Morocco. (Source: Pediatric Neurology)
Source: Pediatric Neurology - August 8, 2023 Category: Neurology Authors: Hicham El Otmani, Bouchra El Moutawakil, Mohamed Daghi, Omar Fadili, Ilham Slassi, Abdessamad El Azhari, Fatiha Essodegui, Lahoucine Barrou, Mohammed Abdoh Rafai, Abdelhakim Lakhdar Tags: Short Communication Source Type: research

Acquired Brain Injuries Across the Perinatal Spectrum: Pathophysiology and Emerging Therapies
The development of the central nervous system can be directly disrupted by a variety of acquired factors, including infectious, inflammatory, hypoxic-ischemic, and toxic insults. Influences external to the fetus also impact neurodevelopment, including placental health, maternal comorbidities, adverse experiences, environmental exposures, and social determinants of health. Acquired perinatal brain insults tend to affect the developing brain in a stage-specific manner that reflects the susceptible cell types, developmental processes, and risk factors present at the time of the insult. (Source: Pediatric Neurology)
Source: Pediatric Neurology - August 7, 2023 Category: Neurology Authors: Jeffrey B. Russ, Bridget E.L. Ostrem Source Type: research

Pediatric Neurology Trainee Award
Each year, the journal is proud to recognize important research from those at a trainee level (i.e., medical student, resident, PhD candidate, fellow). To this end, the Pediatric Neurology Trainee Award Committee has selected this year's awardee from the pool of articles published in 2022 with a trainee contributing as first author. The selection of the award winner is based on the importance of their scientific contribution, quality of research, and overall manuscript preparation. (Source: Pediatric Neurology)
Source: Pediatric Neurology - August 4, 2023 Category: Neurology Authors: J. Nicholas Brenton, Lauren A. Beslow, Audrey C. Brumback, Jay Desai, Francis J. DiMario, Yvonne Wu Tags: Editorial Source Type: research

Editorial Board and Masthead
(Source: Pediatric Neurology)
Source: Pediatric Neurology - August 4, 2023 Category: Neurology Source Type: research

Table of Contents
(Source: Pediatric Neurology)
Source: Pediatric Neurology - August 4, 2023 Category: Neurology Source Type: research

Measuring the Efficacy of Thymectomy for Pediatric Myasthenia Gravis Across Tertiary Children's Hospitals
Thymectomy is a treatment for pediatric myasthenia gravis, but the efficacy over time is unknown. Multi-institutional data are also lacking. Therefore, the objective of this study was to determine the efficacy of thymectomy for pediatric myasthenia gravis using medication burden and health care utilization as proxies for disease severity. (Source: Pediatric Neurology)
Source: Pediatric Neurology - August 4, 2023 Category: Neurology Authors: Christopher De Boer, Suhail Zeineddin, Katherine Ott, Andrew Hu, Samuel Linton, Michael George, Vamshi K. Rao, Fizan Abdullah, Anthony Chin, Seth D. Goldstein Tags: Research Paper Source Type: research

Measuring the Efficacy of Thymectomy for Pediatric Myasthenia Gravis Across Tertiary Children ’s Hospitals
Thymectomy is a treatment for pediatric myasthenia gravis, but the efficacy over time is unknown. Multi-institutional data are also lacking. Therefore, the objective of this study was to determine the efficacy of thymectomy for pediatric myasthenia gravis using medication burden and healthcare utilization as proxies for disease severity. (Source: Pediatric Neurology)
Source: Pediatric Neurology - August 4, 2023 Category: Neurology Authors: Christopher De Boer, Suhail Zeineddin, Katherine Ott, Andrew Hu, Samuel Linton, Michael George, Vamshi K. Rao, Fizan Abdullah, Anthony Chin, Seth D. Goldstein Tags: Research Paper Source Type: research

Sclerotic Bone Lesions as a Clue in the Diagnosis of Three Generations of Tuberous Sclerosis Complex: Case Report and Review of Literature
Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder that can involve multiple organ systems. Diagnosis is based on independent clinical diagnostic criteria and genetic diagnostic criteria (pathogenic variants on TSC1 and TSC2 genes). To make a definitive diagnosis can be especially difficult in oligosymptomatic or asymptomatic patients and in those patients with genetic variants of uncertain significance (VUS). Early diagnosis and lifelong surveillance are paramount to avoid morbidity and potentially life-threatening complications. (Source: Pediatric Neurology)
Source: Pediatric Neurology - August 3, 2023 Category: Neurology Authors: Helena Iznardo, Sara Bernal, Susana Boronat, Esther Ro é Tags: Clinical Observations Source Type: research

Improving Methods of Diagnosis and Treatment of Posthemorrhagic Hydrocephalus in Young Children
One of the most severe perinatal lesions of the central nervous system is intraventricular hemorrhage, which often, especially in prematurely born babies with low gestational age and body weight, is complicated by posthemorrhagic hydrocephalus, which requires good early diagnosis and timely treatment. The purpose of the article is to improve the methods  of diagnosis and treatment of posthemorrhagic hydrocephalus in young children. (Source: Pediatric Neurology)
Source: Pediatric Neurology - August 3, 2023 Category: Neurology Authors: Assem Shakeyeva, Vasilyi Kuzmin, Vasilyi Lozovoy Tags: Research Paper Source Type: research

Sclerotic bone lesions as a clue in diagnosis of three generations of tuberous sclerosis complex: case report and review of literature
Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder that can involve multiple organ systems. Diagnosis is based on independent clinical diagnostic criteria and genetic diagnostic criteria (pathogenic variants on TSC1 and TSC2 genes). To make a definitive diagnosis can be especially difficult in oligosymptomatic or asymptomatic patients, and in those patients with genetic variants of uncertain significance (VUS). Early diagnosis and lifelong surveillance are paramount to avoid morbidity and potentially life-threatening complications. (Source: Pediatric Neurology)
Source: Pediatric Neurology - August 3, 2023 Category: Neurology Authors: H. Iznardo, S. Bernal, S. Boronat, E. Ro é Tags: Short Communication Source Type: research

Improving Methods of Diagnosis and Treatment of Post-Hemorrhagic Hydrocephalus in Young Children
One of the most severe perinatal lesions of the central nervous system is intraventricular haemorrhage, which often, especially in prematurely born babies with low gestational age and body weight, is complicated by posthaemorrhagic hydrocephalus, which requires good early diagnosis and timely treatment. (Source: Pediatric Neurology)
Source: Pediatric Neurology - August 3, 2023 Category: Neurology Authors: Assem Shakeyeva, Vasilyi Kuzmin, Vasilyi Lozovoy Tags: Research Paper Source Type: research

Life on the Frontlines: Caregiver Experience of Pediatric Cerebrospinal Shunt Malfunction
We aimed to characterize the caregiver experience in the detection and evaluation of pediatric cerebrospinal shunt malfunction. (Source: Pediatric Neurology)
Source: Pediatric Neurology - August 1, 2023 Category: Neurology Authors: Rebecca A. Dorner, Renee D. Boss, Turaj Vazifeda, Erin Johnson, Amanda Garz ón, Monica E. Lemmon Tags: Research Paper Source Type: research

Epidemiology and Outcomes of Cerebral Edema in Hospitalized Children
The objective of this study was to describe the prevalence, underlying causes, and outcomes of cerebral edema in hospitalized children. (Source: Pediatric Neurology)
Source: Pediatric Neurology - August 1, 2023 Category: Neurology Authors: Leanna Laor, Prithvi Sendi, Paul Martinez, Balagangadhar R. Totapally Tags: Research Paper Source Type: research