Deep Learning to Optimize Magnetic Resonance Imaging Prediction of Motor Outcomes After Hypoxic-Ischemic Encephalopathy
Magnetic resonance imaging (MRI) is the gold standard for outcome prediction after hypoxic-ischemic encephalopathy (HIE). Published scoring systems contain duplicative or conflicting elements. (Source: Pediatric Neurology)
Source: Pediatric Neurology - September 7, 2023 Category: Neurology Authors: Zachary A. Vesoulis, Shamik B. Trivedi, Hallie F. Morris, Robert C. McKinstry, Yi Li, Amit M. Mathur, Yvonne W. Wu Tags: Research Paper Source Type: research
Deep learning to optimize MRI prediction of motor outcomes after HIE
MRI is the gold standard for outcome prediction after hypoxic-ischemic encephalopathy (HIE). Published scoring systems contain duplicative or conflicting elements. (Source: Pediatric Neurology)
Source: Pediatric Neurology - September 7, 2023 Category: Neurology Authors: Zachary A. Vesoulis, Shamik B. Trivedi, Hallie F. Morris, Robert C. McKinstry, Yi Li, Amit M. Mathur, Yvonne W. Wu Tags: Research Paper Source Type: research
Does Botulinum toxin injection exacerbate sarcopenia and bone mass in individuals with cerebral palsy?
Botulinum toxin (BoNT) causes sarcopenia and low bone mass in animal studies. Whether such effect exists in children and adolescents with spastic cerebral palsy (CP) is not clear yet. To investigate the influences of BoNT on grip strength, skeletal muscle mass, and bone mineral density (BMD) in children and adolescents with spastic CP, we conducted this uncontrolled longitudinal study. (Source: Pediatric Neurology)
Source: Pediatric Neurology - September 7, 2023 Category: Neurology Authors: Yu-Chi Su, Meng-Che Tsai, Chung-Ying Lin, Jen Yang, Pei-Shan Wu, Hsiu-Ching Yang, Yu-Ching Lin Tags: Research Paper Source Type: research
Monogenic Causes of Cerebrovascular Disease in Childhood: A Case Series
Despite an increase in the number of genes associated with pediatric stroke, imaging phenotypes in children have not been well reported. Guidelines are needed to facilitate identification and treatment of patients with monogenic causes of cerebrovascular disorders. (Source: Pediatric Neurology)
Source: Pediatric Neurology - September 6, 2023 Category: Neurology Authors: Bridget E.L. Ostrem, Deena Godfrey, Paul Caruso, Patricia Musolino Tags: Research Paper Source Type: research
Quality of Life in Angelman Syndrome: A Caregivers' Survey
A web-based survey was distributed to caregivers of individuals with Angelman Syndrome (AS) to characterize motor function, cannabidiol (CBD) use, and factors affecting quality of life (QOL).One hundred eighty three individuals with AS (mean age of 19.4 ± 13.4 years; 48.1% female): 72% had sleep problems, 80% had seizures, and 32% had ≥1 ED visits in the previous year. Eighty-eight percent were ambulatory (with or without assistance), and half experienced falls, 10.4% resulting in serious injury. (Source: Pediatric Neurology)
Source: Pediatric Neurology - September 4, 2023 Category: Neurology Authors: Nancy Y. Xia, Mitzie L. Grant, Nicholas L. Benjamin, Ignacio Valencia Tags: Research Paper Source Type: research
Editorial Board and Masthead
(Source: Pediatric Neurology)
Source: Pediatric Neurology - September 2, 2023 Category: Neurology Source Type: research
Table of Contents
(Source: Pediatric Neurology)
Source: Pediatric Neurology - September 2, 2023 Category: Neurology Source Type: research
Limitations of Multigene Next-Generation Sequencing Panel for “Cerebral Palsy” Phenotype and Other Complex Movement Disorders
We report one such case where a patient with spastic hemiplegia underwent a long diagnostic journey before genetic diagnosis was established with exome sequencing and appropriate management was started. (Source: Pediatric Neurology)
Source: Pediatric Neurology - September 2, 2023 Category: Neurology Authors: Marina Eskandar, Laura Tochen, Mi Ran Shin, Bennett Lavenstein, Meira Meltzer, Andrea Gropman, Kuntal Sen Tags: Clinical Observations Source Type: research
Limitations of Multi-Gene Next Generation Sequencing Panel for ‘Cerebral Palsy’ Phenotype and other Complex Movement Disorders
We report one such case where a patient with spastic hemiplegia underwent a long diagnostic journey before genetic diagnosis was established with exome sequencing and appropriate management was started. (Source: Pediatric Neurology)
Source: Pediatric Neurology - September 2, 2023 Category: Neurology Authors: Marina Eskandar, Laura Tochen, Mi Ran Shin, Bennett Lavenstein, Meira Meltzer, Andrea Gropman, Kuntal Sen Tags: Short Communication Source Type: research
Intrafamilial phenotypic overlap with distinct genotypes
We read with interest the article titled “A case series of patients with MYBPC1 gene variants featuring undulating tongue movements as myogenic tremor” by Uneoka et al. that documents phenotypic variability in 3 family members with identical heterozygous c.742G>A (p.Glu248Lys) variants.1 While intrafamilial variability of phenotype due to identical genotype in neurogenetic disorders has been well-documented in the literature, we would like to describe here a family with phenotypic overlap among members but with distinct genotypes. (Source: Pediatric Neurology)
Source: Pediatric Neurology - August 31, 2023 Category: Neurology Authors: Jay Desai, Eesha Singh Tags: Correspondence Source Type: research
Perinatal Hypoxic-Ischemic Encephalopathy: Incidence over Time Within a Modern US Birth Cohort
Recent studies suggest that the incidence of perinatal hypoxic-ischemic encephalopathy (HIE) may be increasing in developed countries. However, this observed increase may be due to increased ascertainment and increased treatment with therapeutic hypothermia rather than an increase in disease burden. In a US population-based cross-sectional study, we determined the incidence of perinatal HIE over time. (Source: Pediatric Neurology)
Source: Pediatric Neurology - August 30, 2023 Category: Neurology Authors: Marie-Coralie Cornet, Michael Kuzniewicz, Aaron Scheffler, Heather Forquer, Emily Hamilton, Thomas B. Newman, Yvonne W. Wu Tags: Research Paper Source Type: research
Genetic Neuromuscular Disorders and Health Services Access, Utilization, and Needs in Zambia
Medical and rehabilitative advances increasingly transform management of rare genetic neuromuscular diseases (GNMDs) for children in the global north. Lack of information about GNMDs and related healthcare needs in sub-Saharan Africa threatens to widen pre-existing health disparities. (Source: Pediatric Neurology)
Source: Pediatric Neurology - August 30, 2023 Category: Neurology Authors: Musambo M. Kapapa, David R. Bearden, Somwe wa Somwe, Gretchen L. Birbeck, Gita Ramdharry, The ICGNMD Consortium, Michelle Kvalsund Tags: Research Paper Source Type: research
Structural Changes in the Brain on Magnetic Resonance Imaging in Malnourished Children: A Scoping Review of the Literature
This review was conducted to summarize the current evidence on the structural findings seen in brain MRI in malnourished children and the effect of optimized nutritional supplementation on brain development as studied through MRI. (Source: Pediatric Neurology)
Source: Pediatric Neurology - August 29, 2023 Category: Neurology Authors: Ahmed Ayaz, Imran Nisar, Ameer Muhammad, Kheezran Ahmed, Prem Chand, Fyezah Jehan Tags: Review Article Source Type: research
Pediatric Neuromuscular Diseases
The diagnostic and referral workflow for children with neuromuscular disorders is evolving, particularly as newborn screening programs are expanding in tandem with novel therapeutic developments. However, for the children who present with symptoms and signs of a potential neuromuscular disorders, anatomic localization, guided initially by careful history and physical examination, continues to be the cardinal initial step in the diagnostic evaluation. It is important to consider whether the localization is more likely to be in the lower motor neuron, peripheral nerve, neuromuscular junction, and muscle. (Source: Pediatric Neurology)
Source: Pediatric Neurology - August 29, 2023 Category: Neurology Authors: Geetanjali Rathore, Peter B. Kang Source Type: research
Leveraging ChatGPT in the Pediatric Neurology Clinic: Practical Considerations for Use to Improve Efficiency and Outcomes
In the current healthcare environment, clinicians juggle myriad responsibilities that extend beyond direct patient care. Among these are administrative tasks that, while critical, can be time-consuming and potentially detract from patient care. In pediatric neurology, these challenges are often amplified, given the complexity of the conditions encountered and the need for nuanced, individualized care plans.1 Large Language Models (LLMs) like ChatGPT can play a significant role in alleviating these burdens, thereby enhancing efficiency and ultimately improving patient care. (Source: Pediatric Neurology)
Source: Pediatric Neurology - August 28, 2023 Category: Neurology Authors: Cemal Karakas, Dylan Brock, Arpita Lakhotia Tags: Opinion Paper Source Type: research
