The Association of Therapeutic Hypothermia With Seizure Burden in Neonates With Hypoxic-Ischemic Encephalopathy
To compare seizure burden between newborn infants treated with therapeutic hypothermia (TH) and those that were not and to compare the need for antiseizure medications (ASM) in a cohort of infants who were diagnosed with neonatal hypoxic-ischemic encephalopathy (HIE). (Source: Pediatric Neurology)
Source: Pediatric Neurology - December 12, 2023 Category: Neurology Authors: Noa Arad, Irina Meledin, Itai Hazan, Iris Noyman, Kyla A. Marks, Ramy Abramsky, Eilon Shany Tags: Research Paper Source Type: research
The Association of Therapeutic Hypothermia with Seizure burden in Neonates with Hypoxic Ischemic encephalopathy
To compare seizure burden between newborn infants treated with therapeutic hypothermia (TH) and those that did not and to compare the need for antiseizure medications (ASM) in a cohort of infants who were diagnosed with neonatal hypoxic ischemic encephalopathy (HIE) (Source: Pediatric Neurology)
Source: Pediatric Neurology - December 12, 2023 Category: Neurology Authors: Noa Arad, Irina Meledin, Itai Hazan, Iris Noyman, Kyla A. Marks, Ramy Abramsky, Eilon Shany Tags: Research Paper Source Type: research
Disruption of cerebellar granular layer as a consequence of germinal-matrix intraventricular hemorrhage (GMH-IVH) in extreme prematurity: an acute direct mechanism too?
In this report, we illustrate how this prevalent complication associated with prematurity may induce secondary cerebellar cortical damage. (Source: Pediatric Neurology)
Source: Pediatric Neurology - December 12, 2023 Category: Neurology Authors: Andrea Calandrino, Diego Minghetti, Giorgia Brigati, Alessandro Parodi, Paolo Nozza, Luca Antonio Ramenghi Tags: Short Communication Source Type: research
Resting-State Functional Magnetic Resonance Imaging Network Association With Mortality, Epilepsy, Cognition, and Motor Two-Year Outcomes in Suspected Severe Neonatal Acute Brain Injury
In acute brain injury of neonates, resting-state functional magnetic resonance imaging (MRI) (RS) showed incremental association with consciousness, mortality, cognitive and motor development, and epilepsy, with correction for multiple comparisons, at six months postgestation in neonates with suspected acute brain injury (ABI). However, there are relatively few developmental milestones at six months to benchmark against, thus, we extended this cohort study to evaluate two-year outcomes. (Source: Pediatric Neurology)
Source: Pediatric Neurology - December 9, 2023 Category: Neurology Authors: Varina L. Boerwinkle, Iliana Manj ón, Bethany L. Sussman, Alyssa McGary, Lucia Mirea, Kirsten Gillette, Jordan Broman-Fulks, Emilio G. Cediel, Martin Arhin, Senyene E. Hunter, Sarah N. Wyckoff, Kimberlee Allred, Deborah Tom Tags: Research Paper Source Type: research
Resting State fMRI Network Association with Mortality, Epilepsy, Cognition, and Motor Two-Year Outcomes in Suspected Severe Neonatal Acute Brain Injury
In acute brain injury of neonates, resting-state functional MRI (RS) showed that disrupted connectivity was incrementally associated with consciousness, mortality, cognitive and motor development, and epilepsy, with correction for multiple comparisons, at 6 months post-gestation in neonates with suspected acute brain injury (ABI). However, there are relatively few developmental milestones at 6 months to benchmark against, and it is more difficult to determine at this younger age if behaviorally an infant is having seizures to raise suspicion for epilepsy. (Source: Pediatric Neurology)
Source: Pediatric Neurology - December 9, 2023 Category: Neurology Authors: Varina L. Boerwinkle, Iliana Manj ón, Bethany L. Sussman, Alyssa McGary, Lucia Mirea, Kirsten Gillette, Jordan Broman-Fulks, Emilio G. Cediel, Martin Arhin, Senyene E. Hunter, Sarah N. Wyckoff, Kimberlee Allred, Deborah Tom Tags: Research Paper Source Type: research
Impact of an Interactive, Animation-Based Electroencephalography Curriculum on Learner Confidence and Knowledge
There is a national need for innovative electroencephalography (EEG) education with efficacy evaluated by rigorous statistical analysis. We created a dynamic, online resource that includes a series of animated videos at a single academic medical center. (Source: Pediatric Neurology)
Source: Pediatric Neurology - December 7, 2023 Category: Neurology Authors: Andrew Silverman, Sarah Hilgenberg, Sa Shen, Emily M. Spelbrink, Jenna Klotz Tags: Research Paper Source Type: research
Impact of an Interactive, Animation-Based Electroencephalography (EEG) Curriculum on Learner Confidence and Knowledge
There is a national need for innovative EEG education with efficacy evaluated by rigorous statistical analysis. We created a dynamic, expert-adjudicated online resource that includes a series of animated videos at a single academic medical center. For the animations and interactive module, we used VideoScribe and Articulate ©, respectively. The module comprised three chapters: (1) Origin& Technical Aspects of EEG, (2) Normal Adult EEG in Wakefulness& Sleep, (3) Abnormal EEG, with appendices on artifacts, variants, activation procedures, seizure/epilepsy classification, and neonatal/pediatric EEG. (Source: Pediatric Neurology)
Source: Pediatric Neurology - December 7, 2023 Category: Neurology Authors: Andrew Silverman, Sarah Hilgenberg, Sa Shen, Emily M. Spelbrink, Jenna Klotz Tags: Research Paper Source Type: research
Childhood Apraxia of Speech: Exploring Gluten Sensitivity and Changes in Glutamate and Gamma-Aminobutyric Acid Plasma Levels
Individuals with childhood apraxia of speech (CAS) were reported to have genetic variations related to gluten sensitivity and some neuroanatomic changes, which could be associated with alterations in neurotransmitters levels such as glutamate and gamma-aminobutyric acid (GABA). The aim was to measure the levels of antigliadin immunoglobulin A (IgA) antibody, glutamate, and GABA in the plasma of children with CAS compared with children with delayed language development (DLD) and neurotypical (NT) children. (Source: Pediatric Neurology)
Source: Pediatric Neurology - December 6, 2023 Category: Neurology Authors: Neveen Hassan Nashaat, Iman Elrouby, Hala M. Zeidan, Ayman Kilany, Ehab Ragaa Abdelraouf, Adel F. Hashish, Hebatallah Sherif Abdelhady, Mohamed M. ElKeblawy, Mariam S. Shadi Tags: Research Paper Source Type: research
Childhood Apraxia of Speech: Exploring Gluten Sensitivity and Changes in Glutamate and GABA Plasma Levels
Individuals with childhood apraxia of speech (CAS) were reported to have genetic variations related to gluten sensitivity and some neuroanatomical changes, which could be associated with alterations in neurotransmitters ’ levels such as glutamate and gamma amino butyric acid (GABA). The aim was to measure the levels of anti-gliadin IgA antibody, glutamate, and GABA in the plasma of children with CAS compared to children with delayed language development (DLD) and neurotypicals (NT). (Source: Pediatric Neurology)
Source: Pediatric Neurology - December 6, 2023 Category: Neurology Authors: Neveen Hassan Nashaat, Iman Elrouby, Hala M. Zeidan, Ayman Kilany, Ehab Ragaa Abdelraouf, Adel F. Hashish, Hebatallah Sherif Abdelhady, Mohamed M. ElKeblawy, Mariam S. Shadi Tags: Research Paper Source Type: research
Transcranial Doppler in Childhood Moyamoya: an Underutilized Tool?
Children with moyamoya are at high risk for incident and recurrent stroke. Transcranial Doppler (TCD) ultrasound is an attractive option to screen high-risk populations for moyamoya and to provide stroke risk stratification information due to its safety and cost effectiveness. We used TCD to evaluate cerebral blood flow velocities in children with presurgical moyamoya and to determine if velocities differ between children with stable versus unstable disease. (Source: Pediatric Neurology)
Source: Pediatric Neurology - December 6, 2023 Category: Neurology Authors: Lisa R. Sun, John R. Gatti, Syed Ameen Ahmad, Noah Burton, Wendy Ziai, Rebecca F. Gottesman, Lori C. Jordan Tags: Short Communication Source Type: research
Child Neurology and Neurodevelopmental Disabilities Program Directors ’ Opinions on Preference Signaling in the 2023-2024 NRMP Match: A Survey
Major changes in the residency match process occurred as a result of or concurrent with the COVID-19 pandemic. Most importantly traditional in-person interviews were replaced by virtual interviews1,2. The United States Medical Licensing Exam (USMLE) Step 2 Clinical Skills exam was also discontinued by the Association of American Medical Colleges (AAMC) because of the pandemic. Occurring just prior to the pandemic in the US was the decision to convert the USMLE Step 1 quantitative scoring system to pass-fail3,4. (Source: Pediatric Neurology)
Source: Pediatric Neurology - December 5, 2023 Category: Neurology Authors: Quinton Mandle, Margie Ream Tags: Research Paper Source Type: research
Developmental skills and neurorehabilitation for children with Batten disease: A Retrospective chart review of a comprehensive Batten clinic
Batten disease is a rare, progressive neurogenetic disorder comprised of 13 genotypes that often presents in childhood. Children present with seizures, vision loss, and developmental regression. Neurorehabilitation services (i.e. physical therapy (PT), occupational therapy (OT), and speech-language therapy (SLP)) can help improve quality of life for children and their families. Due to the rarity of Batten disease, there are no standardized clinical recommendations or outcome assessments. (Source: Pediatric Neurology)
Source: Pediatric Neurology - December 5, 2023 Category: Neurology Authors: Rachel Bican, Virginia Goddard, Nicolas Abreu, Danielle Peifer, Andrea Basinger, Michelle Sveda, Kelly Tanner, Emily C. de los Reyes Tags: Research Paper Source Type: research
Assessing needs and perceptions of research participation in pediatric-onset multiple sclerosis: a multi-stakeholder survey
Patient-powered research networks (PPRNs) for autoimmune disease are widely used in the adult population to recruit patients and drive patient-centered research, but few have included pediatric patients. (Source: Pediatric Neurology)
Source: Pediatric Neurology - December 3, 2023 Category: Neurology Authors: Claudia Gambrah-Lyles, Varun Kannan, Tim Lotze, Aaron Abrams, Teri Schreiner, Moses Rodriguez, T. Charles Casper, John W. Rose, Mark P. Gorman, Tanuja Chitnis, Sarah Loud, Yolanda Wheeler, Soe Mar, US Network of Pediatric MS Centers Tags: Research Paper Source Type: research
Delayed Posthypoxic Leukoencephalopathy: An Unusual Consequence of Prolonged Hypoxia
A four-year-old boy was brought to our hospital after an accidental drowning in the household freshwater tank while playing. He was in cardiac arrest at arrival, and cardiopulmonary resuscitation (CPR) was initiated. Return of spontaneous circulation was achieved after three cycles of CPR, approximately 20 minutes from the time of the drowning. The Glasgow Coma Scale (GCS) was E4VTM5 four hours postresuscitation, and the child started having nonpurposeful eye opening and spontaneous movements of extremities. (Source: Pediatric Neurology)
Source: Pediatric Neurology - December 2, 2023 Category: Neurology Authors: Sujatha Manjunathan, Sai Saranya Kanakam, Smily Sharma, Sarbesh Tiwari, Daisy Khera, Lokesh Saini Tags: Short Communication Source Type: research
Delayed post-hypoxic leukoencephalopathy – An unusual consequence of prolonged hypoxia
A 4-year-old boy was brought to our hospital after an accidental drowning in the household freshwater tank while playing. He was in cardiac arrest at arrival, and cardiopulmonary resuscitation (CPR) was initiated. Return of spontaneous circulation was achieved after three cycles of CPR, approximately twenty minutes from the time of the drowning. The Glasgow coma scale (GCS) was E4VTM5 4 hours post-resuscitation, and the child started having non-purposeful eye-opening and spontaneous movements of extremities. (Source: Pediatric Neurology)
Source: Pediatric Neurology - December 2, 2023 Category: Neurology Authors: Sujatha Manjunathan, Sai Saranya Kanakam, Smily Sharma, Sarbesh Tiwari, Daisy Khera, Lokesh Saini Tags: Short Communication Source Type: research
