Acknowledgement to Reviewers
Pathobiology 2021;88:444 (Source: Pathobiology)
Source: Pathobiology - November 23, 2021 Category: Pathology Source Type: research
Elevated Myeloperoxidase-DNA Complex Levels in Sera of Patients with IgA Vasculitis
Conclusion: The collective findings suggested that NETs are certainly involved in the pathogenesis of IgA vasculitis.Pathobiology (Source: Pathobiology)
Source: Pathobiology - November 23, 2021 Category: Pathology Source Type: research
The Lipopolysaccharide Mutant Re-LPS Is a Useful Tool for Detecting LPS Contamination in Rheumatoid Synovial Cell Cultures
Conclusion: To easily identify LPS contamination during routine experiments, our results suggest that Re-LPS is a better tool for rapid detection of LPS contamination compared to PMB and heat treatment.Pathobiology (Source: Pathobiology)
Source: Pathobiology - November 19, 2021 Category: Pathology Source Type: research
Increase in Chondroitin Sulfate and Decline in Arylsulfatase B May Contribute to Pathophysiology of COVID-19 Respiratory Failure
Conclusion: Decline in ARSB and resulting increases in CS may contribute to the pathobiology of COVID-19, as IL-6 does. Increased expression of CHSTs following activation of Ang-converting enzyme 2 may lead to buildup of CSs.Pathobiology (Source: Pathobiology)
Source: Pathobiology - November 17, 2021 Category: Pathology Source Type: research
Microsatellite Instability Is Rare in the Admixed Brazilian Population of Non-Small Cell Lung Cancer: A Cohort of 526 Cases
Conclusions: The frequency of MSI in Brazilian NSCLC patients is equally rare, a finding that is consistent with the current literature based on other populations such as Europeans, North Americans, and Asians.Pathobiology (Source: Pathobiology)
Source: Pathobiology - November 15, 2021 Category: Pathology Source Type: research
miR-31-5p/SOX4 Axis Affects Autophagy and Apoptosis of Chondrocytes by Regulating Extracellular Regulated Protein Kinase/Mechanical Target of Rapamycin Kinase Signalling
Conclusion: These results demonstrated that miR-31-5p enhanced survival and autophagy of OA chondrocytes through inactivation of mTORC1 via directly targeting SOX4, suggesting that miR-31-5p may play a protective role in OA progression.Pathobiology (Source: Pathobiology)
Source: Pathobiology - November 9, 2021 Category: Pathology Source Type: research
LRP1B Expression as a Putative Predictor of Response to Pegylated Liposomal Doxorubicin Treatment in Ovarian Cancer
Conclusion: Our results support a possible role of LRP1B as a predictor of response to PLD in patients with OC.Pathobiology (Source: Pathobiology)
Source: Pathobiology - October 22, 2021 Category: Pathology Source Type: research
Erratum
Pathobiology (Source: Pathobiology)
Source: Pathobiology - October 19, 2021 Category: Pathology Source Type: research
Frequency of Human Papillomavirus Detection in Chagasic Megaesophagus Associated or Not with Esophageal Squamous Cell Carcinoma
Conclusion: This is the first report of the presence of HPV DNA in CM associated with ESCC. HPV infection was more presence in megaesophagus lesions. Further studies are needed to confirm and better understand the role of persistent HPV infection in patients with CM.Pathobiology (Source: Pathobiology)
Source: Pathobiology - October 12, 2021 Category: Pathology Source Type: research
Unusual Mesenchymal Tumors of the Lower Gastrointestinal Tract: When You Hear Hoofbeats in the Night, Do Not Forget the Zebras
Conclusion: Mesenchymal tumors of the lower GI tract represent a highly heterogeneous group of lesions encompassing GISTs, lipomas, smooth muscle tumors (leiomyoma and leiomyosarcoma), GI schwannomas, inflammatory fibroid polyps, solitary fibrous tumors, and other unusual spindle cell tumors. Immunohistochemistry and, in selected cases, molecular biology remain a useful tool which, in addition to a meticulous study of the morphology, helps the pathologist in the tangled jungle of differential diagnosis.Pathobiology (Source: Pathobiology)
Source: Pathobiology - October 4, 2021 Category: Pathology Source Type: research
Phenotypic Differences of CD103 < sup > + < /sup > Tissue-Resident Memory T Cells Associated with Various Cancers
Conclusion: TRM cell abundance and phenotypes varied among CC, SC, RCC, and BC. Further studies regarding the functional differences of TRM associated with various tumors are warranted.Pathobiology (Source: Pathobiology)
Source: Pathobiology - September 30, 2021 Category: Pathology Source Type: research
High Inter- and Intratumoral Variability of Ki67 Labeling Index in Newly Diagnosed Prostate Cancer with High Gleason Scores
Conclusions: Our data demonstrate major inter- and intratumoral variability of Ki67 LI in high-grade PC with a surprisingly low Ki67 LI in a subset of cases. Further studies are necessary to explore the molecular basis and potential clinical implications of a paradoxically low proliferation rate in high-grade PC.Pathobiology (Source: Pathobiology)
Source: Pathobiology - September 23, 2021 Category: Pathology Source Type: research
The Clinical and Prognostic Significance of Protein Arginine Deiminases 2 and 4 in Colorectal Cancer
Conclusion: High expression of cytoplasmic PADI2, PADI4, and nuclear PADI4 were associated with an increase in overall survival.Pathobiology (Source: Pathobiology)
Source: Pathobiology - September 16, 2021 Category: Pathology Source Type: research
Multifocal Urinary Tract Metastasis of Colorectal Carcinoma
Conclusion: This rare case highlights the limitations of conventional histological processing, including immunohistochemistry, and it underlines the role of molecular investigations in certain circumstances.Pathobiology (Source: Pathobiology)
Source: Pathobiology - September 15, 2021 Category: Pathology Source Type: research
Human Immunodeficiency Virus Infection Promotes Human Papillomavirus-Mediated Anal Squamous Carcinogenesis: An Immunologic and Pathobiologic Review
Background: Anal squamous cell carcinoma (SCC) is a rare gastrointestinal malignancy with rising incidence, both in the United States and internationally. The primary risk factor for anal SCC is human papillomavirus (HPV) infection. However, there is a growing burden of disease in patients with human immunodeficiency virus (HIV) and HPV coinfection, with the incidence of anal SCC significantly increasing in this population. This is particularly true in HIV-infected men. The epidemiologic correlation between HIV-HPV coinfection and anal SCC is established; however, the immunologic mechanisms underlying this relationship are...
Source: Pathobiology - September 14, 2021 Category: Pathology Source Type: research
